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Relationship between Th17 immune response and cancer

World journal of Clinical Oncology 2021年第10期12卷 845-867页

作者： Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos dantas Miranda Dórea Anna Carolina Saúde dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de jesus Dias Fabrício Freire de Melo Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next *** has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer *** Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin *** type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor *** other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 ***(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in ***,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical *** understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets.

关键词： Cancer Immune response Th17 cells Interleukin-17 Tumor microenvironment pathophysiology

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A Laurentian affinity for the Embu Terrane,Ribeira Belt(SE Brazil),revealed by zircon provenance statistical analysis

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Geoscience Frontiers 2023年第1期14卷 149-161页

作者： Bruno V.Ribeiro Frederico M.Faleiros Ginaldo A.C.Campanha peter A.Cawood Christopher L.Kirkland Milo Barham Erin L.Martin Marina Seraine Dina I.G.Cabrita Maria T.A.G.Yogi VidyãV.Almeida Anny j.a.Forero-Ortega Elton L.dantas Timescales of Mineral Systems Group School of Earth and Planetary SciencesCurtin UniversityPerthWA 6102Australia Isotopia Laboratory School of EarthAtmosphere and EnvironmentMonash UniversityClaytonVictoria 3800Australia Department of Mineralogy and Geotectonics University of São PauloRua do Logo 56205508-900 São PauloBrazil Department of Geological Science and Geological Engineering of Queen's University KingstonOntarioCanada Department of Earth Sciences Carleton UniversityOttawaOntarioCanada Geodynamics Division Geological Survey of Brazil(CPRM)Rua Costa 5501304-010 São PauloSPBrazil Institute for Geophysics Pontificia Universidad JaverianaBogotáColombia Institute of Geoscience University of BrasiliaCampus Universitário Darcy RibeiroAna Norte70919-900 BrasiliaDFBrazil

New and compiled detrital zircon U-pb ages from the southern Neoproterozoic-Cambrian Ribeira Belt,SE Brazil,demonstrate Laurentian affinity of the Embu Terrane which is statistically distinct from the adjoining Apiaíand São Roque terranes with cratonic affinity(e.g.,São Francisco Craton).Zircon provenance results indicate that the type-area of the Embu Terrane is dominated by detrital zircon age modes at ca.1200 Ma,1400 Ma,and 1800 Ma,with maximum depositional age of ca.1000 *** contrast,the Apiaíand São Roque terranes are dominated by paleoproterozoic detrital zircon ages(ca.2200-2000 Ma age dominant component),with maximum depositional ages of ca.1400 Ma and 1750 Ma,*** scaling(MDS)analysis of non-parametric similarity measurements on zircon age populations indicates for the first time that the Embu Terrane encompass two statistically distinct detrital zircon age spectra,which is also reflected in the metamorphic zircon age *** statistical characterization of the Embu Terrane through populational metrics allow a quantitative comparison with surrounding tectonic domains and rock samples classified such as *** results clearly highlight the distinction between the statistically differentiated Embu Terrane from the Apiaíand São Roque terranes,supporting an allochthonous *** addition,we demonstrate that rocks samples previously classified as Embu-type are significantly dissimilar to the definition of Embu Terrane,failing to support alternative tectonic models(e.g.,intracontinental evolution).Detrital zircon age spectra reveal that the Apiaíand São Roque terranes have similar zircon provenance to domains sourced from the São Francisco Craton,whereas detrital zircon populations from the Embu Terrane have greater affinity with SW Laurentia basins(and their inferred sediment sources),consistent with previous ***,we interpret the Embu Terrane as a Rodinia descendant developed along the active margin o

关键词： Ribeira belt Embu terrane Detrital zircon Multidimensional scaling Rodinia and gondwana paleogeography

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Effect of Microfocused Ultrasound on Facial Rejuvenation: Clinical and Histological Evaluation

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journal of Biosciences and Medicines 2021年第7期9卷 112-125页

作者： patricia Froes Meyer Michelle Meleck Fabio dos Santos Borges Esteban Fortuny Stephany Luanna Queiroga Farias Felipe Alexander Caldas Afonso Ciro dantas Soares Eneida de Morais Carreiro Rodrigo Marcel Valentim da Silva André Luiz Miranda Barbosa Federal University of Rio Grande do Norte (UFRN) Natal Brazil University Centre of Rio Grande do Norte (UNI-RN) Natal Brazil Michelle Meleck Advanced Aesthetics S&atilde o paulo Brazil Estácio de Sá University Rio de Janeiro Brazil Universidad Finis Terrae Santiago Chile potiguar University (UNp) Natal Brazil Campinas State University (UNICAMp) Campinas Brazil Fellow da West Virginia University Morgantown USA

Introduction: Micro focused ultrasound (MFU) is formed by mechanical waves emitted in a focused manner, concentrating thermal energy on a certain point or region, promoting a clinical improvement in wrinkles. Objective: evaluate the effects of micro focused ultrasound on facial rejuvenation. Methodology: This is an experimental study. The sample consisted of 30 volunteers, who were evaluated before treatment, 45 and 90 days after its beginning. A single application of the MFU was performed across the facial region. The parameters used were: 10 MHz cartridge with depth of 1.5 mm, 7 MHz with depth of 3 mm, and 4 MHz with focal depth of 4.5 mm;doses ranged from 0.1 to 2.0 j, according to the sensitivity of the volunteers treated, and the application time was of approximately 90 minutes. Clinical photographic analysis and facial symmetry analysis using Dolphin Imaging software were performed, and validated questionnaires. Two volunteers were submitted to blepharoplasty surgery, and one to rhytidoplasty surgery 45 days after the application of the MFU. Samples of the treated skin were taken after the surgical procedures and submitted to histological and immunohistochemical analyses. The volunteers answered a questionnaire to assess adverse reactions and satisfaction. Results: We observed a visible clinical improvement on the images by photography, and an improvement of facial symmetry in the measurements of the paralateronasal projection (p = 0.007), left lateral mandibular (p = 0.01), and right lateral mandibular (p = 0.008). The histological analysis showed an increase in the amount of fibroblasts (p = 0.02), blood vessels (p = 0.0062) and inflammatory cells (p = 0.0036), in addition to the production of type 1 collagen. In the immunohistochemical analysis, we observed the presence of the macrophage marker IHQ: CD68, indicating phagocytosis of adipose tissue and the presence of fibrosis. In the analysis of adverse reactions, only transient hyperemia was observed with t

关键词： Skin Aging Mechanical Waves Sagging Wrinkles

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凸轮畸形与欧米茄角,一种新的股骨头-颈形态定量测量方法:无症状者的三维CT性别分析

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国际医学放射学杂志 2017年第4期 484-484页

作者： V.V.Mascarenhas p.Rego p.dantas A.Gaspar F.Soldado j.G.Consciência 朱珍 MSK imaging Unit(UIME) Imaging Center Hospital da Luz

摘要目的本研究的目的是利用3D CT来明确无症状个体中股骨头-颈形态的性别特异性与标准的参数,并使用欧米茄角(Ω°)提供凸轮畸形的位置和放射状延伸的定量数据。方法前瞻性纳入350例个体并通过半自动CT分析评估188例无症状的髋关节。α...

摘要目的本研究的目的是利用3D CT来明确无症状个体中股骨头-颈形态的性别特异性与标准的参数,并使用欧米茄角(Ω°)提供凸轮畸形的位置和放射状延伸的定量数据。方法前瞻性纳入350例个体并通过半自动CT分析评估188例无症状的髋关节。α角(α°)不同的阈值用于分析凸轮畸形并确定Ω°。计算凸轮畸形影像征象(Ω°和周围的α°)的

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Correction to“performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in Brazil”

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World journal of Experimental Medicine 2023年第3期13卷 47-49页

作者： Fabrício Freire de Melo Lilian Martins Oliveira Diniz joséNélio januário joão Fernando Gonçalves Ferreira Rafael Santos dantas Miranda Dórea Breno Bittencourt de Brito Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha pinheiro Gifone Aguiar Rocha Dulciene Maria de Magalhães Queiroz Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Departamento de pediatria Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Departamento de Clínica Médica Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Research in Bacteriology Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

Correction to“Freire de Melo F,Martins Oliveira Diniz L,Nélio januário j,Fernando Gonçalves Ferreira j,Dórea RSDM,de Brito BB,Marques HS,Lemos FFB,Silva Luz M,Rocha pinheiro SL,de Magalhães Queiroz *** of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in *** j Exp Med 2022;12(5):100-103[pMID:36196438 DOI:10.5493/wjem.v12.i5.100]”.In this article,we identified an issue with the“Acknowledgments”***,we then provide a recognition section for our supporting institutions.

关键词： Correction COVID-19 serological testing Serologic tests Rapid diagnostic

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From oral formulations to drug-eluting implants:using 3D and 4D printing to develop drug delivery systems and personalized medicine

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Bio-Design and Manufacturing 2022年第1期5卷 85-106页

作者： Niels G.A.Willemen Margaretha A.j.Morsink Devin Veerman Classius F.da Silva juliana C.Cardoso Eliana B.Souto patrícia Severino Center for Biomedical Engineering Department of MedicineBrigham and Women&HospitalHarvard Medical School65 Landsdowne StreetMA 02139 CambridgeUSA Department of Developmental BioEngineering Faculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteEnschedeThe Netherlands Translational Liver Research Department of Medical Cell BioPhysicsTechnical Medical CentreFaculty of Science and TechnologyUniversity of TwenteEnschedeThe Netherlands Targeted Therapeutics Department of Biomaterials Science and TechnologyFaculty of Science and TechnologyUniversity of TwenteEnschedeThe Netherlands Department of Chemical Engineering Institute of EnvironmentalChemical and Pharmaceutical SciencesFederal University of São PauloRua São Nicolau210Diadema 09913‑030Brazil University of Tiradentes(Unit) and Institute of Technology and Research(ITP)Av.Murilo Dantas300Aracaju 49010‑390Brazil Faculty of pharmacy University of CoimbraPólo das Ciências da SaúdeAzinhaga de Santa Comba3000‑548 CoimbraPortugal CEB‑Centre of Biological Engineering University of MinhoCampus de Gualtar4710‑057 BragaPortugal Tiradentes Institute 150 Mt Vernon StDorchesterMA 02125USA

Since the start of the precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown *** short,personalized medicine is a term that describes medical treatment that is tuned to the *** possible way to realize personalized medicine is 3D *** using materials that can be tuned upon stimulation,4D printing is *** recent years,many studies have been exploring a new field that combines 3D and 4D printing with *** has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an ***,the first 3D printed drug,Spritam®,has already found its way to the *** review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.

关键词： Drug delivery systems 3D/4D printing Drug-eluting implants Microneedles Oral formulations

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Difficulties Faced by physicians in the Diagnosis of Endometriosis in the Brazilian public Health System

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Health（健康） 2023年第7期

作者： Carla patrícia Alves Barbosa Tayná Maria dantas Carozo Calumby Ana paula portela Andrade júlia de Araújo Gomes Maria Renata Suyane Silva de Farias Maria Eduarda dantas Donald Gabrielly pinheiro Marinho Antônia Iva Sampaio Bisneta Francisco Expedito Ramos Aguiar Sobrinho Elizabeth Bacha Gabriela Irene Barbosa Débora Irene Barbosa

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Recovery of polyphenols from camu-camu ( Myrciaria dubia H.B.K. McVaugh) depulping residue by cloud point extraction

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中国化学工程学报（英文版） 2018年第12期

作者： Carlos Eduardo de Araújo padilha juliana Chris Silva de Azevedo Francisco Canindé de Sousa júnior Sérgio dantas de Oliveira júnior Domingos Fabiano de Santana Souza jackson Araújo de Oliveira Gorete Ribeiro de Macedo Everaldo Silvino dos Santos Laboratory of Biochemical Engineering，Chemical Engineering Department，Federal University of Rio Grande do Norte (UFRN) Laboratory of Food Bioactive Compounds and Dairy Technology，Chemical Engineering Department，Federal University of Rio Grande do Norte (UFRN)

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Investigation of the Effects of Glazed Balconies uponThermal Comfort in Hot Tropical Region

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journal of Civil Engineering and Architecture 2019年第12期13卷 762-779页

作者： Érica Coelho pagel Edna Aparecida Nico Rodrigues Cristina Engel de Alvarez Neyval Costa Reis júnior Bruna perovano Sirtuli Filipe Galina Costalonga jordana BernabéCoelho Department of Architecture and City Universidade Vila Velha Av Comissario Jose Dantas De Mello 21Boa Vista IIVila VelhaES29102-920Brazil Department of Architecture and Urbanism Universidade Federal do Espírito SantoAv.Fernando Ferrari 514VitóriaES29060-910Brazil Department of Environmental Engineering Universidade Federal do Espírito SantoAv.Fernando Ferrari 514VitóriaES29060-910Brazil

The balcony is responsible to a series of effects on the environmental behavior of a building,mainly in relation of thermal comfort and air distribution to their indoor *** a very common practice in several metropolitan areas is the closing with retractable glass panels in balcony *** work analyzed the effects of glazed balconies upon thermal comfort in a hot tropical *** parameters were carried out in a flat alternating the conditions of retractable glass panels to *** simulations were performed considering closing or not the glass door that divides the balcony room;the building material used on the balcony sill;and the use of curtains or shading *** results show the maximum mean hourly temperatures recorded on the balcony during the period when the retractable glass panels were closed,reaching peaks between 31.7 and 39.2°C,above the comfort range recommended by ASHRAE *** situations simulated show the thermal discomfort prevails in the use of the closed glass panels reaching DhTD of 94.55°C/***,this practice of using most of the closed retractable glass panels in the balconies presents disadvantages and inefficiencies especially in hot and humid tropical climate regions.

关键词： Glazed balconies thermal comfort hot tropical region.

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