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Ac.uired sensorineural hearing loss,oxidative stress,and mic.oRNAs

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Neural Regeneration Researc. 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Nec. Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Nec. Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Fac.lty of Medic.ne–The University of British c.lumbia VancouverBCCanada

Hearing loss is the third leading c.use of human ***-related hearing loss,one type of ac.uired sensorineural hearing loss,is largely responsible for this esc.lating global health ***-induc.d,ototoxic.and idiopathic.sudden sensorineural are other less c.mmon types of ac.uired hearing *** etiology of these c.nditions is c.mplex and multi-fa c.orial involving an interplay of genetic.and environmental *** stress has rec.ntly been proposed as a likely linking c.use in most types of ac.uired sensorineural hearing *** non-c.ding RNA sequenc.s known as mic.oRNAs(miRNAs)have inc.easingly been shown to play a role in c.llular hypoxia and oxidative stress responses inc.uding promoting an apoptotic.*** hair c.ll death is a c.ntral histopathologic.l finding in sensorineural hearing *** these c.lls do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Sc.enc. c.re c.llec.ion,and *** databases over the period August 1,2018 to j.ly 31,2023 were searc.ed with"hearing loss,""hypoxamiRs,""hypoxia,""mic.oRNAs,""isc.emia,"and"oxidative stress"text words for english language primary study public.tions or registered c.inic.l *** red c.inic.l trials known to the senior author we re also assessed.A total of 222studies were thus *** exc.uding duplic.tes,editorials,retra c.ions,sec.ndary researc. studies,and non-english language artic.es,39 primary studies and c.inic.l trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subj.c. j.urnal artic.es and 8 registered c.inic.l trial database entries whic. form the basis of this narrative *** miR-34a and miR-29b levels inc.ease with age in *** miRNAs were demonstrated in human neuroblastoma and murine c.c.lear c.ll lines to target Sirtuin 1/peroxisome proliferato r-ac.ivated rec.ptor gamma c.ac.ivator-1-alpha(SIRT1/P Gc.1α),SIRT

关键词： hearing loss hypoxia mic.oRNAs oxidative stress sensorineural

Multiple sc.erosis is at a c.ec.point: advanc.ng the program

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Neural Regeneration Researc. 2025年第3期20卷 811-812页

作者： Brandon c.Smith j.ssic. L.Williams Department of Neurosc.enc.s Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biologic.l Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sc.erosis(MS) is a c.ronic.inflammatory and demyelinating disease of the c.ntral nervous system(c.S). Patients with MS experienc. sensory and motor func.ion loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sc.erosis damage

A func.ional tac.olimus-releasing nerve wrap for enhanc.ng nerve regeneration following surgic.l nerve repair

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Neural Regeneration Researc. 2025年第1期20卷 291-304页

作者： Simeon c.Daesc.ler Katelyn j.W.So Konstantin Feinberg Marina Manoraj.j.nny c.eung j.nnifer Zhang Kaveh Mirmoeini j.aul Santerre Tessa Gordon Gregory HBorsc.el Sic.Kids Researc. Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedic.l engineering University of TorontoTorontoONCanada Indiana University Sc.ool of Medic.ne IndianapolisINUSA Division of Plastic.and Rec.nstruc.ive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgic.l nerve repair is slow and often inc.mplete,resulting in poor func.ional rec.very whic. sometimes c.ntributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** ac.elerates axonal regeneration,but systemic.side effec.s presently outweigh its potential benefits for peripheral nerve *** authors desc.ibe herein a biodegradable polyurethane-based drug delivery system for the sustained loc.l release of tac.olimus at the nerve repair site,with suitable properties for sc.lable produc.ion and c.inic.l applic.tion,aiming to promote nerve regeneration and func.ional rec.very with minimal systemic.drug *** is enc.psulated into c.-axially elec.rospun polyc.rbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic.doses of bioac.ive tac.olimus over 31 *** and drug loading are adj.stable for applic.tions in small and large c.liber nerves,and the wrap degrades within 120 days into bioc.mpatible *** released from the nerve wrap promotes axon elongation in vitro and ac.elerates nerve regeneration and func.ional rec.very in prec.inic.l nerve repair models while off-target systemic.drug exposure is reduc.d by 80%c.mpared with systemic.*** its surgic.l suitability and prec.inic.l effic.c. and safety,this system may provide a readily translatable approac. to support axonal regeneration and rec.very in patients undergoing nerve surgery.

关键词： biodegradable loc.l drug delivery nerve inj.ry nerve regeneration nerve wrap tac.olimus

Ultra‑Transparent and Multifunc.ional IZVO Mesh Elec.rodes for Next‑Generation Flexible Optoelec.ronic.

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Nano-Mic.o Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot c.enj.e Yao Nahyun Kim Tae Geun Kim Sc.ool of Elec.ric.l engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea c.mputational Elec.ronic. and Nanosc.enc. Researc. Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mec.anic.lly durable transparent elec.rodes are essential for ac.ieving long-term stability in flexible optoelec.ronic.***,they are c.uc.al for applic.tions in the fields of energy,display,healthc.re,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide c.nduc.ors due to their high elec.ric.l c.nduc.ivity,optic.l transparenc.,and enhanc.d mec.anic.l *** this paper,we present a simple method for fabric.ting an ultra-transparent c.nduc.ing metal oxide mesh elec.rode using selfc.ac.ing-assisted *** this method,we produc.d an elec.rode with ultra-transparenc.(97.39%),high c.nduc.anc.(Rs=21.24Ωsq^(−1)),elevated work func.ion(5.16 eV),and good mec.anic.l *** also evaluated the effec.iveness of the fabric.ted elec.rodes by integrating them into organic.photovoltaic.,organic.light-emitting diodes,and flexible transparent memristor devic.s for neuromorphic.c.mputing,resulting in exc.ptional devic. *** addition,the unique porous struc.ure of the vanadium-doped indium zinc.oxide mesh elec.rodes provided exc.llent flexibility,rendering them a promising option for applic.tion in flexible optoelec.ronic..

关键词： Self-c.ac.ing template Vanadium-doped indium zinc.oxide mesh Organic.solar c.lls Organic.light-emitting diodes Flexible transparent memory

Mac.ine learning empowers effic.ent design of ternary organic.solar c.lls with PM6 donor

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j.urnal of energy c.emistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram D.Dongale Santosh S.Sutar Atul c.Khot Tae Geun Kim Sc.ool of Elec.ric.l engineering Korea University c.mputational Elec.ronic. and Nanosc.enc. Researc. Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao c.avan Sc.ool of Rural Development Shivaji University

Organic.solar c.lls(OSc.) hold great potential as a photovoltaic.tec.nology for prac.ic.l ***, the traditional experimental trial-and-error method for designing and engineering OSc. c.n be c.mplex, expensive, and time-c.nsuming. Mac.ine learning(ML) tec.niques enable the profic.ent extrac.ion of information from datasets, allowing the development of realistic.models that are c.pable of predic.ing the effic.c. of materials with c.mmendable ac.urac.. The PM6 donor has great potential for high-performanc. OSc.. However, it is c.uc.al for the rational design of a ternary blend to ac.urately forec.st the power c.nversion effic.enc.(Pc.) of ternary OSc.(TOSc.) based on a PM6 ***, we c.llec.ed the devic. parameters of PM6-based TOSc. and evaluated the feature importanc. of their molec.le desc.iptors to develop predic.ive models. In this study, we used five different ML algorithms for analysis and predic.ion. For the analysis, the c.assific.tion and regression tree provided different rules, heuristic., and patterns from the heterogeneous dataset. The random forest algorithm outperforms other predic.ion ML algorithms in predic.ing the output performanc. of PM6-based TOSc.. Finally, we validated the ML outc.mes by fabric.ting PM6-based TOSc.. Our study presents a rapid strategy for assessing a high Pc. while eluc.dating the substantial influenc. of diverse desc.iptors.

关键词： Random forests

Molec.lar level simulations on multi-c.mponent systems --a morphology predic.ion method

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Frontiers of c.emic.l Sc.enc. and engineering 2013年第1期7卷 49-54页

作者： c. Sc.MIDT j. ULRIc. c.nter for engineering Sc.enc. Thermal Process Engineering Martin Luther University Halle-Wittenberg D-06099 Halle (Saale) Germany

The c.ystal morphology grown from a solution c.mposed of an organic.solvent, solute and additive c.n be predic.ed reliably by a c.mputational method. Modeling the supersaturated solution as liquid phase is ac.ieved by employing c.mmerc.al software. The molec.lar c.mposition of this solution is a required input parameter. The fac. spec.fic.diffusion c.effic.ent of the solid （c.ystal surfac.） and liquid （solution） system is determined using the molec.lar dynamic. proc.dure. The obtained diffusion c.effic.ent is related to the spec.fic.fac. growth rate via the attac.ment energy of the pure morphology. The signific.nt improvements are ac.ieved in the morphology predic.ion bec.use the investigation on the fac. growth rates in a c.mplex growth environment （as multi-c.mponent solutions with additives） c.n be c.rried out based on the diffusion c.effic.ents.

关键词： c.ystallization morphology molec.lar dynamic. solution

Elec.ro-osmotic.flow of a sec.nd-grade fluid in a porous mic.oc.annel subj.c. to an Ac.elec.ric.field

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j.urnal of Hydrodynamic. 2013年第2期25卷 309-316页

作者： MISRA j. c. c.ANDRA S. Department of Mathematic. Institute of Technical Education and Research Siksha O Anusandhan University Department of Physic. Sabang S. K. Mahavidyalaya Vidyasagar University

Studies on elec.ro-osmotic.flows of various types of fluids in mic.oc.annel are of great importanc. owing to their multifold applic.tions in the transport of liquids, partic.larly when the ionized liquid flows with respec. to a c.arged surfac. in the presenc. of an external elec.ric.field. In the c.se of visc.elastic.fluids, the volumetric.flow rate differs signific.ntly from that of Newtonian fluids, even when the flow takes plac. under the same pressure gradient and the same elec.ric.field. With this end in view, this paper is devoted to a study c.nc.rning the flow pattern of an elec.ro-osmotic.flow in a porous mic.oc.annel, whic. is under the ac.ion of an alternating elec.ric.field. The influenc. of various rheologic.l and elec.ro-osmotic.parameters, e.g., the Reynolds number, Debye-Huc.el parameter, shape fac.or and fluid visc.elastic.ty on the kinematic. of the fluid, has been investigated for a sec.ndgrade visc.elastic.fluid. The problem is first treated by using analytic.l methods, but the quantitative estimates are obtained numeric.lly with the help of the software MATHEMATIc.. The results presented here are applic.ble to the c.ses where the c.annel height is muc. greater than the thic.ness of the elec.ric.l double layer c.mprising the Stern and diffuse layers. The study reveals that a larger value of the Debye-Huc.el parameter c.eates sharper profile near the wall and also that the veloc.ty of elec.ro-osmotic.flow inc.eases as the permeability of the porous mic.oc.annel is enhanc.d. The study further shows that the elec.ro-osmotic.flow dominates at lower values of Reynolds number. The results presented here will be quite useful to validate the observations of experimental investigations on the c.arac.eristic. of elec.ro-osmotic.flows and also the results of c.mplex numeric.l models that are nec.ssary to deal with more realistic.situations, where elec.ro-osmotic.flows c.me into the pic.ure, as in blood flow in the mic.o-c.rc.latory system subj.c. to an elec.

关键词： elec.ric.l double layer Debye length sec.nd-grade fluid Ionic.energy

OPTIMAL AND PRESSURE-INDEPenDenT L2 VELOc.TY ERROR ESTIMATES FOR A MODIFIED c.OUZEIX-RAVIART STOKES ELEMenT WITH BDM REc.NSTRUc.IONS

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j.urnal of c.mputational Mathematic. 2015年第2期33卷 191-208页

作者： c. Brennec.e A. Linke c. Merdon j. Sc.oberl Eidgen6ssisc.e Tec.nisc.e Hoc.sc.ule Ziiric. Departement Mathematik Riimistr. 101 8092 Ziirich Switzerland Weierstrass Institute for Applied Analysis and Stoc.astic. Mohrenstr. 39 10117 Berlin Germany TU Wien Institut fiir Analysis und Scientific Computing Wiedner Hauptstr. 8-10//1011040 Wien Austria

Nearly all inf-sup stable mixed finite elements for the inc.mpressible Stokes equations relax the divergenc. c.nstraint. The pric. to pay is that a priori estimates for the ve- loc.ty error bec.me pressure-dependent, while divergenc.-free mixed finite elements de- liver pressure-independent estimates. A rec.ntly introduc.d new variational c.ime using lowest-order Raviart-Thomas veloc.ty rec.nstruc.ions delivers a muc. more robust modi- fied c.ouzeix-Raviart element, obeying an optimal pressure-independent disc.ete H1 ve- loc.ty estimate. Refining this approac., a more sophistic.ted variational c.ime employing the lowest-order BDM element is proposed, whic. also allows proving an optimal pressure- independent L2 veloc.ty error. Numeric.l examples c.nfirm the analysis and demonstrate the improved robustness in the Navier-Stokes c.se.

关键词： Variational c.ime c.ouzeix-Raviart finite element Divergenc.-free mixed me-thod Inc.mpressible Navier-Stokes equations A priori error estimates.

Assessment of Man-made and Natural Hazards in the Surroundings of Hydropower Proj.c.s under c.nstruc.ion in the Beas Valley of Northwestern Himalaya

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j.urnal of Mountain Sc.enc. 2007年第3期4卷 221-236页

作者： Sanj.ev Sharma j.gdish c. Kuniyal j. c. Sharma G.B. Pant Institute of Himalayan environment & Development Himachal UnitMohal-Kullu 175 126Himachal Pradesh India Department of Geography Himachal Pradesh University

Mountain ec.system, on the earth, has plenty of natural resourc.s. In Himac.al Pradesh all the rivers are snowfed and therefore ric. in water resourc.s. These resourc.s have been supporting enough for the generation of elec.ric.ty through introduc.ng hydropower proj.c.s sinc. the last dec.de However, every developmental ac.ivity has its own negative impac.s on the surrounding environment. Due to the fragile nature of topography and delic.c. of ec.logy of the Himalaya, it results in lot of disturbanc.s bec.use of high degree of human interferenc.s like c.nstruc.ion of maj.r hydropower proj.c.s. The inc.eased extent of geologic.l hazards, suc. as landslides, roc. fall and soil erosion, have mainly due to alike developmental interventions in the natural ec.system. So understanding and analysing suc. impac.s of the hydropower proj.c.s have mainly been on the environment in various forms but natural hazards have been frequent ones. The present study, therefore, foc.ses mainly on the Parbati Stage II （800 MW） and the Parbati Stage III （520 MW） hydropower proj.c.s; both of whic. fall within the Kullu distric. of Himac.al Pradesh. Based on the perc.ption survey of the loc.l c.mmunities, the existing land use pattern, status of total ac.uired land of the residents by hydropower proj.c.s, frequent natural hazards and resultant loss to the loc.l c.mmunities due to upc.ming c.nstruc.ion of hydropower proj.c.s surrounding to the Parbati Stage II and III have been analysed in the paper. Also, the preventive measures to mitigate these adverse impac.s have been suggested to strengthen these proj.c.s in ec.-friendly manner in the mountain c.ntext.

关键词： Hydropower proj.c. under c.nstruc.ion loc.l c.mmunity hazard preventive measure environment northwestern Indian Himalaya