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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.adr.an tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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Universal Hyperthermal Model for Mass Extinctions

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journal of Earth Science 2024年第2期35卷 704-707页

作者： Michael j.Benton Paleobiology Research Group School of Earth SciencesUniversity of BristolLife Sciences BuildingTyndall AvenueBristolBS81TQUK

INTRODUCTION Earth scientists have long sought universal features of past extinction *** can be argued that each past extinction event was a singularity,caused by combinations of circumstances that are unique in each case,and therefore that the search for common causes is ***,a key feature of the uniformitarian approach to geology is that past processes are the same as modern-day processes and,with that in mind,earth scientists are keen to use their knowledge to contribute some understanding to the study of the present and future climate crisis.

关键词： extinction singularity Extinction

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Colorectal cancer:Current imaging methods and future perspectives for the diagnosis, staging and therapeutic response evaluation

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World journal of Gastroenterology 2013年第46期19卷 8502-8514页

作者： Maka Kekelidze Luigia D'Errico Michele Pansini Anthony tyndall joachim Hohmann Clinic of Radiology and Nuclear Medicine University Hospital Basel University of Basel

In the last 10 years the mortality rate of colorectal cancer(CRC)has decreased by more than 20%due to the rising developments in diagnostic techniques and optimization of surgical,neoadjuvant and palliative *** methods currently used in the evaluation of CRC are heterogeneous and can vary within the countries and the *** article aims to discuss in depth currently applied imaging modalities such as virtual computed tomography colonoscopy,endorectal ultrasound,computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of *** focus is put on the potential of recent diagnostic developments as diffusion weighted imaging MRI,MRI biomarkers(dynamic enhanced MRI),positron emission tomography with 2-(fluorine-18)-fluoro-2-deoxy-D-glucose(FDG-PET)combined with computed tomography(PET/CT)and new hepatobiliary MRI contrast *** precise role,advantage and disadvantages of these modalities are evaluated controversially in local staging,metastatic spread and treatment monitoring of ***,the authors will touch upon the future perspectives in functional imaging evaluating the role of integrated FDG-PET/CT with perfusion CT,MRI spectroscopy of primary CRC and hepatic transit time analysis using contrast enhanced ultrasound and MRI in the detection of liver *** of these newer imaging techniques may lead to significant improvements in the management of patients with colorectal cancer.

关键词： Colorectal cancer Imaging Staging Computed tomography Magnetic resonance imaging Diffusion weighted imaging Contrast enhanced ultrasound

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Darwin's Method of Argument

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大学英语 1986年第6期 50-51页

作者： john tyndall

*** shirks no difficulty;and,saturated as the subject waswith his own thought,he must have known,better than his critics,theweakness as well as the strength of his *** of course wouldbe of little avail were his object... 详细信息

关键词： Darwin’s Method of Argument

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Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada

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World journal of Gastroenterology 2018年第11期24卷 1216-1227页

作者： Mawuena Binka Zahid A Butt Stanley Wong Mei Chong jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark tyndall Mel Krajden Naveed Z janjua British Columbia Centre for Disease Control Vancouver BC V5Z4R4Canada School of Population and Public Health University of British ColumbiaVancouver BC V6T1Z3Canada Division of Population and Public Health Ministry of HealthVictoria BC V8W9P1Canada Department of Pathology and Laboratory Medicine University of British ColumbiaVancouver BC V6T1Z2Canada

AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since *** data were integrated with prescription drug,medical visit,hospitalization and mortality *** cases were classified as acute or chronic according to provincial *** compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative ***46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic *** alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative *** multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug *** odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic *** with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV *** odds increased with increasing socioeconomic *** Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,preven

关键词： Hepatitis B virus Ethnicity Drug use Acute hepatitis B BC Hepatitis Testers Cohort North America

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IN-SITU AFM OF POLYMER CRYSTALLIZATION

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Chinese journal of Polymer Science 2003年第2期21卷 135-140页

作者： j.K.Hobbs H. H. Wills Physics Laboratory Tyndall Avenue Bristol BS8 1TL UK

Atomic force microscopy images taken during the crystallization of polyethylene both from processed andquiescent melts are presented. Crystallization from processed melts provides further evidence of a region in front of agrowing lamella that is influenced by the crystallization process, but extending only 40 nm into the melt. High-resolutionimages of the growing crystal tip, taken during crystallization, show no direct evidence of the existence of intermediatephases. The growing tip is shown to be slightly rounded. In-filling crystallization, occurring after the initial flush of growth,is imaged in polyethylene for the first time, and shown to continue to a temperature 8℃ below the initial crystallizationtemperature.

关键词： AFM Polymer crystallization Polyethylene

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Evaluating the performance of nanostructured materials as lithium-ion battery electrodes

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Nano Research 2014年第1期7卷 1-62页

作者： Mark j. Armstrong Colm O'Dwyer William j. Macklin justin. D. Holmes Materials Chemistry & Analysis Group Department of Chemistry and the Tyndall National Institute University College Cork Cork Ireland Applied Nanoscience Group Department of Chemistry and the Tyndall National Institute University College Cork Cork Ireland Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) Trinity College Dublin Dublin 2 Ireland Nexeon Limited Abingdon Oxfordshire UK.

The performance of the lithium-ion cell is heavily dependent on the ability of the host electrodes to accommodate and release Li＋ ions from the local structure. While the choice of electrode materials may define parameters such as cell potential and capacity, the process of intercalation may be physically limited by the rate of solid-state Li＋ diffusion. Increased diffusion rates in lithium-ion electrodes may be achieved through a reduction in the diffusion path, accomplished by a scaling of the respective electrode dimensions. In addition, some electrodes may undergo large volume changes associated with charging and discharging, the strain of which, may be better accommodated through nanostructuring. Failure of the host to accommodate such volume changes may lead to pulverisation of the local structure and a rapid loss of capacity. In this review article, we seek to highlight a number of significant gains in the development of nanostructured lithium-ion battery architectures （both anode and cathode）, as drivers of potential next-generation electrochemical energy storage devices.

关键词： lithium ion batteries nanostructuring anodes cathodes

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On localization with robust power control for safety critical wireless sensor networks

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控制理论与应用（英文版） 2011年第1期9卷 83-92页

作者： Michael j. WALSH Anthony FEE john BARTON Brendan O'FLYNN Martin j. HAYES Cian O'MATHUNA Clarity Center for Web Technologies Microsystems Centre-Tyndall National Institute Lee MaltingsUniversity College CorkCorkIreland Wireless Access Research Center University of LimerickLimerickIreland

A hybrid methodology is proposed for use in low power, safety critical wireless sensor network applications, where quality-of-service orientated transceiver output power control is required to operate in parallel with radio frequency-based localization. The practical implementation is framed in an experimental procedure designed to track a moving agent in a realistic indoor environment. An adaptive time synchronized approach is employed to ensure the positioning technique can operate effectively in the presence of dataloss and where the transmitter output power of the mobile agent is varying due to power control. A deterministic multilateration-based positioning approach is adopted and accuracy is improved by filtering signal strength measurements overtime to account for multipath fading. The location estimate is arrived at by employing least-squares estimation. Power control is implemented at two separate levels in the network topology. First, power control is applied to the uplink between the tracking reference nodes and the centralized access point. A number of algorithms are implemented highlighting the advantage associated with using additional feedback bandwidth, where available, and also the need for effective time delay compensation. The second layer of power control is implemented on the uplink between the mobile agent and the access point and here quantifiable improvements in quality of service and energy efficiency are observed. The hybrid paradigm is extensively tested experimentally on a fully compliant 802.15.4 testbed, where mobility is considered in the problem formulation using a team of fully autonomous robots.

关键词： Wireless sensor network Power control Localization

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术前运动、体感和语言fMRI技术的可行性及局限性:13年随访491例病人

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国际医学放射学杂志 2017年第2期 232-232页

作者： A.j.tyndall j.Reinhardt V.Tronnier L.Mariani C.Stippich 陈皓 Division of Diagnostic and Interventional Neuroradiology University Hospital Basel

摘要目的针对一组颅脑肿瘤和癫病人分别进行1.5 T和3.0 T MR扫描,分析其术前f MRI的长期可行性和局限性。方法研究纳入2000—2012年间的491例病人,于5台

关键词：术前病人体感

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Total Hadronic Cross Sections

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Chinese Physics C 2014年第9期 537-540页

作者： K.A.Olive K.Agashe C.Amsler M.Antonelli j.-F.Arguin D.M.Asner H.Baer H.R.Band R.M.Barnett T.Basaglia C.W.Bauer j.j.Beatty V.I.Belousov j.Beringer G.Bernardi S.Bethke H.Bichsel O.Biebe E.Blucher S.Blusk G.Brooijmans O.Buchmueller University of Minnesota School of Physics and Astronomy 116 Church St.S.E. Minneapolis MN 55455 USA University of Maryland Department of Physics College Park MD 20742-4111 USA Albert Einstein Center for Fundamental Physics Universitat Bern CH-3012 Bern Switzerland Lab.Nazionali di Frascati dell'INFN CP 13 via E.Fermi 40 I-00044 Frascati(Roma) Italy Departement de physique Universite de Montreal C.P.6128 succ.centre-ville Montreal(Quebec) H3C 3j7 Canada Pacific Northwest National Laboratory 902 Battelle Boulevard Richland WA 99352 USA Department of Physics and Astronomy University of Oklahoma Norman OK 73019 USA Department of Physics University of Wisconsin Madison WI 53706 USA Physics Division Lawrence Berkeley National Laboratory 1 Cyclotron Road Berkeley CA 94720 USA CERN European Organization for Nuclear Research CH-1211 Geneve 23 Switzerland Department of Physics The Ohio State University 191 W.Woodruff Ave. Columbus OH 43210 COMPAS Group Institute for High Energy Physics RU- 142284 Protvino Russia LPNHE IN2P3-CNRS et Universites de Paris 6 et 7 F-75252 Paris France Max-Planck-Institute of Physics 80805 Munich Germany Department of Physics University of Washington Seattle WA 98195 USA Ludwig-Maximilians-Universitat Fakultdt für Physik Schellingstr.4 D-80799 München Germany Enrico Fermi Institute and Department of Physics University of Chicago Chicago IL 60637-1433 USA Department of Physics Syracuse University Syracuse NY 13244 USA Department of Physics Columbia University 538 W.120th Street New York NY 10027 USA High Energy Physics Group Blackett Laboratory Imperial College Prince Consort Road London SW7 2AZ UK jefferson Lab 12000 jefferson Ave. Newport News VA 23606 USA Department of Physics University of Virginia PO Box 400714 Charlottesville VA 22904 USA Fermi National Accelerator Laboratory P.O.Box 500 Batavia IL 60510 USA Kavli Institute for Cosmological Physics University of Chicago Chicago IL 60637-1433 USA Department of Physics and Astronomy University of Sussex Falmer Brighton BN1 9QH UK Department o

(Updated September 2013,COMPAS group,fflEP,Protvino)This updated version of the total hadronic cross sections review is based on the first half of 2013 update of the database for total cross section and the ratio of the real-to-imaginary parts of the forward elastic scattering hadronic *** data on total pp coUisions cross sections from CERN-LHC-TOTEM[1]and new data from cosmic rays experiment PAO[2]were *** use a procedure for ranking models as described in[3]to identify the safest parameterizations for ***,the models giving the best fit of accelerator data also reproduce the experimental cosmic ray nucleon-nucleon data extracted from nucleon-air data with no

关键词： Total Hadronic Cross Sections data

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