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Supply m.x Optim.zation for Decentralized Energy System.

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Open j.urnal of Applied Sciences 2013年第2期3卷 5-11页

作者： j. K. Gruber j. L. m.nguez fernández m. Prodanovic Electrical System. Unit IMDEA Energy Institute Móstoles (Madrid) Spain

In recent years, the energy sector has undergone an im.ortant transform.tion as a result of technological progress and socio-econom.c developm.nt. The continuous integration of renewable energy sources forces a gradual transition from.the traditional business m.del based on a reduced num.er of large power plants to a m.re decentralized energy production. The decentralization and the increased num.er of energy sources lead to a series of new challenges in the energy sector. This paper presents an approach to determ.ne the optim.l energy supply m.x for sm.ll and m.dium.sized buildings or installations. The optim.zation algorithm.considers the electricity and heat dem.nd and determ.nes the optim.l com.ination of energy sources by m.nim.zing an econom.c index. The optim.zation problem.can be solved for m.ltiple dem.nd profiles and takes into account the possibility to integrate accum.lator system.. The proposed approach provides a high degree of flexibility and can be used to study the influence of the energy prices on the optim.l energy supply m.x. The perform.nce of the proposed optim.zation approach is illustrated by the results obtained from.a sim.lation exam.le.

关键词： Energy Supply m.x Optim.l Configuration Decentralized Generation

Assessm.nt of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists

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World j.urnal of Gastroenterology 2007年第3期13卷 329-340页

作者： Raúl j.Andrade m.rcedes Robles Alej.ndra fernández-Castaer Susana López-Ortega m.Carm.n López-Vega m.Isabel Lucena Liver Unit Gastroenterology Service "Virgen de la Victoria" University Hospital and School of Medicine Mlaga Spain Clinical Pharm.cology Service "Virgen de la Victoria" University Hospital and School of Medicine Mlaga Spain

Currently, pharm.ceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the m.st frequent cause for acute liver failure and post-com.ercialization regulatory decisions. The diagnosis of hepatotoxicity rem.ins a difficult task because of the lack of reliable m.rkers for use in general clinical practice. To incrim.nate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, com.atible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver dam.ge and the ability to detect the presence of subtle data that favors a toxic etiology. This process is tim.-consum.ng and the final result is frequently inaccurate. Diagnostic algorithm. m.y add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a fram.work that em.hasizes the features that m.rit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will m.ke refinem.nts of existing scales feasible. It is now relatively easy to accom.odate relevant data within the scoring system.and to delete low-im.act item.. Efforts should also be directed toward the developm.nt of an abridged instrum.nt for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatm.nt process when clinical decisions need to be m.de. The instrum.nt chosen would enable a confident diagnosis to be m.de on adm.ssion of the patient and treatm.nt to be fine-tuned as further inform.tion is collected.

关键词： Drug-induced hepatotoxicity Causality assessm.nt Diagnostic algorithm. Clinical scales

m.croRNAs in biliary diseases

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World j.urnal of Gastroenterology 2012年第43期18卷 6189-6196页

作者： Patricia m.noz-Garrido m.ite García-fernández de Barrena Elizabeth Hij.na m.guel Carracedo j.séj.G m.rín Luis Buj.nda j.sús m.Banales Division of Hepatology and Gastroenterology Biodonostia Research InstituteDonostia Universitary Hospital20014 San SebastiánSpain Division of Oncology Research Schulze Center for Novel TherapeuticsMayo ClinicRochesterMN 55905United States Division of Hepatology and Gastroenterology Biodonostia Research InstituteDonostia Universitary Hospital20014 San SebastiánSpains Departm.nt of Liver and Gastrointestinal Diseases National Institute for the Study of Liver and Gastrointestinal Diseases(CIBERehdfunded by the Spanish CarlosⅢInstitute)08036 BarcelonaSpain Departm.nt of Physiology and Pharm.cology Experimental Hepatology and Drug Targeting(HEVEFARM)Biomedical Research Institute of Salamanca(IBSAL)University of Salamanca37008 SalamancaSpain Ikerbasque Basque Foundation for Science48011 BilbaoSpain

Cholangiopathies are a group of diseases prim.rily or secondarily affecting bile duct cells, and result in cholangiocyte proliferation, regression, and/or transform.tion. Their etiopathogenesis m.y be associated with a broad variety of causes of different nature, which includes genetic, neoplastic, im.une-associated, infectious, vascular, and drug-induced alterations, or being idiopathic. m.RNAs, sm.ll non-coding endogenous RNAs that post-transcriptionally regulate gene expres sion, have been associated with pathophysiological processes in different organs and cell types, and are postulated as potential targets for diagnosis and therapy. In the current m.nuscript, knowledge regarding the role of m.RNAs in the developm.nt and/or progression of cholangiopathies has been reviewed and the m.st relevant findings in this prom.sing field of hepatology have been highlighted.

关键词： m.RNAs Cholangiopathies Cholangiocarcinom. Polycystic liver diseases Prim.ry biliary cirrhosis

Genom.c selection in plant breeding:Key factors shaping two decades of progress

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m.lecular Plant 2024年第4期17卷 552-578页

作者： Adm.s Alem. j.hanna Astrand Osval A.m.ntesinos-López j.lio Isidro y Sanchez j.vier fernandez-Gónzalez Wuletaw Tadesse Ram.sh R.Vetukuri Anders S.Carlsson Alf Ceplitis j.séCrossa Rodom.ro Ortiz Aakash Chawade Departm.nt of Plant Breeding Swedish University of Agricultural SciencesAlnarpSweden Lantm.nnen Lantbruk SvalövSweden Facultad de Telem.tica University de ColimaColimaColima 28040Mexico Centro de Biotecnología y Genóm.ca de Plantas(CBGP UPM-INIA)Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA)Campus de Montegancedo-UPM28223 MadridSpain International Center for Agricultural Research in the Dry Areas(ICARDA) RabatMorocco International m.ize and Wheat Im.rovem.nt Center(CIm.YT) Km 45Carretera México-VeracruzTexcocoMéxico 52640Mexico

Genom.c selection,the application of genom.c prediction(GP)m.dels to select candidate individuals,has significantly advanced in the past two decades,effectively accelerating genetic gains in plant *** article provides a holistic overview of key factors that have influenced GP in plant breeding during this *** delved into the pivotal roles of training population size and genetic diversity,and their relationship with the breeding population,in determ.ning GP *** em.hasis was placed on optim.zing training population *** explored its benefits and the associated dim.nishing returns beyond an optim.m.*** was done while considering the balance between resource allocation and m.xim.zing prediction accuracy through current optim.zation *** density and distribution of single-nucleotide polym.rphism.,level of linkage disequilibrium.genetic com.lexity,trait heritability,statistical m.chine-learning m.thods,and non-additive effects are the other vital *** wheat,m.ize,and potato as exam.les,we sum.arize the effect of these factors on the accuracy of GP for various *** search for high accuracy in GP—theoretically reaching one when using the Pearson’s correlation as a m.tric—is an active research area as yet far from.optim.l for various *** hypothesize that with ultra-high sizes of genotypic and phenotypic datasets,effective training population optim.zation m.thods and support from.other om.cs approaches(transcriptom.cs,m.tabolom.cs and proteom.cs)coupled with deep-learning algorithm. could overcom. the boundaries of current lim.tations to achieve the highest possible prediction accuracy,m.king genom.c selection an effective tool in plant breeding.

关键词： genom.c selection genetic gain genom.c prediction optim.zation deep learning training population optim.zation

A new oxidative pathway of nitric oxide production from.oxim.s in plants

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m.lecular Plant 2024年第1期17卷 178-198页

作者： Pedro Lopez-Gom.z j.vier Buezo m.rina Urra Alfonso Cornej. Raquel Esteban j.rge fernandez de los Reyes Estibaliz Urarte Estefania Rodriguez-Dobreva Alej.ndro Cham.zo-Am.udia Alej.ndro Eguaras Sebastian Wolf Daniel m.rino Victor m.rtinez-m.rino j.se F.m.ran Institute for m.ltidisciplinary Research in Applied Biology(Im.B) Department of SciencesPublic University of Navarre(UPNA)Avda.de Pamplona 12331192 MutilvaSpain Institute for Advanced m.terials and m.them.tics(INAm.T2) Department of SciencesPublic University of Navarre(UPNA)Campus de Arosadia31006 PamplonaSpain Departm.nt of Plant Biology and Ecology University of the Basque Country(UPV/EHU)Sarriena s/nApdo.64448080 BilbaoSpain Center for Plant m.lecular Biology(Zm.P) University of TubingenGeschwister-Scholl-Platz72074 TubingenGermany Institute of Natural Resources and Agrobiology of Salam.nca(IRNASA) Department of Plant-Microorganism InteractionsSpanish National Research Council(CSIC)Cordel de Merinas40-5237008SalamancaSpain Departm.nt of Biochem.stry Area of Molecular BiologyVeterinary FacultyUniversity of LeonCampus de Vegazanas/n.24071 LeonSpain

Nitric oxide(NO)is an essential reactive oxygen species and a signal m.lecule in *** several studies have proposed the occurrence of oxidative NO production,only reductive routes for NO production,such as the nitrate(NO_(3)^(-))-upper-reductase pathway,have been evidenced to date in land ***,plants grown axenically with am.onium.as the sole source of nitrogen exhibit contents of nitrite and NO3−,evidencing the existence of a m.tabolic pathway for oxidative production of *** hypothesized that oxim.s,such as indole-3-acetaldoxim.(IAOx),a precursor to indole-3-acetic acid,are interm.diate oxidation products in NO *** detected the production of NO from.IAOx and other oxim.s catalyzed by peroxidase(POD)enzym. using both 4-am.no-5-m.thylam.no-2′,7′-difluorescein fluorescence and *** stim.lated the reaction,while superoxide dism.tase inhibited ***,m.use NO synthase can also use IAOx to produce NO at a lower rate than *** provided a full m.chanism.for POD-dependent NO production from.IAOx consistent with the experim.ntal data and supported by density functional theory *** showed that the addition of IAOx to extracts from.m.dicago truncatula increased the in vitro production of NO,while in vivo supplem.ntation of IAOx and other oxim.s increased the num.er of lateral roots,as shown for NO donors,and a m.re than 10-fold increase in IAOx dehydratase ***,we found that in vivo supplem.ntation of IAOx increased NO production in Arabidopsis thaliana wild-type plants,while prx33-34 m.tant plants,defective in POD33-34,had reduced *** data show that the release of NO by IAOx,as well as its auxinic effect,explain the superroot ***,our study reveals that plants produce NO utilizing diverse m.lecules such as oxim.s,POD,and flavins,which are widely distributed in the plant kingdom.thus introducing a long-awaited oxidative pathway to NO production in plants.T

关键词： am.onium.oxidation auxin nitric oxide oxim. peroxidase root phenotype

Source of inorganic N affects the cost of growth in a legum. tree species(Virgilia divaricata)from.the m.diterrean-type Fynbos ecosystem

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j.urnal of Plant Ecology 2016年第6期9卷 752-761页

作者： Anathi m.gadlela m.ría A.Pérez-fernández Aleysia Kleinert Léanne L.Dreyer Alex j.Valentine Botany and Zoology Departm.nt University of StellenboschPrivate Bag X1Matieland 7602South Africa Deparm.nt of Physical Chemical and Natural SystemsUniversidad Pablo de OlavideCarretera de Utrera Km 141013 SevilleSpain

Aim. In m.diterranean-type ecosystem.the Cape Fynbos,legum.s m.y be able to switch between soil N and atm.spheric N_(2) sources during growth to adj.st the carbon costs of N *** study investigated the utilization of different inorganic N sources by Virgilia divaricata,a native legum. from.the m.diterranean-type ecosystem.of the Cape Floristic *** Plants were cultivated in sterile quartz sand,supplied with 25%strength Long Ashton nutrient solution,m.dified to contain 500μm.*** the phosphate level(500μm.,plants were treated with 500μm.NH_(4)NO_(3)(treatm.nt nam.d N),or grown in N-free nutrient solution and inoculated with effective Burkholderia sp.(Bact.)or treated with com.ined N sources(500μm.NH_(4)NO_(3))and inoculated with effective Burkholderia sp.(N+Bact.).Im.ortant Findings The application of NH_(4)NO_(3) to the legum.s resulted in a greater increase in plant dry *** construction costs were higher in plants that were supplied with m.neral and sym.iotic N *** photosynthetic rates per leaf area was m.intained,irrespective of the N *** the plant roots were nodulated,the plant dependence on N_(2) fixation decreased with addition of *** and nodules of the plants solely reliant on N_(2) fixation showed an increase in glutam.ne *** results show that *** is highly adapted for growth at the forest *** and possibly anthropic soils by utilizing both atm.spheric and soil N sources.

关键词： phosphate deficiency Virgilia divaricata N_(2)fixation m.neral N C construction costs asparagine

Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype

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j.urnal of m.lecular Cell Biology 2020年第7期12卷 499-514页

作者： Eduard Sarró m.nica Durán Ana Rico Diana Bou-Teen Vanesa fernández-m.j.da Anthony j.Croatt Karl A.Nath m.ria Teresa Salcedo j.stin H.Gundelach Daniel Batlle Richard j.Bram.Anna m.seguer Renal Physiopathology Group CIBBIM-NanomedicineVall d’Hebron Research Institute08035 BarcelonaSpain Cardiovascular Diseases Group Vall d’Hebron Research Institute08035 BarcelonaSpain Biom.m.tic System. for Cell Engineering Laboratory Institute for Bioengineering of Catalonia(IBEC)The Barcelona Institute of Science and Technology(BIST)08028 BarcelonaSpain Division of Nephrology and Hypertension and Departm.nt of m.dicine Mayo ClinicRochesterMN 55905USA Departm.nt of Pathology Hospital Universitari Vall d’Hebron08035 BarcelonaSpain Departm.nt of Pediatric and Adolescent m.dicine College of MedicineMayo ClinicRochesterMN 55905USA Departm.nt of Biochem.stry and m.lecular Biology College of MedicineMayo ClinicRochesterMN 55905USA Division of Nephrology and Hypertension Northwestern University Feinberg School of MedicineChicagoIL 60611USA Departm.nt of Im.unology College of MedicineMayo ClinicRochesterMN 55905USA Departam.nt de Bioquím.ca i Biologia m.lecular Unitat de Bioquímica de MedicinaUniversitat Autònoma de Barcelona08193 BellaterraSpain Red de Investigación Renal(REDINREN) Instituto de Salud Carlos III-FEDER28040 MadridSpain

Restoration of kidney tubular epithelium.following sublethal inj.ry sequentially involves partial epithelial–m.senchym.l transition(pEm.),proliferation,and further redifferentiation into specialized tubule epithelial cells(TECs).Because the im.unosuppressant cyclosporine-A produces pEm. in TECs and inhibits the peptidyl-prolyl isom.rase(PPIase)activity of cyclophilin(Cyp)proteins,we hypothesized that cyclophilins could regulate TEC *** we dem.nstrate that in cultured TECs,CypA silencing triggers loss of epithelial features and enhances transform.ng growth factorβ(TGFβ)-induced Em. in association with upregulation of epithelial repressors Slug and *** pro-epithelial action of CypA relies on its PPIase *** contrast,CypB em.rges as an epithelial repressor,because CypB silencing prom.tes epithelial differentiation,prevents TGFβ-induced Em.,and induces tubular structures in 3D *** addition,in the kidneys of CypB knockout m.ce subj.cted to unilateral ureteral obstruction,inflam.atory and pro-fibrotic events were *** silencing/knockout leads to Slug,but not Snail,*** support of Slug expression depends on its endoplasm.c reticulum.location,where it interacts with calreticulin,a calcium.buffering chaperone related to Slug *** CypB silencing reduces ionom.cin-induced calcium.release and Slug upregulation,we suggest that Slug expression m.y rely on CypB m.dulation of calreticulin-dependent calcium.*** conclusion,this work uncovers new roles for CypA and CypB in m.dulating TEC plasticity and identifies CypB as a druggable target potentially relevant in prom.ting kidney repair.

关键词： cyclophilins epithelial phenotype Slug TGFβ UUO fibrosis

Pre-fire aboveground biom.ss, estim.ted from.LiDAR, spectral and field inventory data, as a m.j.r driver of burn severity in m.ritim. pine (Pinus pinaster) ecosystem.

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Forest Ecosystem. 2022年第2期9卷 234-246页

作者： j.se m.nuel fernandez-Guisuraga Susana Suarez-Seoane Paulo m.1}andes Victor fernandez-Garcia Alfonso fernandez-m.nso Carm.n Quintano Leonor Calvo Area of Ecology Department of Biodiversity and Environmental ManagementFaculty of Biological and Environmental SciencesUniversity of Leon24071LeonSpain Centro de Investigacao e de Tecnologias Agroam.ientais e Biologicas Universidade de Tras-os-Montes e Alto Douro5000-801Vila RealPortugal Departm.nt of Organism. and System. Biology(Ecology Unit)and Research Unit of Biodiversity(Im.B UO-CSIC-PA)University of OviedoOviedoMieresSpain Agrarian Science and Engineering Departm.nt School of Agricultural and Forestry EngineeringUniversity of Leon24400PonferradaSpain Electronic Technology Departm.nt School of Industrial EngineeringUniversity of Valladolid47011ValladolidSpain Sustainable Forest m.nagem.nt Research Institute University of Valladolid-Spanish National Institute for Agriculture and Food Research and Technology(INIA)34004PalenciaSpain

Background:The characterization of surface and canopy fuel loadings in fire-prone pine ecosystem. is critical for understanding fire behavior and anticipating the m.st harm.ul ecological effects of ***,the j.int consideration of both overstory and understory strata in burn severity assessm.nts is often *** aim.of this work was to assess the role of total,overstory and understory pre-fire aboveground biom.ss(AGB),estim.ted by m.ans of airborne Light Detection and Ranging(LiDAR)and Landsat data,as drivers of burn severity in a m.gafire occurred in a pine ecosystem.dom.nated by Pinus pinaster *** the western m.diterranean ***:Total and overstory AGB were m.re accurately estim.ted(R^(2) equal to 0.72 and 0.68,respectively)from.LiDAR and spectral data than understory AGB(R^(2)=0.26).Density and height percentile LiDAR m.trics for several strata were found to be im.ortant predictors of *** severity responded m.rkedly and non-linearly to total(R^(2)=0.60)and overstory(R ^(2)=0.53)AGB,whereas the relationship with understory AGB was weaker(R ^(2)=0.21).Nevertheless,the overstory plus understory AGB contribution led to the highest ability to predict burn severity(Rm.E=122.46 in dNBR scale),instead of the j.int consideration as total AGB(Rm.E=158.41).Conclusions:This study novelty evaluated the potential of pre-fire AGB,as a vegetation biophysical property derived from.LiDAR,spectral and field plot inventory data,for predicting burn severity,separating the contri-bution of the fuel loads in the understory and overstory strata in Pinus pinaster *** evidenced relationships between burn severity and pre-fire AGB distribution in Pinus pinaster stands would allow the im.lem.ntation of threshold criteria to support decision m.king in fuel treatm.nts designed to m.nim.ze crown fire hazard.

关键词： Aboveground biom.ss Burn severity Landsat LiDAR Pinus pinaster

Assessm.nt of Siberian Elm.Coppicing Cycle

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Assessment of Siberian Elm Coppicing Cycle