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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Exploring effects of property variation on fragmentation of metal rings using a simple model

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defence Technology（防务技术） 2023年第5期23卷 1-7页

作者： j.d.Robson department of Materials The University of ManchesterManchesterM139PLUK

A simple finite element implementation of the Mott model for fragmentation of a thin walled ring has been implemented and used to explore the effect of local variations in fracture strain around the *** model has successfully reproduced the fragment size distributions previously reported,which follow a characteristic“Mott distribution”form,providing sufficient(1000)simulations are *** has been shown that this form is retained even when there are large differences in the random distribution of fracture strains or a different choice of function used to describe the fracture strain *** these cases,the strain rate has a much stronger effect than fracture strain distribution the on the average fragment size and fragment ***,for cases where there are a small number of local defects that strongly reduce the fracture strain at certain locations around the ring,the predicted fragment size distribution develops a bimodal *** is also the case for large but gradual variations in fracture strain with position around the *** results have implications for cases where a small number of large pre-existing defects exist,or processing has led to macrozones in the *** utility of a simple fast running model to study these cases is discussed.

关键词： Fragmentation Mott model Property variation

Secondary trading of airport slots:Issues and challenges

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Chinese journal of Aeronautics 2023年第12期36卷 1-12页

作者： Yanjun WANG Mengyin WANG Weishan XU Mark hansen College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 210016China Adam Smith Businesses School University of GlasgowGlasgow G128QQUK department of Civil and Environmental Engineering University of CaliforniaBerkeley 94720USA

Most Level 3 airports around the world suffer severe congestion and flight *** have to obtain airport slots in order to schedule flights at such *** main way for airlines to acquire slots is primary slot allocation,in which a slot coordinator distributes slots to airlines according to certain rules and *** to excessive demand for slots and restrictions on allocation rules,it is difficult for some airlines to obtain the desired slots in this *** way for airlines to obtain slots is through secondary slot trading,in which slots can be redistributed among airlines without being returned to slot *** secondary trading of airport slots has played a positive role in promoting the efficient utilization of slot resources,but systematic studies are *** paper discusses the reasons for the existence of slot secondary trading,sorts out the main policies and rules governing the mechanism,investigates its impacts on the industry and society,and points out the major problems and *** paper provides a reference for subsequent research and practical application of airport slot secondary trading in the future.

关键词： Air traffic management Airport capacity Airport slot allocation Market-based mechanism Secondary slot trading

STING palmitoylation as a therapeutic target

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Cellular & Molecular Immunology 2019年第3期16卷 236-241页

作者： Anne Louise hansen Kojiro Mukai Francisco j.Schopfer Tomohiko Taguchi Christian K.Holm department of Biomedicine Aarhus University8000 Aarhus CDenmark Laboratory of Organelle Pathophysiology Department of Integrative Life SciencesGraduate School of Life SciencesTohoku UniversitySendai 980-8578 MiyagiJapan department of Pharmacology and Chemical Biology University of PittsburghPittsburghPA 15213USA

Gain-of-function mutations in the STING-encoding gene TMEM173 are central to the pathology of the autoinflammatory disorder STING-associated vasculopathy with onset in infancy(SAVI).Furthermore,excessive activity of the STING signaling pathway is associated with autoinflammatory diseases,including systemic lupus erythematosus and Aicardi–Goutières syndrome(AGS).Two independent studies recently identified pharmacological inhibitors of ***,both types of compounds are reactive nitrocontaining electrophiles that target STING palmitoylation,a posttranslational modification necessary for STING *** a consequence,the activation of downstream signaling molecules and the induction of type I interferons were *** compounds were effective at ameliorating inflammation in a mouse model of AGS and in blocking the production of type I interferons in primary fibroblasts from SAVI *** mini-review focuses on the roles of palmitoylation in STING activation and signaling and as a pharmaceutical target for drug development.

关键词： STING Palmitoylation Inflammation SAVI Interferonopathies

On the Existence of Robot Zombies and our Ethical Obligations to AI Systems

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journal of Social Computing 2023年第4期4卷 270-274页

作者： Luke R.hansen the Computer Science department Stanford UniversityStanfordCA 94305USA

As artificial intelligence algorithms improve,we will interact with programs that seem increasingly *** may never know if these algorithms are sentient,yet this quality is crucial to ethical considerations regarding their moral *** will likely have to make important decisions without a full understanding of the relevant issues and *** this ignorance,we ought to take seriously the prospect that some systems are *** would be a moral catastrophe if we were to treat them as if they were not sentient,but,in reality they are.

关键词： artificial intelligence sentience ethics

Use of the Spatial kd-Tree in Computational Physics Applications

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Communications in Computational Physics 2007年第3期2卷 545-576页

作者： A.Khamayseh G.hansen Computer Science and Mathematics division Oak Ridge National LaboratoryOak RidgeTN 37831USA. Multiphysics Methods Group Idaho National LaboratoryIdaho FallsIDUSA.

The need to perform spatial queries and searches is commonly encountered within the field of computational *** development of applications ranging from scientific visualization to finite element analysis requires efficient methods of locating domain objects relative to general locations in *** of the time,it is possible to form and maintain spatial relationships between objects either explicitly or by using relative motion constraints as the application evolves in ***,either due to unpredictable relative motion or the lack of state information,an application must perform a general search(or ordering)of geometric objects without any explicit spatial relationship information as a *** previous state information involving domain geometric objects is not available,it is typically an involved and time consuming process to create object adjacency information or to order the objects in ***,as the number of objects and the spatial dimension of the problem domain is increased,the time required to search increases *** paper proposes an implementation of a spatial k-d tree(skd-tree)for use by various applications when a general domain search is *** skd-tree proposed in this paper is a spatial access method where successive tree levels are split along different *** are indexed by their centroid,and the minimum bounding box of objects in a node are stored in the tree *** paper focuses on a discussion of efficient and practical algorithms for multidimensional spatial data structures for fast spatial query *** functions include the construction of a skd-tree of geometric objects,intersection query,containment query,and nearest neighbor query operations.

关键词： Geometric query bounding volume hierarchy skd-tree containment query mesh generation h-refinement remapping.

Geomorphological processes and landforms of glacier forelands in the upper Aktru River basin(Gornyi Altai), Russia: evidence for rapid recent retreat and paraglacial adjustment

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journal of Mountain Science 2020年第4期17卷 824-837页

作者： david W.HEddING Aleksander A.EROFEEV Christel d.hansen Alexey V.KHON Zamir R.ABBASOV department of Geography University of South AfricaJohannesburg 1710South Africa department of Geography Tomsk State UniversityTomsk 637028Russia department of Geography Geoinformatics and MeteorologyUniversity of PretoriaPretoria 0002South Africa Institute of Monitoring of Climatic and Ecological Systems(IMCES) Tomsk State UniversityTomsk 637028Russia

The glaciers in the Aktru River basin of Gornyi Altai, Russia currently represent some of the fastest receding glaciers in the world. Formation of the morainic complexes closest to the contemporary glaciers in the Aktru River basin took place during the 17^th-18^th centuries with recession commencing at the end of the 18 th century. Coupled with this glacial retreat, earth surface processes and vegetation succession are responding to shape the glacier forelands. This article presents the first geomorphological maps for the upper reaches of the Aktru River basin and focuses on the geomorphological landforms that occur in the rapidly changing glacier forelands. Geomorphological mapping is difficult in steep mountainous regions and, thus, mapping was completed using satellite imagery, field mapping and observations coupled with highresolution aerial photography obtained from Unmanned Aerial Vehicles(UAVs). Critical steps of the procedure used to process UAV imagery and difficulties encountered in this mountainous terrain are noted. The acquired spatial data enable the mapping and classification of small-scale transient geomorphological features such as talus, glacial and glaciofluvial landforms. Their dynamics provide insights into supraglacial and subglacial processes of the glaciers of the Aktru River basin and subsequent paraglacial adjustment. The presented highresolution spatial data, which can also be obtained at high temporal resolutions in the future, can act as a reference frame for geomorphologists and ecologists studying the temporal evolution of glacier forelands of the Aktru River basin during paraglacial adjustment and subsequent colonisation and stabilisation by biota.

关键词： Geomorphology Glacier Forelands Unmanned Aerial Vehicle Aktru Altai Russia

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily Lee William j.Mack department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated