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Chinese journal of Mechanical Engineering 2021年第6期34卷 51-62页

作者： M.Nuño j.bühring M.N.Rao K.-U.Schröder Institute of Structural Mechanics and Lightweight Design RWTH Aachen UniversityWüllnerstraβe 752072 AachenGermany

Sandwich structures possess a high bending stiffness compared to monolithic structures with a similar *** makes them very suitable for lightweight applications,where high stiffness to weight ratios are *** common manufacturing methods of sandwich structures involve adhesive bonding of the core material with the ***,adhesive bonding is prone to delamination,a failure mode that is often difficult to *** paper presents the results of delamination testing of fully additive manufactured(AM)AlSi10Mg sandwich structures with pyramidal lattice truss core using Laser Powder bed Fusion(LPbF).The faces and struts are 0.5 mm thick,while the core is 2 mm *** inclination of the struts is 45°.To characterise the bonding strength,climbing drum peel tests and out-of-plane tensile tests are *** formulas are derived to predict the expected failure loads and *** analytics and tests are supported by finite element(FE)*** the analytic approach,design guidelines to avoid delamination in AM sandwich structures are *** study presents a critical face sheet thickness to strut diameter ratio for which the structure can *** ratio is mainly influenced by the inclination of the *** peel tests resulted in face yielding,which can also be inferred from the analytics and *** out-of-plane tensile tests didn’t damage the structure.

关键词： Additive Manufacturing Sandwich Structures Pyramidal Lattice Core

Identification of CD13,CD107a,and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-de-pendent upregulation

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Cell Research 2005年第5期15卷 325-335页

作者： Florian HENNERSDORF,Stefan FLORIAN,Andreas jAKOb,Katharina bAUMGRTNER,Karoline SONNECK,Alfred NORDHEIM,Tilo bIEDERMANN,Peter VALENT,Hans-jrg bühring University Clinic of Tübingen Department of Internal Medicine II Division of Hematology and Immunology Tübingen Germany Medical University Clinic of Vienna Department of Internal Medicine I Division of Hematology and Hemostaseology Vienna Austria University of Tübingen Proteome Center Tübingen Germany University Clinic of Tübingen Department of Internal Medicine II Division of Hematology and Immunology Tübingen Germany Medical University Clinic of Vienna Department of Internal Medicine I Division of Hematology and Hemostaseology Vienna Austria University of Tübingen Proteome Center Tübingen Germany University Clinic of Tübingen Department of Dermatology Tübingen Germany Medical University Clinic of Vienna Department of Internal Medicine I Division of Hematology and Hemostaseology Vienna Austria University Clinic of Tübingen Department of Internal Medicine II Division of Hematology and Immunology Tübingen Germany

Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited an increased reactivity with basophils activated by anti-IgE-mediated cross-linking of the high affinity IgE receptor (FcεRI). These include antibod- ies against CD164 (WS-80160, clone N6b6 and WS-80162, clone 67D2), as well as two reagents with previously unknown specificities that were identified as CD13 (WS-80274, clone A8) and CD107a (WS-80280, clone E63-880). The activation patterns followed either the “CD203c-like” or “CD63-like” activation profile. The CD203c profile is characterized by a rapid and significant upregulation (of CD13, CD164, and CD203c), reaching maximum levels after 5- 15 min of stimulation. The phosphoinositide-3-kinase (PI3K)-specific inhibitor wortmannin inhibited the upregulation of these markers whereas 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced a rapid and FcεRI-independent upregulation within 1-2 min. In the CD63 profile, maximum upregulation (of CD63 and CD107a) was detected only after 20-40 min, and upregulation by TPA reached maximum levels after 60 min. In summary, our data identify CD13, CD107a, and CD164 as novel basophil-activation antigens. based on time kinetics of upregulation, we hypothesize that molecules of the “CD203c group” and the “CD63 group” are linked to two different mechanisms of basophil activation.

关键词： CD203c CD164 CD63 CD107a basophil activation basophil marker.

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Wu69-小鼠抗人白细胞介素2受体的单抗

免疫学杂志 1988年第1期 7-12页

作者：史良如,EM Schneider,GP Pawelec,H-j.bühring,b Uchanska-Ziegler,P Wernet 卫生部武汉生物制品研究所 Medical University Clinic 7400 Tbingen FRG Medical University Clinic 7400 Tbingen FRG Medical University Clinic 7400 Tbingen FRG Medical University Clinic 7400 Tbingen FRG Medical University Clinic 7400 Tbingen FRG 武汉

本文报导应用杂交瘤技术制备的鼠抗人白细胞介素2受体(IL—2R)的单抗—Wu69.免疫沉淀表明它能识别分子量为56Kd的PHA活化的T细胞膜表面的蛋白分子。该抗体只对部分b细胞及非淋巴样生血细胞系呈阳性反应,而白血病T细胞系均为阴性,但对活... 详细信息

本文报导应用杂交瘤技术制备的鼠抗人白细胞介素2受体(IL—2R)的单抗—Wu69.免疫沉淀表明它能识别分子量为56Kd的PHA活化的T细胞膜表面的蛋白分子。该抗体只对部分b细胞及非淋巴样生血细胞系呈阳性反应,而白血病T细胞系均为阴性,但对活化的T细胞及人T细胞克隆有高度的结合力。它可抑制T细胞的同种异体刺激所引起的增殖反应,并与IL—2有竞争作用。进一步应用FACS及顺序免疫沉淀试验证明它与抗Tac完全相同。本文还对抗IL-2R的重要性及抗IL—2R作为免疫抑制剂的可喜前景进行了讨论。

关键词：抗Tac 抗IL—2R 单克隆抗体

Co-contaminants of microplastics in two seabird species from the Canadian Arctic

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Environmental Science and Ecotechnology 2022年第4期12卷 87-96页

作者： Roxana Sühring julia E.baak Robert j.Letcher birgit M.braune Amila de Silva Cody Dey Kim Fernie Zhe Lu Mark L.Mallory Stephanie Avery-Gomm jennifer F.Provencher Department of Chemistry and biology Toronto Metropolitan University(formerly known as Ryerson University)350 Victoria StTorontoONM5B 2K3Canada Department of Natural Resource Science McGill UniversitySainte Anne de BellevueQuebecH9X 3V9Canada Environment and Climate Change Canada National Wildlife Research CentreCarleton UniversityRaven RoadOttawaOntarioK1A 0H3Canada Aquatic Contaminants Research Division Environment and Climate Change CanadaBurlingtonOntarioL7S 1A1Canada Ecotoxicology&Wildlife Health Division Environment and Climate Change CanadaBurlingtonOntarioL7S 1A1Canada Institut des Sciences de la Mer de Rimouski Université du Québec à RimouskiRimouskiQuébecG5L 3A1Canada Department of biology Acadia UniversityWolfvilleNova ScotiaB4P 2R6Canada

Through ingestion and subsequent egestion,Arctic seabirds can bioaccumulate microplastics at and around their colony breeding *** microplastics in Arctic seabirds have been well documented,it is not yet understood to what extent these particles can act as transport vehicles for plastic-associated contaminants,including legacy persistent organic pollutants(POPs),trace metals,and organic *** investigated the occurrence and pattern of organic and inorganic co-contaminants of microplastics in two seabird species from the Canadian Arctic-northern fulmar(Fulmarus glacialis)and black-legged kittiwake(Rissa tridactyla).We found that fulmars had higher levels of plastic contamination and emerging organic compounds(known to be plastic additives)than kittiwakes,whereas higher concentrations of legacy POPs were found in kittiwakes than the ***,fulmars,the species with the much larger foraging range(~200 km),had higher plastic pollution and overall contaminant burdens,indicating that birds may be acting as long-range transport vectors for plasticassociated *** results suggest a potential connection between plastic additive contamination and plastic pollution burdens in the bird stomachs,highlighting the importance of treating plastic particles and plastic-associated organic additives as co-contaminants rather than separate pollution issues.

关键词： Plastic contaminants Contaminants of emerging arctic concern Arctic Seabirds PFAS OPEs PbDEs Trace metals

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硬质合金刀具的物理镀层方法

国外金属热处理 1990年第3期11卷 37-40页

作者： j.Gühring 李敏政

长期以来硬质合金刀具,特别是硬质合金可转位刀片都采用氮化钛镀层。实践证明,这种镀层是可靠的。近年来发展了一种新的镀层方法。尽管今后仍采用氮化钛镀层,但在多数情况下不再使用化学镀层,而采用物理镀层。下面介绍这种镀层的主要特... 详细信息

长期以来硬质合金刀具,特别是硬质合金可转位刀片都采用氮化钛镀层。实践证明,这种镀层是可靠的。近年来发展了一种新的镀层方法。尽管今后仍采用氮化钛镀层,但在多数情况下不再使用化学镀层,而采用物理镀层。下面介绍这种镀层的主要特点。化学和物理镀层方法 CVD方法是通过几种气体(例如,氯化钛、氢和氮、图1)的化学反应而获得镀层。

关键词：硬质合金刀具物理镀覆

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发生于乳房复发性粘液样肉瘤后的双侧乳房癌

德国医学 1996年第2期13卷 119-122页

作者： b.R.Titius U-j.Ghring A.Scharl 武忠弼 Institut für Pathologie Universitt zu KlnJoseph-Stelzmann-Str.9D-5093KlnGermany 同济医科大学

肉瘤在乳房恶性肿瘤中的发生率仅占0.5%～3%,脂肪肉瘤则仅占乳腺肉瘤的0.3%,因而与四肢及腹膜后的肉瘤相比仅属罕见。一些脂肪肉瘤是在乳腺纤维腺瘤的基础上恶变而成,或由叶状囊性肉瘤转化而来,其余则为乳腺的原发性肉瘤。本瘤首先由 Vi... 详细信息

肉瘤在乳房恶性肿瘤中的发生率仅占0.5%～3%,脂肪肉瘤则仅占乳腺肉瘤的0.3%,因而与四肢及腹膜后的肉瘤相比仅属罕见。一些脂肪肉瘤是在乳腺纤维腺瘤的基础上恶变而成,或由叶状囊性肉瘤转化而来,其余则为乳腺的原发性肉瘤。本瘤首先由 Virchow 于1857年描述,第一例由 Neumann于1862年报道,迄今共报道近百例。本文1例为26岁患者,原患粘液样内瘤,组织学上未分化并继之以双侧乳房癌。

关键词：乳腺癌粘液样肉瘤病理

细菌性角膜炎微生物学分析作为指导治疗的依据

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德国医学 2000年第3期17卷 180-182页

作者： Stephen j.Frhlich Herminia MiodeKaspar Thomas Grasbon Caroline Mhring Volker Klauβ Anselm Kampik 杨红 Universitts-Augenklinik Mathildenstraβe.8 D-80336 München Germany 同济医科大学附属同济医院

与睑缘炎和结膜炎相比,细菌性角膜炎是一种较少见的感染,但它又是一个最严重的疾病,因为该病可以在短时间内出现戏剧性的病程并向眼的深部进展而威胁整个眼球。生理上有不同的机制阻止角膜的炎症:其一是眼睑的自然反射以对眼睛进行一定... 详细信息

与睑缘炎和结膜炎相比,细菌性角膜炎是一种较少见的感染,但它又是一个最严重的疾病,因为该病可以在短时间内出现戏剧性的病程并向眼的深部进展而威胁整个眼球。生理上有不同的机制阻止角膜的炎症:其一是眼睑的自然反射以对眼睛进行一定的清洁;

关键词：细菌性角膜炎微生物学诊断治疗

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高品质聚丙烯腈丝绒的连续染色方法

国际纺织导报 2014年第9期42卷 34-36页

作者： Y.Zimmermann S.Pohlers A.Mafalda H.-j.Weiβ M.Weiser U.Mhring 杨茹图林根-福格特兰纺织品研究所(TITV)

分别研究了采用真空抽提和Chromojet喷印技术连续上染聚丙烯腈丝绒的工艺,结果表明两种技术皆具有低耗水及设计易变更的特点。

关键词：真空抽提 Chromojet喷印阳离子染料连续上染

Phosphatidylinositol 4-kinase β mutations cause nonsyndromic sensorineural deafness and inner ear malformation

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journal of Genetics and Genomics 2020年第10期47卷 618-626页

作者： Xiulan Su Yufei Feng Sofia A.Rahman Shuilong Wu Guoan Li Franz Rüschendorf Lei Zhao Hongwei Cui junqing Liang Liang Fang Hao Hu Sebastian Froehler Yong Yu Giannino Patone Oliver Hummel Qinghua Chen Klemens Raile Friedrich C.Luft Sylvia bahring Khalid Hussain Wei Chen jingjing Zhang Maolian Gong Clinical Medicine Research Center Affiliated Hospital of Inner Mongolia Medical UniversityHuhhot010050China Affiliated Hospital of Guangdong Medical University&Key Laboratory of Zebrafish Model for Development and Disease of Guangdong Medical University Zhanjiang524001China Marine Medical Research Institute of Guangdong Zhanjiang Zhanjiang524023China Genomic Medicine Programme UCL Institute of Child Health and Great Ormond Street Hospital for Children30 Guilford StreetLondonWC1N 1EHUK Max-Delbrueck-Center for Molecular Medicine(MDC) Robert-Roessle-Str.10Berlin13125Germany Department of Radiology Affiliated Hospital of Inner Mongolia Medical UniversityHuhhot010050China Affiliated People Hospital of Inner Mongolia Medical University Huhhot010050China Department of biology Southern University of Science and TechnologyShenzhen518055China Guangzhou Women and Children's Medical Center Guangzhou510623China Department of Radiology Beijing Tongren HospitalCapital Medical UniversityBeijing100730China Experimental and Clinical Research Center(ECRC) A Joint Cooperation Between the Charite Medical Faculty and the Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association(MDC)Lindenberger Weg.80Berlin13125Germany Department of Paediatric Medicine Division of Endocrinology Sidra Medical&Research CenterOPCDohaC6-337Qatar Medi-X Institute SUSTec Academy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhen518055China

Congenital hearing loss is a common disorder *** gene variation accounts for approximately 20-25%of such *** investigated a five-generation Chinese family with autosomaldominant nonsyndromic sensorineural hearing loss(SNHL).No wave was detected in the pure-tone audiometry,and the auditory brainstem response was absent in all *** tomography of the patients,as well as of two sporadic SNHL cases,showed bilateral inner ear anomaly,cochlear maldevelopment,absence of the osseous spiral lamina,and an enlarged vestibular *** findings were absent in nonaffected *** used linkage analysis and exome sequencing and uncovered a heterozygous missense mutation in the PI4 Kb gene(***121 Arg)encoding phosphatidylinositol 4-kinaseβ(PI4 Kb)from the patients in this *** addition,3 missense PI4 Kb(***434 Gly,***667 Lys,and ***739 Arg)mutations were identified in five patients with nonsyndromic SNHL from 57 sporadic *** such mutations were present within 600 Chinese controls,the 1000 genome project,gnom AD,or similar *** pi4 kb m RNA expression in zebrafish caused inner ear abnormalities and audiosensory impairment,mimicking the patient ***,overexpression of 4 human missense PI4 Kb mutant m RNAs in zebrafish embryos resulted in impaired hearing function,suggesting dominant-negative *** together,our results reveal that PI4 Kb mutations can cause SNHL and inner ear ***4 Kb should be included in neonatal deafness screening.

关键词： Congenital sensorineural hearing loss Inner ear malformation Phosphatidylinositol 4-kinaseβ Mutations Zebrafish