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自发性脑出血管理指南美国心脏协会／美国卒中协会针对医疗专业人员的指南

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国际脑血管病杂志 2015年第10期23卷 721-739页

作者： j. claude hemphill ⅲ Steven M. Greenberg Craig S. Anderson Kyra Beckelr Bernard R. Bendok Mary Cushman Gordon L. Fung j.shua N. Goldstein R. LochMacdonald Pamela H Mitchell, Phillip A Scott,Magdy H Selim, Daniel Woo 高圆圆徐欣不详南京大学医学院附属鼓楼医院神经内科 210008

目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用PubMed进行规范化文献检索，检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见，采用美国心脏协会／美国卒中协会的疗效确定... 详细信息

目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用PubMed进行规范化文献检索，检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见，采用美国心脏协会／美国卒中协会的疗效确定性水平和证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南草案进行发表前审阅。结果本文为急性脑出血患者的医疗诊治提供了循证指南，重点包括诊断、凝血功能障碍和血压管理、继发性脑损伤防治、颅内压控制、外科治疗的作用、转归预测、康复、二级预防以及将来需要考虑的问题。本指南已纳入最新的3期临床试验结果。结论脑出血是一种需要进行早期积极救治的危重疾病。本指南为脑出血患者的目标导向治疗提供了一个框架。

关键词：美国心脏协会科学声明血压凝血功能障碍诊断脑出血脑室出血外科手术治疗

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动脉瘤性蛛网膜下腔出血患者的重症监护处理：神经危重症监护学会多学科共识会议的推荐意见

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国际脑血管病杂志 2013年第5期21卷 324-347页

作者： Michael N. Diringer Thomas P. Bleck j. claude hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly j. Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alej.ndro Rabinstein, Erich Schmut zhard Nino Stocchetti j.se I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿英英(译) From the Neurology/Neurosurgery Intensive Care Unit Washingion University St. Louis MO USA Rush Medical College Chicago IL USA University of California at San Francisco San Francisco CA USA University of Cambridge Cambridge UK University of Cincinnati Cincinnati OH USA University of California at Los Angeles LOs Angeles CA USA Universit6 de la M.diterranae Marsedle France Columbia University New York NY USA San Gerardo Hospital Monza Italy University of Virginia Charlottesville VA USA Heinrich-Heine University Dttsseldorf Germany University of Florida Gainesville FL USA Mayo Clinic Rochester MN USA University of Pennsylvania Philadelphia PA USA University Hospital Innsbruck lnnsbruck Austria Fondazione IRCCS Ch Granda- Ospedale Policlinico Milan University Milan Italy University of Washington St. Louis MO USA Baylor College of Medicine Houston TX USA Nottingham University Hospitals Nottingham UK University of Utrecht Utrecht The Netherlands Freie Universitit Berlin Berlin Germany Washington University St. Louis MO USA 首都医科大学宣武医院神经内科北京100053

蛛网膜下腔出血（subarachnoidhemorrhage，SAH）是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏，使得治疗方法... 详细信息

蛛网膜下腔出血（subarachnoidhemorrhage，SAH）是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏，使得治疗方法各异，可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防，很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域，此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验，选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价（GradesofRecommendationsAssessment，DevelopmentandEvaluation，GRADE）系统进行文献回顾，结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见，其制定原则不仅强调研究资料的质量，而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见，即使缺乏高质量的证据。

关键词：蛛网膜下腔出血重症监护动脉瘤血管痉挛抗惊厥药低钠血症血管内发热

Phylogenetic Analysis of the Plant-specific Zinc Finger-Homeobox and Mini Zinc Finger Gene Families

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j.urnal of Integrative Plant Biology 2008年第8期50卷 1031-1045页

作者： claude W. dePamphilis Department of Biology and the Huck Institutes of the Life Sciences Pennsylvania State University University ParkPA 16802 USA

Zinc finger-homeodomain proteins （ZHD） are present in many plants; however, the evolutionary history of the ZHD gene family remains largely unknown. We show here that ZHD genes are plant-specific, nearly all intronless, and related to MINI ZINC FINGER （MIF） genes that possess only the zinc finger. Phylogenetic analyses of ZHD genes from representative land plants suggest that *** plant ZHD genes occupy basal positions and angiosperm homologs form seven distinct clades. Several clades contain genes from two or more maj.r angiosperm groups, including eudicots, monocots, magnoliids, and other basal angiosperms, indicating that several duplications occurred before the diversification of flowering plants. In addition, specific lineages have experienced more recent duplications. Unlike the ZHD genes, MIFs are found only from seed plants, possibly derived from ZHDs by loss of the homeodomain before the divergence of seed plants. Moreover, the MIF genes have also undergone relatively recent gene duplications. Finally, genome duplication might have contributed substantially to the expansion of family size in angiosperms and caused a high level of functional redundancy/overlap in these genes.

关键词： gene duplication gene family evolution Mini Zinc Finger Physcomitrella poplar Selaginella zinc finger-homeodomain proteins

Fraunhofer diffraction of irregular apertures by Heisenberg uncertainty Monte Carlo model

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Particuology 2016年第1期14卷 151-158页

作者： Yij.a Yuan Kuanfang Ren claude Roze Shanghaij.ao Tong University-Paris Tech Elite Institute of Technology 800 Dongchuan Rd Shanghai 200240 China CORIA-UMR 6614 Normandie Universite CNRS Universite & INSA de Rouen Avenue de l'Universite BP 12 76801 Saint Etienne du Rouvray France

Geometrical optics and the Monte Carlo method are very flexible in dealing with the interaction of light with non-spherical particles, but usually diffraction is not considered. To cover this gap, the Heisenberg Uncertainty Monte Carlo （HUMC） model is applied to calculate separately the diffraction of a ray or a photon. In this paper, we report an improvement of the HUMC model by specifying the phase of the photon subj.ct to the Fraunhofer diffraction condition. After validating the model by comparing its results with analytical results for apertures of simple shapes, the HUMC model is then applied in simulations of Fraunhofer diffraction by apertures of complex shapes, such as those composed of one or two elliptical openings. We have shown that the diffracted intensity distributions of simple apertures obtained by the HUMC model are in good agreement with the results calculated from analytical expressions. The simulations of diffraction by apertures composed of two square or elliptical openings prove that the HUMC model is a powerful and flexible too] for predicting the Fraunhofer diffraction by a complex optical system.

关键词： Diffraction of a ray/photon Heisenberg uncertainty Monte Carlo model Fraunhofer diffraction Irregular aperture

Capillaric field effect transistors

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Microsystems & Nanoengineering 2022年第2期8卷 59-71页

作者： claude Meffan j.lian Menges Fabian Dolamore Daniel Mak Conan Fee Renwick C.j.Dobson Volker Nock Department of Electrical and Computer Engineering University of CanterburyChristchurch 8041New Zealand Department of Microengineering Kyoto University615-8540 KyotoJapan School of Biological Sciences University of CanterburyChristchurch 8041New Zealand Biomolecular Interaction Centre School of Biological SciencesUniversity of CanterburyChristchurch 8041New Zealand School of Product Design University of CanterburyChristchurch 8041New Zealand Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology InstituteUniversity of MelbourneParkvilleVIC 3010Australia The MacDiarmid Institute for Advanced Materials and Nanotechnology Wellington 6140New Zealand

Controlling fluid flow in capillaric circuits is a key requirement to increase their uptake for assay *** action off-valves provide such functionality by pushing an occluding bubble into the channel using a difference in capillary ***,we utilized the binary switching mode of this structure to develop a powerful set of fundamental fluidic valving *** this work,we study the transistor-like qualities of the off-valve and provide evidence that these structures are in fact functionally complementary to electronic j.nction field effect *** view of this,we propose the new term capillaric field effect transistor to describe these types of *** support this conclusion,we present a theoretical description,experimental characterization,and practical application of analog flow resistance *** addition,we demonstrate that the valves can also be *** show modulation of the flow resistance from fully open to pinch-off,determine the flow rate-trigger channel volume relationship and demonstrate that the latter can be modeled using Shockley's equation for electronic ***,we provide a first example of how the valves can be opened and closed repeatedly.

关键词： transistors effect field

Ontogeny of Drosophila melanogaster female sex-appeal and cuticular hydrocarbons

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Integrative Zoology 2010年第3期5卷 272-282页

作者： Marisa ARIENTI claude ANTONY claude WICKER-THOMAS j.an-Paul DELBECQUE j.an-Marc j.LLON University of Paris South 11 Center of Neurosciences of Paris SouthOrsayFrance Department of Biology Autonoma Metropolitan University-XochimilcoMexico DFMexico EMBL HeidelbergGermany LEGS CNRSGif sur YvetteFrance University of Bordeaux 1 Center of Integrative and Cognitive NeurosciencesTalenceFrance

The chemical communication system in Drosophila melanogaster Meigen,1830 plays a maj.r role in courtship and consists of the male-specific cis-Vaccenyl acetate and sex-specific contact pheromones,cuticular hydrocarbons(CHC),which build up during ontogeny(first 4 days).They replace longer CHCs,common to both sexes and present only after the imaginal eclosion.A detailed quantitative description of the evolution of cuticular unsaturated hydrocarbons with age is presented here for males and females of different *** strains,which have been bred in well controlled *** appear in both sexes at around 12 h,before female *** present paper argues that this is likely linked to the switching on of a new set of ***,which is more abundant in females than in males during this critical period,might control this *** behavioral studies show that whereas female of all ages trigger early mature male courtship steps like wing vibration,only females older than 1 day trigger late courtship steps like attempted *** supports the hypothesis that late male courtship steps might be triggered by the CHCs,which build up after this age,especially female-specific(Z,Z)-7,11-and(Z,Z)-5,9-dienes.

关键词： contact pheromones Drosophila melanogaster ecdysone control ontogeny sex differences

A Review of Metallic Fractal Aggregates

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Open j.urnal of Metal 2011年第2期1卷 17-24页

作者： Rodolfo j. Slobodrian claude Rioux Michel Piché 不详

Metals are the main components of the Earth’s mass and are characterized by high thermal and electrical conductivity as well as high reflectivity of electromagnetic fields. Finely divided metals are efficient catalysers and this indicates the relevance of surfaces when their ratio to volume becomes large. This is a characteristic of fractal aggregates and their constituent monomers (spheroidal or other) in the micrometer to nanometer scales. Exotic fern shaped aggregates are also produced. All aggregates exhibit large ratios of surface to volume. Condensation of metallic vapours allows to obtain particle sizes much smaller than those obtained via grinding techniques and far superior in purity. Exotic alloys of non miscible metals have been obtained at the micrometer scale. Thermal and laser evaporation methods of metals followed by condensation are described. Low gravity aggregation experiments were also carried out on aircraft in parabolic flight.

关键词： Fractals Monomers Aggregates Metals Alloys

Experiment/simulation correlation-based methodology for metallic ballistic protection solutions

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Defence Technology（防务技术） 2023年第11期29卷 24-38页

作者： Yohan Cosquer Patrice Longère Olivier Pantalé claude Gailhac DGA-Techniques Aéronautiques 31130BalmaFrance Institut Clement Ader Universite de ToulouseISAE-SUPAEROIMT Mines AlbiUPSINSACNRS3RueCarolineAigle31400ToulouseFrance Laboratoire Genie de Production INP/ENITUniversitéde Toulouse47Avenued’AzereixF-65016TarbesFrance CNIM Systemes Industriels 83500 La Seyne-sur-MerFrance

A methodology is developed based on the coupling of a finite element code with an optimisation module for the design of land vehicle armouring composed of lightweight aluminium alloy and high strength steel *** an experiment/simulation correlation,a numerical model has been built and calibrated considering monolithic plates and then verified considering a bi-metal protection against tungsten carbide proj.ctile mimicking the core of a 7.62×51 AP8 *** addition,a method is proposed to obtain the v_(res)-v_(i) curve for the full 7.62×51 AP8 bullet from the v_(res)-v_(i) curve obtained from the core only.

关键词： Impact Terminal ballistics Ballistic limit MARS380 Aluminium alloy 7.62×51 AP8

Texture Evolutions in Fe-6.5%Si Produced by Rapid Solidification and Chemical Vapor Deposition

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j.urnal of Materials Science & Technology 2002年第6期18卷 516-518页

作者： Liang ZUO Guangyong HU Yuhui SHA claude ESLING School of Materials Science and Metallurgy Northeastern UniversityShenyang 110004China Laboratoire d'Etude des Textures et Application aux Materiaux CNRS UMR 7078Universite de Metz 57045 Metz Cedex 1France

Fe-Si ribbons and thin sheets with 6.5%Si content were prepared by means of the single roller rapid solidification and chemical vapor deposition (CVD), respectively. The initial textures of rapidly solidified Fe-6.5%Si ribbons were characteristic of the {100} fiber-type, which became weakened during primary recrystallization in various atmospheres. At the stage of secondary recrystallization, the {100} texture formed in Ar and the {110} texture in hydrogen, while there occurred a texture transformation from the {100} type to the {110} type in vacuum with the increase of annealing temperature. For Fe-6.5%Si sheets prepared by Si deposition in cold-rolled Fe-3%Si matrix sheets, their textures were dominated by the η-fiber (//RD) with the maximum density at the {120} orientations. After homogenization annealing, the η-fiber could evolve into the {130} type or become more concentrated on the {120} orientations, depending on the cold rolling modes of Fe-3%Si matrix sheets.

关键词： Fe-6.5%Si alloy Texture Rapid solidification Chemical vapor deposition