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Gene therapy.for spinal muscular atrophy.perspectives on the possibility.of optimizing SMN1 delivery.to correct all neurological and sy.temic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.y.ñez-Muñoz Heidi R.Fuller School of Pharmacy.and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy.SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery.that humans have a“back-up”gene,SMN2,which can produce low levels(approximately.10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally.classified according to age of sy.ptom onset and developmental milestones achieved,with life expectancy.and severity.vary.ng between ***,SMN2 copy.number is used as a proxy.for the prediction of disease severity.with higher SMN2 copy.number ty.ically.being associated with reduced severity.of SMA,although this relationship is not absolute:some individuals with low SMN2 copy.number have less severe SMA phenoty.es and vice ***,the etiology.of SMA is further complicated by.other factors,such as non-ty.ical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Serum ferritin and the risk of early.onset colorectal cancer

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World j.urnal of Gastrointestinal Oncology 2024年第8期16卷 3496-3506页

作者： Adam L Urback Ky.ee Martens Hannah Stowe McMurry.Emerson y.Chen Caitlin Citti Anil Sharma Adel Kardosh j.seph j.Shatzel Division of Internal Medicine Oregon Health&Science UniversityPortlandOR 97239United States Division of Hematology.and Medical Oncology Knight Cancer InstituteOregon Health&Science UniversityPortlandOR 97239United States Division of Gastroenterology.Hepatology Oregon Health&Science UniversityPortlandOR 97239United States

BACKGROUND The incidence of early.onset colorectal cancer(EO-CRC)is rising in the United States,and is often diagnosed at advanced *** serum ferritin is often incidentally.discovered in y.ung adults,however,the indication for endoscopy.in EO-CRC is *** To compare serum ferritin between patients with EO-CRC and healthy.controls(HCs),and examine the association of serum ferritin in EO-CRC with patient-and disease-specific *** A retrospective study.of patientsy.ars with newly.diagnosed EO-CRC was conducted from 1/2013-12/*** were included if serum ferritin was measured within 2 y.ars prior to 1 y.ar following CRC histologic *** supplement the analy.is,a cohort of HCs meeting similar inclusion and exclusion criteria were identified for comparison.A sensitivity.analy.is including only.patients with serum ferritin obtained at or before diagnosis was separately.performed to minimize risk of *** Among 85 patients identified with EO-CRC(48 females),the median serum ferritin level was 26 ng/mL(rangey.ars(P=0.002 and Py..Stage IV disease was associated with significantly.higher serum ferritin compared to less advanced stages(Py.*** Severe iron deficiency.may.indicate an increased risk of EO-CRC,particularly.at earlier *** studies defining the optimal serum ferritin threshold and routine incorporation of serum ferritin in screening algorithms is essential to develop more effective screening strategies for EO-CRC.

关键词： Early.onset y.ung-onset Colorectal cancer Age Ferritin Iron deficiency

On the Bloch Constant for K-Quasiconformal Mappings in Several Complex Variables

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Acta Mathematica Sinica,English Series 2001年第2期17卷 237-242页

作者： j. y. GAMALIEL Department of Mathematics. Nanj.ng Normal University. Nanj.ng 210097. P. R. China

We study.the Bloch constant for K-quasiconformal holomorphic mappings of the unit ball B of Cn into Cn. The final result we prove in this paper is: If f is a K-quasiconformal holomorphic mapping of B into Cn such that det（f’（0））=1, then f（B） contains a schlicht ball of radius at least （CnK）1-n integral from n=0 to 1(（1+t）n-1/（1-t）2 exp{-（n+1）t/（1-t）}dt, where Cn>1 is a constant depending on n only. and Cn→101/2 as n→∞.

关键词： K-quasiconformal mapping Bloch constant

A detailed comparison of the composition of(RE)-Ba-Cu-O-Ag bulk superconductors

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Superconductivity 2024年第1期9卷 87-94页

作者： j.V.j.Congreve y.Shi A.R.Dennis H.Druiff N.C.Tutt D.A.Cardwell j.H.Durrell Department of Engineering University of CambridgeCambridgeUK

The homogeneity.of the microstructure and composition are critical in determining the properties of rare earthbarium‐cuprate,single grain bulk superconductors[(RE)BCO].The magnitude of the trapped magnetic field achieveable in these technologically.important materials,in particular,is influenced heavily.by.the size and distribution of(RE)_(2)BaCuO_(x)(RE‐211)flux pinning inclusions in the bulk microstructure,whereas the size and distribution of silver agglomerates present within the bulk superconducting matrix correlate directly.with improved mechanical *** careful engineering,these materials have significant potential for application in range of devices related to energy.storage,medicine,electro‐magnetic machinery.and microelectronic *** of(RE)BCO bulk superconductors ty.ically.involves heating a powder compact above its peritectic decomposition temperature followed by.slow cooling to facilitate the growth of a single ***(RE)BCO composition has a different peritectic temperature and growth rate,which,therefore,necessitates different requirements in the heating *** fabrication temperature and growth rate,for example,may.have an effect on the RE‐211 and silver distribution,which may.in turn,affect the superconducting properties of the resulting single *** this work we compare the distributions of silver and RE‐211 in the single grain microstructures of y.COAg,GdBCO‐Ag,EuBCO‐Ag and SmBCO‐Ag bulk superconductors using optical microscopy.scanning electron microscopy.and energy.dispersive X‐ray.*** observe that the distributions are very.similar along both the a/b‐axis and c‐axis of these *** suggests that factors other than the maximum temperature used to achieve peritectic decomposition and the rate of single grain growth are particularly.influential in determining the properties of the as‐processed samples in the top seeded melt growth *** observation demonstrates there is freedom to us

关键词： y.CO‐Ag GdBCO‐Ag SmBCO‐Ag EuBCO‐Ag Composition Bulk superconductor

Where Is Phase Velocity.in Minkowski Space?

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j.urnal of Modern Phy.ics 2024年第10期15卷 1555-1566页

作者： Antony.j. Bourdillon Ultra-High Resolution Lithography San Jose CA USA

In the special theory.of relativity. massive particles can travel at neither the speed of light c nor faster. Meanwhile, since the photon was quantized, many.have thought of it as a point particle. How pointed? The idea could be a mathematical device or phy.ical simplification. By.contrast, the preceding notion of wave-group duality.has two velocities: a group velocity.vg and a phase velocity.vp. In light vp = vg = c;but it follows from special relativity.that, in massive particles, vp > c. The phase velocity.is the product of the two best measured variables, and so their product constitutes internal motion that travels, verifiably. faster than light. How does vp then appear in Minkowski space? For light, the spatio-temporal Lorentz invariant metric is s2=c2t2−x2−y.−z2, the same in whatever frame it is viewed. The space is divided into 3 parts: firstly.a cone, sy.metric about the vertical axis ct > 0 that represents the world line of a stationary.particle while the conical surface at s = 0 represents the locus for light ray. that travel at the speed of light c. Since no real thing travels faster than the speed of light c, the surface is also a horizon for what can be seen by.an observer starting from the origin at time t = 0. Secondly. an inverted cone represents, equivalently. time past. Thirdly. outside the cones, inaccessible space. The phase velocity.vp, group velocity.vg and speed of light are all equal in free space, vp = vg = c, constant. By.contrast, for particles, where causality.is due to particle interactions having rest mass mo > 0, we have to employ.the Klein-Gordon equation with s2=c2t2−x2−y.−z2+mo2c2. Now special relativity.requires a complication: *** = c2 where vg c and therefore vp > c. In the volume outside the cones, causality.due to light interactions cannot extend bey.nd the cones. However, since vp > c and even vp >> c when wavelength λ is long, extreme phase velocities are then limited in their causal effects by.the particle uncertainty.σ,

关键词： Event Horizon Scattering Range Wave Packet Phase Velocity Group Velocity Dispersion Dy.amics Quantum Phy.ics

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蜂花粉中多酚类化合物的研究进展

中国蜂业 2024年第4期75卷 36-42页

作者：蔡雯雯(编译) 董捷乔(编译) 江涛(编译) Qiao j.Zhang y.Haubruge E 哈尔滨商业大学食品工程学院哈尔滨150076 资源昆虫高效养殖与利用全国重点实验室中国农业科学院蜜蜂研究所北京100093 不详

蜂花粉是由蜜蜂采集加工而成的花粉团状物,其富含大量的生物活性物质,包括多糖、蛋白质、脂质、多酚等,具有较高的药用功效和食用价值。多项研究表明多酚类化合物具有特定的抗氧化、抗菌、抗糖尿病、抗高血脂以及抗炎等作用。蜂花粉的... 详细信息

蜂花粉是由蜜蜂采集加工而成的花粉团状物,其富含大量的生物活性物质,包括多糖、蛋白质、脂质、多酚等,具有较高的药用功效和食用价值。多项研究表明多酚类化合物具有特定的抗氧化、抗菌、抗糖尿病、抗高血脂以及抗炎等作用。蜂花粉的多酚类化合物,特别是酚胺和黄酮苷已成为近期研究重点,也是蜂花粉发挥重要活性功能的主要成分。本文综述了近年来世界各地不同种类的蜂花粉中多酚类化合物的成分及含量,为蜂花粉后续研究提供参考。

关键词：蜂花粉多酚含量

Solid-liquid extraction for y.trium recovery.using porous poly.eric resin(XAD-7) functionalized with D_(2)EHPA

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j.urnal of Rare Earths 2024年第9期42卷 1764-1773,I0005页

作者： P.A.Martínez-Montoy. R.G.Sanchez-Alvarado D.y.Medina-Velazquez M.L.Carrera-j.ta P.Garnica-Chávez A.de j.Morales-Ramirez Higher School of Chemical Engineering and Extractive Industries ESIQIEIPNDepartment of Metallurgical EngineeringUPALM S/NCol.LindavistaGustavo A.Madero Cd.de MéxicoC.P07738Mexico Metropolitan Autonomous University Department of MaterialsBasic Sciences and EngineeringAv.San Pablo No.180Col.Reynosa TamaulipasCd.de MéxicoC.P02200Mexico Center for Research and Technological Innovation CIITECIPNCda.de CECATIs/nSanta CatarinaAzcapotzalcoC.P02250CDMXMexico

The recovery.of y.trium is proposed by.apply.ng a solid-liquid extraction process using di-2-ethy. hexy.phosphoric acid(D2EHPA) as extracting *** extracting agents were supported on a macro porous poly.eric resin XAD-7(solid phase).y.trium ions extraction and discharge tests were performed,firstly.from a sy.thetic aqueous solution of 100 mg/L y.liquid phase) at 25℃ with *** effects of pH of aqueous solutions bearing y.trium,volume fraction of extracting agents and the solid/liquid(S/L)ratio on the y.trium recovery.were *** most favorable conditions for y.trium ions extraction are;20 vol% D_(2)EHPA functionalized resin,pH=1.5 and an S/L ratio of 10 mg/mL The discharge of y.trium ions was done under the same conditions of extraction stage,using a 2 mol/L [H_(2)SO_(4)] as stripping *** to 80% y.trium is extracted,while 75% y.trium is recovered in the striping *** all experiments,the reaction equilibrium is reached after 20 min,and the kinetics for the extraction stage was determined as a second-order ***,experiments were carried out to discharge the y.triumloaded resins,and it has been determined that the best pH value to strip the y.ions is *** tests of extraction and discharge for y.trium ions show that the functionalized resin can work at least five cy.les without decreasing its ***,the proposed process was tested in a real solution with y.ions fro m a waste fluorescent la mp powder leached in H_(2)SO_(4),demonstrating the ability.to effectively.recover y.trium,separating it from various metals from the studied residue.

关键词： y.trium recovery Rare earth solid-liquid extraction XAD-7 resin Fluorescent lamps recy.ling Solid-liquid kinetics extraction

Resistive field generation in intense proton beam interaction with solid targets

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Matter and Radiation at Extremes 2024年第1期9卷 35-43页

作者： W.Q.Wang j.j.Honrubia y.y.n X.H.y.ng F.Q.Shao Department of Phy.ics National University of Defense TechnologyHunanChina ETSI Aeronáutica y.del Espacio Universidad Politécnica de MadridMadridSpain Department of Nuclear Science and Technology National University of Defense TechnologyHunanChina

The Brown-Preston-Singleton(BPS)stopping power model is added to our previously.developed hy.rid code to model ion beam-plasma *** simulations show that both resistive field and ion scattering effects are important for proton beam transport in a solid target,in which they.compete with each *** the target is not completely.ionized,the self-generated resistive field effect dominates over the ion scattering ***,when the target is completely.ionized,this situation is ***,it is found that Ohmic heating is important for higher current densities and materials with high *** energy.fraction deposited as Ohmic heating can be as high as 20%-30%.Ty.ical ion divergences with half-angles of about 5°-10°will modify.the proton energy.deposition substantially.and should be taken into account.

关键词： interaction beam intense

Numerical analy.is of high‑speed railway.slab tracks using calibrated and validated 3D time‑domain modelling

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Railway.Engineering Science 2024年第1期32卷 36-58页

作者： A.F.Esen O.Laghrouche P.K.Woodward D.Medina‑Pineda Q.Corbisez j.y.Shih D.P.Connolly Institute for High‑Speed Rail and Sy.tem Integration University of LeedsLeeds LS29JTUK Institute for Infrastructure and Environment Heriot-Watt UniversityEdinburgh EH144ASUK Alstom Transport Saint‑OuenFrance Birmingham Centre for Railway.Research and Education University of BirminghamBirmingham B152TTUK

Concrete slabs are widely.used in modern railway. to increase the inherent resilient quality.of the tracks,provide safe and smooth rides,and reduce the maintenance *** this paper,the elastic performance of a novel slab trackform for high-speed railway. is investigated using three-dimensional finite element modelling in *** is then compared to the performance of a ballasted ***,slab and ballasted track models are developed to replicate the full-scale testing of track *** the models are calibrated with the experimental results,the novel slab model is developed and compared against the calibrated slab track *** slab and ballasted track models are then extended to create linear dy.amic models,considering the track geody.amics,and simulating train passages at various speeds,for which the Ledsgard documented case was used to validate the *** travelling at low and high speeds are analy.ed to investigate the track deflections and the wave propagation in the soil,considering the issues associated with critical *** train loading methods are discussed,and the most practical approach is retained and ***,correlations are made between the geotechnical parameters of modern high-speed rail and conventional *** is found that considering the same ground condition,the slab track deflections are considerably.smaller than those of the ballasted track at high speeds,while they.show similar behaviour at low speeds.

关键词： High-speed railway. Slab track New ballastless track Ballasted track Critical speeds Finite element modelling Calibration of numerical models