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Aggregate 2023年第4期4卷 195-209页

作者： Bruce Lin Andrew Hung William Singleton Kevion K.Darmawan Rachael Moses Bicheng Yao Hongkang Wu Anders barlow Marc-Antoine Sani Alastair j.Sloan Mohammed Akhter Hossain john D.Wade Yuning Hong Neil M.O’Brien-Simpson Wenyi Li The Bio21 Institute of Molecular Science and Biotechnology University of MelbourneMelbourneVictoriaAustralia ACTV Research group Melbourne Dental SchoolCentre for Oral Health ResearchUniversity of MelbourneMelbourneVictoriaAustralia School of Science RMIT UniversityMelbourneVictoriaAustralia Melbourne Dental School Division of Basic and Clinical Oral SciencesUniversity of MelbourneMelbourneVictoriaAustralia Department of Biochemistry and Chemistry La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVictoriaAustralia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoriaAustralia School of Chemistry University of MelbourneMelbourneVictoriaAustralia Materials Characterisation and Fabrication Platform University of MelbourneMelbourneVictoriaAustralia

Antimicrobial peptides(AMPs)are potentially powerful alternatives to conven-tional antibiotics in combating multidrug resistance,given their broad spectrum of *** mainly interact with cell membranes through surface electrostatic potentials and the formation of secondary structures,resulting in permeability and destruction of target microorganism *** earlier work showed that two leading AMPs,MSI-78(4–20)and pardaxin(1–22),had potent antimicrobial activ-ity against a range of *** is known that the attachment of moderate-length lipid carbon chains to cationic peptides can further improve the functionality of these peptides through enhanced interactions with the membrane lipid bilayer,inducing membrane curvature,destabilization,and potential ***,in this work,we aimed to investigate the antimicrobial activity,oligomerization propensity,and lipid-membrane binding interactions of a range of N-terminal lipidated analogs of MSI-78(4–20)and pardaxin(1–22).Molecular modeling results suggest that aggregation of the N-lipidated AMPs may impart greater structural stability to the peptides in solu-tion and a greater depth of lipid bilayer insertion for the N-lipidated AMPs over the parental *** experimental and computationalfindings provide insights into how N-terminal lipidation of AMPs may alter their conformations,with subsequent effects on their functional properties in regard to their self-aggregation behavior,membrane interactions,and antimicrobial activity.

关键词： aggregation antimicrobial peptide lipidation membrane active peptide

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Evaluating the sensitivity of SARS-CoV-2 infection rates on college campuses to wastewater surveillance

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Infectious Disease Modelling 2021年第1期6卷 1144-1158页

作者： Tony E.Wong George M.Thurston Nathaniel barlow Nathan D.Cahill Lucia Carichino Kara Maki David Ross jennifer Schneider School of Mathematical Sciences Rochester Institute of TechnologyRochesterNY14623USA School of Physics and Astronomy Rochester Institute of TechnologyRochesterNY14623USA Applied Critical Thinking&Collaboratory for Resiliency&Recovery Rochester Institute of TechnologyRochesterNY14623USA Department of Civil Engineering Technology Environmental Management&SafetyRochester Institute of TechnologyRochesterNY14623USA

As college campuses reopened in fall 2020,we saw a large-scale experiment unfold on the efficacy of various strategies to contain the SARS-CoV-2 *** individual surveillance testing via nasal swabs and/or saliva is among the measures that colleges are pursuing to reduce the spread of the virus on ***,some colleges are testing wastewater on their campuses for signs of infection,which can provide an early warning signal for campuses to locate COVID-positive ***,a representation of wastewater surveillance has not yet been incorporated into epidemiological models for college campuses,nor has the efficacy of wastewater screening been evaluated relative to traditional individual surveillance testing,within the structure of these ***,we implement a new model component for wastewater surveillance within an established epidemiological model for college *** use a hypothetical residential university to evaluate the efficacy of wastewater surveillance for maintaining low infection *** find that wastewater sampling with a 1-day lag to initiate individual screening tests,plus completing the subsequent tests within a 4-day period can keep overall infections within 5%of the infection rates seen with traditional individual surveillance *** results also indicate that wastewater surveillance can effectively reduce the number of false positive cases by identifying subpopulations for surveillance testing where infectious individuals are more likely to be *** a Monte Carlo risk analysis,we find that surveillance testing that relies solely on wastewater sampling can be fragile against scenarios with high viral reproductive numbers and high rates of infection of campus community members by outside *** results point to the practical importance of additional surveillance measures to limit the spread of the virus on campus and the necessity of a proactive response to the initial signs of outbreak.

关键词： Compartment model Sensitivity analysis Risk analysis COVID-19 Pandemic Wastewater

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The nature of the companion of PSR j1719-1438: a white dwarf or an exotic object?

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Research in Astronomy and Astrophysics 2012年第7期12卷 813-816页

作者： j. E. Horvath Instituto de Astronomia Geofísica e Ciências Atmosfricas - Universidade de So Paulo

We raise the possibility that the very dense, compact companion of PSR j1719-1438, which has a jupiter-like mass, is an exotic quark object rather than a light helium or carbon white dwarf. The exotic hypothesis naturally explains some of the observed features, and provides quite strong predictions for this system, to be confirmed or refuted in feasible future studies.

关键词： binary pulsars -- exotic matter-- pulsars: individual (PSR j1719-1438)

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当人工智能搭上云端快车

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机器人产业 2017年第3期 12-19页

作者： Mike barlow 不详

人工智能（AI），人类历史进程中的一次重大变革。人工智能概念追求的是让机器能够模拟人的意识、思维，虽然人工智能不是人的智能，但却能像人一样进行思考，也可能超越人的智能。云端，也指云端软件平台，是一种搭载在服务器上的虚拟... 详细信息

人工智能（AI），人类历史进程中的一次重大变革。人工智能概念追求的是让机器能够模拟人的意识、思维，虽然人工智能不是人的智能，但却能像人一样进行思考，也可能超越人的智能。云端，也指云端软件平台，是一种搭载在服务器上的虚拟技术，可以通过搭建软件资源、软件应用和软件服务平台来为用户提供更为简单流畅、方便快捷的服务体验。那么，当人工智能搭上了云端这辆“快车”之后，是否意味着机器智能将更快的来临？人类的未来又将如何呢？

关键词：人工智能软件平台机器智能历史进程虚拟技术软件资源服务平台服务器

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绝经后妇女激素替代治疗:子宫内膜增生和不规则出血

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生殖与避孕 2006年第10期26卷 618-626页

作者： Lethaby A Farquhar C Sarkis A Roberts H jepson R barlow D 方爱华单位不详

1背景绝经意指:停止来月经,典型发生的年龄介于45-55岁间,平均为51岁。当月经终止持续12月以上,称为绝经后妇女。围绝经期,由于血循环中雌激素水平下降,可引发影响妇女身心健康的一些症状。[第一段]

关键词：绝经后妇女子宫内膜增生激素替代治疗不规则出血雌激素水平围绝经期身心健康血循环

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Helicity Amplitude Analysis of Z_c(3900)~± in e^+e^- →π^+π^-j/ψ

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Chinese Physics Letters 2016年第6期33卷 9-11页

作者：平荣刚 j.G.Messchendorp 苑长征 Institute of High Energy Physics Chinese Academy of Sciences KVI-CART University of Groningen

It is crucial to determine the spin and parity （jR） of Zc（3900）＋ for understanding its structure. We perform a helicity amplitude analysis on Zc（3900）＋ in the process e＋e- →π＋π-j/φ＊ with the hypotheses jP = 0-, 1＋, 1-, 2＋ and 2-. To estimate the significance of jP = 1＋ over other hypotheses, we perform a Monte Carlo simulation study, and we also discuss the prospect of measuring the spin parity in the future experiment with a large data sample.

关键词： of on is Helicity Amplitude Analysis of Z_c in e for that

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阿斯顿火神

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汽车测试报告 2015年第5期 108-115页

作者： jASON barlow TONY

硕大尾翼吓死人，火神伏尔坎更不会容忍如此冒犯的行为，不过它也未必敢和阿斯顿新车对阵当堂。Vulcan，火神。这样的名号才叫响亮嘛，即使用在新款吸尘器上也令人奠名心动，更不必说用j生新型阿斯顿马丁上。尽管TG有必要指出这里所谓... 详细信息

硕大尾翼吓死人，火神伏尔坎更不会容忍如此冒犯的行为，不过它也未必敢和阿斯顿新车对阵当堂。Vulcan，火神。这样的名号才叫响亮嘛，即使用在新款吸尘器上也令人奠名心动，更不必说用j生新型阿斯顿马丁上。尽管TG有必要指出这里所谓的新型阿斯顿·马丁身负588kW以上的自然吸气V12，产量只有24台。

关键词：自然吸气吸尘器 V12 新车

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The supernova remnant CTB 37B and its associated magnetar CXOU j171405.7-381031:evidence for a magnetar-driven remnant

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Research in Astronomy and Astrophysics 2011年第6期11卷 625-630页

作者： j.E.Horvath M.P.Allen Instituto de Astronomia Geofísica e Ciências Atmosféricas-Universidade de So PauloRua do Mato122605508-900 Cidade Universitria So Paulo SPBrazil CEFET So Paulo Rua Pedro Vicente 62501109-010Caninde'So Paulo SPBrazil

We discuss the association between the candidate magnetar CXOU j171405.7-381031 and the supernova remnant CTB *** recent detection of the period derivative of the object allowed an estimation of a young characteristic age of only ～ *** value is too small to be compatible even with the minimum radius of the remnant being ≥ 10 pc,the value corresponding to the lower limit of the estimated distance of 10.2 ± 3.5 kpc,unless the true distance happens to be even smaller than the lower *** argue that a consistent scenario for the remnant＇s origin,in which the latter is powered by the energy injected by a young magnetar,is indeed more accurate to explain the young age,and demonstrates its non-standard（***-driven） nature.

关键词： stars:supernova — stars:neutron

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Safe mining practices under wide spans in underground non-caving mines——Case studies

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International journal of Mining Science and Technology 2019年第4期29卷 535-540页

作者： j.j.Ran Kinross Gold Corporation

Mining under wide span is of concern as it increases the probability of back caving causing personnel injury and equipment damage in underground mines in open stoping and underhand drift-and-fill *** restricting personnel access to well supported lateral development is commonly practiced,it is not always possible to implement this requirement due to various factors such as ore loss control,drilling equipment limitations,availability of remote operating capacity and consideration of *** with rules implemented to limit personnel entry into openings with wide spans,the hazards of equipment damage and back caving still *** the years,different practices have been reported and adopted to minimize risks associated with exposure to large spans in various underground *** from these practices are beneficial to current and future mines with challenges of safe extraction of thick deposits in a non-caving *** paper briefly summarizes practices in mining wide orebodies using the open stoping method without personnel access and underhand mining using the drift-andfill method with personnel exposure in the industry and presents cases from Kinross mines where the hanging pillar design was tested,and stope backs were naturally and artificially supported for extraction under wide spans using the open stoping method.

关键词： Mine safety Wide span Back stability Underhand mining Hanging pillar

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二尖瓣脱垂的近况

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山东医药 1985年第9期 43-46页

作者： Cheitilin M D ,barlow j B ,张文博

二尖瓣脱垂在我国的发病率并不低,但一般临床医生对其比较生疏。本文介绍国外学者对二尖瓣脱垂的一些新观点,以助我们更好地诊断、处理这一常见病。

关键词：二尖瓣脱垂收缩期杂音原发性超声心动图超声波诊断喀喇音二尖瓣闭锁不全二尖瓣关闭不全

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