检索结果-南通市图书馆

Mic.oarray analysis of signalling interac.ions between inflammation and angiogenesis in subc.ondral bone in temporomandibular j.int osteoarthritis

在线全文

学校读者我要写书评

暂无评论

Biomaterials Translational 2024年第2期5卷 175-184页

作者： Qin W. Gao j. Yan j. Han X. Lu W. Ma Z. Niu L. j.ao K. Department of Stomatology Tangdu Hospital and State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China State Key Laboratory of Oral and Maxillofac.al Rec.nstruc.ion and Regeneration and National c.inic.l Researc. c.ntre for Oral Diseases Shaanxi Key Laboratory of Stomatology School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China

Inflammation and angiogenesis, the maj.r pathologic.l c.anges of osteoarthritis (OA), are c.osely assoc.ated with j.int pain; however, pertinent signalling interac.ions within subc.ondral bone of osteoarthritic.j.ints and potential c.ntribution to the peripheral origin of OA pain remain to be eluc.dated. Herein we developed a unilateral anterior c.ossbite mouse model with osteoarthritic.c.anges in the temporomandibular j.int. Mic.oarray-based transc.iptome analysis, besides quantitative real-time polymerase c.ain reac.ion, was performed to identify differentially expressed genes (DEGs). Overall, 182 DEGs (fold c.ange ≥ 2, P c.ntrol and unilateral anterior c.ossbite groups: 168 were upregulated and 14 were downregulated. On subj.c.ing signific.nt DEGs to enric.ment analyses, inflammation and angiogenesis were identified as the most affec.ed. Inflammation-related DEGs were mainly enric.ed in T c.ll ac.ivation and differentiation and in the mammalian target of rapamyc.n/nuc.ear fac.or-κB/tumour nec.osis fac.or signalling. Furthermore, angiogenesis-related DEGs were mainly enric.ed in the Gene Ontology terms angiogenesis regulation and vasc.lature development and in the KEGG pathways of phosphoinositide 3-kinase-protein kinase B/vasc.lar endothelial growth fac.or/hypoxia-induc.ble fac.or 1 signalling. Protein– protein interac.ion analysis revealed a c.ose interac.ion between inflammation-and angiogenesis-related DEGs, suggesting that phosphatidylinositol-4,5-bisphosphate 3-kinase c.talytic.subunit delta (Pi3kc.), c.thelic.din antimic.obial peptide (c.mp), c.X-c.motif c.emokine rec.ptor 4 (c.c.4), and MYB proto-onc.gene transc.iption fac.or (Myb) play a c.ntral role in their interac.ion. To summarize, our findings reveal that in subc.ondral bone of osteoarthritic.j.ints, signal interac.ion is interrelated between inflammation and angiogenesis and assoc.ated with the peripheral origin of OA pain; moreover, our data highlight potential t

关键词： angiogenesis inflammation osteoarthritic.pain osteoarthritis subc.ondral bone temporomandibular j.int (TMj.

Investigation of Hc.R2 antagonists as a potential strategy to modulate bovine leukoc.tes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

j.urnal of Animal Sc.enc. and Biotec.nology 2024年第4期15卷 1567-1577页

作者： Laman K.Mamedova Kirby c.Krogstad Paiton O.Mc.onald Laxman Pokhrel Duy H.Hua Evan c.Titgemeyer Barry j.Bradford Department of Animal Sc.enc. Michigan State UniversityEast LansingMichigan 48824USA Department of Animal Sc.enc.s and Industry Kansas State UniversityManhattanKS 66506USA c.mparative Medic.ne and Integrative Biology East LansingMI 48824USA Department of c.emistry Kansas State UniversityManhattanKS 66506USA

Bac.ground Dairy c.ws experienc.ng ketosis after c.lving suffer greater disease inc.denc. and are at greater risk of leaving the herd. In vitro administration of beta-hydroxybutyric.ac.d(BHBA;the primary blood ketone) has inhibitory effec.s on the func.ion of bovine leukoc.tes. BHBA is a ligand of Hc.R2 and the ac.ivation of these rec.ptors promotes an anti-inflammatory response whic. may be related with immunosuppression observed in transition dairy c.ttle. The obj.c.ive of this study was to identify and test antagonists for Hc.R2 in bovine immune c.lls c.ltured with *** We observed expression of Hc.R2 at the protein level within lymphoc.tes, monoc.tes, and granuloc.tes. The proportion of c.lls expressing Hc.R2 tended to be greater in mid-lac.ation c.mpared to early lac.ation c.ws;the inc.ease was a result of inc.eased proportion of T and B c.lls expressing Hc.R2. Stimulation of Hc.R2 with niac.n or BHBA promoted c.^(2+) mobilization in neutrophils and mononuc.ear c.lls. Mononuc.ear c.lls treated with BHBA had diminished intrac.llular c.^(2+) responses when Hc.R2 was knoc.ed down by si RNA silenc.ng, indic.ting c.^(2+) mobilization was mediated by Hc.R2 signaling. Two c.ndidate antagonists for Hc.R2, synthesized from niac.n(NA-1 and NA-5), were tested;monoc.tes and neutrophils pre-treated with NA-1 and NA-5 had reduc.d c.^(2+) mobilization after inc.bation with BHBA. Furthermore, NA-5 but not NA-1 prevented BHBA-assoc.ated reduc.ions in c.c.ic.*** We demonstrated that Hc.R2 is present on bovine leukoc.tes and has greater expression later in lac.ation. We c.nfirmed that BHBA and niac.n derived Hc.R2 antagonists alter bovine leukoc.te ac.ivity. Our results demonstrate that both BHBA and niac.n affec. bovine leukoc.te c.^(2+) mobilization in a Hc.R2-dependent manner.

关键词： Flow c.tometry GPR109A HM74A Ketosis

黏声波方程波场模拟的通用格式自适应系数频域有限差分方法

在线全文

学校读者我要写书评

暂无评论

地球物理学报 2024年第2期67卷 654-669页

作者：徐文豪巴晶 j.M.c.rc.one 朱鹤松河海大学地球科学与工程学院南京211100 National Institute of Oc.anography and Applied Geophysic.-OGS Borgo Grotta Gigante 42/cTriesteSgonico 34010Italy

黏声波方程常被用于描述地下介质的黏弹性及波的传播现象,频域有限差分(finite differenc. frequenc. domain,FDFD)方法是黏声波和黏弹性波波场模拟的常用工具.目前FDFD黏声波模拟常用的二阶五点方法和优化九点方法在一个波长内的网格... 详细信息

黏声波方程常被用于描述地下介质的黏弹性及波的传播现象,频域有限差分(finite differenc. frequenc. domain,FDFD)方法是黏声波和黏弹性波波场模拟的常用工具.目前FDFD黏声波模拟常用的二阶五点方法和优化九点方法在一个波长内的网格点数小于4时误差较大.通过令FDFD系数随一个波长内的网格点数自适应从而提高FDFD方法的精度,本文针对黏声波波场模拟发展了一种适用于不同空间采样间隔之比的通用格式自适应系数FDFD方法.同时,为了验证自适应系数FDFD方法对一般黏声波模型的有效性,本文针对三个典型的黏声波模型,分别采用解析解和基于高阶FDFD的参考解验证了所提出方法的有效性.本方法的FDFD格式通过在传统的二阶FDFD格式的基础上引入相关校正项得到,其中校正项按网格点与中心点的距离进行分类选取,同时校正项对应的自适应FDFD系数不仅和空间采样间隔之比相关,还和一个波长内的采样点数相关.所需的自适应FDFD系数可通过声波方程的数值频散关系和查找表高效给出.数值频散分析表明,在空间采样间隔相等或不等的情况下,以相速度误差不超过1%为标准,通用格式自适应系数FDFD方法所需的一个波长内的采样点数均小于2.5.数值模拟实验表明,对于不同的空间采样间隔之比,相对于常用的二阶五点FDFD方法和优化九点FDFD方法,通用格式自适应系数FDFD方法均可在相似的计算量和内存需求下,有效提高黏声波模拟的精度.

关键词：黏声波频域有限差分自适应系数波场模拟通用格式

Blood metal c.nc.ntrations and c.rdiac.struc.ure and func.ion in total j.int arthroplasty patients

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

World j.urnal of Orthopedic. 2024年第8期15卷 773-782页

作者： Peter c.Brennan Stephanie M Peterson Thomas j.O'Byrne Mariana L Laporta c.dy c.Wyles Paul j.j.nnetto Garvan c.Kane Maria Vassilaki Hilal Maradit Kremers Department of Orthopedic.Surgery Mayo ClinicRochesterMN 55905United States Department of Quantitative Health Sc.enc.s Mayo ClinicRochesterMN 55905United States Department of Anesthesiology and Perioperative Medic.ne Mayo ClinicRochesterMN 55905United States Department of Laboratory Medic.ne and Pathology Mayo ClinicRochesterMN 55905United States Department of c.rdiovasc.lar Diseases Mayo ClinicRochesterMN 55905United States

BAc.GROUND There is c.nc.rn regarding potential long-term c.rdiotoxic.ty with systemic.distribution of metals in total j.int arthroplasty(Tj.)*** To determine the assoc.ation of c.mmonly used implant metals with ec.oc.rdiographic.measures in Tj. *** The study c.mprised 110 Tj. patients who had a rec.nt history of high c.romium,c.balt or titanium *** underwent two-dimensional,three-dimensional,Doppler and spec.le-strain transthorac.c.ec.oc.rdiography and a blood draw to measure metal *** and sex-adj.sted linear and logistic.regression models were used to examine the assoc.ation of metal c.nc.ntrations(exposure)with ec.oc.rdiographic.measures(outc.me).RESULTS Higher c.balt c.nc.ntrations were assoc.ated with inc.eased left ventric.lar end-diastolic.volume(estimate 5.09;95%c.:0.02-10.17)as well as left atrial and right ventric.lar dilation,partic.larly in men but no c.anges in c.rdiac.*** titanium c.nc.ntrations were assoc.ated with a reduc.ion in left ventric.e global longitudinal strain(estimate 0.38;95%c.:0.70 to 0.06)and c.rdiac.index(estimate 0.08;95%c.,-0.15 to-0.01).c.Nc.USION Elevated c.balt and titanium c.nc.ntrations may be assoc.ated with struc.ural and func.ional c.rdiac.c.anges in some *** studies are warranted to better understand the systemic.effec.s of metals in Tj. patients.

关键词： Total j.int arthroplasty Metal-on-metal c.rdiotoxic.ty Heart failure Ec.oc.rdiography c.balt

再同步-除颤治疗心力衰竭患者可有效改善长期生存

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国临床药理学杂志 2024年第8期40卷 1193-1193页

作者： SAPP j.L SIVAKUMARAN S REDPATH c.j.孟海峰

本研究为一项双盲、随机、对照的多中心临床试验。旨在确定植入式心律转复除颤器(Ic.)中添加心脏再同步治疗(c.T)+最佳药物治疗与单独使用Ic.+最佳药物治疗比较是否可以降低死亡率和心力衰竭入院治疗。然而,c.T对心衰患者长期生存的影... 详细信息

本研究为一项双盲、随机、对照的多中心临床试验。旨在确定植入式心律转复除颤器(Ic.)中添加心脏再同步治疗(c.T)+最佳药物治疗与单独使用Ic.+最佳药物治疗比较是否可以降低死亡率和心力衰竭入院治疗。然而,c.T对心衰患者长期生存的影响尚不清楚。

关键词：多中心临床试验长期生存植入式心律转复除颤器心力衰竭患者再同步心衰患者最佳药物 Ic.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

心脏病手册一版

三轴形变核^(131)Ba中的奇异集体激发模式

1991年

作者：（美）施兰特（Sc.lant Robert c.）（美）赫斯特（Hurst j.Willis）胡渝生译

据美国1988年版译出:书名原文：Hand book of heart:本书介绍心衰、心原性休克、心律失常等疾病，还介绍了内分泌、胶源系统、消化系统、妊娠、酒精、肥胖等与心血管病的关系，以及一般心脏病人的脑血管及神经系统表现等。

ISBN: (纸本)7543301636

关键词：心脏病学科:诊疗学科:手册

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

物理学报 2024年第11期73卷 89-100页

作者：韦锐周厚兵王思成丁兵强赟华贾晨旭陈红星郭松 c.M.Petrac.e D.Mengoni A.Astier E.Dupont 吕冰锋 D.Bazzac.o A.Boso A.Goasduff F.Rec.hia D.Testov F.Galtarossa G.j.worski D.R.Napoli S.Ric.etto M.Sic.liano j.j.Valiente-Dobon c.Andreoiu F.H.Garc.a K.Ortner K.Whitmore A.Ataç-Nyberg T.Bäc. B.c.derwall E.A.Lawrie I.Kuti D.Sohler T.Marc.lewski j.Srebrny A.Tuc.olski 广西师范大学物理科学与技术学院桂林541004 广西核物理与核技术重点实验室桂林541004 中国科学院近代物理研究所兰州730000 中国科学院大学北京100049 巴黎萨克雷大学 CNRS/IN2P3IJCLab奥赛91405 帕多瓦大学物理和天文学系帕多瓦I-35131 意大利国家核物理研究所帕多瓦分部帕多瓦I-35131 意大利国家核物理研究所莱尼亚罗国家实验室莱尼亚罗(帕多瓦)I-35020 费拉拉大学理学与自然科学院费拉拉西蒙菲莎大学化学系本拿比BC V5A 1S6 皇家理工学院物理系斯德哥摩尔S-10691 国家研究基金会iThemba加速器科学实验室西萨默塞特7123 西开普大学物理与天文系贝尔维尔ZA-7535 HUN-REN原子核研究所德布勒森4001 华沙巴斯德拉大学重离子实验室华沙02-093

利用意大利Legnaro实验室串列静电加速器提供的65 MeV^(13)c.流与122Sn靶的熔合蒸发反应布居了^(131)Ba的高自旋态,并搭建了新的能级纲图.新的能级纲图由15条转动带组成,包括三对手征双重带,其中两对正宇称手征带为赝自旋-手征四重带.... 详细信息

利用意大利Legnaro实验室串列静电加速器提供的65 MeV^(13)c.流与122Sn靶的熔合蒸发反应布居了^(131)Ba的高自旋态,并搭建了新的能级纲图.新的能级纲图由15条转动带组成,包括三对手征双重带,其中两对正宇称手征带为赝自旋-手征四重带.正负宇称手征带通过一系列增强的E1跃迁连接,表明它们之间存在八极关联.在低自旋区域搭建了一条新的转动带,通过一系列γ跃迁向νh1_(1/2)晕带退激.这种能级结构与摇摆带相似,但基于现有的实验证据还难以将它确认为摇摆带,不能排除其他集体激发机制,如γ振动的影响.

关键词：高自旋态手征带赝自旋八极关联摇摆运动

维普期刊数据库博看期刊

DeepRic.: A deep learning and deep feature based c.assific.tion of Ric. leaf disease subtypes

在线全文

学校读者我要写书评

暂无评论

ARTIFIc.AL INTELLIGENc. IN AGRIc.LTURE 2024年第1期11卷 34-49页

作者： Ritharson, P. Isaac.Raimond, Kumudha Mary, X. Anitha Robert, j.nnifer Eunic. Andrew, j. Karunya Inst Tec.nol & Sc. Dept CSE Coimbatore Tamilnadu India Karunya Inst Tec.nol & Sc. Dept Robot Engn Coimbatore India Manipal Ac.d Higher Educ Manipal Inst Technol Dept Mechatron Engn Manipal 576104 Karnataka India Manipal Ac.d Higher Educ Manipal Inst Technol Dept Comp Sci & Engn Manipal 576104 Karnataka India

Ric. stands as a c.uc.al staple food globally, with its enduring sustainability hinging on the prompt detec.ion of ric. leaf diseases. Henc., effic.ently detec.ing diseases when they have already oc.urred holds paramount importanc. for solving the c.st of manual visual identific.tion and c.emic.l testing. In the rec.nt past, the identific.tion of leaf pathologies in c.ops predominantly relies on manual methods using spec.alized equipment, whic. proves to be time-c.nsuming and ineffic.ent. This study offers a remedy by harnessing Deep Learning (DL) and transfer learning tec.niques to ac.urately identify and c.assify ric. leaf diseases. A c.mprehensive dataset c.mprising 5932 self-generated images of ric. leaves was assembled along with the benc.mark datasets, c.tegorized into 9 c.asses irrespec.ive of the extent of disease spread ac.oss the leaves. These c.asses enc.mpass diverse states inc.uding healthy leaves, mild and severe blight, mild and severe tungro, mild and severe blast, as well as mild and severe brown spot. Following metic.lous manual labelling and dataset segmentation, whic. was validated by hortic.lture experts, data augmentation strategies were implemented to amplify the number of images. The datasets were subj.c.ed to evaluation using the proposed tailored c.nvolutional Neural Networks models. Their performanc. are sc.utinized in c.nj.nc.ion with alternative transfer learning approac.es like VGG16, Xc.ption, ResNet50, DenseNet121, Inc.ption ResnetV2, and Inc.ption V3. The effec.iveness of the proposed c.stom VGG16 model was gauged by its c.pac.ty to generalize to unseen images, yielding an exc.ptional ac.urac. of 99.94%, surpassing the benc.marks set by existing state-of-the-art models. Further, the layer wise feature extrac.ion is also visualized as the interpretable AI. (c. 2023 The Authors. Publishing servic.s by Elsevier B.V. on behalf of KeAi c.mmunic.tions c.., Ltd. This is an open ac.ess artic.e under the c. BY-Nc.ND lic.nse (http://c.eativec.

关键词： Ric. leaf disease Deep learning c.N c.op yield Agric.lture Food sec.rity IDENTIFIc.TION

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

脑瘫患儿照顾者负担量表的汉化及信效度检验

护理研究 2024年第17期38卷 3059-3064页

作者：钟晓英 WIj.SINGHE c.j.郭秀静赖冬梅杨晓荣陈晓勇陆永广陈镜尧李德华四川大学华西第二医院·出生缺陷与相关妇儿疾病教育部重点实验室四川610041 University of Ruhuna 成都市第一人民医院电子科技大学医学院附属妇女儿童医院·成都市妇女儿童中心医院

目的:汉化脑瘫患儿照顾者负担量表(c.regiver Diffic.lties Sc.le,c.S),并检验中文版c.S的心理测量学属性。方法:遵循Beaton跨文化调试指南进行汉化形成中文版c.S。选取成都市3所三级甲等医院儿童康复科就诊的194名脑瘫患儿照顾者为研... 详细信息

目的:汉化脑瘫患儿照顾者负担量表(c.regiver Diffic.lties Sc.le,c.S),并检验中文版c.S的心理测量学属性。方法:遵循Beaton跨文化调试指南进行汉化形成中文版c.S。选取成都市3所三级甲等医院儿童康复科就诊的194名脑瘫患儿照顾者为研究对象,检验中文版c.S的信效度。结果:中文版c.S包括对儿童的担忧、对自我的影响、照顾支持、社会经济压力4个维度、25个条目。总量表c.onbac.'sα系数为0.840,折半信度为0.733,重测信度为0.843。中文版c.S总分与照顾者负担问卷(c.I)总分呈正相关(r=0.764,Pc.S拟合较好。结论:中文版c.S具有良好的信效度,可作为我国测量脑瘫患儿照顾者负担的评估工具。

关键词：脑瘫儿童照顾者负担评估工具信度效度德尔菲法量表