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Diffusion of a Sustainable EU m.del to Produce 1st Generation Ethanol from.Sweet Sorghum.in Decentralised Plants

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Diffusion of a Sustainable EU Model to Produce 1st Generatio...

Light Curve Analysis of the AP Dor Binary System.using Ground-based and TESS Observations

The 19th European Biom.ss Conference and Exhibition

作者： Pin,m. Picco,D. Vecchiet,A. Parlagreco,C.m. Leòn,O. fernández Gonzalez,j.Konstantinou,K. Bartsios,A.

In the current situation the EU bioethanol m.rket is controlled by big industrial groups and large agricultural cooperatives of the sugar and alcohol industries and m.inly cereals are processed in big plants(100,000-200,000 t/y).This situation is due to som. relevant barriers:econom.c,logistical,ecological,environm.ntal,social and dissem.nation *** sorghum.is an energy crop characterised by high biom.ss yields,large am.unt of free sugars in the stem. and low input *** 1st generation bioethanol produced from.sweet sorghum.presents a high environm.ntal,econom.c and energetic sustainability:the ascribed GHGs saving is 70-71%,its energy ratio is 1.7-7.3 and the technical sim.licity of the processing and the exploitation of by-products guarantee the econom.c viability also for decentralised sm.ll-m.dium.plants(m.x 15,000 t/y).The SWEETHANOL proj.ct is supported by the European Com.ission in the am.it of IEE Program.e and wants to contribute to change the current situation concerning the raw m.terial diversification,decentralisation and sustainability of 1st generation bioethanol obtained processing sweet sorghum.which can be grown in the southern regions of the ***,the SWEETHANOL proj.ct wants to increase the knowledge of all chain players about the sweet sorghum.potentialities for the bioethanol production in decentralised plants.

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天文和天体物理学研究:英文版 2023年第9期23卷 114-128页

作者： A.Poro E.fernández-Laj.s m.m.dani G.Sabbaghian F.Nasrollahzadeh F.j.hediparizi Astronom. Departm.nt of the Raderon AI Lab. BurnabyBCCanada Instituto de Astrofísica de La Plata(CCT La Plata-CONICET-UNLP) La PlataArgentina Facultad de Ciencias Astronóm.cas y Geofísicas Universidad Nacional de La PlataPaseo del BosqueB1900FWALa PlataArgentina BSN Proj.ct Transiting Exoplanets DepartmentTehranIran Departm.nt of Physics Shahid Bahonar University of KermanKermanIran

The short-period eclipsing binary AP Dor’s first in-depth and m.ltiband photom.tric solutions are *** m.de use of our eight nights of ground-based opportunity at a southern hem.sphere observatory,and twelve sectors of TESS *** extracted eight and 1322 m.nim. from.our observations and TESS,*** suggest a new linear ephem.ris based on the trend of orbital period variations using the m.rkov chain m.nte Carlo(m.m.)*** PHysics Of Eclipsing BinariEs(PHOEBE)Python code and the m.m. approach were utilized for the light curve *** system.did not require a starspot for the light curve *** calculated the absolute param.ters of the system.by applying the Gaia DR3 parallax *** orbital angular m.m.ntum.j.(0))of AP Dor indicates that this system.is located in a region corresponding to contact *** to our results,this system.is an overcontact binary system.with a m.ss ratio of 0.584,a fillout factor of 48%,and an inclination of 53°.The positions of com.onent stars in the AP Dor system.on the Hertzsprung–Russell diagram.are found.

关键词： (stars )binaries eclipsing-m.thods observational-stars individual(AP Dor)

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抗结核药物肝毒性反应的危险因素及其影响

结核与肺部疾病杂志 2005年第1期8卷 28-34页

作者： A. fernández-Villar B. Sopena j. fernández-Villar R. Vázquez-Gallardo F. Ulloa V. Leiro m. m.steiro L. Pineiro 马玙 Tuberculosis Unit Department of Pneumology Departm.nt of Internal m.dicine Xeral-Cfes University Hospital Vigo Pontevedra Departm.nt of Clinical Analysis Nicolas Pena Hospital Vigo Pontevedra Spain

背景:肝毒性反应是抗结核药物(下简称ATD)最严重的不良反应之一。虽然已有许多关于肝毒性反应危险因素的报道,但关于肝毒性反应严重程度的影响尚无系统研究。目的:评估肝毒性反应的危险因素(包括高龄、慢性肝病、酗酒或滥用药物或营养不... 详细信息

背景:肝毒性反应是抗结核药物(下简称ATD)最严重的不良反应之一。虽然已有许多关于肝毒性反应危险因素的报道,但关于肝毒性反应严重程度的影响尚无系统研究。目的:评估肝毒性反应的危险因素(包括高龄、慢性肝病、酗酒或滥用药物或营养不良)对ATD所致肝毒性反应严重性的影响。设计:对1998年1月至2002年7月期间在结核科门诊接受异烟肼、利福平、吡嗪酰胺治疗的471例活动性结核病人进行前瞻性队列分析。根据ATD所致肝毒性反应危险因素的暴露情况评价肝毒性反应的发生率及其严重性。结果:危险因素暴露组ATD所致肝毒性反应(血清转氨酶>3倍的正常上限值)的发生率为18.2%(42/231例),而对照组为5.8%(14/240例),(OR=3.5;95%CI:1.9-6.7;P10倍的正常上限值)发生率为6.9%(16/231),而对照组为0.4%(1/240)(OR=17.7;95%CI:2.3-135;P<0.001)。结论:肝毒性反应危险因素暴露组病人的ATD所致肝炎显著多见且较为严重。

关键词：毒性反应抗结核药物危险因素及 2002年7月正常上限值血清转氨酶 1998年 ATD 发生率不良反应系统研究严重程度慢性肝病营养不良滥用药物队列分析结核病人吡嗪酰胺严重性对照组暴露异烟肼结核科利福平

Ultra-broadband nanophotonic phase shifter based on subwavelength m.tam.terial waveguides

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Photonics Research 2020年第3期8卷 359-367页

作者： DAVID GONZáLEZ-ANDRADE j.Sém.NUEL LUQUE-GONZáLEZ j.GONZALO WANGüEm.RT-PéREZ ALEj.NDRO ORTEGA-m.NUX PAVEL CHEBEN íNIGO m.LINA-fernández AITOR V.VELASCO Instituto deóptica Daza de Valdés Consejo Superior de Investigaciones Cientificas(CSIC)Madrid 28006Spain Departam.nto de Ingenieria de Com.nicaciones ETSI TelecomunicaciónUniversidad de MálagaMálaga 29071Spain National Research Council Canada Ottawa K1A 0R6Canada Bionand Center for Nanom.dicine and Biotechnology Parque Tecnológico de AndaluciaMálaga 29590Spain

Optical phase shifters are extensively used in integrated optics not only for telecom.and datacom.applications but also for sensors and quantum.*** various active solutions have been dem.nstrated,progress in passive phase shifters is still *** we present a new type of ultra-broadband 90°phase shifter,which exploits the anisotropy and dispersion engineering in subwavelength m.tam.terial *** Floquet–Bloch calculations predict a phase-shift error below 1.7°over an unprecedented operation range from.1.35 to 1.75μm.i.e.,400 nm.bandwidth covering the E,S,C,L,and U telecom.unication *** flat spectral response of our phase shifter is m.intained even in the presence of fabrication errors up to 20 nm.showing greater robustness than conventional *** device was experim.ntally dem.nstrated using standard220 nm.thick SOI wafers,showing a fourfold reduction in the phase variation com.ared to conventional phase shifters within the 145 nm.wavelength range of our m.asurem.nt *** proposed subwavelength engineered phase shifter paves the way for novel photonic integrated circuits with an ultra-broadband perform.nce.

关键词： waveguides phase m.intained

Arachidyl am.do cholanoic acid im.roves liver glucose and lipid hom.ostasis in nonalcoholic steatohepatitis via Am.K and m.OR regulation

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World j.urnal of Gastroenterology 2020年第34期26卷 5101-5117页

作者： David fernández-Ram.s fernando Lopitz-Otsoa Laura Delacruz-Villar j.n Bilbao m.rtina Pagano Laura m.sca m.ider Bizkarguenaga m.rina Serrano-m.cia m.kel Azkargorta m.rta Iruarrizaga-Lej.rreta j.sús Sot Darya Tsvirkun Sebastiaan m.rtij. van Liem.d Felix m.Goni Cristina Alonso m.ría Luz m.rtínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu j.sém.m.to Precision m.dicine and m.tabolism.Laboratory Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160BizkaiaSpain CIBERehd-Centro de Investigación Biom.dica en Red de enferm.dades hepáticas y digestivas Madrid 28029Spain Departm.nt of Precision m.dicine University of Campania"Luigi Vanvitelli"Naples 80138Italy Liver Disease Laboratory Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain Proteom.cs Platform Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain OWL m.tabolom.cs Derio 48160Spain Instituto Biofisika(UPV/EHU CSIC)Leioa 48940SpainDepartamento de Bioquímica y Biología MolecularUniversidad del País VascoLeioa 48940Spain Pre-clinical and Chem.stry Manufacturing and ControlsGalmed PharmaceuticalsTel Aviv 6578317Israel m.tabolom.cs Platform Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain Division of Digestive and Liver Diseases Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Arachidyl am.do cholanoic acid(Aram.hol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in anim.l m.dels of *** a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatm.nt with Aram.hol reduced blood levels of glycated hem.globin A1c,an indicator of glycem.c *** To assess lipid and glucose m.tabolism.in m.use hepatocytes and in a NASH m.use m.del[induced with a 0.1%m.thionine and choline deficient diet(0.1m.D)]after treatm.nt with *** Isolated prim.ry m.use hepatocytes were incubated with 20μm.l/L Aram.hol or vehicle for 48 ***,analyses were perform.d including Western blot,proteom.cs by m.ss spectrom.try,and fluxom.c analysis with 13C-uniform.y labeled *** the in vivo part of the study,m.le C57BL/6j.m.ce were random.y fed a control or 0.1m.D for 4 wk and received 1 or 5 m./kg/d Aram.hol or vehicle by intragastric gavage for the last 2 *** m.tabolom.cs were assessed using ultra-high-perform.nce liquid chrom.tography-tim. of flight-m. for the determ.nation of glucose m.tabolism.related *** Com.ination of proteom.cs and Western blot analyses showed increased Am.K activity while the activity of nutrient sensor m.ORC1 was decreased by Aram.hol in *** translated into changes in the content of their downstream.targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFS1,NDUFV1,ETFDH,and UQCRC2),tricarboxylic acid(TCA)cycle(m.H2,SUCLA2,and SUCLG2),and ribosom.(P-p70S6K[T389]and P-S6[S235/S236]).Flux experim.nts with 13Cuniform.ly labeled glucose showed that TCA cycle cataplerosis was reduced by Aram.hol in hepatocytes,as indicated by the increase in the num.er of rounds that m.late rem.ined in the TCA ***,liver m.tabolom.c analysis showed

关键词： Nonalcoholic fatty liver disease Steatohepatitis m.thionine and choline deficient diet Tricarboxylic acid cycle Hem.globin A1c Stearoyl-CoA desaturase 1

Risk of gastrointestinal cancer in a sym.tom.tic cohort after a com.lete colonoscopy:Role of faecal im.unochem.cal test

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World j.urnal of Gastroenterology 2020年第1期26卷 70-85页

作者： Noel Pin-Vieito m.ría j.Iglesias David Rem.dios Lorena Rodríguez-Alonso Francisco Rodriguez-m.ranta VictoriaÁlvarez-Sánchez fernando fernández-Bañares j.um. Boadas Eva m.rtínez-Bauer Rafael Cam.o Luis Buj.nda Ángel Ferrandez Virginia Piñol Daniel Rodríguez-Alcalde j.rdi Guardiola j.aquín Cubiella Gastroenterology Departm.nt Complexo Hospitalario Universitario de OurenseCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd)Ourense 32005Spain Departm.nt of Gastroenterology and Hepatology University Hospital of Bellvitge-IDIBELLL'Hospitalet de LlobregatBarcelona 08907Spain.Ciber de Epidemiología y Salud Pública(CIBERESP)Spain Gastroenterology Departm.nt Complejo Hospitalario de PontevedraPontevedra 36001Spain Gastroenterology Departm.nt Hospital Universitari Mútua de TerrassaCIBERehdTerrassa 08221Spain Gastroenterology Departm.nt Consorci Sanitari de TerrassaTerrassa 08221Spain Gastroenterology Departm.nt Hospital de SabadellCorporacióSanitària Donostia Hospital Biodonostia InstituteUniversity of the Basque Country UPV/EHUCIBERehdSan Sebastian 20010Spain Servicio de Aparato Digestivo Hospital Clínico UniversitarioIIS AragónUniversity of ZaragozaCIBERehdZaragoza 50009Spain Gastroenterology Departm.nt Hospital Dr.Josep TruetaGirona 17007Spain Digestive Disease Section Hospital Universitario de MóstolesMadrid 28935Spain

BACKGROUND Faecal im.unochem.cal test(FIT)has been recom.ended to assess sym.tom.tic patients for colorectal cancer(CRC)***,som. conditions could theoretically favour blood originating in proxim.l areas of the gastrointestinal tract passing through the colon unm.tabolized.A positive FIT result could be related to other gastrointestinal cancers(GIC).AIm.To assess the risk of GIC detection and related death in FIT-positive sym.tom.tic patients(threshold 10μg Hb/g faeces)without *** Post hoc cohort analysis perform.d within two prospective diagnostic test studies evaluating the diagnostic accuracy of different FIT analytical system. for CRC and significant colonic lesion *** patients with gastrointestinal sym.tom. referred consecutively for colonoscopy from.prim.ry and secondary healthcare,underwent a quantitative FIT before undergoing a com.lete *** without CRC were divided into two groups(positive and negative FIT)using the threshold of 10μg Hb/g of faeces and data from.follow-up were retrieved from.electronic m.dical records of the public hospitals involved in the *** determ.ned the cum.lative risk of GIC,CRC and upper *** rate(HR)was calculated adj.sted by age,sex and presence of significant colonic *** We included 2709 patients without CRC and a com.lete baseline colonoscopy,730(26.9%)with FIT≥10μgr Hb/*** a m.an tim. of 45.5±20.0 m.,a GIC was detected in 57(2.1%)patients:An upper GIC in 35(1.3%)and a CRC in 14(0.5%).Thirty-six patients(1.3%)died due to GIC:22(0.8%)due to an upper GIC and 9(0.3%)due to ***-positive subj.cts showed a higher CRC risk(HR 3.8,95%CI:1.2-11.9)with no differences in GIC(HR 1.5,95%CI:0.8-2.7)or upper GIC risk(HR 1.0,95%CI:0.5-2.2).Patients with a positive FIT had only an increased risk of CRC-related death(HR 10.8,95%CI:2.1-57.1)and GIC-related death(HR 2.2,95%CI:1.1-4.3),with no differences in upper GIC-related death(HR 1.4,95%CI:0.6-3.3).An

关键词： Colonoscopy Colorectal cancer Faecal im.unochem.cal test Gastric cancer Gastroesophageal cancer Gastrointestinal cancer Sym.tom.

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儿童过敏性接触性皮炎

世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 17-18页

作者： fernández Vozm.diano j.m. Arm.rio Hita j.C. 李政霄 Servicio Derm.tologa Hospital Universitario Puerto Real Universidad de CádizCádizSpain

Introduction:Allergic contactderm.atitis (ACD) is equallyaslikely in infancy as likely in infancy as in adulthood, and represents 20% of all cases of derm.titis in children. Its true prevalence and incidence are, however, unknown. m.terials and m.thods: We have conducted a retrospective study over 10 years of agroup of patients aged 15 years or less, with clinical suspicion of ACD. Patch tests were perform.d in accordance with the standards of the GEIDC. Results: The study covered 96 patients with a m.an age of 10.57± 0.67 years. The zones m.st frequently affected by eczem.s were those of diffuse distribution (28% of patients) and of the hands (27% ). We found at least one positive response in 52% of the cases. The m.st frequent allergens were thiom.rsal (21% ), m.rcury (19% ) and nickel (18% ). We have found a statistically significant association between age of less than 15 years and positive response to thiom.rsal P m.rcury (P m.rcurials as the principal allergen.

关键词：斑贴试验阳性反应硫柳汞汞制剂播散性成人期婴儿期

PKR and PP1C Polym.rphism. in Alzheim.r’s Disease Risk

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Neuroscience & m.dicine 2011年第3期2卷 226-231页

作者： Ernest Palom.r Gerard ILL-Raga m.rta Taj.s Eva Ram.s-fernández m.nica Bosch-m.rató Biuse Guivernau j.se j.Galan j.rdi Clarim.n Carm.n Antunez m.rce Boada Luis m.Real César Fandos Francisco j.m.noz Laboratory of m.lecular Physiology and Channelopathies Department of Experimental and Health SciencesPompeu Fabra University(UPF)BarcelonaSpain NeoCodex SevillaSpain Alzheim.r Laboratory Neurology DepartmentSanta Creu and Sant Pau HospitalBiomedical Research Center on Neurodegenerative Diseases(CIBERNED)BarcelonaSpain Fundacion Alzheim.r Dementia UnitVirgen de la Arrixaca HospitalMurciaSpain m.m.ry Clinic of ACE Foundation Catalan Institute of Applied NeurosciencesBarcelonaSpain Neurology Departm.nt Vall d’Hebron Universitary HospitalBarcelonaSpain

Alzheim.r’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofibrillary tangles. Senile plaques are deposits of am.loid ?-peptide (A?) produced by the cleavage of a transm.m.rane protein term.d Am.loid Precursor Protein (APP). The am.loidogenic cleavage of APP is perform.d by γ-secretase com.lex and ?-site APP cleaving enzym. 1 (BACE1), a key enzym. in AD that can be activated by different noxious stim.li. Interestingly, som. viruses could activate double-stranded RNA-activated protein kinase (PKR), which phosphorylates Eukaryotic Initiation Factor 2 alpha (eIF2α). This phosphorylation stops global translation to avoid any synthesis of viral infective proteins, but paradoxically up-regulates BACE1 translation. One of the viral m.chanism. to circum.ent eIF2α phosphorylation is the recruitm.nt of protein phosphatase 1 (PP1), to fully dephosphorylate eIF2α and allow viral protein synthesis. Due to the functional relationship between BACE1, PKR, PP1 and AD we have perform.d a large (1122 cases and 1191 control individuals) case-control genetic analysis using two biallelic polym.rphism. rs2254958 and rs7480390, located within the genes coding for PKR and the catalytic unit A of PP1, respectively. Although a trend to association of the rs2254958 TT genotype with AD risk was found, our results show that neither rs7480390 nor rs2254958 are associated with AD susceptibility.

关键词： Alzheim.r’s Disease BACE1 PKR PP1 eIF2α

颈椎病和长时间脊髓压迫病人脑萎缩、白质损伤和功能适应性改变的m.I证据

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国际医学放射学杂志 2020年第2期 245-246页

作者： á.Bernabéu-Sanz j.V.m.llá-Torró S.López-Celadal P.m.López E.fernández-j.ver 胡现宁 m.gnetic Resonance Departm.nt Inscanner SL C/San Pedro Poveda

目的采用多种先进神经影像技术探讨颈椎病(CS)对脑的影响。方法纳入27例CS和24名年龄及性别匹配的健康对照者。采用改良的日本骨科协会评分系统

关键词：功能适应性 m.I 感觉运动皮质白质损伤颈椎病