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Effect of cerium/lanthanum addition on microstructure and mechanical properties of Al7075 alloy via mechanical alloying and sintering

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journal of Rare Earths 2016年第4期34卷 420-427页

作者： R.Pérez-Bustamante A.Reyna-Cruz D.C.Acosta-Pena C.R.santillán-Rodríguez j.A.Matutes-Aquino F.Pérez-Bustamante M.C.Maldonado-Orozco j.aguilar-santillán R.Martínez-Sánchez Research Center in Advanced Materials(CIMA V) National Laboratory of NanotechnologyMiguel de Cervantes No.120C.P.31109ChihuahuaChih.Mexico Faculty of Engineering Autonomous University of Chihuahua(UACH)Circuito No.1 Nuevo Campus UniversitarioC.P.31 125ChihuahuaChih.Mexico Faculty of Chemical Sciences Autonomous University of Chihuahua(UACH)Circuito No.1 Nuevo Campus UniversitarioC.P.31125ChihuahuaChih.Mexico Materials&Tools LLC 4118 E Washington CtGilbertAZUSA 85234

The effect of the Al-6Ce-3La（ACL） on the microstructural behavior of the Al7075 was investigated. Materials were synthesized by mechanical alloying with variation in the ACL content and milling time. Products were characterized and studied in the as-milled condition and mechanically evaluated after sintering. The synergetic effect of milling time and ACL content in the modified materials led to a reduction in the particle size. Results from electron microscopy showed a homogeneous dispersion of Ce/La phases up to 20 wt.% of ACL content after 10 h of milling. Mechanical evaluation under compressive test showed an improved performance for those alloys reinforced with 0.2 wt.% and 0.5 wt.% of ACL.

关键词： mechanical alloying rare earths aluminum microstructure sintering

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X-ray diffraction analysis by Rietveld refinement of FeAl alloys doped with terbium and its correlation with magnetostriction

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journal of Rare Earths 2023年第8期41卷 1217-1224,I0004页

作者： j.S.Uribe-Chavira G.Herrera-Pérez C.R.santillán-Rodríguez R.j.Sáenz-Hernández j.A.Matutes-Aquino M.C.Grijalva-Castillo Materials Physics Department Centro de Investigación en Materiales AvanzadosS.C.Miguel de Cervantes 120Chihuahua31136ChihMexico COnACYT–Centro de Investigación en Materiales Avanzados S.C.Miguel de Cervantes 120Chihuahua31136ChihMexico

Fe_(81)Al_(19) polycrystalline alloys doped with Tb(0-0.25 at%) were obtained by arc melting.The introduction of Tb favors the formation of columnar grains in the micro structure of the alloys,which develops a texture in the [100]crystal direction.Microstructural examination shows that the alloys are composed in great proportion by the disordered body-centered cubic(bcc),A2 phase and by a small proportion of the ordered bcc,B2 phase.As a consequence of doping with Tb,the lattice parameter increases,so the calculated apparent crystallite size increases,indicating a decrease in dislocation density and therefore in microstrains.The change in the magnetostriction with the magnetic field,dλ_(T)/dH,is directly related to strain anisotropy that can favor the iron easy magnetization axis on the [100] direction.An increase in total magnetostriction is found in the doped alloys with a maximum of 90 × 10^(-6) at 300 K for the alloy containing 0.027 at% Tb.This enhancement is a threefold value of the undoped alloy,which is attributed to the smaller maximum strain value and the preferential orientation formation by the columnar grains.

关键词： FeAl alloy Magnetostriction Rietveld refinement Microstrains Preferred orientation Rare earths

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Morphological and biochemical effects of weekend alcohol consumption in rats: Role of concentration and gender

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World journal of Hepatology 2018年第2期10卷 297-307页

作者： josé A Morales-González María de Lourdes Sernas-Morales ángel Morales-González Laura Ligía González-López Eduardo Osiris Madrigal-santillán nancy Vargas-Mendoza Tomás Alejandro Fregoso-aguilar Liliana Anguiano-Robledo Eduardo Madrigal-Bujaidar Isela álvarez-González Germán Chamorro-Cevallos Laboratorio de Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Escuela Superior de Cómputo Instituto Politécnico Nacional área Académica de nutrición ICSa Universidad Autónoma del Estado de Hidalgo Depto. de Fisiología Laboratorio de Hormonas y Conducta ENCB campus Zacatenco Instituto Politécnico Nacional Laboratorio de Farmacología Molecular Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina-Instituto Politécnico Nacional Laboratorio de Genética Escuela Nacional de Ciencias Biológicas IPN Departamento de Farmacia Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional

AIM To examine the association between weekend alcohol consumption and the biochemical and histological alterations at two different concentrations of alcohol in both genders in rats.METHODS Wistar rats weighing 170-200 g were divided into groups as follows:(1) Control groups; and(2) weekend alcohol-consumption group: 2 d/weekly per 12 wk, at two different concentrations:(1) Group of males or females with a consumption of a solution of alcohol at 40%; and(2) group of males or females with a consumption of a solution of alcohol at 5%. At the end of the experiment, serum and liver samples were obtained. The following enzymes and metabolites were determined in serum: Alanine Aminotransferase(ALT), Aspartate Aminotransferase(AST), Lactate Dehydrogenase, and Gamma-Glutamyltransferase, and glucose, triglycerides, cholesterol, bilirubin, and albumin. Liver samples from each group were employed to analyze morphological abnormalities by light microscopy.RESULTS In all of the weekend alcohol-consumption groups, AST activity presented a significant, 10-fold rise. Regarding ALT activity, the groups with weekend alcohol consumption presented a significant increase that was six times greater. Bilirubin levels increased significantly in both groups of females. We observed a significant increase in the parameters of fatty change and inflammation due to weekend alcohol consumption. Only the group of females that consumed alcohol at 40% presented slight hepatocel ular disorganization COnCLUSIOn The results obtained herein provide solid evidence that weekend alcohol consumption gives rise to liver damage, demonstrated by biochemical and histological alterations, first manifested acutely, and prolonged weekend alcohol consumption can cause greater, irreversible damage.

关键词： Weekend alcohol consumption Liver morphology Transaminases Damage

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novel LIPA mutations in Mexican siblings with lysosomal acid lipase deficiency

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World journal of Gastroenterology 2015年第3期21卷 1001-1008页

作者： Yuritzi santillán-Hernández Enory Almanza-Miranda Winnie W Xin Kendrick Goss Aurea Vera-Loaiza María T Gorráez-de la Mora Raul E Pina-aguilar Medical Genetics Department Centro Médico Nacional "20 de Noviembre"ISSSTEMéxico City 03100México Pediatric Gastroenterology Department Centro Médico Nacional "20 de Noviembre"ISSSTEMéxico City 03229México neurogenetics DnA Diagnostic Laboratory Massachusetts General HospitalBostonMA 02114United States Pathology Department Centro Médico Nacional "20 de Noviembre"ISSSTEMéxico City 03229México Medical Genomics Division Centro Médico Nacional "20 de Noviembre"ISSSTEMéxico City 03100México

Lysosomal acid lipase(LAL) deficiency is an underrecognized lysosomal disease caused by deficient enzymatic activity of LAL.In this report we describe two affected female Mexican siblings with early hepatic complications.At two months of age,the first sibling presented with alternating episodes of diarrhea and constipation,and later with hepatomegaly,elevated transaminases,high levels of total and low-density lipoprotein cholesterol,and low levels of highdensity lipoprotein.Portal hypertension and grade 2 esophageal varices were detected at four years of age.The second sibling presented with hepatomegaly,elevated transaminases and mildly elevated lowdensity lipoprotein and low high-density lipoprotein at six months of age.LAL activity was deficient in both patients.Sequencing of LIPA revealed two previously unreported heterozygous mutations in exon 4:c.253C>A and c.294C>G.These cases highlight the clinical continuum between the so-called Wolman disease and cholesteryl ester storage disease,and underscore that LAL deficiency represents a single disease with a degree of clinical heterogeneity.

关键词： Cholesteryl ester storage disease Liver fibrosis Dyslipidemia Liver steatosis Wolman disease

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Review of natural products with hepatoprotective effects

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World journal of Gastroenterology 2014年第40期20卷 14787-14804页

作者： Eduardo Madrigal-santillán Eduardo Madrigal-Bujaidar Isela álvarez-González María Teresa Sumaya-Martínez josé Gutiérrez-Salinas Mirandeli Bautista ángel Morales-González Manuel García-Luna y González-Rubio j Leopoldo aguilar-Faisal josé A Morales-González Laboratorio Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón Col. Casco de Santo Tomás Del. Miguel Hidalgo México DF 11340 México Laboratorio de Genética Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Unidad profesional Adolfo López Mateos Col. Lindavista Delegación Gustavo A. Madero México DF 07738 México Secretaria de Investigación y Estudios de Posgrado Universidad Autónoma de Nayarit "Ciu-dad de la Cultura Amado Nervo" Nayarit 28000 México Laboratorio de Bioquímica y Medicina Experimental División de Investigación Biomédica Centro Médico Nacional "20 de Noviembre" ISSSTE México DF 03100 México área Académica de Farmacia Instituto de Ciencias de la Salud UAEH Pachuca Hidalgo 42000 México Escuela Superior de Cómputo Instituto Politécnico Nacional Av. Juan de Dios Bátiz s/n esquina Miguel Othón de Mendizabal Unidad Profesional Adolfo López Mateos México DF 07738 Mexico Facultad de Odontología UNAM México DF 04510 Mexico

The liver is one of the most important organs in the body,performing a fundamental role in the regulationof diverse processes,among which the metabolism,secretion,storage,and detoxification of endogenous and exogenous substances are prominent.Due to these functions,hepatic diseases continue to be among the main threats to public health,and they remain problems throughout the world.Despite enormous advances in modern medicine,there are no completely effective drugs that stimulate hepatic function,that offer complete protection of the organ,or that help to regenerate hepatic cells.Thus,it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases,with the aim of these alternatives being more effective and less toxic.The use of some plants and the consumption of different fruits have played basic roles in human health care,and diverse scientific investigations have indicated that,in those plants and fruits so identified,their beneficial effects can be attributed to the presence of chemical compounds that are called phytochemicals.The present review had as its objective the collecting of data based on research conducted into some fruits(grapefruit,cranberries,and grapes)and plants[cactus pear(nopal)and cactus pear fruit,chamomile,silymarin,and spirulina],which are consumed frequently by humans and which have demonstrated hepatoprotective capacity,as well as an analysis of a resin(propolis)and some phytochemicals extracted from fruits,plants,yeasts,and algae,which have been evaluated in different models of hepatotoxicity.

关键词： Hepatoprotection Grapefruit Vaccinium spp Vitis vi

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