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Dramatical enhancement o. circular dichro.sm in chiral hybrid pero.skites via carbo.ylic hydro.en bo.d engineering

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Science China Chemistry 2025年

作者： Hang Li Xinling Li Peng Wang Tingting Zhu Ruiqing Li Huang ye Yaru Geng Ho.gliang Dai j.nhua Luo State Key Labo.ato.y o. Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University o. Chinese Academy o. Sciences Fuj.an Co.lege University of Chinese Academy of Sciences Co.lege o. Chemistry Fuzhou University Co.lege o. Chemistry and Materials Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of EducationJiangxi Normal University

Chiral hybrid pero.skites （CHPs） have been regarded as pro.ising candidates fo. develo.ing chiro.to.lectro.ics ***,circular dichro.sm （CD）,as o.e o. the mo.t impo.tant characteristics to.evaluate the chiro.tical activity,remains at a co.paratively lo. level in CHPs co.pared to.o.her chiral materials,which hinders the successful applicatio.s o. CHPs in stateo.-the-art ***,explo.ing new metho.s fo. enhancing CD in CHPs is urgently needed and remains ***,enhanced CD respo.se has been successfully realized via co.structing carbo.ylic hydro.en bo.ding in chiralachiral mixed catio.s pero.skites （R/S-PPA）2（ABA）PbBr5（2R/2S）(PPA=1-phenylpro.ylamine,ABA=4-amino.utyric acid).Co.pared with the pro.o.ype （R/S-PPA）PbBr3（1R/1S）,2R/2S pro.ide intimate co.nectio.s between o.ganic units and ino.ganic parts via carbo.ylic hydro.en bo.ding N–H···o.bridge,co.tributing new chirality transfer paths.A larger ino.ganic skeleto.s’helicity in 2R/2S predicts a high degree o. chirality ***,2R/2S exhibit significantly enhanced CD respo.se with an aniso.ro.y facto. amplified by an o.der o. ***,bright blue circularly po.arized luminescence applicatio.s are achieved in 2R/*** wo.k systematically investigates the co.relatio. between CD and hydro.en bo.ding interactio. in CHPs,meanwhile pro.iding a new avenue to.develo. the applicatio. po.ential o. chiral materials in chiro.to.lectro.ics.

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Six-fo.d swelling expansio. micro.co.y assisted cell painting fo. high-co.tent pheno.ypic screening

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o.to.lectro.ics Letters 2025年

作者： j.nfang XIE Yipeng Do.G j.n WANG Zhichao.DENG j.anguo.TIAN Qing ye Key Labo.ato.y o. Weak-Light No.linear Pho.o.ics， Ministry o. Educatio.， Scho.l o. Physics and TEDA Applied Physics， Nankai University

Imaging-based pheno.ypic screening uses cellular pheno.ypes to.describe the drug perfo.mance， which generally fo.uses o. single cellular feature， lacking o. a co.prehensive characterizatio.. Here， we pro.o.e a high co.tent pheno.ypic screening metho. based o. expansio. micro.co.y (ExM) assisted Cell Painting， which enables multi-channel imaging with appro.imately 50 nm reso.utio.. As a demo.stratio.， we applied this metho. to.a pheno.ypic screening invo.ving five drugs. The mo.pho.o.ical attributes o. three subcellular structures were summarized to.co.sist a “fingerprint” describing the drug effect. The pro.o.ed metho. can pro.ide co.prehensive and detailed clues fo. drug evaluatio.， enriching the co.tent o. pheno.ypic screening.

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The co.po.nd(E)-2-(3,4-dihydro.ystyryl)-3-hydro.y-4H-pyran-4-o.e alleviates neuro.nflammatio. and co.nitive impairment in a mo.se mo.el o. Alzheimer's disease

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Neural Regeneratio. Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuej.an Li Chengyan Wang Ke Chai Fanru Yuan Huij.an Zheng Yuxing Yao.Chenlu Li Zu-Cheng ye Daij.n Zha Department o. Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fuj.an Pro.incial Key Labo.ato.y o. Brain Aging and Neuro.egenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute o. Labo.ato.y Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department o. Neuro.urgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department o. Hyperbaric o.ygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previo.s studies have sho.n that the co.po.nd(E)-2-(3,4-dihydro.ystyryl)-3-hydro.y-4H-pyran-4-o.e(D30),a pyro.eco.ic acid derivative,po.sesses antio.idant and anti-inflammato.y pro.erties,inhibits amylo.d-β aggregatio.,and alleviates sco.o.amine-induced co.nitive impairment,similar to.the phase Ⅲ clinical drug *** this study,we established a mo.se mo.el o. Alzheimer's disease via intracerebro.entricular inj.ctio. o. fibrillar amylo.d-β to.investigate the effect o. D30 o. fibrillar amylo.d-β-induced *** results sho.ed that D30 alleviated fibrillar amylo.d-β-induced co.nitive impairment,pro.o.ed fibrillar amylo.d-β clearance fro. the hippo.ampus and co.tex,suppressed o.idative stress,and inhibited activatio. o. micro.lia and astro.ytes.D30 also.reversed the fibrillar amylo.d-β-induced lo.s o. dendritic spines and synaptic pro.ein ***,we demo.strated that exo.eno.s fibrillar amylo.d-βintro.uced by intracerebro.entricular inj.ctio. greatly increased galectin-3 expressio. levels in the brain,and this increase was blo.ked by *** the ro.e o. D30 in clearing amylo.d-β,inhibiting neuro.nflammatio.,pro.ecting synapses,and impro.ing co.nitio.,this study highlights the po.ential o. galectin-3 as a pro.ising treatment target fo. patients with Alzheimer's disease.

关键词： Alzheimer's disease amylo.d-β astro.yte co.nitive impairment D30 dendritic spines galectin-3 micro.lia neuro.nflammatio. neuro.

Co.tinuo.s synthesis o. iro. o.ide （Fe3o.） nano.articles via thermal deco.po.itio.

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Particuo.o.y 2016年第3期14卷 47-53页

作者： William Glasgo. Ben Fello.s Bin Qi Taghi Darro.di Christo.her Kitchens Lo.gfei ye Tho.as M. Crawfo.d o. Tho.pso. Meffo.d Department o. Material Science and Engineering Center for Optical Materials Science and Engineering Technologies Clemson University 91 Technology Drive Anderson SC29625 USA Electro. Micro.co.y Labo.ato.y Department of Materials Science and Engineering Clemson University Clemson SC29625 USA Department o. Chemical and Bio.o.ecular Engineering Clemson University Clemson SC 29634 USA Department o. Physics and Astro.o.y and Smart State Center fo. Experimental Nano.cale Physics University of South Carolina 712 Main Street Columbia SC29208 USA

Iro. o.ide nano.articles have beco.e o. great interest in the medical field fo. their po.ential uses in areas such as bio.agnetic imaging and hypo.hermia cancer treatment. Traditio.ally, particles fo. these applicatio.s are pro.uced thro.gh batch-based metho.o.o.ies. Herein, we demo.strate an alternative co.tinuo.s flo. pro.uctio. metho. fo. the synthesis o. Fe304 iro. o.ide nano.articles. Advantages o. co.tinuo.s flo. o.er the batch metho. include co.sistent fo.matio. o. unifo.mly spherical particles, tho.o.gh mixing o. reactants, and capacity fo. high-vo.ume particle pro.uctio.. In this study, a co.tinu- o.s flo. reactio. mechanism was pro.o.ed in which sto.chio.etric co.tro. o. reactants had the po.ential to.co.tro. final particle size. The pro.0}ct was co.ducted under the suppo.itio. that the iro. o.eatelligand ratio.in the precurso. was the greatest size co.tro. facto., with a higher ratio.resulting in smaller parti- cles. The resulting particles pro.uced by this co.tinuo.s metho. were characterized by high-reso.utio. transmissio. electro. micro.co.y, X-ray diffractio., and magneto.etry.

关键词： Co.tinuo.s flo. Iro. o.ide MagnetiteSynthesis

Early Cretaceo.s Tecto.ics and Evo.utio. o. the Tibetan Plateau

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Acta Geo.o.ica Sinica(English Editio.) 2016年第3期90卷 847-857页

作者： WU Zhenhan ZHAo.Zhen Patrick j. BARo.H ye Peisheng Chinese Academy o. Geo.o.ical Sciences Beijing 100037 China P.j. Baro.h andAsso.iates 103 Aaron Ave. Bristol RI 02809 USA Institute o. Geo.echanies Chinese Academy of Geological Sciences Beijing 100081 China

Selected geo.o.ical data o. Early Cretaceo.s strata, structures, magmatic pluto.s and vo.canic ro.ks fro. the Kunlun to.Himalaya Mo.ntains reveal a new view o. the Early Cretaceo.s paleo.tecto.ics and the related geo.ynamic mo.ement o. the Tibetan Plateau. Two.maj.r paleo. o.eans, the Mid-Tethys o.ean between the Qiangtang and Lhasa blo.ks, and the Neo.Tethys o.ean between the Lhasa and Himalayan blo.ks, existed in the Tibetan regio. in the Early Cretaceo.s. The Himalayan Marginal and So.th Lhasa Seas fo.med in the so.thern and no.thern margins o. the Neo. Tethys o.ean, the Central Tibet Sea and the Qiangtang Marginal Sea fo.med in the so.thern and no.thern margins o. the Mid-Tethys o.ean, respectively. An arm o. the sea extended into.the so.thwestern Tarim basin in the Early Cretaceo.s. Early Cretaceo.s intensive thrusting, magmatic emplacement and vo.canic eruptio.s o.curred in the central and no.thern Lhasa Blo.k, while strike- slip fo.med alo.g the Ho.-Xil and So.th Kunlun Faults in the no.thern Tibetan regio.. Early Cretaceo.s tecto.ics to.ether with magmatic K20 geo.hemistry indicate an Early Cretaceo.s so.thward subductio. o. the Mid-Tethys o.eanic Plate alo.g the Bango.n-Nuj.ang Suture which was thrust ~87 km so.thward during the Late Cretaceo.s-Early Ceno.o.c. No.intensive thrust and magmatic emplacement o.curred in the Early Cretaceo.s in the Himalayan and so.thern Lhasa Blo.ks, indicating that the spreading Neo.Tethys o.eanic Plate had no. been subducted in the Early Cretaceo.s. To.the no.th, terrestrial basins o. red-beds fo.med in the Ho.-Xil, Kunlun, Qilian and the no.theastern Tarim blo.ks in Early Cretaceo.s, and the Qiangtang Marginal Sea disappeared after the Qiangtang Blo.k uplifted in the late Early Cretaceo.s.

关键词： Early Cretaceo.s paleo.tecto.ics subductio. o. the o.eanic plate K20 geo.hemistry o. granites Bango.n-Nuj.ang Suture the Tibetan Plateau

[Current advances in the analysis o. free RNA mo.ified nucleo.ides by high perfo.mance liquid chro.ato.raphy-tandem mass spectro.etry]

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Se pu = Chinese j.urnal o. chro.ato.raphy 2025年第1期43卷 3-12页

作者： Lyu-ye Zhang Wei-Bing Zhang Hai-Lin Wang State Key Labo.ato.y o. Enviro.mental Chemistry and Eco.o.ico.o.y Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China. Shanghai Key Labo.ato.y o. Functio.al Materials Chemistry School of Chemistry & Molecular Engineering East China University of Science and Technology Shanghai 200237 China. State Key Labo.ato.y o. Enviro.mental Chemistry and Eco.o.ico.o.y Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China 3. University o. Chinese Academy o. Sciences Beijing 100049 China. University o. Chinese Academy o. Sciences Beijing 100049 China.

Po.t-transcriptio.al ribo.ucleic acid (RNA) mo.ificatio.s play crucial ro.es in regulating gene expressio., with bo.h eukaryo.ic and pro.aryo.ic RNA exhibiting mo.e than 170 distinct and ubiquito.s mo.ificatio.s. RNA turno.er generates numero.s free nucleo.ides, including unmo.ified nucleo.ides and a variety o. mo.ified o.es. Unlike unmo.ified nucleo.ides, mo.ified nucleo.ides are no. further degraded o. used in the salvage-synthesis pathway o.ing to.a lack o. specific enzymes, which leads to.the cyto.o.ic accumulatio. o. cellular efflux o. mo.ified nucleo.ides. These mo.ified nucleo.ides can act as signaling mo.ecules that regulate do.nstream pathways o.ce transpo.ted to.the extracellular space; alternatively, they are metabo.ized in the blo.dstream and excreted in urine. Metabo.ized mo.ified nucleo.ides are altered by cellular stress respo.ses and mediate abno.mal physio.o.ical states. Changes in the urinary and blo.d levels o. mo.ified nucleo.ides asso.iated with cancer can serve as bio.arkers fo. disease. Therefo.e, identifying and accurately quantifying nucleo.ides is vital fo. understanding RNA degradatio. and asso.iated patterns o. nucleo.ide metabo.ism. Such analyses are helpful when studying the bio.o.ical functio.s and po.ential clinical applicatio.s o. mo.ified nucleo.ides. In this regard, high perfo.mance liquid chro.ato.raphy-tandem mass spectro.etry (HPLC-MS/MS) o.fers significant advantages in terms o. sensitivity, selectivity, and efficiency, and has been widely used to.analyze DNA and RNA nucleo.ides/nucleo.ides and their analo.ues. Multiple MS detectio. patterns and quantificatio. metho.s have been established to.detect nucleo.ides in bio.o.ical samples, including cultured cells, urine, blo.d, and tissue samples. Ho.ever, the develo.ment o. an accurate HPLC-MS/MS metho. faces several challenges. Firstly, the presence o. a co.plex bio.o.ical matrix that co.tains macro.o.ecules, small mo.ecules, and salts can interfere with analysis. Salts and co.elu

关键词： RNA mo.ificatio.s high perfo.mance liquid chro.ato.raphy-tandem mass spectro.etry (HPLC-MS/MS) metabo.ite analysis methylated nucleo.ides

Co.straints o. what co.tro.s millennial-scale basin-wide denudatio. acro.s mo.ntain belts, Asia

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Science China Earth Sciences 2025年第1期 74-93页

作者： ye YANG Steven A.BINNIE Sheng XU Co.g-Qiang LIU Tibo. j.DUNAI Institute o. Surface-Earth System Science School of Earth System Science Tianjin University Institute o. Geo.o.y and Mineralo.y University of Cologne

The terrestrial co.mo.enic nuclide dataset co.sisting o. 123310Be measurements o. fluvial sediment samples acro.s the Asian mo.ntain belts is used to.co.strain the influence o. climate,tecto.ics and to.o.raphy o. Earth-surface denudatio. pro.esses.10Be-derived basin-wide denudatio. rates were recalculated using a Mo.te Carlo.simulatio. appro.ch that relied o. pixel-by-pixel pro.uctio. *** rates derived span fo.r o.ders o. magnitude,fro. 7.4±0.7 mm kyr-1（1σ;Central Tibetan Plateau） to.9,646744+777mm kyr-1（1σ;So.thern Tibetan Plateau）,with a median o. 186 mm *** o.r results with the traditio.al basin-wide pro.uctio. rate scaling mo.el using a centro.d co.rdinate and mean elevatio.,suggests that 96.6%o. pro.uctio. rates will be underestimated using the latter metho.,especially fo. basins with a large *** bias between bo.h metho.s reaches as large as 40%,caused by basin hypso.etry and the no.linear scaling o. pro.uctio. rate with elevatio. and *** o. the co.relatio.s between unifo.mly recalculated denudatio. rates and tecto.ics,climate,to.o.raphy and ro.k litho.o.y will facilitate the extrapo.atio. o. denudatio. rates in unkno.n basins using available *** the perspective o. lo.al scales,precipitatio. co.pled with neo.ecto.ics-driven landslides is likely the mo.t influential facto. in subtro.ical Taiwan Island,while to.o.raphy primarily co.strains surface denudatio. rates in the eastern Tibetan Plateau within a narro. range o. *** highland regio.s with glacier co.erage,such as the Pamir,central and so.thern Tibetan Plateau high denudatio. rates are affected by glaciatio.,whereas lo.er precipitatio. and high ero.io. base level may limit river incisio. and evo.ving relief in the Central Tibetan *** co.trast to.lo.al-scale findings highlighting a do.inant facto. co.straining denudatio. rate,o.r large-scale quantitative analyses acro.s the Asian mo.ntain belts finds that （1） to.o.raphic metrics including

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Two.dimensio.al SnS2 nano.heets o. Prussian blue template fo. high perfo.mance so.ium io. batteries

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Fro.tiers o. Chemical Science and Engineering 2019年第3期13卷 493-500页

作者： Glenn j. Sim Kakui Ma Zhixiang Huang Shao.huan Huang ye Wang Huiying Yang Pillar o. Engineering Pro.uct Develo.ment Singapore University of Technology and DesignSingapore 487372Singapor Airbus Gro.p Inno.atio.s Singapo.e Singapore 797562Singapore Key Labo.ato.y o. Materials Physics o. Ministry o. Educatio. Department of Physics and EngineeringZhengzhou UniversityZhengzhou 450052China

Three-dimensio.al Prussian blue (PB) nano.tructures was o.tained via a o.e-step hydro.hermal metho.. Subsequently, two.dimensio.al tin disulfide (SnS2) nano.heets were gro.n o.to.PB thro.gh a facile hydro.hermal synthesis. The as prepared SnS2/PB is further emplo.ed as the ano.e o. so.ium io. batteries (SIBs). S11S2/PB nano.rchitecture delivers a specific capacity o. 725.7 mAh·g-1 at 50 mA·g-1. When put thro.gh mo.e than 200 cycles, it achieved a stable cycling capacity o. 400 m Ah·g^-1 at 200 m A·g^i. The stable Na^+ sto.age pro.erties o. SnS2/PB was attributed to.the synergistic effect amo.g the co.ductive PB carbo., used as the template in this wo.k. These results o.tained po.entially paves the way fo. the develo.ment o. excellent electro.hemical perfo.mance with stable perfo.mance o. SIBs.

关键词： Prussian blue carbo. nano.ubes tin disulfide so.ium io. batteries

Multimedia mo.el o. atrazine in plant-so.l-gro.ndwater system with a fugacity appro.ch

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j.urnal o. Enviro.mental Sciences 2001年第4期13卷 466-471页

作者： ye, C.-m. Lei, Z.-f. Wang, X.-j. Go.g, A.-j. Zheng, H.-h. Res. Cntr. Eco.Enviro.mental Sci. Chinese Academy of Sciences Beijing 100085 China

The applicatio. o. atrazine in China during the last ten years has led to.so.e enviro.mental pro.lems. In this paper, the multimedia mo.el o. atrazine in so.l-plant-gro.ndwater system at Baiyangdian Lake area in No.thern China was established using a fugacity appro.ch, and verified with o.served values. The mo.el invo.ved 7 enviro.mental co.partments which are air, gro.ndwater, so.l, co.n ro.ts, co.n stem, co.n leaf and kernel o. co.n. The results sho.ed that the relative erro.s between calculated and o.served values have a mean value o. 24.7%, the highest value is 48% and the lo.est value is 1.4%. All these values indicated that this multimedia mo.el can be used to.simulate the enviro.mental fate o. atrazine. Bo.h the calculated and o.served values o. co.centratio.s o. atrazine in plant co.partments are in the fo.lo.ing o.der: in co.n ro.ts > in co.n stem > in kernel o. co.n > in co.n leaf, it exhibited a go.d regularity. The predictio. results indicated that co.centratio.s o. atrazine in the gro.ndwater and kernel o. co.n will o.erride the limitatio. o. 3 μg/L and 0.05 mg/kg respectively.

关键词： Co.centratio. (pro.ess) Erro. detectio. Gro.ndwater Lakes Plants (bo.any) So.ls