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High affinity soluble ILT2 receptor:a potent inhibitor of CD8^(+)T cell activation

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Protein & Cell 2010年第12期1卷 1118-1127页

作者： Ruth K.Moysey Yi Li Samantha j.Paston Emma E.Baston Malkit S.Sami Brian j.Cameron jessie Gavarret Penio Todorov Annelise Vuidepot Steven M.Dunn Nicholas j.Pumphrey Katherine j.Adams Fang Yuan Rebecca E.dennis Deborah H.Sutton Andy D.johnson joanna E.Brewer Rebecca Ashfield Nikolai M.Lissin Bent K.jakobsen Immunocore Limited 57c Milton ParkAbingdonOxonOX144RXUK Current address:Oxford Nanopore Technologies UK Current address:Geneva Merck Serono S.A. Switzerland Current address:Adaptimmune Limited UK

Using directed mutagenesis and phage display on a soluble fragment of the human immunoglobulin superfamily receptor ILT2(synonyms:LIR1,MIR7,CD85j),we have selected a range of mutants with binding affinities enhanced by up to 168,000-fold towards the conserved region of major histocompatibility complex(MHC)class I *** in a dimeric form,either by chemical cross-linking with bivalent polyethylene glycol(PEG)derivatives or as a genetic fusion with human IgG Fc-fragment,the mutants exhibited a further increase in ligand-binding strength due to the avidity effect,with resident half-times(t1/2)on the surface of MHC I-positive cells of many *** novel compounds antagonized the interaction of CD8 co-receptor with MHC I in vitro without affecting the peptide-specific binding of T-cell receptors(TCRs).In both cytokine-release assays and cell-killing experiments the engineered receptors inhibited the activation of CD8^(+)cytotoxic T lymphocytes(CTLs)in the presence of their target cells,with subnanomolar potency and in a dose-dependent *** a selective inhibitor of CD8^(+)CTL responses,the engineered high affinity ILT2 receptor presents a new tool for studying the activation mechanism of different subsets of CTLs and could have potential for the development of novel autoimmunity therapies.

关键词： CD8^(+)T cells cellular activation autoimmunity cell surface molecules binding affinity phage display

Ponseti method treatment of neglected idiopathic clubfoot:Preliminary results of a multi-center study in Nigeria

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世界骨科杂志：英文版 2017年第8期8卷 624-630页

作者： Olayinka O Adegbehingbe Adeoye j Adetiloye Ladipo Adewole dennis U Ajodo Nosirudeen Bello Oluwadare Esan Alex C Hoover james Ior Omolade Lasebikan Owolabi Ojo Anthony Olasinde David Songden jose A Morcuende Department of Orthopedic Surgery and Traumatology Obafemi Awolowo University Gwarinpa General Hospital Federal Capital Territory Lagos State University College of Medicine Federal Medical Center Keffi Federal Medical Center Abeokuta Carver College of Medicine University of Iowa NKST Hospital Mkar National Orthopedic Hospital Federal Medical Center Owo Ekiti State Teaching Hospital

AIM To evaluate the effectiveness of the Ponseti method for initial correction of neglected clubfoot cases in multiple centers throughout *** Patient charts were reviewed through the International Clubfoot Registry for 12 different Ponseti clubfoot treatment centers and 328 clubfeet(225 patients) met inclusion criteria. All patients were treated by the method described by Ponseti including manipulation and casting with percutaneous Achilles tenotomy as *** A painless plantigrade foot was obtained in 255 feet(78%) without the need for extensive soft tissue release and/or bony *** We conclude that the Ponseti method is a safe, effective and low-cost treatment for initial correction of neglected idiopathic clubfoot presenting after walking age. Longterm follow-up will be required to assess outcomes.

关键词： Ponseti method Neglected clubfoot Nigeria Walking age

当代麻醉机设计概要—今日的麻醉机及其发展趋势

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中外医疗器械 1991年第4期 1-9页

作者： dennis,j 蔡国方

Stable low pressure polymeric insulating phases of carbon monoxide predicted using first principles methods

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Stable low pressure polymeric insulating phases of carbon mo...

Statistics for business and economics / 7th ed.

第十八届中国高压科学学术会议

作者：夏康 jian Sun Chris j.Pickard dennis D.Klug Richard j.Needs National Laboratoryof Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures and School of PhysicsNanjing University Departmentof Materials Science&Metallurgy University of Cambridge Steacie Institute for Molecular Sciences National Research Council of Canada

We have used crystal structure prediction methods and first-principles caculations to explore low-energy and pressure structures of carbon monoxide(CO).The most stable structure at low pressures is found to be a crystalline polymeric structure of Pna21 symmetry rather than a molecular *** Pna21 structure is insulating,in contrast to an earlier prediction of a metalic ground state structure for *** Pna21structure is insulating,in contrast to an earlier prediction of a metallic ground state

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Estimation of erosion induced nutrients loss under different land uses: A case study in Miandam Valley, Swat Pakistan

1999年

作者： David R. Anderson dennis j. Sweeney Thomas A. Wi

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International journal of Agricultural and Biological Engineering 2021年第2期14卷 135-141页

作者： Nowsher Yousaf Bushra Khan dennis C.Flanagan Ishaq Ahmad Mian javaid Iqbal Irfan Rashid Salma Khalid Nasreen Ghaffar Sadaf Manzoor Muhammad Bilal Department of Environmental Sciences University of PeshawarKhyber Pakhtunkhwa 25120Pakistan USDA-Agricultural Research Service National Soil Erosion Research LaboratoryPurdue UniversityWest LafayetteIN 47907USA Department of Soil and Environmental Sciences The University of AgriculturePeshawarKhyber Pakhtunkhwa 25000Pakistan Department of Botany University of KashmirSrinagarJ&K 190006India Prime Institute of Public Health Prime FoundationRiphah International UniversityIslamabad 44000Pakistan Islamia College Peshawar Khyber Pakhtunkhwa 25120Pakistan

In order to design Sustainable Land Management(SLM)plans or interventions it is important to understand the land use change and subsequent *** basic aim of this study was to assess the impact of land use land cover(LULC)change on soil physico-chemical properties and nutrients loss under different land use/land cover changes within Miandam watershed of Swat valley,*** study area was divided into three major types on the basis LULC type(Dense forest,Moderate forest and Agriculture land).A total of 81 soil samples were collected from the study area(27 from each land use)through stratified random sampling and were transferred to the *** prepared soil samples were then tested for various physico-chemical properties such as pH,electrical conductivity,contents of organic matter,organic carbon,sand,silt,clay,nitrogen,phosphorus,potassium,iron,copper and *** showed that LULC significantly affected all soil parameters except electrical conductivity and *** all the nutrients assessed,the enrichment ratio was greater than 1 which showed that the most fertile layer of the soil in the cropped areas was transported through soil *** this study,time-series satellite images were used to determine the spatiotemporal changes in the LULC of Miandam valley of Swat,Pakistan,and the possible effect of LULC on soil properties was *** information generated on the soil properties as indicators of soil health could be used to inform the stakeholders about the effect of LULC change in the study ***-temporal image acquired by Landsat sensors for the year 2018 was used for quantifying changes in the study *** Landsat images for the year 2018 were classified into six land cover/land use *** increase in agricultural activities caused an increase in the land farming areas which led to an increase in the rate of deforestation in the ***,the present study results reveal that the use of the soil for agriculture i

关键词： land use/land cover soil properties soil nutrients Miandam Swat valley

Short Communication: Analysis of Grain Size Distribution through Image Analysis

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American journal of Plant Sciences 2018年第12期9卷 2339-2346页

作者： dennis C. Gitz III jeffrey T. Baker Paxton Payton Zhanguo Xin Robert j. Lascano USDA-ARS Cropping Systems Research Laboratory Lubbock TX USA

Herein we describe an approach to measure the volume and to characterize the volume distribution of large numbers of individual small regularly shaped seeds. The results of a preliminary investigation into the distribution of seed size of a multi-seeded sorghum mutant, as compared to the wild type from which it was developed are also reported, and are used as an example of the method’s utility.

关键词： Seed Size Grain Size Sorghum Twin Seed Multi-Seed Image Analysis

A Portable and Mobile Rainfall Simulator

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Open journal of Soil Science 2019年第10期9卷 207-218页

作者： Robert j. Lascano john E. Stout Timothy S. Goebel dennis C. Gitz III Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA Department of Plant and Soil Science Texas Tech University Lubbock TX USA.

An existing Purdue-type rainfall simulator (RFS) was designed to be transported using a commercial flatbed trailer that was modified by cutting out a section of the wooden bed allowing the RFS to be positioned directly above the target area to measure soil erosion and water runoff. To allow water to pass through the trailer undisturbed, the axle of the trailer was removed and replaced with axle-free wheel hubs and springs. Additionally, a remote control mover rated for 2000 kg was incorporated in our design. The final result was a portable and mobile RFS that can be moved to fields using a trailer hitch and can be operated by two individuals. The cost of the hardware, not including the RFS, is $5300 (USD) and detailed design plans are available.

关键词： Mobile Transport Trailer Plot and Field Studies Infiltration Runoff Soil Erosion