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The influence of nanotopography on cell behaviour through interactions with the extracellular matrix-A review

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Bioactive Materials 2022年第9期7卷 145-159页

作者： j.aj.n Luo Matthew Walker Yinbo Xiao Hannah Donnelly Matthew j.Dalby Manuel salmeron-Sanchez Centre for the Cellular Microenvironment University of GlasgowGlasgowG128LTUK

Nanotopography presents an effective physical approach for biomaterial cell manipulation mediated through material-extracellular matrix *** extracellular matrix that exists in the cellular microenvironment is crucial for guiding cell behaviours,such as determination of integrin ligation and interaction with growth *** interactions with the extracellular matrix regulate downstream mechanotransductive pathways,such as rearrangements in the cytoskeleton and activation of signal *** adsorption onto nanotopography strongly influences the conformation and distribution density of extracellular matrix and,therefore,subsequent cell *** this review,we first discuss the interactive mechanisms of protein physical adsorption on ***,we summarise advances in creating nanotopographical features to instruct desired cell ***,we focus on the cellular mechanotransductive pathways initiated by *** review provides an overview of the current state-of-the-art designs of nanotopography aiming to provide better biomedical materials for the future.

关键词： Nanotopography Cell-material interaction Protein adsorption Biomaterials

Study and ICH validation of a reverse-phase liquid chromatographic method for the quantification of the intact monoclonal antibody cetuximab

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j.urnal of Pharmaceutical Analysis 2016年第2期6卷 117-124页

作者： Antonio Martinez-Ortega Agustin Herrera Antonio salmeron-Garcia j.se Cabeza Luis Cuadros-Rodriguez Natalia Navas Department of Analytical Chemistry University of Granada Faculty of Science Campus Fuentenueva s/n E-18071 Granada Spain UGC intercentro Interniveles Farmacia Granada San Cecilio Hospital Biomedical Research Institute ibs. GRANADA. Hospitales Universitarios de Granada University of Granada E-18012 Granada Spain Department of Analytical Chemistry Science Faculty Biomedical Research Institute ibis. GRANADA University of Granada Campus Fuentenuevo s/n E-18071 Granada Spain

Cetuximab （CTX） is a potent chimeric mouse/human monoclonal antibody （mAb） approved worldwide for treatment of metastatic colorectal cancer. Among the various biological and physical analyses per- formed for full study on this biopharmaceutic, the determination of the concentration preparations throughout manufacturing and subsequent handling in hospital is particularly relevant. In the present work, the study and validation of a method for quantifying intact CTX by reverse-phase high-perfor- mance liquid chromatography with diode array detection （（RP）HPLC/DAD） is presented. With that end, we checked the performance of a chromatographic method for quantifying CTX and conducted a study to validate the method as stability-indicating in accordance with the International Conference on Harmo- nization guidelines （ICH） for biotechnological drugs; therefore, we evaluated linearity, accuracy, preci- sion, detection and quantification limits, robustness and system suitability. The specificity of the method and the robustness of the mAb formulation against external stress factors were estimated by compre- hensive chromatographic analysis by subj.cting CTX to several informative stress conditions. As de- monstrated, the method is rapid, accurate, and reproducible for CTX quantification. It was also suc- cessfully used to quantify CTX in a long-term stability study performed under hospital conditions.

关键词： Reverse-phase high performance liquidchromatography Diode detector Stress study Biopharmaceuticals Cetuximab

Use of subcutaneous tocilizumab to prepare intravenous solutions for COVID-19 emergency shortage:Comparative analytical study of physicochemical quality attributes

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j.urnal of Pharmaceutical Analysis 2020年第6期10卷 532-545页

作者： Natalia Navas j.sús Hermosilla Anabel Torrente-Lopez j.se Hernandez-j.menez j.se Cabeza Raquel Perez-Roblesa Antonio salmeron-García Department of Analytical Chemistry Science Faculty/Biomedical Research Institute ibs.GranadaUniversity of GranadaGranadaE-18071Spain UGC Farmacia Hospitalaria Biomedical Research Institute ibs.Granada.Hospital Universitario San Cecilio de GranadaGranadaE-18012Spain

COVID-19,a disease caused by the novel coronavirus SARS-Co V-2,has produced a serious emergency for global public health,placing enormous stress on national health systems in many *** studies suggest that cytokine storms(interleukins)may play an important role in severe cases of *** key inflammatory factors in cytokine release syndrome(CRS)could therefore be of great value in reducing the mortality ***(TCZ)in its intravenous(IV)form of administration-Ro Actemra?20 mg/m L(Roche)-is indicated for treatment of severe CRS *** investigations have concluded that inhibition of IL-6 with TCZ appears to be efficacious and safe,with several ongoing clinical *** has led to a huge increase in demand for IV TCZ for treating severe COVID-19 patients in hospitals,which has resulted in drug ***,we present a comparability study assessing the main critical physicochemical attributes of TCZ solutions used for infusion,at 6 mg/m L and 4 mg/m L,prepared from Ro Actemra?20 mg/m L(IV form)and from Ro Actemra?162 mg(0.9 m L solution pre-filled syringe,subcutaneous(SC)form),to evaluate the use of the latter for preparing clinical solutions required for IV administration,so that in a situation of shortage of the IV medicine,the SC form could be used to prepare the solutions for IV delivery of *** is important to remember that during the current pandemic all the medicines are used off-label,since none of them has yet been approved for the treatment of COVID-19.

关键词： COVID-19 Tocilizumab Critical quality attributes IV and SC medicines

利用可持续指标监测与调控“大昆明区”区域城镇发展

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国外城市规划 2001年第5期16卷 44-46页

作者： Willy A. Schmid Schultz Barbara salmeron Diego 米世文瑞士联邦理工大学国家、区域与地方规划研究所

本文阐述了"大昆明区"区域城镇发展的监测和控制理念,着重于指导规划的战略层次,提出一套用于控制目标达到与否的可持续发展核心指标,其前提是在昆明的行政体系中形成相应机制.同时提出了一个控制体系统的程序与职责的建议.最后向昆明... 详细信息

本文阐述了"大昆明区"区域城镇发展的监测和控制理念,着重于指导规划的战略层次,提出一套用于控制目标达到与否的可持续发展核心指标,其前提是在昆明的行政体系中形成相应机制.同时提出了一个控制体系统的程序与职责的建议.最后向昆明有关机构提出了瑞方的推荐意见.

关键词：昆明市区域规划城镇规划监测控制

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滇中城市群优化发展模式研究

城市发展研究 2010年第11期17卷 25-33页

作者：刘学迭戈·萨麦隆罗卿苏曼·拉纳刘志安云南省住房和城乡建设厅苏黎世联邦理工大学云南省城乡规划设计研究院

本文以滇中城市群规划为例,结合中外合作编制《云南省滇中城市群规划》实践,采用多情景发展模拟,将GIS工具与传统规划手段紧密耦合,针对"离散型"、"区域型"、"都市型"、"网络型"四种发展模式进行情景分析,并从中探索适合滇中城市群未来... 详细信息

本文以滇中城市群规划为例,结合中外合作编制《云南省滇中城市群规划》实践,采用多情景发展模拟,将GIS工具与传统规划手段紧密耦合,针对"离散型"、"区域型"、"都市型"、"网络型"四种发展模式进行情景分析,并从中探索适合滇中城市群未来发展的、相对合理的规划方案。最终得出一个阶段性发展方案,即在2030年以前滇中城市群以"区域型"模式为主导,2030年以后以"网络型"模式为主的发展模式,推进滇中地区稳步、有序发展,逐步实现生态安全、资源集约、经济繁荣三者高度统一。

关键词：城市群规划 GIS 空间网络化

国土空间保护下茶马古道大理珥西段区域空间特征研究

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住区 2024年第1期 127-136页

作者：王连迭戈·萨尔梅隆程海帆周峰越昆明理工大学建筑与城市规划学院城乡规划系昆明理工大学瑞士LEP规划咨询公司

以大理市国土空间总体规划专题研究之茶马古道修复及保护利用为例,探讨茶马古道洱西段(龙首关-龙尾关)沿线“点-线-面”文化空间廊道特征,综合评估划定沿线文化空间,量化分析与描述沿线空间形态,提出沿线分段保护修复及发展建议,探索再... 详细信息

以大理市国土空间总体规划专题研究之茶马古道修复及保护利用为例,探讨茶马古道洱西段(龙首关-龙尾关)沿线“点-线-面”文化空间廊道特征,综合评估划定沿线文化空间,量化分析与描述沿线空间形态,提出沿线分段保护修复及发展建议,探索再现茶马古道沿线区域空间特征。在新时代国土空间规划“一张图”体系及地理信息系统建设基础上,研究贯穿了建立历史道路名录信息库的科学方法,并为茶马古道“点-线-面”全要素集及保护修复提出一点参考。

关键词：滇藏茶马古道大理洱西段古驿道文化遗产空间特征线性文化遗产网络古驿道信息入库

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软饮料和无热量软饮料摄入及其与血压的关联性:健康工作者队列研究

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中华高血压杂志 2022年第12期30卷 1224-1224页

作者： Hernandez-Lopez R Canto-Osorio F Vidana-Peaarez D Torres-Ibarra L Rivera-Paredez B Gallegos-Carrillo K Velazquez R Ramirez P Barrientos-Gutierrez T salmeron j.Lopez-Olmedo N. 袁源(译) 练桂丽(审) 不详

本前瞻性研究旨在调查软饮料和无热量软饮料的摄入,并分析与血压的关联性。方法:采用2004—2018年健康工作者队列研究(thehealthworkerscohortstudy)中的数据(1324名成年人),采用半定量食物频率问卷评估软饮料和无热量软饮料摄入。采用... 详细信息

本前瞻性研究旨在调查软饮料和无热量软饮料的摄入,并分析与血压的关联性。方法:采用2004—2018年健康工作者队列研究(thehealthworkerscohortstudy)中的数据(1324名成年人),采用半定量食物频率问卷评估软饮料和无热量软饮料摄入。采用多元校正固定效应模型分析软饮料和无热量软饮料摄入与收缩压和舒张压的关联性。模型校正了潜在混杂因素并且考虑到基线时高血压状态的潜在影响。

关键词：软饮料队列研究固定效应模型模型校正多元校正混杂因素关联性血压