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抗癫癎药物应用指南Ⅱ:新型抗癫癎药物的药力和耐受性:难治性癫癎的治疗美国神经病学学会治疗学和技术评定分委会和质量标准分委会及美国癫癎协会报告

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神经病学与神经康复学杂志 2008年第4期5卷 265-277页

作者：陆钦池冯智英李颖季伟华 j.A.French A.M.Kanner j.bautista B.Abou-Khalil T.Browne C.L.Harden W.H.Theodore C.Bazil j.Stern S.C.Schachter D.Bergen D.Hirtz G.D.Montouris M.Nespeca B.Gidal W.j.Marks jr. W.R.Turk j.H.Fischer B.Bourgeois A.Wilner R.E.Faught jr. R.C.Sachdeo A.Beydoun T.A.Glauser 上海交通大学医学院附属仁济医院神经内科上海200127

目的对有关7种用以治疗儿童和成人部分性和全面性难治性癫癎的新型抗癫癎药物(AEDs):加巴喷丁(gabapentin, GBP)、拉莫三嗪(lamotrigine,LTG)、托吡酯(topiramate,TPM)、噻加宾(tiagabine,TGB)、奥卡西平(oxcarbazepine,OXC)、左乙拉西坦(levetiracetam,LEV)和唑尼沙胺(zonisamide,ZNS)的药力(efficacy)、耐受性和安全性进行评估。方法由23位成人神经病学家、小儿神经病学家、癫癎病学家和药理学家组成的专家组,依据从1987年到2002年9月Medline,Current Contents和Cochrane上发表的相关文献和2003年以前的指南提供的证据进行循证医学评估。结果所有新型抗癫癎药物都适用于成人难治性部分性癫癎的添加治疗,加巴喷丁对混合性癎性发作有效,加巴喷丁、拉莫三嗪、托吡酯和奥卡西平对儿童难治性部分性癫癎有效。有限的证据还表明,拉莫三嗪和托吡酯对成人和儿童特发性全面性发作和Lennox-Gastaut综合征的添加治疗也有效。结论抗癫癎药物的选择要考虑癫癎发作和/或癫癎综合征的类型、患者的年龄、合用的药物、药物的耐受性、安全性和药力等因素。循证医学评估结果提供了难治性癫癎患者的抗癫癎药物应用指南,但尚需更为有力的证据用以鉴定其在癫癎型或综合征中疗效。

关键词：药物应用指南耐受性难治性癫治疗学美国神经病学技术评定质量标准分 antiepileptic drugs new society american quality technology refractory epilepsy 拉莫三嗪加巴喷丁托吡酯

Effects on physiologic measures of appetite from intragastric balloon and endoscopic sleeve gastroplasty: results of a prospective study

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Chinese Medical journal 2022年第10期135卷 1234-1241页

作者： Babusai Rapaka Daniel B.Maselli Gontrand Lopez-Nava Inmaculada bautista-Castano Reem Matar Veeravich jaruvongvanich Eric j.Vargas Andrew C.Storm Andres Acosta Barham K.Abu Dayyeh Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905USA Madrid Sanchinarro University Hospital MadridSpain

Background: Endoscopic bariatric therapies can help address widening management gaps in obesity. Their ability to facilitate weight loss is largely tied to influences on appetite through perturbations of gastric emptying and accommodation. As these tools gain traction in obesity therapy, their physiologic underpinnings require exploration, which may enhance efficacy, tolerance, and patient-tailored ***: We prospectively assessed consecutive subjects with fluid-filled intragastric balloons (IGBs) (n = 18) placed between October 2016 and june 2017 or underwent endoscopic sleeve gastroplasty (ESG) (n = 23) from March 2018 to june 2018. Patients underwent physiologic appraisal at 3 months with13C-spirulina-based gastric emptying breath test to determine time to half emptying (T50), as well as maximum tolerated volume (MTV) of a standard nutrient drink test. Changes in T50 and MTV at 3 months were compared with percent total body weight loss (%TBWL) at 3 and 6 months using best-fit linear ***: The change in T50 at 3 months correlated with %TBWL at 3 months for IGB (P = 0.01) and ESG (P = 0.01) but with greater impact on %TBWL in IGB compared to ESG (R2 = 0.42vs. 0.26). Change in T50 at 3 months was predictive of weight loss at 6 months for IGB (P = 0.01) but not ESG (P = 0.11). ESG was associated with greater decrease in MTV compared to IGB (340.25 ± 297.97 mLvs. 183.00 ± 217.13 mL,P = 0.08), indicting an enhanced effect on satiation through decreased gastric accommodation. Changes in MTV at 3 months did not correlate with %TBWL for either IGB (P = 0.26) or ESG (P = 0.49) but trended toward significance for predicting %TBWL at 6 months for ESG (P = 0.06) but not IGB (P = 0.19).Conclusion: IGB and ESG both induce weight loss but likely through distinct gastric motor function phenotypes, and gastric emptying may predict future weight loss in patients with IGB.

关键词： Intragastric balloon Endoscopic sleeve gastroplasty Gastric emptying Gastric accommodation Obesity

Influence of growing location and cultivar on Rhyzopertha dominica （Coleoptera： Bostrichidae） and Sitophilus oryzae （Coleoptera： Curculionidae） infestation of rough rice

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Insect Science 2007年第3期14卷 231-239页

作者： FRANK H. ARTHUR RUSTY C. bautista TERRENCE j. SIEBENMORGEN USDA-ARS Grain Marketing and Production Research Center Manhattan Kansas Department of Food Science University of Arkansas Fayetteville Arkansas USA

Long-grain rice cultivars Cocodrie, Wells, and XP 723 grown in three locations （Hazen, MO; Essex and Newport, AR, USA）, and medium-grain rice cultivars Bengal and XP 713 grown in two locations （jonesboro and Lodge Corner, AR, USA）, were harvested and assayed for susceptibility to Rhyzopertha dominica （F.）（Coleoptera： Bostrichidae）, the lesser grain borer, and Sitophilus oryzae （L.）（Coleoptera： Curculionidae）, the rice weevil, on rice held at 27℃, 57% and 75% relative humidity （RH）. Separate samples from the same harvest lots were also analyzed for the physical characteristics of brown rice yield, percentage whole kernels and kernel thickness. Progeny production and feeding damage of R. dominica were significantly different among long-grain cultivars within two of the three locations （P 〈 0.05）, but not for location or RH （P ≥ 0.05）, while progeny production of S. oryzae was different among cultivars, location, and RH （P 〈 0.05）. On medium-grain rice, both cultivar and location were significant for progeny production of R. dominica, but not RH, while cultivar and RH were significant for progeny production of S. oryzae, but not location. On both rice types, feeding damage of R. dominica followed the same trends and was always strongly positively correlated with progeny production （P 〈 0.05）, but for S. oryzae there were several instances in which progeny production was not correlated with feeding damage （P ≥ 0.05）. Physical characteristics of both rice types were statistically significant （P 〈 0.01） but actual numerical differences were extremely small, and were generally not correlated with progeny production of either species. Results indicate that the location in which a particular rice cultivar is grown, along with its characteristics, could affect susceptibility of the rice to R. dominica and S. oryzae.

关键词： rough rice cultivars stored-product insects Rhyzopertha dominica Sitophilus oryzae

抗癫癎药物应用指南Ⅰ:新型抗癫癎药物的药力和安全性:新发癫癎的治疗美国神经病学学会治疗学和技术评定分委会和质量标准分委会及美国癫癎协会报告

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神经病学与神经康复学杂志 2008年第3期5卷 190-197页

作者：高枚春陆钦池 j.A.French A.M.Kanner j.bautista B.Abou-Khalil T.Browne C.L.Harden W.H.Theodore C.Bazil j.Stern S.C.Schachter D.Bergen D.Hirtz G.D.Montouris M.Nespeca B.Gidal W.j.Marks W.R.Turk j.H.Fischer B.Bourgeois A.Wilner R.E.Faught R.C.Sachdeo A.Beydoun T.A.Glauser 上海交通大学医学院附属仁济医院神经内科上海200127

目的对有关7种用以治疗儿童和成人新诊断部分性和全身性癫癎的新型抗癫癎药物(AEDs):加巴喷丁(gabapentin,GBP)、拉莫三嗪(lamotrigine,LTG)、托吡酯(topiramate,TPM)、噻加宾(tiagabine,TGB)、奥卡西平(oxcarbazepine,OXC)、左乙拉西坦(levetiracetam,LEV)和唑尼沙胺(zonisamide,ZNS)的药力(efficacy)、耐受性和安全性按序进行评估(这些药物已受到美国食品与药品管理局FDA的批准)。方法由23位成人神经病学家、儿科神经病学家、癫癎病学家及药理学家组成的,依据从1987年到2002年9月Medline,Current Contents和Cochrane上发表的相关文献和2003年以前的指南提供的证据进行专家组循证医学评估。结果有证据通过对照试验或剂量控制试验显示:加巴喷丁、拉莫三嗪、托吡酯和奥卡西平单药治疗对新诊断的青少年和成人部分性或混合性癫癎是有效的。亦有证据显示,拉莫三嗪对于新诊断的儿童失神发作有效。但尚缺乏证据证明新型抗癫癎药物对新诊断的其他类型的全身性癫癎综合征是否有效。结论循证医学评估结果提供了新诊断癫癎患者的抗癫癎药物应用指南,但尚需更多的证据用以鉴定其在癫癎的类型或综合征中的疗效。

关键词：抗癫药物新诊断噻加宾加巴喷丁癫癎卡马西平托吡酯妥泰拉莫三嗪利必通抗癫癎药物丙戊酸盐苯妥英钠抗心律失常药奥卡西平部分性应用指南技术评定治疗学临床医学质量

Leuprolide acetate induces structural and functional recovery of injured spinal cord in rats

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Neural Regeneration Research 2015年第11期10卷 1819-1824页

作者： Carmen Díaz Galindo Beatriz Gómez-González Eva Salinas Denisse Calderón-Vallejo Irma Hernández-jasso Eduardo bautista j Luis Quintanar Laboratory of Neurophysiology Department of Physiology and Pharmacology Universidad Autónoma de Aguascalientes Area of Neuroscience Department of Reproductive Biology CBS Universidad Autónoma Metropolitana Laboratory of Immunology Department of Microbiology Centro de Ciencias Básicas Universidad Autónoma de Aguascalientes

Gonadotropin-releasing hormone（Gn RH） and its synthetic analog leuprolide acetate, a Gn RH agonist, have neurotrophic properties. This study was designed to determine whether administration of leuprolide acetate can improve locomotor behavior, gait, micturition reflex, spinal cord morphology and the amount of microglia in the lesion epicenter after spinal cord injury in rats. Rats with spinal cord compression injury were administered leuprolide acetate or saline solution for 5 weeks. At the 5th week, leuprolide acetate-treated rats showed locomotor activity recovery by 38%, had improvement in kinematic gait and exhibited voiding reflex recovery by 60%, as compared with the 1st week. By contrast, saline solution-treated rats showed locomotor activity recovery only by 7%, but voiding reflex did not recover. More importantly, leuprolide acetate treatment reduced microglial immunological reaction and induced a trend towards greater area of white and gray matter in the spinal cord. Therefore, leuprolide acetate has great potential to repair spinal cord injury.

关键词： nerve regeneration spinal cord injury leuprolide acetate gonadotropin-releasing hormone neurotrophic factor microglia micturition reflex gait inflammation neural regeneration

Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells

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World journal of Stem Cells 2017年第2期9卷 26-36页

作者： Estefania Caballano-Infantes josé Terron-bautista Amparo Beltrán-Povea Gladys M Cahuana Bernat Soria Hajji Nabil Francisco j Bedoya juan R Tejedo Andalusian Center for Molecular Biology and Regenerative Medicine-University Pablo de Olavide 41092 SevilleSpain Biomedical Research Network on Diabetes and Related Metabolic Diseases(CIBERDEM) Instituto de Salud CarlosⅢ28029 MadridSpain Andalusian Center for Molecular Biology and Regenerative Medicine(CABIMER) 41092 SevilleSpain Andalusian Center for Molecular Biology and Regenerative Medicine Fundación Progreso y Salud41092 SevilleSpain Centre for Pharmacology and Therapeutics Division of Experimental MedicineImperial College LondonHammersmith Hospital CampusLondon W12 0NNUnited Kingdom

Mitochondrial dysfunction and endoplasmic reticulum stress(ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide(NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca^(2+) flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstratedthe need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies.

关键词： Endoplasmic reticulum stress Mitochondrial function Nitric oxide Pluripotency Cell differentiation Mitochondrial biogenesis

Site-Specific Conjugation of Cell Wall Polyrhamnose to Protein SpyAD Envisioning a Safe Universal Group A Streptococcal Vaccine

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Infectious Microbes & Diseases 2021年第2期3卷 87-100页

作者： Nina j.Gao Satoshi Uchiyama Lucy Pill Samira Dahesh joshua Olson Leslie bautista Shilpa Maroju Aym Berges janet ZLiu Raymond HZurich Nina Mvan Sorge jeff Fairman Neeraj Kapoor Victor Nizet Division of Host-Microbe Systems and Therapeutics Department of PediatricsUC San DiegoLa JollaCaliforniaUSA Vaxcyte Inc.Foster CityCaliforniaUSA Department of Medical Microbiology and Infection Prevention Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Netherlands Reference Laboratory for Bacterial Meningitis Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Skaggs School of Pharmacy and Pharmaceutical Sciences UC San DiegoLa JollaCaliforniaUSA

Development of an effective vaccine against the leading human bacterial pathogen group A Streptococcus(GAS)is a public health *** species defining group A cell wall carbohydrate(GAC,Lancefield antigen)can be engineered to remove its immunodominant N-acetylglucosamine(GlcNAc)side chain,implicated in provoking autoimmune cross-reactivity in rheumatic heart disease,leaving its polyrhamnose core(GACPR).Here we generate a novel protein conjugate of the GACPR and test the utility of this conjugate antigen in active *** of conjugation to a standard carrier protein,we selected SpyAD,a highly conserved GAS surface protein containing both B-cell and T-cell epitopes relevant to the bacterium that itself shows promise as a vaccine *** was synthesized using the XpressTM cell-free protein expression system,incorporating a non-natural amino acid to which GACpr was conjugated by site-specific click chemistry to yield high molecular mass SpyAD-GACPR conjugates and avoid disruption of important T-cell and B-cell immunological *** conjugated SpyAD-GACPR elicited antibodies that bound the surface of multiple GAS strains of diverse M types and promoted opsonophagocytic killing by human *** immunization of mice with a multivalent vaccine consisting of SpyAD-GACPR,together with candidate vaccine antigens streptolysin O and C5a peptidase,protected against GAS challenge in a systemic infection model and localized skin infection model,without evidence of cross reactivity to human heart or brain tissue *** general approach may allow GAC to be safely and effectively included in future GAS subunit vaccine formulations with the goal of broad protection without autoreactivity.

关键词： group A Streptococcus Streptococcus pyogenes group A carbohydrate Lancefield antigen conjugate vaccine XpressCFTM non-natural amino acids SpyAD Introduction

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菲利宾在摸索中渡过困难时期

铸造纵横 2009年第10期 49-50页

作者： j.Hermes D.bautista PMAL

自2008年以来，监管菲律宾金属业的政府部门——金属工业研究发展中心（MIRDC），单方面地将铸造业列为低等级的行业，这意味着资源将会优先被用于其他较为高级的行业当中，如模具行业等。变更后将不会再有关于铸造方面的工业统计数据... 详细信息

自2008年以来，监管菲律宾金属业的政府部门——金属工业研究发展中心（MIRDC），单方面地将铸造业列为低等级的行业，这意味着资源将会优先被用于其他较为高级的行业当中，如模具行业等。变更后将不会再有关于铸造方面的工业统计数据。这使铸造业的发展就像“驾驶汽车时没有了侧视镜和后视镜”。因此铸造行业只能被认为是在摸索中发展，也就是“瞎做”。

关键词：菲律宾金属工业研究发展中心模具行业铸造业政府部门统计数据铸造行业后视镜

Clinical and microbiological features of vulvovaginitis in Mexican girls

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Open journal of Obstetrics and Gynecology 2013年第2期3卷 243-248页

作者： Mario I.Ortiz Edna j.Arreola-bautista Beatriz A.Sánchez-Reyes Georgina Romo-Hernández Marco A.Escamilla-Acosta Area Académica de Medicina del Instituto de Ciencias de la Salud de la Universidad Autónoma del Estado de Hidalgo PachucaHidalgoMexico Universidad del Futbol y Ciencias del Deporte San Agustín TlaxiacaHidalgoMexico Hospital del Nino DIF Hidalgo PachucaHidalgoMexico

Study Objective: To determine the prevalence of vulvovaginitis, predisposing factors, microbial etiology and therapy in patients treated at the Hospital del Nino DIF, Pachuca, Hidalgo, Mexico. Design. This was an observational and descriptive study from 2006 to 2009. Setting: Hospital del Nino DIF, Pachuca, Hidalgo, Mexico. Participants. Patients from 0 to 16 years, with vulvovaginitis and/or vaginal discharge were included. Interventions: None. Main Outcome Measures: Demographic data, etiology, clinical features, risk factors and therapy were analyzed. Results: Four hundred twenty seven patients with diagnosis of vulvovaginitis were included. The average prevalence to 4 years in the study period was 0.19%. The age group most affected was schoolchildren (225 cases: 52.69%). The main signs and symptoms presented were leucorrhea (99.3%), vaginal hyperemia (32.6%), vulvar itching (32.1%) and erythema (28.8%). Identified risk factors were poor hygiene (15.7%), urinary tract infection (14.7%), intestinal parasites (5.6%) and obesity or overweight (3.3%). The main microorganisms found in vaginal cultures were enterobacteriaceae (Escherichia coli, Klebsiella and Enterococcus faecalis), Staphylococcus spp, and Gardnerella vaginalis. Several inconsistent were found in the drug prescription of the patients. Conclusion: Vulvovaginitis prevalence in Mexican girls is low and this was caused mainly by opportunist microorganisms. The initial treatment of vulvovaginitis must include hygienic measure and an antimicrobial according to the clinical features and microorganism found.

关键词： Vulvovaginitis Prevalence Etiologic Microorganisms Mexican Children and Adolescents