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科技译丛（长沙） 1994年第1期 23-26页

作者： carl.,j 张慧芳

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评定洁净室用手套的耗散特性

洁净与空调技术 2001年第1期 46-47+49-50+56页

作者： Andrew j.Magenheim,carl Newburg Ph.D

两个物体相接触时总会产生一定数量的电荷。减少静电放电(ESD)损害的主要机理是把电荷导入地下。可以用两种测量方法来评定一种材料或一种产品耗散电荷的能力;电荷衰减时间和电阻。如果电阻是已知的,就可预知沿相同路径的衰减时间。这... 详细信息

两个物体相接触时总会产生一定数量的电荷。减少静电放电(ESD)损害的主要机理是把电荷导入地下。可以用两种测量方法来评定一种材料或一种产品耗散电荷的能力;电荷衰减时间和电阻。如果电阻是已知的,就可预知沿相同路径的衰减时间。这里只提到了电阻—对洁净室用手套的测量结果,并对电阻及手套材料之间的相关性进行了探讨。

关键词：手套操作员洁净室净化室电阻测量集中参数测量电荷测量结果

微型电子计算机在渔业研究与管理上的应用及展望

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国外水产 1991年第3期 35-38页

作者： carl j.Walters 仝龄

当今你可以在大多数渔业管理机构和科研实验室中见到微型电子计算机(简称微电脑),它们的服务范围从简单的字处理工作到精确的统计分析和模拟系统.但是,对微电脑在渔业上的发展前景,有些不切实际的观点.从长远观点看,微电脑不仅仅是一种... 详细信息

当今你可以在大多数渔业管理机构和科研实验室中见到微型电子计算机(简称微电脑),它们的服务范围从简单的字处理工作到精确的统计分析和模拟系统.但是,对微电脑在渔业上的发展前景,有些不切实际的观点.从长远观点看,微电脑不仅仅是一种省时的数值处理设备,而且是一种激励用户去进行更深刻和更精确分析的手段.微电脑在渔业上的主要发展领域有立体图象处理、数据管理网络和为教学及政策分析服务的对策模拟系统.

关键词：渔业研究管理微机应用

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精通Microsoft Windows 2000和Windows XP安全技术

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Detection and Characterization of β-Lactamase Encoding Genes in Carbapenem Non-Susceptible Gram-Negative Bacteria and Susceptibility of Isolates to Ceftazidime-Avibactam at a New York City Community Hospital

2003年

作者：（美）Ed Bott （美）carl Siechert 梁超等译

本书内容包括Windows 安全工具及安全技术、管理用户帐户和密码、多用户电脑的安全性、维护系统安全、保护电子邮件的安全、网络安全等20章。

ISBN: (数字)7894940933

ISBN: (纸本)7894940933

本书内容包括Windows 安全工具及安全技术、管理用户帐户和密码、多用户电脑的安全性、维护系统安全、保护电子邮件的安全、网络安全等20章。

关键词：安全技术窗口软件网络服务器

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Open journal of Medical Microbiology 2016年第4期6卷 150-157页

作者： carl Urban Rita Colon-Urban Vincent j. LaBombardi Noriel Mariano Nishant Prasad Geeti Dhillon Marina Guralnik Sorana Segal-Maurer The Dr. james j. Rahal Jr. Division of Infectious Diseases Department of Medicine New York-Presbyterian/Queens Flushing NY USA The Dr. james j. Rahal Jr. Division of Infectious Diseases Department of Medicine NewYork-Presbyterian/Queens Flushing NY USA Department of Biological Sciences SUNY Old Westbury Old Westbury New York NY USA Department of Pathology NewYork-Presbyterian/Queens Flushing NY USA

A surveillance study was undertaken to identify prominent β-lactamase encoding genes in 131 carbapenem non-susceptible gram-negative clinical isolates at a New York City community hospital. KPC carbapenemases were detected in 89% of Enterobacteriaceae as well as additional TEM, SHV, and CTX-M class A enzymes. OXA-23 and OXA-24 were the prevalent class D carbapenemases identified in Acinetobacter species. One OXA-23 in M. morganii and one OXA-48 in K. pneumoniae were also identified. Among class C β-lactamases CMY, ACT/MIR, DHA, and FOX were detected. The in vitro activity of ceftazidime-avibactam by E-test methodology was tested with minimal inhibitory concentrations (MIC) of ≤3 μg/ml for 97.8% of all Enterobacteriaceae, MIC50/90 of 16/>256 μg/ml for carbapenem non-susceptible Acinetobacter, and 3/6 μg/ml for carbapenem non-susceptible Pseudomonas aeruginosa. Periodic surveillance of isolates to characterize current and emerging β-lactamase genotypes present in local isolates may help identify outbreak situations, provide assistance to infection control and antibiotic stewardship programs, and potentially improve patient outcomes.

关键词： Carbapenem Non-Susceptible Check-MDR CT103 XL Microarray β-Lactamase Detection Resistance Mechanisms Ceftazidime-Avibactam

Macrophage-specific inhibition of the histone demethylase jMjD3 decreases STING and pathologic inflammation in diabetic wound repair

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Cellular & Molecular Immunology 2022年第11期19卷 1251-1262页

作者： Christopher O.Audu William j.Melvin Amrita D.joshi Sonya j.Wolf jadie Y.Moon Frank M.Davis Emily C.barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer james Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore johann EGudjonsson Andrew MSmith Katherine A.Gallagher Department of Surgery Section of Vascular SurgeryUniversity of MichiganAnn ArborMIUSA Department of Microbiology and Immunology University of MichiganAnn ArborMIUSA Department of Medicinal Chemistry University of MichiganAnn ArborMIUSA Department of Surgery Section of General SurgeryUniversity of MichiganAnn ArborMIUSA Department of Bioengineering University of IllinoisUrbana-ChampaignChampaignILUSA Department of Dermatology University of MichiganAnn ArborMIUSA Department of Pathology University of MichiganAnn ArborMIUSA Department of Surgery University of Texas Southwestern Medical CenterDallasTXUSA

Macrophage plasticity is critical for normal tissue repair following *** pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are ***,using single-cell RNA sequencing of human diabetic wounds,we identified increased jMjD3 in diabetic wound macrophages,resulting in increased inflammatory gene ***,we report that in wound healing,jMjD3 directs early macrophage-mediated inflammation via jAK1,3/STAT3 ***,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates jMjD3 expression in diabetic wound macrophages via the jAK1,3/STAT3 pathway and that this late increase in jMjD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 ***,RNA sequencing of wound macrophages isolated from mice with jMjD3-deficient myeloid cells(jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by jMjD3 in wound *** limits inflammatory cytokine production by wound macrophages during ***,in diabetic mice,its role changes to limit wound repair and enhance *** finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time ***,we demonstrate that macrophage-specific,nanoparticle inhibition of jMjD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and *** together,this work highlights the central role of jMjD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds.

关键词： wound healing epigenetics diabetes jMjD3 STING

Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review

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World journal of Gastrointestinal Oncology 2015年第9期7卷 132-140页

作者： Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford j Whatcott Zoran Gatalica Michael T barrett Derek Cridebring Daniel D Von Hoff Honor Health Research Institute Virginia G. Piper Cancer Center Translational Genomics Research Institute Caris Life Sciences Imaging Endpoints Mayo Clinic

Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of *** characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease.

关键词： Adenosquamous carcinoma of the pancreas Molecular

定量药理学:一个促进药物开发及转换型研究严谨思考的多学科领域

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中国临床药理学与治疗学 2008年第5期13卷 481-493页

作者： jeffrey S barrett Michael j Fossler K.David Cadieu Marc R Gastonguay 沈杰谢海棠孙瑞元 Laboratory for Applied PKPD Clinical Pharmacology & Therapeutics Divisionthe Children's Hospital of PhiladelphiaPediatrics DepartmentSchool of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Clinical Pharmacokinetics Modeling and SimulationGlaxoSmithKlineKing of PrussiaPennsylvania 19406USA KDC Group Inc.New JerseyNJ 08648USA Metrum Institute ConnecticutUSA 皖南医学院弋矶山医院药物临床评价中心

尽管从事定量药理学研究的科学工作者一再强调将定量分析的原则应用于促进新药研发的决策,定量药理学的发展还是超过了上述领域。普通研究和决策领域总是期望着常规和传统的研究范例发生进步,当与定量药理学相关的领域自身在发展并与其... 详细信息

尽管从事定量药理学研究的科学工作者一再强调将定量分析的原则应用于促进新药研发的决策,定量药理学的发展还是超过了上述领域。普通研究和决策领域总是期望着常规和传统的研究范例发生进步,当与定量药理学相关的领域自身在发展并与其交互作用时,自然便产生对临床药理学的协同作用。创新性和可塑性训练计划和策略均是将来临床研究工作中必不可少的要素。掌握定量药理学领域的知识成为对药理科学家的要求,具有定量药理学背景的人员可望获得更高的薪水。目前定量药理学相关培训计划,教学资料,及学术权威均比较贫乏,学生们可以从企业化、调控性的背景的教师等多种机构的教职员那获得指导,此外也可以通过在线课程,可视化教学进修课程,与他们的导师保持联系。对课程和学位的管理可以采取灵活的态度,这样可在短期内培养更多的定量药理学工作者。

关键词：定量药理学关键路径国立卫生研究院(NIH)路线图教育临床药理学(Pharmacometrics)

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赢在科学科学游戏面面观

LAMOST Experiment for Galactic Understanding and Exploration (LEGUE)——The survey's science plan

丛书名：科学走廊书系

2001年

作者：（美）卡尔·j.辛德曼（carl j.Sindermann）柳士强译

本书分三部分：第一部分为科学战略家入门、第二部分科学战略家的关键问题、第三部分科学战略家的特殊兴趣所在。

ISBN: (纸本)7532359506

本书分三部分：第一部分为科学战略家入门、第二部分科学战略家的关键问题、第三部分科学战略家的特殊兴趣所在。

关键词：科学方法论普及读物

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Research in Astronomy and Astrophysics 2012年第7期12卷 735-754页

作者： Li-Cai Deng Heidi jo Newberg Chao Liu jeffrey L. carlin Timothy C. Beers Li Chen Hsu-Tai Lee carl j. Grillmair Puragra Guhathakurta] Zhan-Wen Han jin-Liang Hou Sebastien Lepine jing Li Xiao-Wei Liu Kai-Ke Pan j. A. Sellwood Bo Wang Hong-Chi Wang Fan Yang Brian Yanny Hao-Tong Zhang Yue-Yang Zhang Zheng Zheng Zi Zhu Key Lab for Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China licai@*** Department of Physics Applied Physics and Astronomy Rensselaer Polytechnic Institute 1108th Street Troy NY 12180 USA National Optical Astronomy Observatory Tucson AZ 85719 USA Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Astronomy and Astrophysics Academia Sinica EO. Box 23-141 Taipei 106 China University of Heidelberg Landessternwarte K6nigstuhl 12 D-69117 Heidelberg Germany Spitzer Science Center 1200 E. California Blvd. Pasadena CA 91125 USA Department of Astronomy and Astrophysics University of California Santa Cruz 1156 HighStreet Santa Cruz CA 95064 USA Yunnan Astronomical Observatory Chinese Academy of Sciences Kunming 650011 China American Museum of Natural History Central Park West at 79th Street New York NY 10024USA School of Physics and Electronic Information China West Normal University Nanchong637000 China ' Department of Astronomy & Kavli Institute of Astronomy and Astrophysics Peking University Beijing 100871 China Apache Point Observatory PO Box 59 Sunspot NM 88349 USA Department of Physics and Astronomy Rutgers University 136 Frelinghuysen RoadPiscataway NJ 08854-8019 USA Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China Fermi National Accelerator Laboratory Batavia IL 60510 USA Department of Physics and Astronomy University of Utah Salt Lake City UT 84112 USA School of Astronomy and Space Science Nanjing University Nanjing 210008 China

We describe the current plans for a spectroscopic survey of millions of stars in the Milky Way galaxy using the Guo Shou jing Telescope （GSjT, formerly calledthe Large sky Area Multi-Object fiber Spectroscopic Telescope -- LAMOST）. The survey will obtain spectra for 2.5 million stars brighter than r 〈 19 during dark/grey time, and 5 million stars brighter than r 〈 17 or j 〈 16 on nights that are moonlit or have low transparency. The survey will begin in the fall of 2012, and will run for at least four years. The telescope＇s design constrains the optimal declination range for observations to 10~ 〈 di 〈 50~, and site conditions lead to an emphasis on stars in the direction of the Galactic anticenter. The survey is divided into three parts with different target selection strategies： disk, anticenter, and spheroid. The resulting dataset will be used to study the merger history of the Milky Way, the substructure and evolution of the disks, the nature of the first generation of stars through identification of the lowest metallicity stars, and star formation through study of open clusters and OB associations. Detailed design of the LAMOST Experiment for Galactic Understanding and Exploration （LEGUE） survey will be completed in summer 2012, after a review of the results of the pilot survey.

关键词： techniques: spectroscopic -Galaxy: structure - Galaxy: evolution -Galaxy: kinematics and dynamics -- Galaxy: disk -- Galaxy: halo -- spectroscopy

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