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Humid Little Ice Age in arid central Asia documented by Bosten Lake, Xinj.ang, China

Science China Earth Sciences 2006年第12期49卷 1280-1290页

作者： j. A. Holmes ECRC Department of Geography University College London

Short sediment cores retrieved from Bosten Lake, the largest inland freshwater lake in China, were used to explore humidity and precipitation variations in arid central Asia during the past millennium. The chronology of the cores was established using 137Cs, 210Pb and AMS 14C dating re- sults. Multi-proxy high-resolution analysis, including pollen ratios of Artemisia and Chenopodiaceae (A/C), carbonate content and grain size, indicates that the climate during the past millennium can be divided into three stages: a dry climate between 1000―1500 AD, a humid climate during the Little Ice Age (LIA) (c. 1500―1900 AD), and a warm dry period after 1900 AD. On centennial timescales, the climate change in northwestern China during the past 1000 years is characterized by oscillations between warm-dry and cold-humid climate conditions. All the proxies changed significantly and indi- cate increased precipitation during the LIA, including increased pollen A/C ratios and pollen concen- trations, decreased carbonate content and increased grain size. The humid period during the LIA re- corded by the Bosten Lake sediments is representative of arid central Asia and is supported by nu- merous records from other sites. During the LIA, the water runoff into the Keriya River and Tarim River in the Tarim Basin increased, while the ice accumulation in the Guliya ice core increased. Additionally, the lake levels of the Aral and Caspian Sea also rose, while tree-ring analysis indicates that precipita- tion increased. We hypothesize that both the lower temperature within China and the negative anomalies of North Atlantic Oscillation (NAO) during this period may have contributed to the humid climate within this area during LIA.

关键词： multiproxy analyses,Bosten Lake,humid Little Ice Age,past millennium,arid central Asia.

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a maj.r contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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MODELING THE KNOWLEDGE CREATION PROCESS OF GRADUATE RESEARCH

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j.urnal of Systems Science and Systems Engineering 2018年第6期27卷 790-809页

作者： j. Sun j. Tian V.N. Huynh Y. Nakamori School of Knowledge Science Japan Advanced lnstitute of Science and Technology lshikawa Japan School of Computer Science and Technology Wuhan University of Technology Wuhan China

Graduate students who are beginning academic research want to learn how to create and verify new knowledge in their research. Their supervisors, on the other hand, are seeking appropriate research environments including effective research guidance methods. In order to meet these demands, this paper proposes a knowledge creation model that supports the obj.ctives of both graduate students and their supervisors. This is an academic knowledge creation model for individuals supported by a group and its origin can be traced back to a famous organizational knowledge creation model. Since this type of model is constructed from empirical knowledge, it is not easy to prove its obj.ctive significance. But, this paper tries to show the effectiveness of the proposed model as an initial stage of model validation based on a questionnaire survey of students in a graduate school in China.

关键词： Knowledge creation model graduate students research ability research environment

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The unusual life history of a southern Iberian Peninsula population of Torleya maj.r （Ephemeroptera： Ephemerellidae）

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Insect Science 2011年第5期18卷 583-589页

作者： M. j. Lopez-Rodriguez j. M. Tierno de Figueroa j. Alba-Tercedor Departamento de Biologia Animal Facultad de Ciencias Universidad de Granada Granada Spain

The nymphal biology of a population of Torleya maj.r （Klapalek） in southem Iberian Peninsula was studied. An atypical life cycle pattern is described, with eggs hatching in August producing a fast-developing cohort with adults emerging in autumn and a second slow-developing cohort with adults emerging in spring of the following year. Nymphal growth occurred primarily in summer-autumn （in the first cohort） and in spring （in the second）. The origin of such a life history is discussed. Nymphs were collector-gatherers, consuming mainly detritus. Although ontogenetic shifts on the use of trophic resources were detected, similar food was utilized during the months when both cohorts cohabited, eliminating the possibility that the rapid growth of the first cohort could be related to the utilization of different food resources.

关键词： collector-gatherer life cycle mayfly nymphal feeding southern Iberian Peninsula

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Advancing engineered approaches for sustainable wound regeneration and repair:Harnessing the potential of green synthesized silver nanoparticles

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Engineered Regeneration 2024年第3期5卷 306-325页

作者： j.Nandhini E.Karthikeyan E.Elizabeth Rani V.S.Karthikha D.sakthi Sanj.na H.j.evitha S.Raj.shkumar Vij.yan Venugopal A.Priyadharshan Department of Pharmaceutics Saveetha College of PharmacySaveetha Institute of Medical and Technical SciencesChennai 602105India Department of Pharmaceutical Chemistry Saveetha College of PharmacySaveetha Institute of Medical and Technical SciencesChennai 602105India Department of Pharmacology Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical SciencesChennaiIndia Department of Pharmaceutics School of PharmacySri Balaji Vidyapeeth(Deemed to be university)PuducherryIndia Department of conservative Dentistry and Endodontics Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia

Wound healing is a crucial biological process for tissue repair and regeneration,preventing infections and ***’s been a growing interest in exploring sustainable wound healing strategies in recent *** review examines the use of green-synthesized silver nanoparticles(AgNPs)in sustainable wound healing *** highlights the need for innovative approaches and the challenges posed by *** current wound therapies and treatments,highlighting gaps in existing methodologies,are *** review provides a com-prehensive overview of the current state-of-the-art in green synthesis techniques for the synthesis of *** properties and characterization of AgNPs are elucidated,providing insights into their *** biocompati-bility of AgNPs in wound healing is also explored,emphasizing safety in medical *** synthesized AgNPs incorporated wound dressings are detailed,showcasing their potential in clinical *** and future perspectives are discussed,addressing hurdles to widespread *** conclusion consolidates key findings,offering a synthesized perspective on the potential of green-synthesized AgNPs in revolutionizing current knowledge on innovative approaches for sustainable wound healing practices.

关键词： Green synthesis Wound healing AgNPs Wound healing mechanism Eco-friendly synthesis

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Harnessing artificial intelligence for identifying conflicts of interest in research

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World j.urnal of Methodology 2025年第1期15卷 6-8页

作者： Abdulqadir j.Nashwan Department of Nursing&Midwifery Research Hamad Medical CorporationDoha 3050Qatar

This editorial explores the transformative potential of artificial intelligence(AI)in identifying conflicts of interest(COIs)within academic and scientific *** harnessing advanced data analysis,pattern recognition,and natural language processing techniques,AI offers innovative solutions for enhancing transparency and integrity in *** editorial discusses how AI can automatically detect COIs,integrate data from various sources,and streamline reporting processes,thereby maintaining the credibility of scientific findings.

关键词： Artificial intelligence Conflicts of interest Transparency Research integrity Natural language processing

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Effect of Air Plasma Processing on the Adsorption Behaviour of Bovine Serum Albumin on Spin-Coated PMMA Surfaces

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j.urnal of Bionic Engineering 2008年第3期5卷 204-214页

作者： Chaozong Liu Brian j. Meenan Advanced Materials and Biomaterials Research Centre School of Engineering The Robert Gordon University Aberdeen ABIO 1FR UK Northern ireland Bioengineering Centre University of Ulster Newtownabbey BT37 OQB Northern Ireland UK

This paper reports the adsorption of Bovine Serum Albumin （BSA） onto Dielectric Barrier Discharge （DBD） processed Poly（methyl methacrylate）（PMMA） surfaces by a Quartz Crystal Microbalance with Dissipation monitoring （QCM-D） technique. The purpose is to study the influence of DBD processing on the nature and scale of BSA adsorption on PMMA surface in vitro. It was observed that DBD processing improves the surface wettability of PMMA film, a fact attributable to the changes in surface chemistry and topography. Exposure of the PMMA to Phosphate Buffed Saline （PBS） solution in the QCM-D system resulted in surface adsorption which reaches an equilibrium after about 30 minutes for pristine PMMA, and 90 minutes for processed PMMA surface. Subsequent inj.ction of BSA in PBS indicated that the protein is immediately adsorbed onto the PMMA surface. It was revealed that adsorption behaviour of BSA on pristine PMMA differs from that on processed PMMA surface. A slower adsorption kinetics was observed for pristine PMMA surface, whilst a quick adsorption kinetics for processed PMMA. Moreover, the dissipation shift of protein adsorption suggested that BSA forms a more rigid structure on pristine PMMA surface that on processed surface. These data suggest that changes in wettability and attendant chemical properties and surface texture of the PMMA surface may play a significant role in BSA adsorption process.

关键词： in vitro test protein adsorption surface modification polymethylmethacrylate QCM-D

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Effects of various parameters on the attrition of bed material in a recirculating fluidized bed with a draft tube

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Particuology 2018年第3期16卷 61-70页

作者： Shivali Chourasia Babu j. Alappat Department of Civil Engineering Indian Institute of Technology Delhi Hauz Khas New Delhi 110016 India

We performed an experimental study to investigate the effects of various parameters on the attrition of bed material and its size distribution with increasing operation time in a recirculating fluidized bed （RCFB）. The studied parameters included superficial velocity of fluidizing air, bed inventory, and spacing between the j.t top and draft tube bottom （spacer height）. The bed material was prepared from Indian Standard （IS） Grade I sand from sieves with a size range of 2.20-1.00 mm. Experiments were performed at ambient conditions, with the superficial air velocity ranging from 7.13-9.16 m/s, a bed inventory of 7-10 kg, spacing of 0.085 and 0.045 m between the j.t top and draft tube bottom, and an operating time of 40 h. We investigated the influence of these parameters in terms of changes in the size distribution of particles, changes in the %-weight of particles of different size ranges, generation of particles with smaller diameters, the decrease of the downcomer bed height, variations in the coefficient of uniformity and coefficient of curvature, and material loss from entrainment of fines with increasing operation time. The mode of attrition was abrasion in all experiments. We found that with increasing operation time and other parameters （bed inventory, superficial air velocity, and spacer height） attrition of the bed material also increased. Generation and elutriation of fines were more pronounced at higher superficial air velocity, bed inventory, and spacer height.

关键词： Attrition Recirculating fluidized bed (RCFB) Fluidization Elutriation Fines

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Host-parasite interactions under extreme climatic conditions

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Current Zoology 2011年第3期57卷 390-405页

作者： j. MARTINEZ S. MERINO Departamento de Microbiologfa y Parasitologfa Facultad de Farmacia Universidad de Alcala Alcala de Henares Madrid Spain Departamento de Ecologfa Evolutiva Museo Nacional de Ciencias Naturales Consejo Superior de Investigaciones Cientfficas Madrid Spain

The effect that climatic changes can exert on parasitic interactions represents a multifactor problem whose results are difficult to predict. The actual impact of changes will depend on their magnitude and the physiological tolerance of affected organisms. When the change is considered extreme （i.e. unusual weather events that are at the extremes of the historical distribution for a given area）, the probability of an alteration in an organisms＇ homeostasis increases dramatically. However, factors determining the altered dynamics of host-parasite interactions due to an extreme change are the same as those acting in response to changes of lower magnitude. Only a deep knowledge of these factors will help to produce more accurate predictive models for the effects of extreme changes on parasitic interactions. Extreme environmental conditions may affect pathogens directly when they include free-living stages in their life-cycles and indirectly through reduced resource availability for hosts and thus reduced ability to produce efficient anti-parasite defenses, or by effects on host density affecting transmission dynamics of diseases or the frequency of intraspecific contact. What are the consequences for host-parasite interactions？ Here we summarize the present knowledge on three principal factors in determining host-parasite associations; biodiversity, population density and immunocompetence In addition, we analyzed examples of the effects of environmental alteration of anthropogenic origin on parasitic systems because the effects are analogous to that exerted by an extreme climatic change [Current Zoology 57 （3）： 390405, 2011].

关键词： Biodiversity Climate change Immunocompetence Parasite-host interactions Pollution Population density

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Mitotic Spindle Organization by the Preprophase Band

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Molecular Plant 2008年第6期1卷 950-960页

作者： j. Christian Ambrose Richard Cyr The Pennsylvania State University Department of Biology The Huck Institutes of the Life Sciences Integrative Biosciences Graduate Degree Program PlantPhysiology Program University Park PA 16802 USA Present address: Department of Botany University of British Columbia Vancouver British Columbia V6T 1Z4 Canada

In higher plants, the preprophase band （PPB） of microtubules （MTs） forecasts the cell division site prior to mitosis and specifies the organization of MTs into a bipolar prophase spindle surrounding the nucleus. However, the mechanisms governing this PPB-dependent establishment of bipolarity are unclear. Here, we present evidence from live cell imaging studies that suggest a role for the MTs bridging the PPB and the prophase nucleus in mediating this function. Results from drug treatments, along with genetic evidence from null kinesin plants, suggest that these MTs contribute to the bipolarity, orientation, and position of the prophase spindle. Specifically, the absence of these bridge MTs is associated with lack of bipolarity, while non-uniform distributions of bridge MTs correlate with prophase spindle migration, deformation, and enhanced bipolarity toward the region of highest bridge MT density. This behavior does not require actomyosin-based forces, and is enhanced by suppressing MT dynamics with taxol. These observations occur during late prophase, and are coincident with the gradual closing of annular spindle poles. Based on these data, we describe a hypothetical mechanism for bridge MT-dependent organization of prophase spindles.

关键词： preprophase band mitosis acentrosomal spindle microtubule kinesin ATK5 cytokinesis.

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