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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Damage modeling of ballistic penetration and impact behavior of concrete panel under low and high velocities

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Defence Technology（防务技术） 2021年第1期17卷 202-211页

作者： Chahmi Oucif j.S.Kalyana Rama K.Shankar Ram Farid abed Institute of Structural Mechanics(ISM) Bauhaus-Universitat WeimarMarienstraße 15D-99423WeimarGermany Department of Civil Engineering BITS Pilani-Hyderabad CampusHyderabad500072India Department of Civil Engineering Vignana Bharathi Institute of TechnologyHyderabad501301India Department of Civil Engineering University of CaliforniaBerkeleyBerkeleyCAUnited States Department of Civil Engineering American University of SharjahP.O.Box 26666United Arab Emirates

This work presents a numerical simulation of ballistic penetration and high velocity impact behavior of plain and reinforced concrete *** paper is divided into two *** first part consists of numerical modeling of reinforced concrete panel penetrated with a spherical projectile using concrete damage plasticity(CDP)model,while the second part focuses on the comparison of CDP model and johnson-Holmquist-2(jH-2)damage model and their ability to describe the behavior of concrete panel under impact *** first and second concrete panels have dimensions of 1500 mm1500 mm150 mm and 675 mm675 mm200 mm,respectively,and are meshed using 8-node hexahedron solid *** impact object used in the first part is a spherical projectile of 150 mm diameter,while in the second part steel projectile of a length of 152 mm is modeled as rigid *** and scabbing characteristics are studied in the first *** the second part,the comparison results are presented as damage contours,kinetic energy of projectile and internal energy of the *** results revealed a severe fracture of the panel and high kinetic energy of the projectile using CDP model comparing to the jH-2 *** addition,the internal energy of concrete using CDP model was found to be less comparing to the jH-2 model.

关键词： johnson-Holmquist-2 Concrete damage plasticity Concrete panel Damage Impact loads

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

A modified gas flow model in the near wellbore region below dew point pressure

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Petroleum 2021年第3期7卷 294-302页

作者： abed Inan Chowdhury Md Mostafijul Karim Department of Petroleum and Mining Engineering Chittagong University of Engineering&TechnologyChittagongBangladesh

When pressure in gas reservoirs fall below the dew point,condensate banking occurs around the wellbore which alters the fluid flow *** state of the knowledge on this flow behavior is yet not fully-developed;which leads to severe problems in *** this study,the Al-Hussainy,Ramey,and Crawford Solution Technique has been modified to accurately resemble the real gas flow behavior for this ***,a primary investigation was conducted to observe the severity of the problem in three condensate banked *** this study involved Constant Composition Expansion tests for determining the dew point,Prode Properties software for modeling the reservoir fluid properties,Flowing Material Balance(or Dynamic P/Z Material Balance)for identifying the pressure distribution of the selected *** real field data along with the determined(analytical,computational,and experimental)data were incorporated to check the validity of the *** modification proposes a Dimensionless Correction Factor(CD)for any condensate banked reservoir and identifies parameters such as the Perforation Factor(Pf)and Heterogeneity Factor(n).It is found that the Modified Al-Hussainy,Ramey,and Crawford Solution Technique successfully models the actual flow characteristics of the stated condition.

关键词： Condensate banking Effective permeability Gas flow modeling Model fitting

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Electrodeposition and characterization of Cu2O thin films using sodium thiosulfate as an additive for photovoltaic solar cells

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Chinese journal of Chemical Engineering 2018年第2期26卷 421-427页

作者： Hassiba Rahal Rafiaa Kihal abed Mohamed Affoune Samia Rahal Laboratoire d'Analyses lndustrielles et Genie des Materiaux Departement de Genie des ProcedesFaculte des Sciences et de la TechnologieUniversite 8 Mai 1945 GuelmaBP 401 Cuelma 24000Algeria Universite 20 Aout 1955 Skikda BP 26Route El-Hadaiek21000Algeria Universite Abbes Laghrour Khenchela BP 1252Rue de BatnaKhenchela 40004Algeria Laboratoire d'Etude des Surfaces et Interfaces de la Matiere Solide LESIMS Departement de PhysiqueFaculte des SciencesBadji Mokhtar UniversiteAnnabaAlgeria

Cuprous oxide （Cu2O） thin films have been grown by electrodeposition technique onto ITO-coated glass substrates from aqueous copper acetate solutions with addition of sodium thiosulfate at 60 ℃ The effects of sodium thiosulfate on the electrochemical deposition of Cu2O films were investigated by cyclic voltammetry and chronoamperometry techniques. Deposited films were obtained at - 0.58 V vs. SCE and characterized by X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FrIR）, scanning electron microscopy （SEM）, and optical, photoelectrochemical and electrical measurements. X-ray diffraction results indicated that the synthesized Cu2O films had a pure cubic phase with a marked preferential orientation peak along （200） plane and with lattice constants a = b = c = 0.425 rim. FFIR results confirmed the presence of Cu2O films at peak 634 cm 1. SEM images of Cu2O films showed a better compactness and spherical-shaped composition. Optical properties of Cu2O films reveal a high optical transmission （〉80%） and high absorption coefficient （α 〉 104 cm- 1 ） in visiblelight region. The optical energy band gap was found to be 2.103 eV. Photoelectrochemical measurements indicated that Cu2O films had n-type semiconductor conduction, which confirmed by Hall Effect measurements. Electrical properties of Cu2O films showed a low electrical resistivity of 61.30 Ω. cm-1, carrier concentration of-4.94×1015cm -3andmobility of20.61cm2.V 1,*** Cu2O thin films with suitable properties are promising semiconductor material for fabrication of photovoltaic solar cells,

关键词： Electrodeposition Cuprous oxide Thin films Semiconductor Cyclic voltammetry Photoelectrochemical measurements

Selective metal leaching from technosols based on synthetic root exudate composition

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journal of Environmental Sciences 2020年第10期32卷 85-92页

作者： Hussein jaafar Kanbar Zeinab Matar Ghina abed-AlHadi Safa Veronique Kazpard Research and Aralysis Platform for Enuironmental Sciences(PRASE) Doctoral School of Sciences and Techrology(EDST)The Lebanese UniversityP.O.5Rafic Hariri CampusHadatLebanon Department of Chemistry UmeàUniversitySE-90187UmeàSweden Department of Earth and Life Sciences Faculty of SciencesThe Lebanese UniversityRafic Hariri CampusHadatLebanon Laboratory of Georesources Geosciences and Enuironment(1.2GE)Faculty of SciencesThe Lebanese UniversityFanarLebanon

This study focused on metal release from technosols induced by synthetic root exudate(SRE).The effect of SRE composition on metal release was studied using six *** was done by treating the technosols with SRE solutions having varying concentrations of low molecular weight organic acids (LMWOAs),namely oxalic,citric,and malic ***,the physico-chemical parameters (p H and electric conductivity),Ca,Mg,Fe,Zn,and Cu release (by atomic absorption spectroscopy,AAS),chemical changes (by Fourier transform infrared,FT-IR),and organic parameters (by fluorescence) were *** release showed to be dependent on the SRE composition and technosol *** acid selectively released Ca,Mg,Zn,and Cu from technosols in a concentration-dependent manner;oxalic acid showed a significant role in the release of Mg and *** relatively high LMWOA concentrations,particulate organo-mineral complexes ***,technosol weathering was seen by the dissolution of humic substances and ferriallophanes,which in turn caused metal ***,re-precipitation of these phases showed to re-sorb metals,thus underestimating the role of LMWOAs in metal ***,the selective metal leaching was highly dependent on the SRE composition and LMWOA concentrations on one hand,and on the mineral,organic,and organo-mineral components of the technosols on the *** understanding of such processes is crucial for proposing and implementing environmental management strategies to reduce metal leaching or for the beneficial re-usage of metals (e.g.,for agromining) from technosols.

关键词： Technosols Oxalic acid Citric acid Metals Desorption Organo-mineral complexes

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily Lee William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated