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The Stochastic Regression Analysis as a Tool in Ecotoxicological QSAR Studies

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Biomedical and Environmental Sciences 1989年第4期2卷 385-393页

作者： j.DEVILLERS D.ZAKARYA M.CHASTRETTE j.C.dore CTIS Laboratoire

Correspondence factor analysis(CFA)was used in conj.nction with linear regression analysis to examine the structure-activity relationships of 50 benzene derivatives tested on Pimephales *** nine molecular descriptors(numbers of C,H,O,N,Br,Cl,NO_2,OH,and NH_2 included in the molecules),CFA made it possible to define five new independent variables which were introduced in a stepwise regression analysis procedure to describe the acute toxicity(96-h LC_(50))of the aromatic *** model log 1/C=-0.727F_1+1.248F_3+4.052(r=0.918; s=0.270)is more relevant to describe the ecotoxicological behavior of the studied compounds on the fathead minnow than that obtained with principal components(log 1/C=0.151 PC_1 -0.271 PC_2+4.124;r=0.737;s=0.460).The heuristic potency of this particular statistical analysis,which is called stochastic regression analysis,is discussed in detail.1989 Academic Press,Inc.

关键词： QSAR The Stochastic Regression Analysis as a Tool in Ecotoxicological QSAR Studies

The effects of water flow and temperature on thermal regime around a culvert built on permafrost

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Research in Cold and Arid Regions 2014年第5期6卷 415-422页

作者： Loriane Périer Guy Doré C.R.Burn Loriane Perier Guy dore.C. R. Bum Laval University Center for Northern Studies (CEN) 1035 Avenue De la m~decine QuObec Canada G1A OA6 Carleton University Dept. of Geography and Environmental Studies Ottawa Ontario Canada K1S 5B6

Temperature and water flow through a culvert beneath the Alaska Highway near Beaver Creek,Yukon,were measured at hourly intervals between j.ne and October *** data were used to simulate the effect of the culvert on the thermal regime of the road embankment and subj.cent permafrost.A 2-D thermal model of the embankment and permafrost was developed with TEMP/W and calibrated using field *** relations were obtained between water temperatures at the entrance to the culvert,flow into the culvert,and water temperatures inside the *** temperatures at the entrance and inside the culvert had a linear relation,while water temperatures inside the culvert and water flow were associated by a logarithmic relation.A multiple linear regression was used to summarize these *** this relationship,changes in the flow rate and water temperatures at the entrance of the culvert were simulated to obtain predicted water temperatures in the *** temperatures in the culvert were used in the thermal model to determine their effects on the ground thermal regime near the *** of ±10% in water flow rate had no impact on the thermal regime underneath the *** of water temperature at the entrance of the culvert had a noticeable influence on the thermal regime.A final simulation was conducted without insulation beneath the *** thaw depth was 30 cm with insulation,and 120 cm without insulation,illustrating the importance of insulation to the ground thermal regime.

关键词： culvert thermal regime water flow water temperature modeling permafrost

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尊老传统与《红楼梦》老年人物形象分析

青年文学家 2012年第3期 237-238页

作者： dore.j.Levy 杨秀苗美国布朗大学比较文学学院山东大学文学与新闻传播学院

尊老是中国文化中一个古老的传统。在中国把人的年龄与美德联系在一起可以追溯到遥远的古代,受到了巫术中祖先崇拜的影响。

关键词：尊老传统《红楼梦》

乙型或丙型肝炎病毒感染者的癌症发生率:一项基于社区的大型连锁研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 50-51页

作者： Amin j. dore.G.j. O'Connell D.L. 陈云茹 National Centre in HIV Epidemiology and Clinical Research SydneyAustralia

Background/Aims:Risks of hepatocellular carcinoma(HCC) following hepatitis B and/or hepatitis C virus(HBV/HCV) infection are well known,those for other cancers are less well *** aim was to quantify the risk of cancers among persons diagnosed with HBV/HCV ***:The data from a cohort of 39109 HBV,75834 HCV,and 2604 HBV/HCV co-infected persons notified to the State health department,1990-2002,were probabilistically linked to the Cancer Registry and standardised incidence ratios(SIRs) for cancer were ***:The match rate for any cancer was 2.7%,2.3% and 3.3% for HBV,HCV and HBV/HCV co-infected *** for HCC were 30.6(95% CI 25.7-36.5) ,22.7(95% CI 19.1-26.5) and 30.3(95% CI 13.6-67.5) ,*** risk was detected for Burkitt’s lymphoma and HBV(SIR 12.9,95% CI 5.4-30.9) and immunoproliferative malignancies following HCV(SIR 5.6,95% CI 1.8-17.5) .Conclusions:The risk of HCC in the infected cohort was 20-30 times greater than in the uninfected population with SIRs two to three times greater than those for the other HBV/HCV infection associated *** modest though significant risk of immunoproliferative malignancies associated with HCV infection is consistent with recent findings.

关键词：丙型肝炎病毒肝细胞肝癌感染人群队列研究卫生部门匹配率增生性淋巴瘤

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母牛增生性肾小球肾炎导致肾综合征一例

动物医学进展 1988年第4期 17-18页

作者： Monique dore.丁伯良

肾病综合征的临床特征为大量蛋白尿、低白蛋白血症、全身水肿和高胆固醇血症。这种综合征在牛通常由肾淀粉样变所致。迄今,仅有一篇文献记载一头小母牛发生肾病综合征的增生性肾小球肾炎的自然病例。牛肾小球肾炎作为临床病例的发生是... 详细信息

肾病综合征的临床特征为大量蛋白尿、低白蛋白血症、全身水肿和高胆固醇血症。这种综合征在牛通常由肾淀粉样变所致。迄今,仅有一篇文献记载一头小母牛发生肾病综合征的增生性肾小球肾炎的自然病例。牛肾小球肾炎作为临床病例的发生是罕见的。通常大多数牛的肾小球肾炎是无症状的,多在屠宰后才偶然发现。

关键词：增生性肾小球肾炎病例肾小球性肾炎低白蛋白血症大量蛋白尿母牛肾病综合征肾变病

Ibuprofen-Induced Toxic Epidermal Necrolysis:A Case Report

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International j.urnal of Dermatology and Venereology 2024年第2期7卷 108-110页

作者： Nevin Kannappilly Mohamed Z.Peediyakkal Mohamad Y.Khatib dore.C.Ananthegowda Moustafa S.Elshafei Hani El Zeer Karimulla S.Shaik Moayad M.AlFayoumi Dyaneshwar P.Mutkule Ahmed A.Soliman Abdulqadir j.Nashwan Critical Care Department Hamad Medical Corporation(HMC)Doha 3050Qatar

Introduction:Toxic epidermal necrolysis(TEN)is a medical emergency that most commonly occurs as an adverse effect of certain ***,we describe a case of a 41-year-old man with no comorbid illness who developed *** presentation:The patient had been prescribed ibuprofen for myalgia and developed skin lesions after the single *** lesions were erythematous papules and macules distributed all over the body after ibuprofen *** was diagnosed based on the patient’s clinical presentation and laboratory *** was treated with intravenous dexamethasone,intravenous immunoglobulin,and *** dressing changes and skin care was done with saline,chlorhexidine,and liquid *** patient was intubated and tracheostomized,and he gradually improved and ***,he developed septicemia in the intensive care unit and was treated ***:The management of TEN includes cessation of the causative cause,multidisciplinary intensive care unit(ICU)care,prevention and early detection of sepsis,fluid and electrolyte balance,adequate analgesia and temperature control,proper organ support,aggressive nutritional management,and good psychological *** pharmacological therapy for TEN includes corticosteroids,intravenous immunoglobulin,and *** key elements of management are aseptic care and proper dressing of the ***:TEN is associated with high mortality if not managed in a systemic and protocolized way.

关键词： ibuprofen toxic epidermal necrolysis erythema drug-induced erythema

多孔钽假体治疗早期股骨头坏死的生物力学和临床评价

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骨科动态 2006年第2期2卷 104-108页

作者： A.K. TSAO j.R. ROBERSON Mj. CHRISTIE D.D. dore.D.A. HECK D.D.ROBERTSON R.A. POGGIE 刘鹏（译）高忠礼（译）不详吉林大学中日联谊医院骨科 130033

简介股骨头坏死是因股骨头血运破坏所导致的一种影响功能的疾病。其主要在年轻人中发病。病因包括酗酒、激素药物应用史、创伤、血液系统病、放射治疗以及气压1-30在美国，估计每年有10,000到30,000例发生。其中5％到10％须用人工关节... 详细信息

简介股骨头坏死是因股骨头血运破坏所导致的一种影响功能的疾病。其主要在年轻人中发病。病因包括酗酒、激素药物应用史、创伤、血液系统病、放射治疗以及气压1-30在美国，估计每年有10,000到30,000例发生。其中5％到10％须用人工关节置换术治疗。对股骨头和软骨下板塌陷前的早期坏死进行手术治疗似更有效。早期阶段，病理改变通常局限于股骨头上方负重部位的楔形坏死区。随着疾病的进展。坏死区将塌陷并在存活骨和坏死骨接合处发生骨折。

关键词：早期股骨头坏死放射治疗临床评价生物力学人工关节置换术假体药物应用史血液系统病手术治疗