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the Fourth World Congress of Structural and Multidisciplinary Optimization

作者： R.Ansola j.Canales j.a.tárrago j.Rasmussen Departamento de Ingeniería Mecánica.Escuela Superior de Ingenieros de Bilbao UPV/EHU.Alda.Urquijo s/n 48013 BilbaoSpain Departamento de Ingeniería Mecánica.Escuela Superior de Ingenieros de Bilbao UPV/EHU.Alda.Urquijo s/n 48013 BilbaoSpain Departamento de Ingeniería Mecánica.Escuela Superior de Ingenieros de Bilbao UPV/EHU.Alda.Urquijo s/n 48013 BilbaoSpain Institute of Mechanical *** University.Pontoppidanstraede 101 DK-9220 AalborgDenmark

＜正＞the global scope of this work is to develop an integrated shape and topology optimization system for the optimum design of shell structures, which are now finding widespread use in aeronautical, automotive, civil and mechanical engineering. the proposed investigation project aims to progress on a brand new work line which has captured the mind of many researchers: the shape and topology optimization for "Computer Aided Optimal Design" [1]. this project is based on the combination of shape and topology optimization techniques, with the aim of finding the optimal shape and material distribution that maximizes the stiffness of the shell. Most research in the last decades considered both optimization techniques separately, seeking an initial optimal topology and refining the shape of the solution later [2]. the method implemented in this work uses a combined approach, were the shape of the shell structure and material distribution are optimized simultaneously. this formulation involves a variable ground structure for topology optimization, since the shape of the shell is modified in the course of the process. the presented method will enhance the exploration of better designs for carrying the applied loads, due to the ability of optimizing not only the shape of the structure, but also the material distribution over the shell. this technique would provide the designer with a tool which would help to conceive the best configuration of the element considered in each situation. the method has been implemented into a general optimization software called ODESSY, developed at the Institute of Mechanical Engineering in Aalborg. the computational model was successfully tested in several numerical applications to illustrate and validate the approach, discussing the efficiency and feasibility of the method.

关键词： Shell structure optimization topology homogenization.

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

traumatic brain injury(tBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).tBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).this,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

the year 2024 marks the 60^(th)anniversary of title IX and 25 years since the New York times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual times

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:the brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).the structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua jo jonggeol Na j.jay Liu Young-ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. to cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. to compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. the market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. this indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. the results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

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the mean value concept in mono-linear regression of multi-variables and its application to trace studies in geosciences

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Science China Earth Sciences 2007年第12期50卷 1828-1834页

作者： A j t jULL NSF-AMS laboratory University of Arizona

the "mean value concept" in a mono-linear regression of multi-variables is *** applications to reconstruction of the past 90-year salinity of the sea surface water in Xisha Islands and to tracing the past 80 ka paleo-geomagnetic events from the Luochuan loess 10Be record are introduced in detail,which show the significance and the potential of the "mean value concept" in geoscience research.

关键词： mean value concept, linear regression, trace, reconstruction

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Effect of surface layer softening from previous electrochemical corrosion on electrochemical cold drawing of Q235 steel bar

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journal of Iron and Steel Research International 2022年第5期29卷 819-835页

作者： j.L.Guo t.j.Chen State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou730050GansuChina

the effects of H_(2)SO_(4)concentration and current in electrochemical corrosion on surface layer softening or plasticizing of Q235 steel bar and their effects on subsequent electrochemical cold drawing(ECD)were *** results indicate that the electrochemical corrosion can soften or plasticize the surface layer of Q235 steel bar and then make the subsequent ECD be conducted more *** softening degree and thickness of the surface layer are continuously enhanced with increasing corrosion rate,i.e.,increasing H_(2)SO_(4)concentration or current,due to the generation of more vacancy clusters in deeper regions of surface *** vacancy clusters then relax dislocations through being absorbed during ECD,and the formation and movement of additional dislocation flux are thereby enhanced,resulting in the further obvious decrease in the drawing *** is also due to the enhanced formation and movement of additional dislocation flux that the dislocation density and thus the hardness of the surface layer are decreased,as well as that the texture structure is *** behaviors are enhanced as the corrosion rate increases.

关键词： Electrochemical corrosion Electrochemical cold drawing Surface layer softening Vacancy Additional dislocation flux

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Performance and Internal Flow of Sirocco Fan Using Contra-Rotating Rotors

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journal of thermal Science 2008年第1期17卷 35-41页

作者： j.Fukutomi t.Shigemitsu t.Yasunobu Institute of Science and technology The University of Tokushima2-1 Minamijyosanjima-choTokushima 770-8506JAPAN Institute of Science and technology The University of Tokushima2-1 Minamijyosanjima-choTokushima 770-8506JAPAN Research Associate Graduate School of Advanced technology and Science The University of Tokushima2-1 Minamijyosanjima-choTokushima 770-8506JAPAN

A sirocco fan using contra-rotating rotors in which an inner rotor is settled inside the sirocco fan rotor and each rotor rotates in an opposite direction was proposed for the purpose of getting the higher pressure and making the structure of a sirocco fan more compact. If the high discharge pressure is obtained with the adoption of the contra-rotating rotors, it could be used for various purposes. Pressure coefficient of a sirocco fan with contra-rotating rotors is 2.5 times as high as the conventional sirocco fan and the maximum efficiency point of contra-rotating rotors shifts to larger flow rate than a conventional sirocco fan. On the other hand, it was clarified from the flow measurement results that circumferential velocity component at the outlet of the outer rotor of contra-rotating ro- tors becomes larger than a conventional one. In the present paper, the performance of a conventional sirocco fan and a sirocco fan with contra-rotating rotors are shown and the internal flow field at the outlet of outer rotor of both cases is clarified. then, the effect of different kind of contra-rotating rotors on the performance and internal flow field is investigated and the rotor design with higher performance would be discussed.

关键词： Sirocco fan High pressure Contra-rotating rotors Slow angle Circular arc blade Aerofoil blade

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