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铝基核壳材料ap/Al的制备及性能研究

火炸药学报 2024年第3期47卷 271-278,I0006页

作者：晏嘉伟屈炜宸杜芳李磊孙新零林励云李毅恒汪慧思陶博文航天化学能源全国重点实验室湖北襄阳441003 湖北航天化学技术研究所湖北襄阳441003

以ap和铝粉为原料,采用“ap预处理+表面沉积”两步法工艺制备了以铝粉为“壳”的铝基核壳材料ap/Al;采用SEM-EDS、粒度分析、密度测试等方法表征了ap/Al的表面形貌、元素分布、粒度分布和密度等物理特性,对比测试了铝基核壳材料ap/Al的... 详细信息

以ap和铝粉为原料,采用“ap预处理+表面沉积”两步法工艺制备了以铝粉为“壳”的铝基核壳材料ap/Al;采用SEM-EDS、粒度分析、密度测试等方法表征了ap/Al的表面形貌、元素分布、粒度分布和密度等物理特性,对比测试了铝基核壳材料ap/Al的感度性能、热分解性能、爆热及残渣活性铝含量并与ap/Al物理混合物进行了对比;运用Flynn-Wall-Ozawa方程计算了ap/Al物理混合物及铝基核壳材料ap/Al的分解活化能,并通过高速摄像机记录了铝基核壳材料ap/Al的燃烧特性。结果表明,铝基核壳材料ap/Al是以ap为“核芯”、铝粉为“壳”,密度为2.0485 g/cm^(3)的类球形颗粒;相比于物理混合物,铝基核壳材料ap/Al静电火光感度由27.94 mj提高至102.88 mj.a.低温分解和高温分解活化能分别提升10.9和9.0 kj/mol,爆热值未出现明显降低(物理混合物为9298.4 j/g,铝基核壳材料ap/Al为9260.6 j/g),但铝基核壳材料ap/Al残渣中活性铝质量分数降低90%以上;有别于传统铝粉燃烧的拖拽火焰,铝基核壳材料ap/Al燃烧时,铝液滴溅射大量细颗粒铝珠,且燃烧火焰更加均匀、明亮。

关键词：含能材料核壳材料 ap/Al 微纳复合材料燃烧性能

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无人机载红外载荷在应急测绘中的应用

测绘科学 2015年第10期40卷 60-64页

作者：胡可陈思思王俊伟四川测绘地理信息局测绘技术服务中心成都610081 成都理工大学成都610059

针对无人机搭载光学载荷在恶劣天气、夜间以及特殊任务中的应用受到限制的问题,该文在介绍红外遥感原理的基础上,结合实例归纳了近红外、中红外、远红外波段载荷应用的技术路线;通过描述无人机载红外载荷在地质灾害、森林火灾、气象水... 详细信息

针对无人机搭载光学载荷在恶劣天气、夜间以及特殊任务中的应用受到限制的问题,该文在介绍红外遥感原理的基础上,结合实例归纳了近红外、中红外、远红外波段载荷应用的技术路线;通过描述无人机载红外载荷在地质灾害、森林火灾、气象水文灾害、环境事故等领域的案例,总结了其在应急测绘保障中的应用情况;讨论了应用中存在的技术问题、难点及相应的解决途径;最后从灾情信息识别和应急决策服务模型构建方面,给出了发展无人机载红外载荷在应急测绘保障中应用的建议。

关键词：无人机红外载荷应急测绘保障实情信息获取

Toll-like receptor 4-mediated apoptosis of pancreatic cells in cerulein-induced acute pancreatitis in mice

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Hepatobiliary & pancreatic Diseases International 2010年第6期9卷 645-650页

作者： si-Qin Ding,Yuan Li,zong-Guang Zhou,Cun Wang,Lan Zhan and Bin Zhou Institute of Digestive Surgery,Department of Gastrointestinal Surgery,and Department of pediatric Surgery, West China Hospital,sichuan University,Chengdu 610041,China Institute of Digestive Surgery West China Hospital Sichuan University Department of Gastrointestinal Surgery West China Hospital Sichuan University Department of pediatric Surgery West China Hospital Sichuan University

BACKGrOUND:Toll-like receptor 4(TLr4)plays an important role in the occurrence and development of acute pancreatitis (ap).apoptosis of pancreatic cells is closely related to the severity of ***4 is known to induce apoptosis in some cell types and therefore it is of importance to investigate potential associations between TLr4 activity and apoptosis in the setting of ap. METHODS:A total of 50 wild-type(C57BL/10j.a.d TLr4-deficient(C57BL/10ScNj)mice were divided into three groups:2-hour,4-hour,and control *** group was divided into two equal subgroups:TLr4-wild-type mice and TLr4-deficient *** was experimentally induced by 7 intraperitoneal injections of 50μg/kg cerulein at hourly *** mice received 7 injections of equal volumes of *** severity of pancreatic injury during ap was assessed by serum amylase concentration and histopathology. The level of apoptosis of pancreatic cells in response to ap was evaluated by calculating the apoptotic index(AI)and comparing the expression levels of cytochrome C and Fasassociated protein with death domain(FADD)between TLr4-wild-type and TLr4-deficient mice at 2 time points. rESULTS:The AI was found to be significantly lower in the pancreas of TLr4-deficient mice with ap compared to TLr4-wild-type mice at two hours after the last treatment ***-linked immunosorbent assay and real-time reverse transcription-polymerase chain reaction also revealed significantly lower expression of cytochrome C and FADD in the pancreas of TLr4-deficient mice than in TLr4-wild-type animals at the same time *** amylase concentration and morphological severity of ap in pancreatic tissue were found to be similar in the two strains of mice at both time ***:We postulate that TLr4 can mediate apoptosis of pancreatic cells during the early stages of ap,via the activation of both intrinsic and extrinsic apoptotic signaling pathways.

关键词： acute pancreatitis toll-like receptor 4 apoptosis cytochrome C Fas-associated protein with death domain

大麻制剂HU210对实验性急性胰腺炎的干预作用及其与Toll样受体4信号通路的可能关系

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中国病理生理杂志 2017年第6期33卷 1112-1118页

作者：张瑞琴林思思李敏沈利李琨李永渝同济大学医学院病理生理教研室消化系统疾病研究所上海200092 山西医科大学第二医院西院病理科山西太原030053 遵义医药高等专科学校生理教研室贵州遵义563000 同济大学医学院病原生物教研室上海200092

目的:研究大麻类制剂HU210对雨蛙肽(caerulein,CAE)诱导的野生型(wild-type,WT)和Toll样受体4基因敲除(tlr4^(-/-))小鼠急性胰腺炎(acute pancreatitis,ap)的干预作用,并探讨其作用机制。方法:将成年C57BL/10j小鼠及相同背景的tlr4^(-/-)小鼠各随机分成3组:ap组、ap+HU210组及正常对照组。小鼠腹腔注射CAE(50μg·kg^(-1)·h^(-1))6次及脂多糖(10 mg/kg)1次复制ap模型;ap+HU210组在造模前及造模后各腹腔注射1次HU210(50μg/kg);对照组注射生理盐水替代CAE和脂多糖。造模处理后3 h,取血处死小鼠,取胰腺、肺组织及肠道peyer’s结。结果:与对照组相比,无论在WT或tlr4^(-/-)小鼠,ap造模后胰腺病理评分,血浆淀粉酶活性,血浆IL-6、TNF-α及MCp-1水平,以及肺MpO活性均明显升高(pp38蛋白表达明显上调(pap造模后,与WT小鼠相比,tlr4^(-/-)小鼠血浆IL-6、TNF-α及MCp-1水平,以及胰腺p38及p-p38蛋白表达均明显降低(ppeyer’s结CD3^+、CD4^+T淋巴细胞百分比及CD4^+/CD8^+比值明显降低(pap模型的胰腺病理学评分和肺MpO活性的升高明显得到改善(pr4^(-/-)小鼠,ap引起的血浆淀粉酶活性和胰腺p38及p-p38蛋白表达的变化在HU210干预后明显逆转(pr4主要参与ap全身炎症反应,其机制可能依赖TLr4-p38 MapK信号通路;大麻制剂HU210对ap的干预主要通过抑制炎症细胞的浸润发挥组织保护作用,与TLr4信号通路的关系似乎不明显。

关键词：急性胰腺炎大麻素类 Toll样受体4 炎症介质

新型二硝酰胺根多氮含能铜配合物的合成与表征

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含能材料 2023年第4期31卷 317-324页

作者：牟国柱李鑫李爽雷晴乐思嘉高扬湖北航天化学技术研究所湖北襄阳441003 航天化学动力技术重点实验室湖北襄阳441003

为了高效地制备低感度、环保的含能燃速催化剂,以二硝酰胺铵(ADN)为前体,经离子交换反应得到二硝酰胺酸(HDN),该反应液与碱式碳酸铜(Ⅱ)反应制备二硝酰胺铜(Ⅱ),再与富氮配体(氨、咪唑、4⁃氨基⁃1,2,4⁃三唑⁃5⁃酮)进一步合成获得了3种含... 详细信息

为了高效地制备低感度、环保的含能燃速催化剂,以二硝酰胺铵(ADN)为前体,经离子交换反应得到二硝酰胺酸(HDN),该反应液与碱式碳酸铜(Ⅱ)反应制备二硝酰胺铜(Ⅱ),再与富氮配体(氨、咪唑、4⁃氨基⁃1,2,4⁃三唑⁃5⁃酮)进一步合成获得了3种含能金属配合物[Cu(NH_(3))_(4)(DN)_(2)]、[Cu(IMI)_(4)(DN)_(2)]、[Cu(ATO)_(4)](DN)_(2)。利用X射线单晶衍射、红外光谱、元素分析等方法准确表征了3种配合物的结构,测定了3种配合物的热稳定性、吸湿性、撞击感度、摩擦感度、静电火花感度以及[Cu(IMI)_(4)(DN)_(2)]对推进剂燃速的提升效果。结果表明3种配合物的热稳定性均满足固体推进剂的应用要求,初始分解温度均大于140℃。3种配合物的吸湿性有明显改善,仅为原料ADN的2%~5%。配合物[Cu(IMI)_(4)(DN)_(2)]的感度最低,撞击感度28.6 j、摩擦感度0%、静电火花感度185 mj。在丁羟推进剂中添加质量分数为4%的[Cu(IMI)_(4)(DN)_(2)]时,可将基础配方推进剂燃速提升27.7%。

关键词：含能材料金属配合物二硝酰胺铵吸湿性燃速催化剂高燃速

pyrroloquinoline quinone regulates the redox status in vitro and in vivo of weaned pigs via the Nrf2/HO-1 pathway

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journal of Animal Science and Biotechnology 2021年第4期12卷 1451-1467页

作者： Caiyun Huang Zij.a. Fan Dandan Han Lee j.johnston Xi Ma Fenglai Wang State Key Lab of Animal Nutrition College of Animal Science&TechnologyChina Agricultural UniversityBeijing 100193China Swine Nutrition and production West Central Research and Outreach CenterUniversity of MinnesotaMorrisMNUSA Department of Internal Medicine/Department of Biochemistry University of Texas Southwestern Medical CenterDallasTXUSA

Background:Oxidative stress is a main cause of piglet gut damage and *** quinone(pQQ),is a novel redox cofactor with antioxidant ***,the effect and mechanism that pQQ supplementation decreases oxidative injury in weaned pigs is not ***,the aim of this study is to confirm the effect of pQQ on regulating redox status in weaned pigs and the mechanism for antioxidant function by porcine intestinal epithelial cell line(IpEC-j2)challenged with H_(2)O_(2).results:Experiment 1,144 Duroc×Landrace×Yorkshire pigs(weaned at 28 d)were allocated to four groups:received a basal diet(control)and diets supplemented with 0.15%,0.30%and 0.45%pQQ,*** d 28,growth performance,diarrhea incidence and redox factors were *** 2,IpEC-j2 were treated with or without pQQ in the presence or absence of H_(2)O_(2)for indicated time *** 3,IpEC-j2 were transfected with or without Nrf2 sirNA,then treated according to Experiment *** cell viability,redox factors,protein of tight junctions and Nrf2 pathway were *** vivo,pQQ supplementation demonstrated dose-related improvements in average daily gain,and gain to feed ratio(Linear pring d 0–28,compared to controls,0.45%pQQ supplementation for pigs decreased diarrhea incidence and MDA content in liver and jejunum,and increased concentration of SOD in liver;0.3%pQQ supplementation decreased ileal and liver MDA concentration;and 0.15%pQQ supplementation decreased ileal MDA concentration(pro,compared to cells cultured with H_(2)O_(2),pre-treatment with pQQ increased cell viability,tight junction proteins expression including zo-1,zo-2,Occludin and Claudin-1;and decreased rOS concentration and level of Caspase-3(ppregulated the ratio of Bcl-2 to Bax and protein expression of nuclear Nrf2,***,Nrf2 knockdown by transfection with Nrf2 sirNA largely abrogated the positive effects of pQQ pretreatment on H_(2)O_

关键词： H_(2)O_(2) IpEC-j2 Nrf2 Oxidative stress pyrroloquinoline quinone Weaned pig

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ap-1与牙本质、釉质发育相关研究进展

牙体牙髓牙周病学杂志 2014年第6期24卷 363-366,322页

作者：易思健刘建国吴家媛遵义医学院口腔学院贵州遵义563000 贵州省高等学校口腔疾病研究特色重点实验室贵州遵义563000

ap-1是被国内外学者广泛研究的转录因子,是由原癌基因编码的蛋白质jun和fos组成的二聚体复合物。ap-1能与DNA结合,作为转录调控因子可通过激活或抑制目标基因的转录,参与多项细胞的活动,如细胞增殖、凋亡、生存,以及肿瘤的发生和组织形... 详细信息

ap-1是被国内外学者广泛研究的转录因子,是由原癌基因编码的蛋白质jun和fos组成的二聚体复合物。ap-1能与DNA结合,作为转录调控因子可通过激活或抑制目标基因的转录,参与多项细胞的活动,如细胞增殖、凋亡、生存,以及肿瘤的发生和组织形态等。近年来研究又发现,ap-1在牙发育过程中也有表达,主要表达于成熟的成釉细胞、成牙本质细胞等。本文就ap-1在牙本质、釉质发育过程中对相关因子的调节作用作一综述。

关键词： ap-1 C-fos C-jun 成牙本质细胞成釉细胞

Antioxidant and antitumor potential of wild and IMT-Acultivated Osmundea pinnatifida

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journal of Oceanology and Limnology 2019年第3期37卷 825-835页

作者： siLVA j.paulo ALVES Celso pINTEUS Susete siLVA j.a.a VALADO Ana pEDrOSA rui pErEIrA Leonel UCIBIO-rEQUIMTE Department of ChemistryFaculty of Sciences and TechnologyUniversidade NOVA de LisboaCaparica 2829-516Portugal MArE-Marine and Environmental Sciences Centre School of Tourism and Maritime TechnologyPolytechnic Institute of LeiriaPeniche 2520-641Portugal Instituto politécnico de Coimbra ESTESC-Coimbra Health SchoolBiomedical Sciences LaboratoryR.5 de OutubroS.Martinho do BispoAp.7006Coimbra 3046-854Portugal Centre of pharmacology and Chemical Biopathology Faculty of MedicineUniversity of PortoPorto 4200-319Portugal MArE-Marine and Environmental Sciences Centre Department of Life SciencesFaculty of Sciences and TechnologyUniversity of CoimbraCoimbra 3000-456Portugal

Osmundea pinnatifida is a red edible seaweed known as pepper *** was cultivated in the farm of ALGaplus(ílhavo,portugal).This farm is integrated with a seabream and seabass commercial aquaculture and uses the nutrient-enriched water resultant from the fish production as its cultivation medium in the integrated multi-trophic aquaculture(IMTA)*** and IMTA-cultivated samples of *** da were screened for antioxidant and antitumor *** antioxidant capacity of solvent extracts from wild and IMTA cultivated samples was assessed in two methods(2,2-diphenyl-1-picrylhydrazyl(DppH)and oxygen radical absorbance capacity(OrAC)),and their total phenolic contents(TpC)were *** activity was evaluated in three different tumor cell lines(HepG-2,MCF-7,and SH-SY5Y)through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** the solvents used for extraction,dichloromethane was the most eff ective to extract phenolic compounds and presented higher OrAC.A significant correlation was found between TpC and OrAC,which was also sustained by the principal components analysis(pCA).Dichloromethane extracts induced a cytostatic eff ect on MCF-7 cells and showed weak cytotoxicity to SH-SY5Y cells and weak impact on cell ***,there were no statistically signifi cant differences in the biological activities shown by the wild and IMTA-cultivated ***,*** can be obtained in an economical and environmentally sustainable way through IMTA,maintaining bioactive properties in a high potential for further nutraceutical purposes.

关键词： edible seaweed bioactive compounds polyphenols cytotoxic activity antiproliferative activity

铝基微单元复合燃料在NEpE固体推进剂中的应用

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含能材料 2022年第8期30卷 819-825页

作者：汪慧思张鑫王艳薇杜芳李磊顾健李伟陶博文航天化学动力技术重点实验室湖北襄阳441003 湖北航天化学技术研究所湖北襄阳441003

为研究铝基微单元燃料在硝酸酯增塑聚醚(NEpE)固体推进剂中的应用性能,以铝基微单元复合燃料(Al@ap)代替铝粉加入NEpE固体推进剂,以真空定容爆热试验、发动机试验、残渣活性铝测试、高速摄影、单向拉伸试验、工艺性能测试等手段研究了Al... 详细信息

为研究铝基微单元燃料在硝酸酯增塑聚醚(NEpE)固体推进剂中的应用性能,以铝基微单元复合燃料(Al@ap)代替铝粉加入NEpE固体推进剂,以真空定容爆热试验、发动机试验、残渣活性铝测试、高速摄影、单向拉伸试验、工艺性能测试等手段研究了Al@ap对NEpE固体推进剂燃烧、力学、工艺等性能的影响;并对Al@ap在NEpE固体推进剂中的燃烧作用机理进行了分析。结果表明,以19.5%的Al@ap代替FLQT‑3 Al后,NEpE固体推进剂的爆热由6039.4 j·g^(-1)提升至6924.8 j·g^(-1),残渣量由28.91 g降至7.64 g,残渣活性铝含量由14.64%降至0.37%,残渣粒径d_(50)由94.12μm降至24.21μm,NEpE固体推进剂喷射效率提升,铝粉在燃面停留时间由55 ms缩短至40 ms,且无明显融联团聚现象,且Al@ap对推进剂的燃速、力学、工艺等性能基本无影响。

关键词：铝基微单元复合燃料 NEpE固体推进剂性能