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Isochrone Fitting of Ga.a.tic Globula. Clusters—Ⅵ.High-la.itude Clusters NGC 5024 (m.3),NGC 5053,NGC 5272 (m.),NGC 5466,a.d NGC7099 (m.0)

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Resea.ch in a.tronom. a.d a.trophysics 2024年第6期24卷 170-190页

作者： G.a.Gontcha.ov S.S.Sa.chenko a.a.m.rchuk C.j.Bona.to O.S.Ryutina.m.Yu.Khovritchev V.B.il'in a.V.m.senkov D.m.Polia.ov a.a.Sm.rnov Centra.(Pulkovo)a.tronom.ca. Observa.ory Russian Academy of SciencesPulkovskoye chaussee 65/1St.Petersburg 196140Russia Sa.nt Petersburg Sta.e University Universitetskij pr.28St.Petersburg 198504Russia Specia. a.trophysica. Observa.ory Russian Academy of Sciences369167 Nizhnij ArkhyzRussia Depa.ta.0}nto de a.tronom.a Instituto de FísicaUFRGSAv.Bento Gonçalves9500Porto AlegreRSBrazil Sa.nt Petersburg University of a.rospa.e Instrum.nta.ion Bol.Morskaya ul.67ASt.Petersburg 190000Russia Depa.tm.nt of Physics a.d a.tronom. Brigham Young UniversityN283 ESCProvoUT 84602USA

We fit va.ious color–m.gnitude dia.ra.0}(Cm.s) of the high-la.itude Ga.a.tic globula. clusters NGC 5024(m.3),NGC 5053,NGC 5272(m.),NGC 5466,a.d NGC 7099(m.0) by isochrones from.the Da.tm.uth Stella. Evolution Da.a.a.e a.d Ba. of Stella. Tra.ks a.d Isochrones for α–enrichm.nt [α/Fe] = +*** the Cm.s,we use da.a.sets from.Hubble Spa.e Telescope,Ga.a.a.d other sources utilizing,a. lea.t,25 photom.tric filters for ea.h *** obta.n the following cha.a.teristics with their sta.istica. uncerta.nties for NGC 5024,NGC 5053,NGC 5272,NGC 5466,a.d NGC 7099,respectively:m.ta.licities [Fe/H] =-1.93 ± 0.02,-2.08 ± 0.03,-1.60 ± 0.02,-1.95 ± 0.02,a.d-2.07 ± 0.04 dex with their system.tic uncerta.nty 0.1 dex;a.es 13.00 ± 0.11,12.70 ± 0.11,11.63 ± 0.07,12.15 ± 0.11,a.d 12.80 ± 0.17 Gyr with their system.tic uncerta.nty 0.8 Gyr;dista.ces(system.tic uncerta.nty a.ded) 18.22 ± 0.06 ± 0.60,16.99 ± 0.06 ± 0.56,10.08 ± 0.04 ± 0.33,15.59 ±0.03 ± 0.51,a.d 8.29 ± 0.03 ± 0.27 kpc;reddenings E(B-V) = 0.023 ± 0.004,0.017 ± 0.004,0.023 ± 0.004,0.023 ± 0.003,a.d 0.045 ± 0.002 m.g with their system.tic uncerta.nty 0.01 m.g;extinctions a.= 0.08 ± 0.01,0.06 ± 0.01,0.08 ± 0.01,0.08 ± 0.01,a.d 0.16 ± 0.01 m.g with their system.tic uncerta.nty 0.03 m.g,which suggest the tota. Ga.a.tic extinction a.= 0.08 a.ross the whole Ga.a.tic dust to extra.a.a.tic obj.cts a. the North Ga.a.tic *** horizonta. bra.ch m.rphology difference of these clusters is expla.ned by their different m.ta.licity,a.e,m.ss-loss efficiency,a.d loss of low-m.ss m.m.ers in the evolution of the core-colla.se cluster NGC 7099 a.d loose clusters NGC 5053 a.d NGC 5466.

关键词： (sta.s:)Hertzsprung Russell a.d C-m.dia.ra.0} (ISm.)dust extinction (Ga.a.y:)globula. clusters:genera. (Ga.a.y:)globula. clusters:individua.(NGC 5024,NGC 5053,NGC 5272,NGC 5466,NGC7099)

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Further investiga.ion on the fusion of ^(6)Li with ^(209)Bi ta.get a. nea.-ba.rier energies

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Chinese Physics C 2024年第7期48卷 106-117页

作者：张高龙焦振威张广鑫 m.R.Cortes 胡世鹏钱建强 D.m.ngoni 屈卫卫李聪博郑云张焕乔孙慧斌王楠张春雷 j.j.Va.iente-Dobón D.Testov m.m.zzocco a.Gozzelino C.Pa.a.ca.dolo D.Pierroutsa.ou m.La.Com.a.a.a.Goa.duff D.Ba.za.co D.R.Na.oli F.Ga.ta.ossa.F.Recchia.a.illa.a.S.Ba.es I.Za.on S.a.din G.de a.gelis m.Sicilia.o R.m.nega.zo S.m.Lenzi j.L.Ferreira.j.Ra.gel Serka. a.koyun L.F.Ca.to j.Lubia. School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclea. Engineering a.d Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340NiteróiRio de JaneiroBrazil Institute for a.va.ced Study in Nuclea. Energy&Sa.ety Shenzhen UniversityShenzhen 518060China Shenzhen Key La.ora.ory of Resea.ch a.d m.nufa.ture of High Purity Germ.nium.m.teria.s a.d Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPadovaItaly Dipa.tim.nto di fisica.a.tronom.a.dell'Universita.di pa.ova PadovaItaly Sta.e Key La.ora.ory of Ra.ia.ion m.dicine a.d Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China.Institute of a.om.c Energy Beijing 102413China The Key La.ora.ory of Bea.0}Technology a.d m.teria. m.difica.ion of m.nistry of Educa.ion College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China INFN Laboratori Nazionali di LegnaroI-35020 LegnaroItaly INFN Sezione di NapoliI-80126 NapoliItaly Dipa.tim.nto di Fa.m.cia Universitàdi Napoli"Federico II"I-80131 NapoliItaly Depa.tm.nt of Na.ura. a.d m.them.tica. Sciences Faculty of EngineeringTarsus University33480 MersinTurkiye Physics Division Argonne National LaboratoryLemont-ILUSA Depa.ta.0}nto de m.tem.ética Física e Computaç˜ao Universidade do Estado do Rio de JaneiroFaculdade de Tecnologia27537-000ResendeRio de JaneiroBrazil Depa.tm.nt of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroCP 6852821941-972Rio de JaneiroBrazil

The com.lete a.d incom.lete fusion cross sections for ^(6)Li+^(209)Bi were m.a.ured using the in-bea.0}-ra. m.thod a.ound the Coulom. *** cross sections of(deuteron ca.tured)incom.lete fusion(ICF)products were re-qua.tified experim.nta.ly for this rea.tion *** results revea. tha. the ICF cross section is equiva.ent to tha. of com.lete fusion(CF)a.ove the Coulom. ba.rier a.d dom.na.t nea. or below the Coulom. ba.rier.a.theoretica. ca.cula.ion ba.ed on the continuum.discretized coupled cha.nel(CDCC)m.thod wa. perform.d for the a.orem.ntioned CF a.d ICF cross sections;the result is consistent with the *** universa. fusion function(UFF)wa. a.so com.a.ed with the m.a.ured CF cross section for different ba.rier pa.a.0}ters,dem.nstra.ing tha. the CF suppression fa.tor is significa.tly influenced by the choice of potentia.,which ca. reflect both dyna.0}c a.d sta.ic effects of brea.up on the fusion process.

关键词： cross section incom.lete fusion suppression fa.tor wea.ly bound nuclei

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One-neutron stripping process in the^(209)Bi(^(6)Li,^(5)Li)^(210)Bi*rea.tion rea.tion

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Nuclea. Science a.d Techniques 2024年第6期35卷 120-129页

作者： Ga.-Long Zha.g Zhen-Wei j.a. Gua.g-Xin Zha.g E.N.Ca.dozo B.Pa.s Shi-Peng Hu j.a.-Qia.g Qia. Da.iele m.ngoni Wei-Wei Qu Cong-Bo Li Yun Zheng Hua.-Qia. Zha.g Hui-Bin Sun Na. Wa.g Chun-Lei Zha.g j.j.Va.iente-Dobón D.Testov m.m.zzocco a.Gozzelino C.Pa.a.ca.dolo D.Pierroutsa.ou m.La.Com.a.a.a.Goa.duff D.Ba.za.co D.R.Na.oli F.Ga.ta.ossa.F.Recchia.a.illa.a.S.Ba.es I.Za.on S.a.din Gde a.gelis m.Sicilia.o R.m.nega.zo S.m.Lenzi S.a.koyun L.F.Ca.to j.Lubia. School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclea. Engineering a.d Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340 NiteróiRio de JaneiroBrazil La.ora.orio Ta.Da. Comisión Nacional de Energía AtómicaBKNA1650 San MartíınArgentina Institute for a.va.ced Study in Nuclea. Energy a.d Sa.ety Shenzhen UniversityShenzhen 518060China Shenzhen Key La.ora.ory of Resea.ch a.d m.nufa.ture of High Purity Germ.nium.m.teria.s a.d Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPaduaItaly Dipa.tim.nto di fisica.a.tronom.a.dell’Universita.di pa.ova PaduaItaly Sta.e Key La.ora.ory of Ra.ia.ion m.dicine a.d Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China.Institute of a.om.c Energy Beijing 102413China The Key La.ora.ory of Bea.0}Technology a.d m.teria. m.difica.ion of m.nistry of Educa.ion College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China La.ora.ori Na.iona.i di Legna.o INFN35020 LegnaroItaly INFN Sezione di Napoli80126 NaplesItaly Dipa.tim.nto di Fa.m.cia Universitàdi Napoli“Federico II”80131 NaplesItaly Depa.tm.nt of Na.ura. a.d m.them.tica. Sciences Faculty of EngineeringTarsus University33480 MersinTurkey Physics Division Argonne National LaboratoryLemontILUSA Depa.tm.nt of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroRio de Janeiro CP 6852821941-972Brazil

One-neutron stripping process between^(6)Li a.d^(209)Bi wa. studied a. 28,30,a.d 34 m.V using the in-bea.0}γ-ra. spectroscopy ***γ-γcoincident a.a.ysis clea.ly identified twoγ-ra.s feeding the ground a.d long-lived isom.ric sta.es,which were em.loyed to determ.ne the cross *** one-neutron stripping cross sections were sim.la. to the cross sections of com.lete fusion in the^(6)Li+^(209)Bi system.but the one-neutron stripping cross sections decrea.ed m.re gra.ua.ly a. the sub-ba.rier region.a.coupled-rea.tion-cha.nel ca.cula.ion wa. perform.d to study the deta.led rea.tion m.cha.ism.of the one-neutron stripping process in^(6)*** ca.cula.ions indica.ed tha. the first excited sta.e of 5 Li is critica. in the a.tua. one-neutron tra.sfer m.cha.ism.a.d the va.ence proton of 209Bi ca. be excited to the low-lying excited sta.e in(^(6)Li,^(5)Li)rea.tion,unlike in the(d,p)rea.tion.

关键词： Tra.sfer rea.tion Wea.ly bound nuclei Cross section

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Stoichiom.tric Ti3C2Tx Coa.ing for Inhibiting Dendrite Growth in a.ode-Free Lithium.m.ta. Ba.teries

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Energy & Environm.nta. m.teria.s 2024年第4期7卷 153-162页

作者： Xia.grong Zeng m.nm.tha.m.ha.o Woong Oh Hyunj.on Yoo Va. Hiep Nguyen Sa.woong Oh Geetha.Va.urouthu Soon-Ki j.ong Chi Won a.n Yury Gogotsi il-Kwon Oh Na.iona. Crea.ive Resea.ch Initia.ive for Functiona.ly a.ta.onistic Na.o-Engineering Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) Depa.tm.nt of m.teria.s Science & Engineering and A. J. Drexel Nanomaterials Institute Drexel University Depa.tm.nt of Energy Engineering Soonchunhyang University Na.iona. Na.ofa. Center (NNFC) Korea Advanced Institute of Science and Technology (KAIST)

Lithium.m.ta. ba.teries (Lm.s) a.d a.ode-free Lm.s (a.Lm.s) present a.solution to the need for ba.teries with a.significa.tly superior theoretica. energy ***,their a.option is hindered by low Coulom.ic efficiency (CE) a.d ra.id ca.a.ity fa.ing,prim.rily due to the form.tion of unsta.le solid electrolyte interpha.e (SEI) la.er a.d Li dendrite growth a. a.result of uneven Li pla.ing.

关键词： a.ode-free lithium.m.ta. ba.teries stoichiom.tric m.ene solid electrolyte interpha.e surfa.e term.na.ions

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Utiliza.ion of RNa.sequencing to investiga.e olfa.tory dysfunction in chronic rhinosinusitis without na.a. polyps:a.pilot study

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World j.urna. of Otorhinola.yngology-Hea. a.d Neck Surgery 2024年第1期10卷 29-36页

作者： j.rge a.Gutierrez III j.rem. L.Ba.th Rodney j.Schlosser Thom.s S.Edwa.ds Tim.thy L.Sm.th Za.ha.y m.Soler Depa.tm.nt of Otola.yngology-Hea. a.d Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Depa.tm.nt of Regenera.ive m.dicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Depa.tm.nt of Otola.yngology-Hea. a.d Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Obj.ctives:Prior resea.ch on olfa.tory dysfunction in chronic rhinosinusitis(CRS)ha. focused on pa.ients with polyps a.d suggests tha. direct infla.1}a.ion of the olfa.tory cleft m.cosa.pla.s a.contributory *** purpose of this study wa. to eva.ua.e gene expression in superior turbina.e m.cosa. specim.ns,com.a.ing norm.sm.c a.d dysosm.c CRS pa.ients without polyps(CRSsNP).m.thods:Tissue sa.1}les were obta.ned from.the superior turbina.es of pa.ients with CRSsNP a. the tim. of endoscopic sinus *** subsequently underwent RNa.sequencing a.d functiona. a.a.ysis to investiga.e biologica. pa.hwa.s a.socia.ed with differentia.ly expressed genes between dysosm.c(n=7)a.d norm.sm.c(n=4)***:Differentia. gene expression a.a.ysis com.a.ing dysosm.c a.d norm.sm.c CRSsNP pa.ients showed upregula.ion of 563 genes a.d downregula.ion of 327 *** stringent criteria.for m.ltiple com.a.isons,one upregula.ed gene(Im.edia.e Ea.ly Response 3[IER3])ha. a. fa.se discovery ra.e(FDR)correction a.j.stedP va.ue considered sta.istica.ly significa.t(Pa.ge 2.69).Rea.tom. functiona. a.a.ysis revea.ed eight biologica. pa.hwa.s significa.tly different between dysosm.c a.d norm.sm.c pa.ients(Pil-4 a.d il-13 signa.ing,il-10 signa.ing,a.d rhodopsin-like ***:RNa.sequencing of the superior turbina.es in pa.ients with CRSsNP ca. provide va.ua.le inform.tion rega.ding biologica. pa.hwa.s a.d genes involved in olfa.tory *** study supports litera.ure suggesting tha. Type 2 infla.1}a.ion m.y pla. a.role in olfa.tory dysfunction in a. lea.t som. pa.ients with *** study a.so prom.ts questions rega.ding the role of il-10,rhodopsin-like receptors,a.dIER3 in the pa.hogenesis of olfa.tory dysfunction.

关键词： chronic rhinosinusitis without na.a. polyps olfa.tory dysfunction RNa.sequencing

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m.ta.olic reprogra.0}ing by Syntenin-1 directs Ra.FLS a.d endothelia. cell-m.dia.ed infla.0}a.ion a.d a.giogenesis

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Cellula. & m.lecula. Im.unology 2024年第1期21卷 33-46页

作者： a.j. m.yer Stepha.ie R.Za.k Wes Nij.m.a.el Burgos Vishwa.Pa.el Bria. Za.otti m.cha.l V.Volin m.a.if a.1}n m.les j.Lewis Costa.tino Pitza.is Shiva.a.a.1} j.seph a.Ka.a.1}Na.era.j.Sweiss Shiva.Sha.ra.a j.sse Brown Va.m.dica. Center ChicagoILUSA Depa.tm.nt of m.dicine Division of RheumatologyThe University of Illinois at ChicagoChicagoILUSA Depa.tm.nt of m.crobiology a.d Im.unology Midwestern UniversityDowners GroveILUSA Division of Rheum.tology a.d Clinica. a.toim.unity Center of Excellence University of MichiganAnn ArborMIUSA Centre for Experim.nta. m.dicine a.d Rheum.tology William Harvey Research InstituteBarts and The London School of Medicine and DentistryQueen Mary University of LondonLondonUnited Kingdom Centre for Experim.nta. m.dicine&Rheum.tology William Harvey Research InstituteQueen Mary University of London and Barts NIHR BRC&NHS TrustLondonUK Depa.tm.nt of Biom.dica. Sciences Humanitas Universityand Humanitas Research HospitalMilanItaly Depa.tm.nt of Orthopedic Surgery the University of Illinois at ChicagoChicagoILUSA

a.novel rheum.toid a.thritis(Ra.synovia. fluid protein,Syntenin-1,a.d its receptor,Syndeca.-1(SDC-1),a.e coloca.ized on Ra.synovia. tissue endothelia. cells a.d fibrobla.t-like synoviocytes(FLS).Syntenin-1 exa.erba.es the infla.0}a.ory la.dsca.e of endothelia. cells a.d Ra.FLS by upregula.ing tra.scription of IRF1/5/7/9,il-1β,il-6,a.d CCL2 through SDC-1 liga.ion a.d HIF1α,or m.OR ***,Syntenin-1 orchestra.es Ra.FLS a.d endothelia. cell inva.ion via.SDC-1 a.d/or m.OR *** Syntenin-1 reprogra.0}ed endothelia. cells,the dyna.0}c expression of m.ta.olic interm.dia.es coincides with esca.a.ed glycolysis a.ong with uncha.ged oxida.ive fa.tors,a.0}K,PGC-1α,citra.e,a.d ina.tive oxida.ive ***,Ra.FLS rewired by Syntenin-1 displa.ed a.m.dest glycolytic-a.P a.com.a.ied by a.robust m.tochondria.-a.P *** enriched m.tochondria.-a.P detected in Syntenin-1 reprogra.0}ed Ra.FLS wa. coupled with m.tochondria. fusion a.d fission reca.itula.ed by esca.a.ed m.tofusin-2 a.d DRP1 *** found tha. VEGFR1/2 a.d Notch1 networks a.e responsible for the crossta.k between Syntenin-1 rewired endothelia. cells a.d Ra.FLS,which a.e a.so represented in Ra.*** to Ra.expla.ts,m.rphologica. a.d tra.scriptom. studies a.thentica.ed the im.orta.ce of VEGFR1/2,Notch1,Ra.TOR,a.d HIF1αpa.hwa.s in Syntenin-1 a.thritic m.ce a.d their obstruction in SDC-1 deficient ***,dysregula.ion of SDC-1,m.OR,a.d HIF1αnega.ed Syntenin-1 infla.0}a.ory phenotype in Ra.expla.ts,while inhibition of HIF1αim.a.red synovia. a.giogenic im.rint a.0}lified by *** conclusion,since the current thera.ies a.e ineffective on Syntenin-1 a.d SDC-1 expression in Ra.synovia. tissue a.d blood,ta.geting this pa.hwa. a.d its interconnected m.ta.olic interm.dia.es m.y provide a.novel thera.eutic stra.egy.

关键词： Syntenin-1 Syndeca.-1 Ra.FLS Ra.expla.ts im.unom.ta.olism

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Network a.a.yses:Inhibition of a.drogen receptor signa.ing reduces infla.0}a.ion in the lung through a.-m.F-il6 signa.ing a.es

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Genes & Disea.es 2024年第3期11卷 140-143页

作者： a.bert R.Wa.g a.drew m.Ba.chna.el Zij.a. Ni Sea. R.Brenna. Hypa.ia.K.Newton Da.ya.Buehler Christina.Kendziorski Ra.da.l j.Kim.le Gopa. lyer Depa.tm.nt of Hum.n Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Depa.tm.nt of Biom.dica. Engineering University of Wisconsin-MadisonMadisonWI 53705USA University of Wisconsin Ca.bone Ca.cer Center MadisonWI 53705USA Depa.tm.nt of Biosta.istics a.d m.dica. Inform.tics University of Wisconsin-MadisonMadisonWI 53706USA Depa.tm.nt of Biology Tufts UniversityMedfordMA 02155USA Depa.tm.nt of Pa.hology a.d La.ora.ory m.dicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

a.drogen receptor(a.)is a.m.j.r tra.scription fa.tor tha. pla.s a.role in infla.0}a.ory response including interleukin-6(il6)signa.ing.1 While a. regula.ion through pa.a.rine loop signa.ing in prosta.e tissue is well-studied,its im.a.t through a. il6 a.tocrine loop in the lung ha. not been wellstudied despite the orga.'s response to respira.ory vira. *** inhibition a.d RNa.knockdown of a. identified a.bZIP tra.scription fa.tor m.F to be a.com.on ta.get of infla.0}a.ion using these perturba.ions in lung cells.

关键词： infla.0}a.ion lung respira.ory

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m.na.em.nt of recurrent recta. ca.cer:a.popula.ion ba.ed study in grea.er a.0}terda.

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World j.urna. of Ga.troenterology 2008年第39期14卷 6018-6023页

作者： Roel Ba.x Otto visser j.dith j.sso Sybren m.ij.r j.Frederik m.Slors j.j.n B va. La.schot Depa.tm.nt of Surgery Academic Medical CentreAmsterdam AZ 1105Netherlands Com.rehensive Ca.cer Centre a.0}terda. Amsterdam CX 1066Netherlands Depa.tm.nt of Surgery Free University Medical CentreAmsterdam HV 1081Netherlands Presently a. the Era.m.s m.dica. Center Rotterdam CE 3015Netherlands

a.m. To a.a.yze, retrospectively in a.popula.ionba.ed study, the m.na.em.nt a.d surviva. of pa.ients with recurrent recta. ca.cer initia.ly trea.ed with a.m.croscopica.ly ra.ica. resection obta.ned with tota. m.sorecta. excision （Tm.）. m.THODS： a.l recta. ca.cinom.s dia.nosed during 1998 to 2000 a.d initia.ly trea.ed with a.m.croscopica.ly ra.ica. resection （632 pa.ients） were selected from.the a.0}terda.0}Ca.cer Registry. For pa.ients with recurrent disea.e, inform.tion on trea.m.nt of the recurrence wa. collected from.the m.dica. records. RESULTS： Loca. recurrence with or without clinica.ly a.pa.ent dista.t dissem.na.ion occurred in 62 pa.ients （10%）. Thirty-two pa.ients ha. a. isola.ed loca. recurrence. Ten of these 32 pa.ients （31%） underwent ra.ica. re-resection a.d experienced the highest surviva. （three qua.ters survived for a. lea.t 3 yea.s）. Eight pa.ients （25%） underwent non-ra.ica. surgery （m.dia. surviva. 24 rno）, seven pa.ients （22%） were trea.ed with ra.io- a.d/or chem.thera.y without surgery （m.dia. surviva. 15 m.） a.d seven pa.ients （22%） only received best supportive ca.e （m.dia. surviva. 5 too）. Dista.t dissem.na.ion occurred in 124 pa.ients （20%） of whom.30 pa.ients a.so ha. a.loca. recurrence. The m.j.rity （54%） of these pa.ients were trea.ed with ra.io- a.d/or chem.thera.y without surgery （m.dia. surviva. 15 m.）. Twenty-seven percent of these pa.ients only received best supportive ca.e （m.dia. surviva. 6 m.）, while 16% underwent surgery for their recurrence. Surviva. wa. best in the la.ter group （m.dia. surviva. 32 m.）. CONCLUSION： a.though trea.m.nt options a.d surviva. a.e lim.ted in ca.e of recurrent recta. ca.cer a.ter ra.ica. loca. resection obta.ned with Tm., pa.ients ca. benefit from.a.ditiona. trea.m.nt, especia.ly if a.ra.ica. resection is fea.ible.

关键词： Recta. ca.cer Tota. m.sorecta. excision Loca. recurrence Rela.ive surviva.

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m.crobia. sta.ch-binding dom.ins a.e superior to gra.ule-bound sta.ch syntha.e I for a.choring lucifera.e to pota.o sta.ch gra.ules

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Progress in Na.ura. Science:m.teria.s Interna.iona. 2006年第12期16卷 1295-1299页

作者： j.a.-Pa.l VINCKEN Luc C.j.m. SUURS Richa.d G.F. visser La.ora.ory of Pla.t Breeding Department of Plant Sciences Wageningen University Wageningen The Netherlands

m.crobia. sta.ch-binding dom.ins (SBD) a.d gra.ule-bound sta.ch syntha.e I (GBSSI) a.e proteins which a.e a.cum.la.ed in pota.o sta.ch gra.ules. The efficiency of SBD a.d GBSSI for ta.geting a.tive lucifera.e reporter proteins to gra.ules during sta.ch biosynthesis wa. com.a.ed. GBSSI or SBD sequences were fused to the N- or C-term.nus of the lucifera.e (LUC) gene, via.a. a.tificia. Pro-Thr encoding linker sequence. The genes were introduced into a. a.0}lose-free (a.0}) pota.o m.ta.t. It a.pea.ed tha. SBD wa. superior to GBSSI a. a.ta.geting sequence, m.inly beca.se the lucifera.e reta.ned higher a.tivity in the SBD-conta.ning fusion proteins tha. in the GBSSI-conta.ning ones.

关键词： lucifera.e GBSS I SBD a.0} pota.o.

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m.ta.olic syndrom. a.d the urina.y m.crobiom. of pa.ients undergoing percuta.eous nephrolithotom.

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a.ia. j.urna. of Urology 2024年第2期11卷 316-323页

作者： Rya. a.Dornbier Chira. P.Doshi Sha.in C.Desa. Peta. Ba.0}c m.chelle Va. Kuiken m.rk Khem.a.i a.m.r V.Fa.ooq La.issa.Bresler Thom.s m.T.Turk a.a. j.Wolfe Kristin G.Ba.dea Loyola.University m.dica. Center Department of UrologyMaywoodILUSA Loyola.University Chica.o Department of Microbiology and ImmunologyMaywoodILUSA

Obj.ctive:To identify possible stone-prom.ting m.crobes,we com.a.ed the profiles of m.crobes grown from.stones of pa.ients with a.d without m.ta.olic syndrom.(m.tS).The a.socia.ion between m.tS a.d urina.y stone disea.e is well esta.lished,but the exa.t pa.hophysiologic rela.ionship rem.ins *** evidence suggests urina.y tra.t dysbiosis m.y lea. to increa.ed nephrolithia.is ***:a. the tim. of percuta.eous nephrolithotom.,bla.der urine a.d stone fra.m.nts were collected from.pa.ients with a.d without *** sa.1}le types were subj.cted to expa.ded qua.tita.ive urine culture(EQUC)a.d 16 S ribosom.l RNa.gene ***:Fifty-seven pa.ients included 12 controls(21.1%)a.d 45 m.tS pa.ients(78.9%).Both cohorts were sim.la. with respect to dem.gra.hics a.d non-m.tS *** controls ha. uric a.id stone *** EQUC,ba.teria.were detected m.re frequently in m.tS stones(42.2%)com.a.ed to controls(8.3%)(p=0.041).Ba.teria.a.so were m.re a.unda.t in stones of m.tS pa.ients com.a.ed to *** va.ida.e our EQUC results,we perform.d 16 S ribosom.l RNa.gene *** 12/16(75.0%)sequence-positive stones,EQUC relia.ly isola.ed a. lea.t one species of the sequenced *** were detected in both“infectious”a.d“non-infectious”stone ***:Ba.teria.a.e m.re com.on a.d m.re a.unda.t in m.tS stones tha. control *** findings support a.role for ba.teria.in urina.y stone disea.e for pa.ients with m.tS rega.dless of stone com.osition.

关键词： Nephrolithia.is Urolithia.is m.ta.olic syndrom. Urina.y m.crobiom. Percuta.eous nephrolithotom.

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