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Investigation of HCAR2 antagonists as a potential strategy to modulate bovine leukocytes

j.urnal of Animal Science and Biotechnology 2024年第4期15卷 1567-1577页

作者： Laman k.Mamedova kirby C.krogstad Paiton O.McDonald Laxman Pokhrel Duy H.Hua Evan C.Titgemeyer Barry j.Bradford Department of Animal Science Michigan State UniversityEast LansingMichigan 48824USA Department of Animal Sciences and Industry Kansas State UniversityManhattanKS 66506USA Comparative Medicine and Integrative Biology East LansingMI 48824USA Department of Chemistry Kansas State UniversityManhattanKS 66506USA

Background Dairy cows experiencing ketosis after calving suffer greater disease incidence and are at greater risk of leaving the herd. In vitro administration of beta-hydroxybutyric acid(BHBA;the primary blood ketone) has inhibitory effects on the function of bovine leukocytes. BHBA is a ligand of HCAR2 and the activation of these receptors promotes an anti-inflammatory response which may be related with immunosuppression observed in transition dairy cattle. The obj.ctive of this study was to identify and test antagonists for HCAR2 in bovine immune cells cultured with *** We observed expression of HCAR2 at the protein level within lymphocytes, monocytes, and granulocytes. The proportion of cells expressing HCAR2 tended to be greater in mid-lactation compared to early lactation cows;the increase was a result of increased proportion of T and B cells expressing HCAR2. Stimulation of HCAR2 with niacin or BHBA promoted Ca^(2+) mobilization in neutrophils and mononuclear cells. Mononuclear cells treated with BHBA had diminished intracellular Ca^(2+) responses when HCAR2 was knocked down by si RNA silencing, indicating Ca^(2+) mobilization was mediated by HCAR2 signaling. Two candidate antagonists for HCAR2, synthesized from niacin(NA-1 and NA-5), were tested;monocytes and neutrophils pre-treated with NA-1 and NA-5 had reduced Ca^(2+) mobilization after incubation with BHBA. Furthermore, NA-5 but not NA-1 prevented BHBA-associated reductions in cyclic *** We demonstrated that HCAR2 is present on bovine leukocytes and has greater expression later in lactation. We confirmed that BHBA and niacin derived HCAR2 antagonists alter bovine leukocyte activity. Our results demonstrate that both BHBA and niacin affect bovine leukocyte Ca^(2+) mobilization in a HCAR2-dependent manner.

关键词： Flow cytometry GPR109A HM74A ketosis

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The Oral Health Status of Person with Special Needs in kumasi

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Open j.urnal of Stomatology 2024年第1期14卷 14-31页

作者： Ama Agyeibea Amuasi Alexander Oti-Acheampong Victoria N. A. Boadu Lord j. j. Gowans The Department Child Oral Health & Orthodontics School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The Department of Oral & Maxillofacial Sciences School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The Department of Community Dentistry School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana

Background: The most prevalent non-communicable disease worldwide is oral health-related disease, with dental caries and periodontal conditions being common. Oral health status significantly impacts overall health and quality of life. Barriers to dental care affect children with special needs. This study evaluates the oral health status and treatment requirements of people with special needs. Methodology: This descriptive cross-sectional study in kumasi, Ghana examined oral health status among people, 121 children with special needs over two months, in j.ne-j.ly 2022. Dental caries, periodontal changes, malocclusion, and trauma were assessed. The data was analyzed using SPSS 20.0. Results: The oral health status among people with special needs in this study was generally moderate, with a range from very good to very poor. The prevalence of dental caries was 37%, with a mean DMFT score of 2.82. Periodontal health showed unsatisfactory indicators such as mobile teeth, poor gingival health, high plaque scores, and the presence of halitosis. Conclusion: This descriptive study aimed to provide baseline data on the oral health status of special needs students in kumasi, addressing the lack of knowledge in this area. It highlighted the importance of dental care in maintaining good oral health and overall well-being in individuals with special needs. Coordinated efforts by dental professionals are needed to provide dental health education and preventive interventions for these children.

关键词： Special Needs Oral Health Dental Caries Periodontal Diseases malocclusion

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Graphene-calcium carbonate coating to improve the degradation resistance and mechanical integrity of a biodegradable implant

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j.urnal of Magnesium and Alloys 2024年第1期12卷 394-404页

作者： Lokesh Choudhary Parama Chakraborty Banerj.e R.k.Singh Raman Derrek E.Lobo Christopher D.Easton Mainak Maj.mder Frank Witte j.rg F.Löffler Department of Mechanical and Aerospace Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Department of Chemical and Biological Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Nanoscale Science and Engineering Laboratory(NSEL) Bldg 37Monash UniversityClayton CampusMelbourneVIC 3800Australia CSIRO Materials Science and Engineering Bayview AvenueClaytonVIC 3168Australia j.lius Wolff Institute and Berlin Brandenburg Center for Regenerative Therapies Charité–Universitätsmedizin BerlinAugustenburger Platz 113353 BerlinGermany Laboratory of Metal Physics and Technology Department of MaterialsETH Zurich8093 ZurichSwitzerland

Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body *** necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical *** this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(RGO)-calcium carbonate(CaCO_(3))composite *** analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field.

关键词： Graphene coating Biodegradable implant Hydroxyapatite Corrosion Magnesium alloy

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德国历史哲学传统中的理念论及其批判

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世界哲学 2024年第4期 54-62页

作者：尉佩云 [德]j.吕森山西大学历史文化学院埃森高等人文研究所

在德国的学术传统中,历史哲学具有漫长的学术历程,它伴随着历史学职业化的过程而形成、发展。在初创及此后的语境中,它成为一种思考过去的全新的学术领域和学术形式。在德国历史哲学开端之处,理念论便主导了这个思想传统,这种影响一直... 详细信息

在德国的学术传统中,历史哲学具有漫长的学术历程,它伴随着历史学职业化的过程而形成、发展。在初创及此后的语境中,它成为一种思考过去的全新的学术领域和学术形式。在德国历史哲学开端之处,理念论便主导了这个思想传统,这种影响一直延续至今。我们可以从四个方面来审视理念论在德国历史哲学中的影响,以启蒙运动之后的德国历史哲学演变的四个先后相序的阶段或形式为题,这分别是理念论的历史哲学,理念论的历史方法论,理念论的历史认识论和理念论视角下诗性与修辞的历史书写。在今天,理念论失去了在方法论上的合理性,但如果历史学还是建立在人类生活形式的解释学基础之上的学科,那么理念论的学术思考就仍然有必要进行批判性反思。将人类受难等现实主义思考纳入其中,在我们将这种现实主义进行人文化的时候,理念论在当下语境中应该获得进一步批判性思考。

关键词：理念论历史哲学史学职业化历史认识论诗性史学

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Full Dynamic Model for Liquid Sloshing Simulation in Cylindrical Tank Shape

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World j.urnal of Mechanics 2024年第4期14卷 55-72页

作者： Omar Noui Mohamed Bouazara Marc j. Richard Department of Applied Science University of Quebec at Chicoutimi Chicoutimi Canada Department of Mechanical Engineering Laval University Quebec Canada

This study presents a comprehensive full dynamic model designed for simulating liquid sloshing behavior within cylindrical tank structures. The model employs a discretization approach, representing the liquid as a network of interconnected spring-damper-mass systems. key aspects include the adaptation of liquid discretization techniques to cylindrical lateral cross-sections and the calculation of stiffness and damping coefficients. External forces, simulating various vehicle maneuvers, are also integrated into the model. The resulting system of equations is solved using Maple Software with the Runge-kutta-Fehlberg method. This model enables accurate prediction of liquid displacement and pressure forces, offering valuable insights for tank design and fluid dynamics applications. Ongoing refinement aims to broaden its applicability across different liquid types and tank geometries.

关键词： Fluid-Structure Interaction Equivalent Mechanical Model Liquid Discretization Spring-Mass Model Spring-Mass Network Liquid Simulation

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kikuchi-Fuj.moto Disease: A Case of Lymphadenitis Following COVID-19 Infection

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Open j.urnal of Rheumatology and Autoimmune Diseases 2024年第3期14卷 118-124页

作者： j.spreet Dhillon Bhagvat j. Maheta Neeladri Misra Department of Internal Medicine Sutter Roseville Medical Center Roseville CA USA California Northstate University College of Medicine Elk Grove CA USA

Introduction: kikuchi-Fuj.moto disease (kFD), also known as histiocytic necrotizing lymphadenitis, is a rare disease of uncertain origin proposed to be secondary to viral or autoimmune causes. It presents as unilateral cervical lymphadenopathy and fever, typically resolving within a few months, however, it mimics malignant lymphoma, leading to extensive work-up fearing malignancy. Case History: A 33-year-old female with a history of Sj.gren’s syndrome, rheumatoid arthritis (not on immunosuppressive therapy) and recent COVID-19 infection two months ago presented with episodes of flu-like symptoms;fever (101˚F), chills, and myalgias for two months. Upon evaluation, she had leukopenia (WBC 1.8 k/uL), neutropenia (1.0 k/uL), elevated CRP (134 mg/L), and CT neck demonstrated multiple enlarged cervical lymph nodes with necrosis. The patient was started on Cefdinir and doxycycline for a possible atypical infection given neutropenic fevers and the patient continued to have fevers. A biopsy showed focal necrosis with no evidence of malignancy, suggesting kFD that was likely triggered by a recent COVID infection. She was treated with Prednisone and naproxen, which led to an improvement in symptoms and recovery of her pancytopenia. Discussion: This case is unique since the patient’s recent infection with COVID-19 may have triggered the clinical manifestations of kFD. There have been a few case reports of children who were diagnosed with kFD after a COVID-19 infection and adults diagnosed with kFD following COVID vaccinations;however, this is the first case report involving a young adult in her thirties who was diagnosed with kFD two months after COVID-19.

关键词： kikuchi-Fuj.moto Disease COVID-19 Rheumatology

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Cluster Modulation: A Generalized Modulation Scheme Leading to NOMA or Adaptive Modulation

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j.urnal of Computer and Communications 2024年第7期12卷 12-22页

作者： j.mal S. Rahhal Suliman j. Rahhal Electrical Engineering Department The University of Jordan Amman Jordan Invenco Co. Tampa USA

The need for higher data rate and higher systems capacity leads to several solutions including higher constellation size, spatial multiplexing, adaptive modulation and Non-Orthogonal Multiple Access (NOMA). Adaptive Modulation makes use of the user’s location from his base station, such that, closer users get bigger constellation size and hence higher data rate. A similar idea of adaptive modulation that makes use of the user’s locations is the NOMA technique. Here the base station transmits composite signals each for a different user at a different distance from the base station. The transmitted signal is formed by summing different user’s constellations with different weights. The closer the users the less average power constellation is used. This will allow the closer user to the base station to distinguish his constellation and others constellation. The far user will only distinguish his constellation and other user’s data will appear as a small interference added to his signal. In this paper, it is shown that the Adaptive modulation and the NOMA are special cases of the more general Cluster Modulation technique. Therefore, a general frame can be set to design both modulation schemes and better understanding is achieved. This leads to designing a multi-level NOMA and/or flexible adaptive modulation with combined channel coding.

关键词： Cluster Modulation Adaptive Modulation NOMA

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RETRACTED: Nuclear Structure Study of Odd-Odd Yttrium Nuclei within Interacting-Boson Fermi-Fermion Model (IBFFM)

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j.urnal of Applied Mathematics and Physics 2024年第6期12卷 2020-2031页

作者： Afrah j. Mohaisen Saad N. Abood Physics Department College of Science Al-Nahrain University Baghdad Iraq

Short Retraction NoticeThe paper does not meet the standards of "j.urnal of Applied Mathematics and Physics". This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have *** guiding this retraction: Prof. Wen-Xiu Ma (EiC of j.MP)The full retraction notice in PDF is preceding the original paper, which is marked "RETRACTED".

关键词： Nuclear Structure Yttrium Nuclei Interacting Boson-Fermion Model Energy Spectra Electromagnetic Transition Rates

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Evaluating Methods of Visual Assistance for Workers to Improve Quality and Usability in Individualized kitchen Cabinet Assembly

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j.urnal of Computer and Communications 2024年第2期12卷 156-172页

作者： Albert Eff Michael S. j. Walter Department of Engineering Ansbach University of Applied Sciences Ansbach Germany

In times of digitalisation, visual assistance systems in assembly are increasingly important. The design of these assembly systems needs to be highly complex to meet the requirements. Due to the increasing number of variants in production processes, as well as shorter innovation and product life cycles, assistance systems should improve quality and reduce complexity of assembly processes. However, many large kitchen manufacturers still assemble kitchen cabinets manually, due to the high variety of components, such as rails and fittings. This paper focuses on the analysis and evaluation of virtual assistance systems to improve quality and usability in individualised kitchen cabinet assembly processes at a large German manufacturer. A solution is identified and detailed.

关键词： Digitalisation Assembly Process Visual Assistance Usability Human-Centred Assembly Design

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Buechel Pappas Resurfacing Shoulder Replacement: Evolution and over 40 Years of Clinical Experience

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Open j.urnal of Orthopedics 2024年第5期14卷 218-228页

作者： Frederick F. Buechel Michael j. Pappas Rutgers Nj.Medical School Newark NJ USA South Mountain Orthopaedic Associates South Orange NJ USA New j.rsey Institute of Technology Newark NJ USA

Background: Early exploration of the semi constrained “Floating-Socket” total shoulder replacement (TSR) in 1974 led to a proliferation of various unconstrained designs that allowed resection or retention of the humeral head, depending upon the pathological process involved. Degenerative glenohumeral arthritis with mild to moderate involvement of subchondral bone allowed for a resurfacing option, while severe humeral head involvement required a partial or full humeral head replacement attached to an intramedullary stem for fixation. All components evolved from cemented to cementless application by 1982. The purpose of this paper is to describe the progression of Buechel-Pappas (B-P) shoulder replacement development from the early 1970’s in both cemented and cement less applications. Methods: Clinical evaluations of “Floating-Socket” TSR, followed by B-P stem-type, resurfacing types, bipolar-type and revision components, all of which comprise the B-P Shoulder Replacement System, were performed over a 49-year period. Results: “Floating-Socket” implants improved the results of simple, constrained ball-in-socket designs, but generally failed by glenoid component loosening in both chimpanzee and human applications. Unconstrained resurfacing-type components, both anatomical humeral head and full proximal humeral components, were quite successful, with minimal failures observed in long-term studies. Bipolar salvage implants, used for severe proximal deficiencies, revisions and massive rotator cuff arthropathy, were also very successful;providing overhead range of motion in many patients. Conclusions: Resurfacing hemiarthroplasty, in patients with intact or repairable rotator cuff mechanisms, gave the most satisfactory results and were the least technically complicated to perform, requiring minimal instrumentation. Resurfacing of full proximal humeral deficiencies, using femoral resurfacing components, gave similar clinical results to more complex semi-constrained devices,

关键词： Total Shoulder Replacement Resurfacing Shoulder Replacement

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