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Gas-phase electrocatalytic conversion of cO_2 to chemicals on sputtered cu and cu–c catalysts electrodes

journal of Energy chemistry 2019年第4期28卷 46-53页

作者： N.Gutiérrez-Guerra j.A.González j.c.serrano-ruiz E.López-Fernández j.L.Valverde A.de Lucas-consuegra Departamento de Ingeniería Química Facultad de Ciencias y Tecnologías Químicas Universidad de Castilla-La Mancha Instituto Regional de Investigación científica Aplicada (IRIcA) and Departamento de Física Aplicada Universidad de Castilla-La Mancha Departamento de Ingeniería Universidad Loyola Andalucía

A novel gas-phase electrocatalytic cell containing a low-temperature proton exchange membrane(PEM)was developed to electrochemically convert cO_2into organic *** different cu-based cathode catalysts(cu and cu–c)were prepared by physical vapor deposition method(sputtering)and subsequently employed for the gas-phase electroreduction of cO_2at different temperatures(70–90°c).The prepared electrodes cu and cu–c were characterized by X-ray diffraction(XRD),X-ray photoemission spectroscopy(XPS)and scanning electron microscopy(SEM).As revealed,cu is partially oxidized on the surface of the samples and the cu and cu–c cathodic catalysts were comprised of a porous,continuous,and homogeneous film with nanocrystalline cu with a grain size of 16 and 8 nm,*** influence of the applied current and temperature on the electro-catalytic activity and selectivity of these materials was *** the two investigated electrodes,the pure cu catalyst film showed the highest cO_2specific electrocatalytic reduction rates and higher selectivity to methanol formation compared to the cu–c electrode,which was attributed to the higher particle size of the former and lower cu O/cu *** obtained results show potential interest for the possible use of electrical renewable energy for the transformation of cO_2into valuable products using low metal loading cu based electrodes(0.5 mg cu cm^(-2))prepared by sputtering.

关键词： cO_2 valorization Electro-reduction cu catalyst PEM Selectivity Methanol production

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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Status and prospects for symmetric organic redox flow batteries

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journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： christopher j.O’connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle college of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(capizzi et al.,2020).

关键词： sustained orange dynamic

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Prediction of ground-borne vibration induced by impact pile driving:numerical approach and experimental validation

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Earthquake Engineering and Engineering Vibration 2023年第4期22卷 921-935页

作者： A.colaço P.Alves costa c.Ferreira c.Parente j.Fernandez-ruiz cONSTRUcT-FEUP University of PortoRua Dr.Roberto Frias4200-465 PortoPortugal University of La coruña Department of Civil EngineeringCampus de Elviña 15071La CoruñaSpain

Deep foundations are currently used in engineering practice to solve problems caused by weak geotechnical characteristics of the *** pile driving is an interesting and viable solution from economic and technical points of ***,it is necessary to ensure that the environmental drawbacks,namely ground-borne vibration,are adequately *** this purpose,the authors propose an axisymmetric finite element method-perfectly matched layer(FEM-PML)approach,where the nonlinear behavior of the soil is addressed through an equivalent linear *** the complexity of the problem,an experimental test site was developed and fully *** experimental work comprised in-situ and laboratory soil characterization,as well as the measurement of vibrations induced during pile *** comparison between experimental and numerical results demonstrated a very good agreement,from which it can be concluded that the proposed numerical approach is suitable for the prediction of vibrations induced by impact pile *** experimental database is available as supplemental data and may be used by other researchers in the validation of their prediction models.

关键词： pile driving ground-borne vibrations numerical modeling experimental validation

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Verification and Validation for data marketplaces via a blockchain and smart contracts

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Blockchain(Research and Applications) 2022年第4期3卷 91-108页

作者： Will serrano The Bartlett University college London WC1E 6BTLondonUnited Kingdom

Actual challenges with data in physical infrastructure include:1)the adversity of its velocity based on access and retrieval,thus integration;2)its value as its intrinsic quality;3)its extensive volume with a limited variety in terms of systems;and finally,4)its veracity,as data can be modified to obtain an economical *** infrastructure design based on Agile project management and minimum viable products provides benefits against the traditional waterfall *** supports an early return on investment that promotes circular reinvesting while making the product more adaptable to variable social-economical ***,Agile also presents inherent issues due to its iterative ***,project information requires an efficient record of the aims,requirements,and governance not only for the investors,owners,or users but also to keep evidence in future health&safety and other statutory *** order to address these issues,this article presents a Validation and Verification(V&V)model for data marketplaces with a hierarchical process;each data V&V stage provides a layer of data abstraction,value-added services,and authenticity based on Artificial Intelligence(AI).In addition,this proposed solution applies Distributed Ledger Technology(DLT)for a decentralised approach where each user keeps and maintains the data within a *** presented model is validated in real data marketplace applications:1)live data for the Newcastle Urban Observatory Smart city Project,where data are collected from sensors embedded within the smart city via APIs;2)static data for University college London(UcL)—Real Estate—PEARL Project,where different project users and stakeholders introduce data into a Project Information Model(PIM).

关键词： Data marketplace Project information model Smart cities Smart buildings Real estate Distributed ledger technology Blockchain Smart contracts Artificial intelligence

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Sustainable geotourism using digital technologies along a rural georoute in Monsagro(Salamanca,Spain)

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International journal of Digital Earth 2017年第2期10卷 121-138页

作者： A.M.Martínez-Graña L.serrano j.A.González-Delgado c.j.Dabrio P.Legoinha Department of Geology Faculty of SciencesUniversity of SalamancaSalamancaSpain Department of Stratigraphy Faculty of GeologyComplutense UniversityMadridSpain GeoBioTec Departamento de Ciências da TerraFaculdade de Ciências e TecnologiaUniversidade Nova de LisboaCaparicaPortugal

Rural geotourism looks at the natural resources of the territory as a means of promoting a specialized,educational,sustainable *** is an increasingly sought-after *** paper presents a rural georoute across a high mountain village,highlighting the remarkable value of the geological heritage of biological trace fossils and physical sedimentary structures exposed on street pavements and façades of houses.A series of tourist georesources were created and implemented:educational and interpretive panels,videos,QR codes,geoapps and games,all of which promote and disseminate the exceptional geological content and the history of the earth through the use of new technologies(smartphones,ipod,etc.).All this is intended as a means to make geotourism a natural tourism,favoring experiences,whilst explaining the natural environment and its temporal and spatial dimensions,offering opportunities for socio-economic development and job creation in rural areas with problems of depopulation.

关键词： Digital geotourism geological heritage georoute sustentability geotourism tourist georesources

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cellular Auxin Homeostasis： Gatekeeping Is Housekeeping

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Molecular Plant 2012年第4期5卷 772-786页

作者： Michel ruiz Rosquete Department of Applied Genetics and cell Biology University of Applied Life Sciences and Natural Resources (BOKU) 1190 Vienna Austria Department of Plant Systems Biology VIB and Department of Plant Biotechnology and Bioinformatics Ghent University 9052 Gent Belgium

The phytohormone auxin is essential for plant development and contributes to nearly every aspect of the plant life cycle. The spatio-temporal distribution of auxin depends on a complex interplay between auxin metabolism and cell-to-cell auxin transport. Auxin metabolism and transport are both crucial for plant development; however, it largely remains to be seen how these processes are integrated to ensure defined cellular auxin levels or even gradients within tissues or organs. In this review, we provide a glance at very diverse topics of auxin biology, such as biosynthesis, conjugation, oxidation, and transport of auxin. This broad, but certainly superficial, overview highlights the mutual importance of auxin metabolism and transport. Moreover, it allows pinpointing how auxin metabolism and transport get integrated to jointly regulate cellular auxin homeostasis. Even though these processes have been so far only separately studied, we assume that the phytohormonal crosstalk integrates and coordinates auxin metabolism and transport. Besides the integrative power of the global hormone signaling, we additionally introduce the hypothetical concept considering auxin transport components as gatekeepers for auxin responses.

关键词： auxin conjugation auxin homeostasis auxin metabolism auxin transport.

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