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An In Vivo Experimental Validation of a Computational Model of Human Foot

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j.urnal of Bionic Engineering 2009年第4期6卷 387-397页

作者： Christopher j.Nester david Howard Centre for Health Sport and Rehabilitation Sciences ResearchUniversity of Salford Salford M5 4WTUK

Reliable computational foot models offer an alternative means to enhance knowledge on the biomechanics of human foot. Model validation is one of the most critical aspects of the entire foot modeling and analysis *** paper presents an in vivo experiment combining motion capture system and plantar pressure measure platform to validate a three-dimensional finite element model of human *** Magnetic Resonance Imaging(MRI)slices for the foot modeling and the experimental data for validation were both collected from the same volunteer *** validated components included the comparison of static model predictions of plantar force,plantar pressure and foot surface deformation during six loading conditions,to equivalent measured *** the whole experiment,foot surface deformation,plantar force and plantar pressure were recorded simultaneously during six different loaded standing *** predictions of the current FE model were in good agreement with these experimental results.

关键词： human foot computational model plantar pressure

Controlling resistant hypertension

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Stroke & Vascular Neurology 2018年第2期3卷 69-75页

作者： j.david Spence Stroke Prevention&Atherosclerosis Research Centre Robarts Research InstituteWestern UniversityLondonOntarioCanada

Resistant hypertension(failure to achieve target blood pressures with three or more antihypertensive drugs including a diuretic)is an important and preventable cause of *** is highly prevalent in China(>60%of persons above age 65),and only~6%of hypertensives in China are controlled to target *** strokes occur among persons with resistant hypertension;approximately half of strokes could be prevented by blood pressure *** for uncontrolled hypertension include(1)non-compliance;(2)consumption of substances that aggravated hypertension,such as excess salt,alcohol,licorice,decongestants and oral contraceptives;(3)therapeutic inertia(failure to intensify therapy when target blood pressures are not achieved);and(4)diagnostic inertia(failure to investigate the cause of resistant hypertension).In China,an additional factor is lack of availability of appropriate antihypertensive therapy in many healthcare *** restriction in combination with a diet similar to the Cretan Mediterranean or the DASH(Dietary Approaches to Stop Hypertension)diet can lower blood pressure in proportion to the severity of *** individualised therapy for hypertension based on phenotyping by plasma renin activity and aldosterone can markedly improve blood pressure *** hypertension(high renin/high aldosterone)is best treated with angiotensin receptor antagonists;primary aldosteronism(low renin/high aldosterone)is best treated with aldosterone antagonists(spironolactone or eplerenone);and hypertension due to overactivity of the renal epithelial sodium channel(low renin/low aldosterone;Liddle phenotype)is best treated with *** latter is far more common than most physicians suppose.

关键词： hypertension hypertensive markedly

Modelling of a Human Driver’s Interaction with Vehicle Automated Steering Using Cooperative Game Theory

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IEEE/CAA j.urnal of Automatica Sinica 2019年第5期6卷 1095-1107页

作者： Xiaoxiang Na david j.Cole Department of Engineering University of Cambridge

The introduction of automated driving systems raised questions about how the human driver interacts with the automated system. Non-cooperative game theory is increasingly used for modelling and understanding such interaction, while its counterpart, cooperative game theory is rarely discussed for similar applications despite it may be potentially more suitable. This paper describes the modelling of a human driver’s steering interaction with an automated steering system using cooperative game theory. The distributed Model Predictive Control approach is adopted to derive the driver’s and the automated steering system’s strategies in a Pareto equilibrium sense, namely their cooperative Pareto steering strategies. Two separate numerical studies are carried out to study the influence of strategy parameters, and the influence of strategy types on the driver’s and the automated system’s steering performance. It is found that when a driver interacts with an automated steering system using a cooperative Pareto steering strategy, the driver can improve his/her performance in following a target path through increasing his/her effort in pursuing his/her own interest under the driver-automation cooperative control goal. It is also found that a driver’s adoption of cooperative Pareto steering strategy leads to a reinforcement in the driver’s steering angle control, compared to the driver’s adoption of non-cooperative Nash strategy. This in turn enables the vehicle to return from a lane-change maneuver to straight-line driving swifter.

关键词： Automated driving system cooperative game theory driver modelling

DNA damage, NF-κB and accelerated aging

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Asian j.urnal of Andrology 2012年第6期14卷 811-812页

作者： david G Le Couteur david j.Handelsman ANZAC Medical Research Institute Sydney 2139 Australia Centre for Education and Research on Ageing (CERA) Concord Hospital and University of Sydney Concord NSW 2139 Australia

The aging process is the maj.r risk factor for disease and disability yet the cel- lular mechanisms for aging are uncertain.

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

A structural topological optimization method for multi-displacement constraints and any initial topology configuration

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Acta Mechanica Sinica 2010年第5期26卷 735-744页

作者： j. H. Rong j. H. Yi School of Automotive and Mechanical Engineering Changsha University of Science and TechnologyChangsha 410076 China

In density-based topological design, one expects that the final result consists of elements either black （solid material） or white （void）, without any grey areas. Moreover, one also expects that the optimal topology can be obtained by starting from any initial topology configuration. An improved structural topological optimization method for multidisplacement constraints is proposed in this paper. In the proposed method, the whole optimization process is divided into two optimization adj.stment phases and a phase transferring step. Firstly, an optimization model is built to deal with the varied displacement limits, design space adj.stments, and reasonable relations between the element stiffness matrix and mass and its element topology variable. Secondly, a procedure is proposed to solve the optimization problem formulated in the first optimization adj.stment phase, by starting with a small design space and advancing to a larger deign space. The design space adj.stments are automatic when the design domain needs expansions, in which the convergence of the proposed method will not be affected. The final topology obtained by the proposed procedure in the first optimization phase, can approach to the vicinity of the optimum topology. Then, a heuristic algorithm is given to improve the efficiency and make the designed structural topology black/white in both the phase transferring step and the second optimization adj.stment phase. And the optimum topology can finally be obtained by the second phase optimization adj.stments. Two examples are presented to show that the topologies obtained by the proposed method are of very good 0/1 design distribution property, and the computational efficiency is enhanced by reducing the element number of the design structural finite model during two optimization adj.stment phases. And the examples also show that this method is robust and practicable.

关键词： Topological optimization Displacement constraint Continuum structure Design space adj.stment Rational approximation material model

Oil-bearing fluid inclusions from the Palaeoproterozoic:A review of biogeochemical results from time-capsules >2.0 Ga old

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Science China Earth Sciences 2009年第1期52卷 1-11页

作者： Simon C. GEORGE Adriana DUTKIEWICZ Herbert VOLK j.hn RIDLEY david j. MOSSMAN Roger BUICK Department of Earth and Planetary Sciences Macquarie University School of Geosciences University of Sydney CSIRO Petroleum Department of Geosciences Colorado State University Department of Geography Mount Allison University Department of Earth and Space Sciences & Astrobiology Program University of Washington

The observation of oil inclusions trapped prior to 2.0 Ga in Palaeoproterozoic rocks and the ability to obtain detailed molecular geochemical information from them provide a robust way for understanding the early biog... 详细信息

关键词： Palaeoproterozoic fluid inclusion oil biomarker blank

NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.E.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Unimodal Sequences of Gorenstein Ideals of Codimension 4

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Acta Mathematica Sinica,English Series 1998年第4期14卷 563-568页

作者： Hyoung j. Ko Department of Mathematics. Yonsei University 134 Shinchon-dong Seodaemun-gu. Seoul Korea 120-749

We present Gorenstein ideals of condimension 4 which have unimodal Hilbert functions.

关键词： k-configuration Hilbert function Minimal free resolution Gorenstein ideal of codimension 4