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International journal of Dermatology and Venereology 2023年第3期6卷 168-171页

作者： Alexa j.cohen Laura K.Gleason Safiyyah A.Bhatti Neda Nikbakht Department of Dermatology and Cutaneous Biology Thomas Jefferson UniversityPhiladelphiaPA 19107USA Department of Hematology&Oncology Thomas Jefferson UniversityPhiladelphiaPA 19107USA

Introduction:Neutrophilic panniculitis(NP)is a rare subtype of neutrophilic dermatosis,a group of neutrophilrich inflammatory skin disorders that can present in association with myeloid *** is defined by the presence of a neutrophilic infiltrate in the fat lobules of the subcutis in the absence of either infection or *** herein describe a 65-year-old woman with a recent diagnosis of myelodysplastic syndrome/myeloproliferative neoplasm overlap syndrome(MDS/MPN)who abruptly developed painful,pruritic nodules consistent with *** presentation:A 65-year-old woman with MDS/MPN presented for evaluation of painful and pruritic nodules on her upper and lower extremities.A biopsy revealed a lobular neutrophilic infiltrate in the subcutis without evidence of microorganisms or *** patient was diagnosed with NP and treated with oral *** 1 month of treatment,she reported complete resolution of the ***:Similar to other neutrophilic dermatoses,NP may arise in association with hematologic malignancies of myeloid origin,such as MDS/MPN.A literature review revealed that most cases of NP associated with MDS occur after the onset of MDS and respond to systemic corticosteroids,not *** should be ruled out before initiating treatment with systemic ***:Although the mechanism is still unknown,it is important for clinicians to be aware that NP is associated with MDS;thus,hematological malignancies should be investigated on diagnosis of *** diagnosed,NP is easily treated and has an excellent response to systemic corticosteroids.

关键词： neutrophilic panniculitis myelodysplastic syndrome neutrophilic dermatoses

8-氨基-3-四氢呋喃甲基苯并吗吩烷的合成及药理活性(英文)

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药学学报 2003年第10期38卷 748-753页

作者：周群段文虎Department of Chemistry Rensselaer Polytechnic Institute Dana j.cohen jean M.Bidlack Mark P.Wentland Department of Chemistry Rensselaer Polytechnic Institute Department of Pharmacology & Physiology University of Rochester Rochester

目的　设计并合成与环佐辛有类似的阿片受体亲和活性、在体内具有较长作用时间的 3 四氢呋喃甲基苯并吗吩烷类似物。方法　 8 三氟甲磺酸酯 3 四氢呋喃甲基苯并吗吩烷经催化氨化制得目标物 ,对目标物进行受体亲和力测定。结果　 8 氨基... 详细信息

目的　设计并合成与环佐辛有类似的阿片受体亲和活性、在体内具有较长作用时间的 3 四氢呋喃甲基苯并吗吩烷类似物。方法　 8 三氟甲磺酸酯 3 四氢呋喃甲基苯并吗吩烷经催化氨化制得目标物 ,对目标物进行受体亲和力测定。结果　 8 氨基及 8 苯氨基化合物在体外与 μ ,δ和κ受体的亲和力均较相应的 8 羟基化合物低。结论　目标化合物的体外受体亲和力相对较低 ,但此结果尚不能完全说明其在体内的作用情况及其可否用于毒品成瘾的治疗。

关键词：环佐辛类似物合成阿片受体亲和力

Serological Targeted Analysis of an ITIH4 Peptide Isoform: A Preterm Birth Biomarker and Its Associated SNP Implications

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journal of Genetics and Genomics 2015年第9期42卷 507-510页

作者： Zhou Tan Zhongkai Hu Emily Y.Cai Cantas Alev Ting Yang Zhen Li joyce Sung Yasser Yehia El-Sayed Gary M.Shaw David K.Stevenson Atul j.Butte Guojun Sheng Karl G.Sylvester Harvey j.cohen Xuefeng B.Ling Institute of Developmental and Regenerative Biology Hangzhou Normal University Department of Surgery Stanford University Lab for Early Embryogenesis RIKEN Center for Developmental Biology Department of Obstetrics and Gynecology Stanford University Department of Pediatrics Stanford University Stanford

Over 11% of all pregnancies in the US result in preterm birth, greatly contributing to perinatal morbidity and mortality （Goldenberg and Rouse, 1998）. Preterm birth etiologies remain largely unknown, and effective prevention methods have yet to be developed. The use of biofluid （e.g., serum or urine） for the analysis of the naturally occurring peptidome （MW 〈 4000） as a source of biomarkers has been reported for different diseases （Villanueva et al., 2006; Ling et al., 2010a, 2010b, 2010c, 2011）. Mass spectrometry-based profiling of naturally occurring peptides can provide an extensive in- ventory of serum peptides derived from either high-abundant endogenous circulating proteins or cell and tissue proteins （Liotta and Petricoin, 2006）.

关键词： Serological Targeted Analysis of an ITIH4 Peptide Isoform A Preterm Birth Biomarker and Its Associated SNP Implications SNP

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工作于室温的近红外成象摄象机

红外 1996年第2期17卷 7-10页

作者： Marshall j.cohen 顾聚兴美国传感器无限公司

砷镓铟焦平面列阵为用于监视、光谱学和热成象技术的近红外成象摄象机提供了传感器。

关键词：红外成象摄象机 InGaAs 焦平面列阵

密度泛函理论计算物质能带间隙的精度的改进:从分子到固体

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密度泛函理论计算物质能带间隙的精度的改进:从分子到固体

中国化学会第28届学术年会

作者：郑晓 Aron j.cohen Paula Mori-Sanchez 胡向前杨伟涛中国科学技术大学合肥微尺度物质科学国家实验室(筹) Universidad Autonoma de Madrid Departamento de QuimicaMardrid28049Spain Duke University Department of ChemistryDurhamNorth Carolina27708United States

＜正＞为改进密度泛函理论对于物质能带间隙的计算精度,我们提出了一个新颖的非经验性的标度修正方法。对于尺寸有限的体系,该修正方法使得由密度泛函理论计算得到的体系总能量与电子数目之间较好的趋近于线性标度关系。该方法可用于修... 详细信息

＜正＞为改进密度泛函理论对于物质能带间隙的计算精度,我们提出了一个新颖的非经验性的标度修正方法。对于尺寸有限的体系,该修正方法使得由密度泛函理论计算得到的体系总能量与电子数目之间较好的趋近于线性标度关系。该方法可用于修正多种主流的近似密度泛函,包括局域密度自旋近似

关键词：密度泛函理论交换相关泛函能带间隙前线轨道

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癫痫与偏头痛

国外医学（脑血管疾病分册） 2004年第2期12卷 110-118页

作者： M.E.Bigal R.B.Lipton j.cohen S.D.Silberstein 曹立梅李浩毕桂南不详广西医科大学第二附属医院神经内科，南宋530007

偏头痛和癫痫均为慢性疾病，其特征为反复发作的神经症状，可伴有不同的头痛、胃肠道、自主神经和精神症状。偏头痛和癫痫在症状表现、伴发病症(comordity)和治疗方面均存在联系。一种疾病的存在也使另一种疾病存在的可能性增加。另外... 详细信息

偏头痛和癫痫均为慢性疾病，其特征为反复发作的神经症状，可伴有不同的头痛、胃肠道、自主神经和精神症状。偏头痛和癫痫在症状表现、伴发病症(comordity)和治疗方面均存在联系。一种疾病的存在也使另一种疾病存在的可能性增加。另外，很多偏头痛综合征可与癫痫相混淆。对每种疾病的诊断和治疗必须要考虑到存在另一种疾病的可能性。在此，我们对癫痫与偏头痛之间的相互关系进行综述，讨论采用国际头痛协会标准来诊断偏头痛，强调极易误诊为癫痫的偏头痛的变异型。我们还对偏头痛和癫痫的有关流行病学证据作一概述，对偏头痛与癫痫之间特殊的相互关系进行讨论。

关键词：癫痫偏头痛治疗诊断

Fetal Head Compression: Its Possible Role in Neurologic Injury

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Open journal of Obstetrics and Gynecology 2024年第1期14卷 124-143页

作者： Barry S. Schifrin Brian j. Koos Wayne R. cohen Department of Obstetrics and Gynecology The Western University of Health Sciences Pomona USA The David Geffen School of Medicine at UCLA Los Angeles USA The University of Arizona College of Medicine Tucson USA

It is widely assumed that fetal ischemic brain injury during labor derives almost exclusively from severe, systemic hypoxemia with marked neonatal depression and acidemia. Severe asphyxia, however, is one of several causes of perinatal neurological injury and may not be the most common;most neonates diagnosed with hypoxic-ischemic encephalopathy do not have evidence of severe asphyxia. Sepsis, direct brain trauma, and drug or toxin exposure account for some cases, while mechanical forces of labor and delivery that increase fetal intracranial pressure sufficiently to impair brain perfusion may also contribute. Because of bony compliance and mobile suture lines, the fetal skull changes shape and redistributes cerebrospinal fluid during labor according to constraints imposed by contractions, and bony and soft tissue elements of the birth canal as the head descends. These accommodations, including the increase in intracranial pressure, are adaptive and necessary for efficient descent of the head while safeguarding cerebral blood flow. Autonomic reflexes mediated through central receptors normally provide ample protection of the brain from the considerable pressure exerted on the skull. On occasion, those forces, which are transmitted intracranially, may overcome the various adaptive anatomical, cardiovascular, metabolic, and neurological mechanisms that maintain cerebral perfusion and oxygen availability, resulting in ischemic brain injury. Accepting the notion of a potentially adverse impact of fetal head compression suggests that avoidance of excessive uterine activity and of relentless pushing without steady progress in descent may offer protection for the fetal brain during parturition. Excessive head compression should be considered in the differential diagnosis of ischemic encephalopathy.

关键词： Fetal Brain Injury Fetal Head Compression Ischemic Encephalopathy Neonatal Encephalopathy

A randomized controlled trial of Promoting Physical Activity in Regional and Remote Cancer Survivors(PPARCS)

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journal of Sport and Health Science 2024年第1期13卷 81-89页

作者： Sarah j.Hardcastle Chloe Maxwell-Smith Vinicius Cavalheri Terry Boyle Marta Leyton Román Cameron Platell Michael Levitt Christobel Saunders Frank Sardelic Sophie Nightingale jacob McCormick Craig Lynch Paul A.cohen Max Bulsara Dana Hince Sport and Physical Activity Research Centre Sheffield Hallam UniversitySheffieldS102BPUK Institute for Health Research The University of Notre DameFremantleWA 6959Australia Curtin School of Population Health Curtin UniversityPerthWA 6845Australia Curtin School of Allied Health Curtin UniversityPerthWA 6845Australia Allied Health South Metropolitan Health ServiceMurdochWA 6150Australia Australian Centre for Precision Health University of South AustraliaAdelaideSA 5001Australia Department of Didactics of Musical Plastic and Body ExpressionUniversity of ExtremaduraCaceres 10071Spain St.john of God Subiaco Hospital PerthWA 6008Australia Department of Surgery University of MelbourneMelbourneVIC 3010Australia Tamara Private Hospital TamworthNSW 2340Australia Peter MacCallum Cancer Centre MelbourneVIC 3000Australia College of Health and Medicine Australian National UniversityCanberraACT 2600Australia Division of Obstetrics and Gynaecology Medical SchoolUniversity of Western AustraliaPerthWA 6009Australia

Background:Physical activity(PA)is important for cancer *** of remotely delivered interventions are needed to assist in reaching under-served non-metropolitan cancer *** objective of this study was to ascertain whether wearable technology,coupled with health coaching was effective in increasing PA in breast and colorectal cancer survivors living in regional and remote areas in ***:Cancer survivors from 5 states were randomized to intervention and control *** participants were given a Fitbit Charge 2TMand received up to 6 telephone health coaching *** participants received PA print *** assessments at baseline and 12 weeks measured moderate-to-vigorous PA(MVPA),light PA,and sedentary ***:Eighty-seven participants were recruited(age=63±11 years;74(85%)female).There was a significant net improvement in MVPA of 49.8 min/week,favoring the intervention group(95%confidence interval(95%CI):13.6-86.1,p=0.007).There was also a net increase in MVPA bouts of 39.5 min/week(95%CI:11.9-67.1,p=0.005),favoring the intervention *** groups improved light PA and sedentary behavior,but there were no between-group ***:This’s the first study to demonstrate that,when compared to standard practice(i.e.,PA education),a wearable technology intervention coupled with distance-based health coaching,improves MVPA in non-metropolitan cancer *** results display promise for the use of scalable interventions using smart wearable technology in conjunction with phone-based health coaching to foster increased PA in geographically disadvantaged cancer survivors.

关键词： Behavior change Exercise Health disparities Oncology Wearable technology

公元前1920年溃决洪水为中国大洪水传说和夏王朝的存在提供依据

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中国水利 2017年第3期 1-5页

作者：吴庆龙赵志军刘莉 Darryl E.Granger 王辉 David j.cohen 吴小红叶茂林 Ofer Bar-Yosef 陆斌张进张培震袁道阳齐乌云蔡林海白世彪陈菁(编译) 李荣富(编译) 刘志(编译) 肖晨光(编译) 周程婷(编译) 毕博(编译) 北京大学、考古学与博物馆学院北京100871 南京师范大学、地理科学学院南京210023 中国地震局、地质研究所、地震动力学国家重点实验室北京100029 斯坦福大学、东亚语言与文化学院美国斯坦福94305 普渡大学、地球大气与行星科学学院美国西拉法叶47907 中国社会科学院、考古研究所北京100710 台湾大学、人类学学院中国台北10617 哈佛大学、人类学学院美国剑桥02138 西安研究所、中煤科工集团西安710077 中国地质科学院地质研究所北京100037 中国地震局、兰州地震学研究所兰州730000 青海省文物考古研究所西宁810007 江苏地理信息资源开发与应用协作创新中心南京210023 中山大学、地球科学与地质工程学院广州510275 不详

中国传统史学讲述了一个在治理洪水成功后建立夏朝并开启文明史的故事。然而,洪水和夏朝的历史真实性一直存在争议。本文重建了约公元前1920年黄河上游地震引发的滑坡坝体的溃决洪水,为一万年以来地球上发生的最大的内陆洪水之一,可以... 详细信息

中国传统史学讲述了一个在治理洪水成功后建立夏朝并开启文明史的故事。然而,洪水和夏朝的历史真实性一直存在争议。本文重建了约公元前1920年黄河上游地震引发的滑坡坝体的溃决洪水,为一万年以来地球上发生的最大的内陆洪水之一,可以解释中国传说的大洪水。本文将夏朝的开端确定为约公元前1900年,比传统的认识晚了2~3个世纪。测定结果表明,此年代的黄河流域状态与新石器向青铜器时代大变迁时的状态相吻合,这同时也佐证了初级国家形态——二里头文化是夏朝存在的考古证据的假说。

关键词：神话传说大洪水溃决洪水中国大禹治水中华民族水旱灾害考古证据