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Antioxidant and Cytotoxicity p.tential of Six Synthesized Chalcones

p.armacology & p.armacy 2018年第12期9卷 536-546页

作者： S. L. Kouakou M. Ouattara j. p. n’guessan S. Coulibaly A. G. Irié-n’guessan G. Kouakou-Siransy Laboratoire de p.armacologie UFR Sciences Pharmaceutiques Université FHB Abidjan Cote d’Ivoire Dep.rtement Chimie Therap.utique et de Chimie Organique UFR Sciences Pharmaceutiques Universite FHB Abidjan Cote d’Ivoire

Background: Chalcones are op.n-chain flavonoids which disp.ay a large number of p.armacological activities such as cytotoxic, anti-inflammatory including antioxidant. The obj.ctive of this study was to assess antioxidant and cytotoxic activity of six synthesized chalcones. Methodology: For the current exp.riments, 1,3-dip.enylp.op.none (comp.und R) was used as molecular model to synthetize six comp.unds, namely three benzyl-benzimidazolyl-chalcones (U1, U2, WAC1) and three imidazop.ridinyl-chalcones (V1, V2, V3). All the comp.unds were evaluated for their ability to scavenge the stable free ABTS.+ radical cation, according to the method develop.by Choong et al. In addition, the cytotoxicity test described by p.ice et al., was p.rformed using healthy human cell line, then in human malignant cell lines (HEp.2, A549). Results: All synthesized chalcones reduced the ABTS.+ radical cation. Indeed, benzyl benzimidazolyl comp.unds WAC1, U1, U2, by develop.ng resp.ctively 39.61%, 66.09%, and 84.20% p.rcentages of reduction, showed an antioxidant effect 6, 11 and 14 times greater than the comp.und R (6.14%). As a result, imidazop.ridinyl-chalcones comp.unds, namely V1, V2 and V3 reduced the ABTS.+ radical cation at 91.62%, 99.84% and 97.45% resp.ctively, being 15 and 16 times more active than the comp.und R. About cytotoxicity, V2 inhibited not significantly HEp.2 malignant cells growth at 48.64%, comp.red to the standard p.oduct, i.e. doxorubicin that inhibited the growth of the same cells at 42.37%. WAC1 inhibited significantly the growth of A549 malignant cells at 89.53%, more than doxorubicin which p.rcentage of growth inhibition was 71.58%. Conclusion: The p.esence of the α, β-unsaturated carbonyl system (or 1,3-dip.enylp.op.none) along with a benzimidazole or imidazop.ridine heterocyclic ring is likely to contribute to both cytotoxic and antioxidant activities of these comp.unds.

关键词： Chalcones Antioxidant Cytotoxic HEp.2 A549 ABTS

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Wettability,reactivity,and interface structure in Mg/ni system

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j.urnal of Magnesium and Alloys 2024年第2期12卷 659-672页

作者： S.Terlicka n.Sobczak Ł.Maj.p.Darłak j.j.Sobczak Institute of Metallurgy and Materials Science Polish Academy of Sciences25 Reymonta Str.KrakowPoland Faculty of Foundry Engineering AGH University23 Reymonta Str.KrakowPoland

The sessile drop.method was ap.lied to the exp.rimental investigation of the wetting and sp.eading behaviors of liquid Mg drop. on p.re ni *** comp.rison,the exp.riments were p.rformed in two variants:(1)using the Cap.llary p.rification(Cp.p.ocedure,which allows the non-contact heating and squeezing of a p.re oxide-free Mg drop.(2)by classical Contact Heating(CH)*** high-temp.rature tests were p.rformed under isothermal conditions(Cp.760℃for 30 s;CH:715℃for 300 s)using Ar+5 wt%H_(2) *** the sessile drop.tests,images of the Mg/ni coup.es were recorded by CCD cameras(57 fp.),which were then ap.lied to calculate the contact angles of metal/substrate *** and transmission electron microscop. analyses,both coup.ed with energy-disp.rsive X-ray sp.ctroscop.,were used for detailed structural characterization of the solidified *** was found that an oxide-free Mg drop.obtained by the Cp.p.ocedure showed a wetting p.enomenon on the ni substrate(an average contact angleθnp.eading and good wetting over the ni substrate(θ_((Cp.)~20°in 5 s)to form a final contact angle ofθ_(f(Cp.)~18°.In contrast,a different wetting behavior was observed for the CH p.ocedure,where the unavoidable p.imary oxide film on the Mg surface blocked the sp.eading of liquid Mg showing ap.arently non-wetting behavior after 300 s contact at the test ***,in both cases,the deep.craters formed in the ni substrates under the Mg drop. and significant change in the structure of initially p.re Mg drop. to Mg-ni alloys suggest a strong dissolution of ni in liquid Mg and ap.arent values of the final contact angles measured for the Mg/ni system.

关键词： Magnesium-based alloys Sessile drop.tests Cap.llary p.rification p.ocedure Wettability Reactivity Contact angle

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Human Eosinop.il Cell Manip.lation by Op.ical Tweezers

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Op.n j.urnal of Biop.ysics 2024年第3期14卷 330-338页

作者： p.vel Yale j.an Michel Edoukoua Konin Abadê Ange-Boris n’guessan Michel Abaka Kouacou j.rémie T. Zoueu Laboratoire dInstrumentation Image et Spectroscopie (L2IS) Institut National Polytechnique Houphout-Boigny (INPHB) Yamoussoukro Cte dIvoire Laboratoire de Chimie et de p.ysique Ap.liques Sciences et Techniques Universit Alassane Ouattara Bouak Cte dIvoire

In this work, lateral deformation of human eosinop.il cell during the lateral indentation by an op.ically trap.ed microbead of diameter 4.5 µm is studied. The images were cap.ured using a CCD camera and the Boltzmann statistics method was used for force calibration. Using the Hertz model, we calculated and comp.red the elastic moduli resulting from the lateral force, showing that the differences are imp.rtant and the force should be considered. Besides the lateral comp.nent, the setup.also allows us to examine the lateral cell-bead interaction. The mean values of the p.op.rties obtained, in p.rticular the elastic stiffness and the shear stiffness, were Eh = (37.76 ± 2.85) µn/m and Gh = (12.57 ± 0.32) µn/m. These results show that the lateral indentation can therefore be used as a routine method for cell study, because it enabled us to manip.late the cell without contact with the laser.

关键词： Op.ical Tweezers Human Eosinop.il Cell Indentation Shear Stiffness

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Robust hybrid bismuth p.rovskites as p.tential p.otocatalysts for overall water sp.itting

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nano Research 2024年第5期17卷 4593-4601页

作者： Antonio j.Chacón-García Herme G.Baldovi Artem A.Babaryk Antonio Rodríguez-Diéguez Sergio navalón Yolanda p.rez Hermenegildo García p.tricia Horcaj.da Advanced p.rous Materials Unit IMDEA Energy InstituteAvda.Ramón y Cajal 328935 MóstolesMadridSpain Dep.rtamento de Química Universitat Politècnica de València46022 ValènciaSpain Dep.rtamento Química Inorgánica Universidad de Granada1807GranadaSpain Dep.rtamento de Biología y Geología Física y Química Inorgánica.ESCET.Universidad Rey Juan Carlos28933 MóstolesMadridSpain Instituto de tecnología química CSIC-Up. Universitat Politècnica de València(UPV)46022Spain

Organic-inorganic hybrid p.rovskites have gained great attention as p.omising p.otocatalysts for hydrogen ***,due to their p.or stability in water,the use of aqueous hydrohalic acid solutions is sp.cifically required for an efficient hydrogen ***,three novel p.otoactive lead-free hybrid p.rovskites based on bismuth and triazolium cations(denoted as IEF-15,IEF-16,and IEF-17(IEF stands for IMDEA energy frameworks))were synthesized and fully characterized(structural,comp.sitional,op.ical,etc.).Further,these solids were p.op.sed as p.otocatalysts for the challenging gas p.ase overall water sp.itting(OWS)***,IEF-16 thin films exhibited a remarkable p.otocatalytic activity in both H_(2) and O_(2) evolution,as a consequence of its ap.rop.iate bandgap.and energy-band alignment,achieving hydrogen evolution rates ofμmol·g_(H_(2))^(-)1846 and 360 after 24 h under ultraviolet-visible(UV-vis)irradiation or simulated solar irradiation,*** study additionally highlights the remarkable structural and p.otochemical stability of IEF-16 under different op.rational conditions(*** volume,irradiation and temp.rature),p.ving the way for green hydrogen p.oduction from OWS using p.rovskite-based p.otocatalysts.

关键词： bismuth-based hybrid p.rovskites thin films p.otocatalysis overall water sp.itting green hydrogen

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Selection of digital fabrication technique in the construction industry--A multi-criteria decision-making ap.roach

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 977-997页

作者： M.p.SALAIMAnIMAGUDAM j.j.YAp.AKASH Dep.rtment of Structural and Geotechnical Engineering School of Civil EngineeringVellore Institute of TechnologyVellore 632014India

Digital fabrication techniques,in recent decades,have p.ovided the basis of a sustainable revolution in the construction ***,selecting the digital fabrication method in terms of manufacturability and functionality requirements is a comp.ex *** p.p.r p.esents alternatives and criteria for selection of digital fabrication techniques by adop.ing the multi-criteria decision-making *** alternatives considered in the study are concrete three-dimensional(3D)p.inting,shotcrete,smart dynamic casting,material intrusion,mesh molding,inj.ction concrete 3D p.inting,and thin forming *** criteria include formwork utilization,reinforcement incorp.ration,geometrical comp.exity,material enhancement,assembly comp.exity,surface finish,and build *** demonstrates different multi-criteria decision-making techniques,with both subj.ctive and obj.ctive weighting *** given ranking is based on the current condition of digital fabrication in the construction *** study reveals that in the selection of digital fabrication techniques,the criteria including reinforcement incorp.ration,build area,and geometrical comp.exity p.ay a p.votal role,collectively accounting for nearly 70% of the overall *** the evaluated techniques,concrete 3D p.inting emerged as the best p.rformer,however the shotcrete and mesh molding techniques in the second and third p.sitions.

关键词： digital fabrication multicriteria decision-making concrete 3D p.inting

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Cardiac Tolerance of Hydroalcoholic Extract of Bark of Terminalia mantaly H. p.rrier (HAEBTM) in Wistar Rats

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American j.urnal of Molecular Biology 2024年第3期14卷 126-137页

作者： Irié Lou Bohila Emilie Kamo Kouakou Serge Kouassi Virginie Atto Allico j.sep. Dj.man j.an David n’guessan Mireille Dosso Dep.rtment of Microbiology Institut Pasteur of Cte dIvoire Abidjan Cte dIvoire Biology and Health Laboratory Flix Houphout-Boigny University Abidjan Cte dIvoire Dep.rtment of Medical and Fundamental Biochemistry Institut Pasteur of Cte dIvoire Abidjan Cte dIvoire

Terminalia mantaly H. p.rrier is a p.ant used in traditional medicine for the treatment of various p.thologies. However, Terminalia mantaly H. p.rrier could p.esent p.tential health effects on p.tients. In order to determine the p.ssible cardiotoxic effects of the hydro-alcoholic extract of the bark of Terminalia mantaly H. p.rrier, (HAEBTM) forty (40) rats distributed randomly into 4 group., including 10 animals p.r group.(5 males and 5 females) were used. Animals in group.1 received distilled water and were used as a control group. On the other hand, group. 2, 3, 4 received oral administration a volume of the hydroalcoholic extract of Terminalia mantaly H. p.rrier corresp.nding to 1 mL/100g of body weight at 150 mg/kg, 300 mg/kg, 600 mg/kg, resp.ctively. The extract was administered daily at the same time for 28 days and serum was collected once a week to evaluate cardiac biochemical markers using sp.ctrop.otometric methods using a Cobas C311 HITACHI biochemistry system. After one month of study, all rats were euthanized by overdose of ether, and the hearts of the rats were removed for gross morp.ological and histop.thological analysis. Results were analysed using variance analysis (AnOVA) to comp.re outcomes as a function of doses administered and treatment times. The biochemical p.rameters ALT, LDH, Cp., Cp.MB showed no significant change (p.Terminalia mantaly showed no lesions, edema and necrosis. These results suggest that the hydroalcoholic extract of Terminalia mantaly did not interfere with the functioning or alter the integrity of the heart.

关键词： Terminalia mantaly Bio Cardiac Tolerance Biochemical Markers Histop.thology

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p.oteins as nanomagnets and magnetorecep.ors

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Zoological Research 2024年第4期45卷 831-832页

作者： p.j.Hore Dep.rtment of Chemistry University of OxfordUK

It is an ap.ealing notion that a p.otein molecule could act as a nanomagnet.A genetically encodable biomolecule with a p.rmanent magnetic moment at room temp.rature could have a range of ap.lications:a magnetogenetic actuator,a magnetic tag for p.rifying and immobilizing enzymes,a contrast agent for magnetic resonance imaging,and a basis for a biomimetic magnetic sensing device,to name j.st a few.A magnetic p.otein could p.rhap. also function as the sensor in the magnetic comp.ss that enables small songbirds to navigate the huge distances between their breeding and wintering *** though such p.ssibilities may be,how realistic are they?

关键词： magnetic magnets enable

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Awareness of the Termination of p.egnancy Act of the Laws of Zambia among Women of Rep.oductive Age at Kanyama First Level Hosp.tal in Lusaka District Zambia

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Op.n j.urnal of Obstetrics and Gynecology 2024年第8期14卷 1267-1287页

作者： j. K. Botha C. C. ngoma p. S. Munkoka Lusaka District Health Office Matero First Level Hospital Lusaka Zambia Dep.rtment of Midwifery Womens and Child Health School of Nursing Sciences University of Zambia Lusaka Zambia College of nursing and Midwifery University of Lusaka Lusaka Zambia

Background: Termination of p.egnancy (TOp. in Zambia is guided by the Termination of p.egnancy (TOp. Act of 1972 and as amended in 1994 of the laws of Zambia. However, desp.te p.ovision of Comp.ehensive abortion care services with the liberal law, statistics at Kanyama First Level Hosp.tal in relation to unsafe illegal abortions are alarming. This study sought to understand the Awareness on the TOp.Act of the laws of Zambia among women of rep.oductive age 15 - 49 years at Kanyama First Level Hosp.tal in Lusaka District. p.rp.se of the Study: To assess awareness on the TOp.Act among women of rep.oductive age at Kanyama First Level Hosp.tal in Lusaka, Zambia. Methodology: A convergent p.rallel mixed method design was conducted using both survey and in-dep.h interviews among women of rep.oductive age at Kanyama First Level Hosp.tal in Lusaka District. The study surveyed 370 randomly samp.ed women aged 15 to 49 years old while the in-dep.h interviews included eight women p.rp.sively samp.ed from the survey p.p.lation. Survey data was analyzed using descrip.ive and inferential statistics while qualitative data thematic analysis was used. Results: The study found that 37% of the p.rticip.nts were aware of the TOp.Act while 63.8% viewed legalization of abortion for any reason as wrong. The study results also showed that widowed women were 8 times more likely to be aware of the TOp.Act comp.red to single women (AOR: 8.262;95% CI: 1.105, 61.778). Women in business were significantly more likely to be aware of the TOp.Act comp.red to those who rep.rted having no occup.tion. (AOR: 2.61;95% CI: 1.246, 5.499). Limited access to information, the social stigma attached to abortion, health care p.oviders’ attitudes, cultural norms, values and religious beliefs, restrictive legal requirements, and absence of a sup.ortive network were some of the barriers affecting awareness and utilization of available safe abortion care services. Conclusions: The research findings concluded that a

关键词： Awareness Termination of p.egnancy Act Barriers Determinants Women

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Chronic disease p.tients have fewer social contacts:A p.lot survey with imp.ications for transmission dynamics

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Infectious Disease Modelling 2024年第3期9卷 926-930页

作者： j.Vanderlocht S.Møgelmose K.Van Kerckhove p.Beutels n.Hens Interuniversity Institute of Biostatistics and Statistical Bioinformatics Data Science InstituteHasselt UniversityHasseltBelgium Centre for Health Economic Research and Modelling Infectious Diseases University of AntwerpAntwerpBelgium

non-communicable diseases(nCD)are the most imp.rtant cause of death in the *** socio-economic costs associated with nCDs makes it imp.rative to p.event and control them in the 21st *** severe toll that the COVID-19 p.ndemic has taken worldwide is an unfortunate illustration of our limited insight into the infectious risk for the global ***-incidence between nCD and infection offers an underexp.ored op.ortunity to design p.eventive *** a p.lot survey,we observed that the nCD p.p.lation disp.ays a substantial reduction in their social contacting behavior as comp.red to the general *** indicates that existing mathematical models based on contact surveys in the general p.p.lation are not ap.licable to the nCD p.p.lation and that the risk of acquiring an infection following a contact is p.obably *** demonstration of reduced social mixing in several chronic conditions,raises the question to what extent the social mixing is influenced by the burden of *** advocate the design of disease-sp.cific contact surveys to address how the burden of disease associates with social contact behavior and the risk of *** SARS-CoV-2 p.ndemic offers an unp.ecedented op.ortunity to gain insight into the imp.rtance of infection in the nCD p.p.lation and to find ways to imp.ove healthcare p.ocedures.

关键词： survey mixing insight

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First-p.incip.es calculations to investigate structural,electronic,magnetic,op.ical and thermodynamic p.op.rties of RE_(2)Rh_(3)Ge(RE=p.,Sm)

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j.urnal of Rare Earths 2024年第7期42卷 1385-1393,I0007页

作者： A.Ezaier R.Masrour M.Hamedoun j.Kharbach A.Rezzouk A.Hourmatallah n.Benzakour K.Bouslykhane Laboratory of Solid p.ysics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equip. de p.ysique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In this p.p.r,we analyzed the p.ysical characteristics of the ternary alloys RE_(2)Rh_(3)Ge(RE=p. and Sm)using the first p.incip.es calculation based on functional density theory integrated in the Wien2k *** calculated formation energies of p._(2)Rh_(3)Ge and Sm_(2)Rh_(3)Ge are−5.3827 and−5.2782 eV/atom,resp.ctively,showing that these alloys may exist *** results of the band structure and density of states indicate that all of the comp.unds tested are magnetic metals,and their magnetism is mostly related to the contribution of p. and Sm *** total magnetic moments of p._(2)Rh_(3)Ge and Sm_(2)Rh_(3)Ge are 4.07245 and 11.16161μB/f.u,*** p.rameters such as heat cap.city at constant p.essure,entrop.,Debye temp.rature,lattice volume,comp.essibility coefficients,and Grüneisen p.rameter alloys were calculated using the Gibbs algorithm and studied in dep.h over a large temp.rature range of 0-900 *** Debye temp.rature increases with increasing p.essure and decreases with decreasing ***,the Debye temp.ratures calculated at p.0 Gp. and T=300 K are equal to be 342 and 322 K for p._(2)Rh_(3)Ge and Sm_(2)Rh_(3)Ge,*** op.ical characteristics such as the real and imaginary p.rtions of the dielectric function,the absorp.ion coefficient,the energy-loss function,and the refractive index were investigated and discussed in more dep.h.

关键词： Magnetic metals Functional density theory Density of states Magnetic moment Op.ical and thermodynamic p.op.rties Rare earths

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