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The hyperpycnite problem: comment

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j.urnal of Palaeogeography 2019年第3期8卷 314-320页

作者： A.j.(Tom) van Loon Heiko Hüneke Thierry mulder Geocom Consulting Valle del Portet 17 03726 Benitachell Spain College of Earth Science and Engineering Shandong University of Science and Technology Qingdao 266590 Shandong China Institute of Geography and Geology Greifswald University Greifswald Germany UMR CNRS EPOC University of Bordeaux Allee Geoffroy St-Hilaire 33615 Pessac Cedex France

A recent review article("The hyperpycnite problem") by Shanmugam(j.urnal of Palaeogeography 7(3):197–238,2018) in this j.urnal has some shortcomings, comes to scientifically incorrect conclusions, and calls for student education in a way that would significantly diminish the students’ changes for a geological career. Having studied--and still studying--hyperpycnites in the field, it seems only appropriate to inform the readers of this j.urnal about our concerns regarding the review article mentioned ***, the article by Shanmugam(j.urnal of Palaeogeography 7(3):197–238, 2018) is not a review paper but rather a comment, criticizing al researchers who have come to the conclusion, on the basis of both field research and theory,that hyperpycnal flows result in sediments(hyperpycnites) with characteristics that make it possible to distinguish them from deposits formed in another way. This is also the essence of Shanmugam’s comment: as he states himself, he is"an ardent critic of al genetic facies models".

关键词： review Shanmugam critic

Nonalcoholic fatty liver disease: An overview of current insights in pathogenesis, diagnosis and treatment

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World j.urnal of Gastroenterology 2008年第16期14卷 2474-2486页

作者： Tim CMA Schreuder Bart j.Verwer Carin Mj.van Nieuwkerk Chris j. mulder Department of Gastroenterology and Hepatology VU University Medical Center

Estimates of people suffering from overweight (one billion) and obesity (300 million) are increasing. The accumulation of triglycerides in the liver, in the absence of excess alcohol intake, has been described in the early sixties. It was not until 1980, however, that Ludwig et al named this condition nonalcoholic steatohepatitis (NASH). Subsequently, nonalcoholic fatty liver disease (NAFLD) has been used as a general name for conditions ranging from simple steatosis through steatohepatitis to end-stage liver disease (cirrhosis). Many studies have demonstrated the significant correlation with obesity and insulin resistance. Other studies have revealed a signifi- cant correlation between hepatic steatosis, cardiovascu- lar disease and increased intima-media thickness. WHO estimated that at least two million patients will develop cirrhosis due to hepatic steatosis in the years to come. Longitudinal cohort studies have demonstrated that those patients with cirrhosis have a similar risk to devel- op hepatocellular carcinoma as those with other causes of cirrhosis. Taken all together, NAFLD has become the third most important indication for liver transplantation. There- fore, training programmes in internal medicine, gastroen- terology and hepatology should stress the importance of diagnosing this entity and treat properly those at risk for developing complications of portal hypertension and con- comittant cardiovascular disease. This review will focus on the clinical characteristics, pathophysiology, imaging tech- niques and the readily available therapeutic options.

关键词： Non-alcoholic fatty liver disease Non-alcoholicsteatohepatitis Insulin resistance Liver Obesity Steatosis

Evaluation of Cladribine treatment in refractory celiac disease type Ⅱ

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World j.urnal of Gastroenterology 2011年第4期17卷 506-513页

作者： Greetj. j.Tack Wieke HM Verbeek Abdul Al-Toma Dirk j.Kuik Marco Wj.Schreurs Otto Visser Chris j. mulder Department of Gastroenterology and Hepatology VU University Medical Center Department of Gastroenterology and Hepatology St. Antonius Hospital Department of Epidemiology and Biostatistics VU University Medical Center Department of Pathology VU University Medical Center Department of Haematology VU University Medical Center

AIM: To evaluate cladribine [2-chlorodeoxyadenosine (2-CdA)] therapy in refractory celiac disease (RCD) Ⅱ. METHODS: An open-label cohort-study of RCD Ⅱ patients treated with 2-CdA was performed between 2000 and 2010. Survival rate, enteropathy associated T-cell lymphoma (EATL) occurrence, clinical course, and histological and immunological response rates were evaluated. RESULTS: Overall, 32 patients were included with a median follow-up of 31 mo. Eighteen patients responded well to 2-CdA. Patients responsive to 2-CdA had a statistically significant increased survival compared to those who were unresponsive. The overall 3- and 5-year survival was 83% in the responder and 63% and 22% in the non-responder group, respectively. The overall 2-year clinical, histological and immunological response rates were 81%, 47% and 41%, respectively. Progression into EATL was reported in 16%, all of these patients died. CONCLUSION: Treatment of RCD Ⅱ with 2-CdA holds promise, showing excellent clinical and histological response rates, and probably less frequent transition into EATL.

关键词： Cladribine Refractory celiac disease Clinical course Enteropathy associated T-cell lymphoma Survival

Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review

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World j.urnal of Gastroenterology 2016年第40期22卷 9012-9021页

作者： Berrie Meij.r Chris j. mulder Godefridus j.Peters Adriaan A van Bodegraven Nanne KH de Boer Department of Gastroenterology and Hepatology VU University Medical Center Department of Medical Oncology VU University Medical Center Department of Gastroenterology Geriatrics Internal and Intensive Care Medicine (Co-MIK) Zuyderland Medical Center

AIM To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease(IBD) patients, irrespective of the(hepato-) toxicity *** A systematic literature search of the MEDLINE database using Pub Med was performed using the keywords "thioguanine", "6-TG", "thioguanine", "inflammatory bowel disease", "IBD", "Crohn's disease", "Ulcerative colitis" and "effectiveness" in order to identify relevant articles published in English starting from 2000. Reference lists of the included articles were crosschecked for missing articles. Reviewed manuscripts concerning the effectiveness of thioguanine treatment in IBD were reviewed by the authors and the data were extracted. Data were subsequently analyzed with descriptive statistics. Due to the lack of standardized outcomes, a formal meta-analysis was not *** A total of 11 applicable studies were found that involved the effectiveness of thioguanine therapy in IBD. Eight studies were conducted in a prospectivemanner, in the remaining three studies, data was collected retrospectively. In total, 353 IBD-patients(225 patients with Crohn's disease, 119 with ulcerative colitis and nine with unclassified IBD) with prior azathioprine/mercaptopurine resistance and/or intolerance(n = 321) or de novo thioguanine administration(n = 32) were included for analysis, of which 228(65%) had clinical improvement on thioguanine therapy, based on standard IBD questionnaires, biochemical parameters or global physician assessments. Short-term results were based on 268 treatment years(median follow-up 9 mo, range 3-22 mo) with a median daily dose of 20 mg(range 10-80 mg). Discontinuation, mostly due to adverse events, was reported in 72 patients(20%). CONCLUSION The efficacy of thioguanine therapy in IBD patients intolerant to conventional thiopurine therapy is observed in 65%, with short term adverse events in 20% of patients.

关键词： Thiopurines Thioguanine Inflammatory bowel disease Crohn’s disease Ulcerative colitis

Perception of the Psychosocial Aspects of Subfertility by Parents Following Successful Medically Assisted Conception: A Qualitative Study

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Open j.urnal of Obstetrics and Gynecology 2016年第13期6卷 830-845页

作者： j. Catj. Warmelink j.niek M. Meij.r Nienke mulder Sybren mulder Mirj.m T. van Lohuizen Department of Midwifery Science AVAG and the EMGO Institute for Health and Care Research VU University Medical Centre Amsterdam The Netherlands Midwifery Academy Amsterdam Groningen Groningen The Netherlands

Nearly 5% of new-borns in the Netherlands are now born following Medically Assisted Conception (MAC), a steadily increasing number. Our qualitative study explored the subj.ctive impact of subfertility and fertility treatment for parents who successfully achieve pregnancy following MAC and make health professionals more aware of the psychological needs of those clients. The study was based on the constructive/interpretative paradigm using a constant comparison/grounded theory design. Two men and nine women in the Netherlands who conceived as a result of MAC were interviewed in 2011. Our findings show that MAC-parents were exposed to a range of emotions such as disappointment, hope and uncertainty during the subfertile period, and these feelings were even felt after successful fertility treatment. The relationship and social support from friends and others in the same position were very important. Regarding the relationship with the partner during the subfertile period, the main thing the couple have to do is to keep talking with one another. Although they did not always agree on all issues, it was found that maintaining the communication strengthened the links between them by the end of the process. We concluded that the feelings and emotions during fertility treatment play a big role during the subfertile period and remain important during pregnancy and even after childbirth. Subfertile clients want maternity care providers to ask those who successfully achieve pregnancy following MAC about their experiences during fertility treatment, check that they still are receiving adequate social support, and involve the partner in prenatal checks.

关键词： Subfertility Fertility Treatment Maternity Care Perception Qualitative Research

A Status Report of the KVI-AECR

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Chinese Physics C 2007年第S1期31卷 90-93页

作者： H.R.Kremers j.P.M.Beij.rs S.Brandenburg j.mulder Kernfysisch Versneller Instituut University of GroningenZernikelaan 259747AA GroningenNetherlands

In this paper the first results of the new ECR source at the KVI are *** source has been built following the design of j.v(?)skyl(?) University,which is based on the AECR-U of *** the commissioning is going on,it seems that the extraction and analysing systems inherited from the old source are the limiting factors for the performance of the new *** currents achieved with the source are at the moment a factor of 3 lower than the AECR source used at the j.v(?)skyl(?) *** modifications to improve the source performance will be discussed.

关键词： ECR beam perveance

Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease

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World j.urnal of Gastroenterology 2009年第8期15卷 955-960页

作者： Muhammed Hadithi Chris j. mulder Frank Stam j.shan Azizi j.Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders Department of Gastroenterology VUmc University Medical Center Amsterdam PO Box 7057 Amsterdam 1007 MB The Netherlands Department of Internal Medicine VUmc University Medical Center Amsterdam PO Box 7057 Amsterdam 1007 MB The Netherlands Laboratory of Immunogenetics Department of Pathology VUmc University Medical Center Amsterdam PO Box 7057 Amsterdam 1007 MB The Netherlands Department of Internal Medicine Academic Hospital Maastricht P. Debyelaan 25 6229 HX Maastricht The Netherlands

AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management.

关键词： Celiac disease Homocysteine Vitamin supplements

Porous solid inspired hyper-crosslinked polymer liquids with highly efficient regeneration for gas purification

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Science China Materials 2022年第7期65卷 1937-1942页

作者： Stefan j.D.Smith Colin D.Wood Paul H.M.Feron Hamidreza Mahdavi Roger j.mulder Cara M.Doherty Matthew R.Hill Xavier Mulet CSIRO Manufacturing Private Bag 10Clayton SouthVIC 3169Australia Department of Chemical Engineering Monash UniversityClaytonVIC 3800Australia Australian Resources Research Centre KensingtonWA 6155Australia CSIRO Energy P.O.Box 330NewcastleNSW 2300Australia

Separation media that combine the desired material properties within a single material for a given process remain an ongoing challenge for the gas separations in *** integration of porous solid adsorbents is difficult due to their limited volumetric capacity,whereas issues of volatility and high regeneration temperatures exist for liquid amines and physical ***,we report a family of polymer liquids inspired by hyper-crosslinked polymers(HCPs),a class of highly swellable network *** with a chemically similar porous solid,the HCP-liquids demonstrate good volumetric capacity and improved selectivity of carbon dioxide over *** appears to be enhanced by intramolecular swelling of the HCP-liquids at elevated pressures,while guests are strongly rej.cted from the HCP-liquids at slightly elevated temperatures,leading to highly efficient *** of adsorption and specific heat capacity of the HCP-liquids are also low,further suggesting favourable process *** being easily prepared at scale,the presented HCP-liquids represent a promising step towards a material with the requisite properties to replace conventional scrubbing solvents to drastically reduce the footprint and energy needs of gas separations.

关键词： hyper-crosslinked polymers swellable network efficient regeneration porous liquids gas sorption

Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population

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World j.urnal of Gastroenterology 2008年第20期14卷 3183-3187页

作者： Muhammed Hadithi Marcel Cazemier Gerrit A Meij.r Elisabeth Bloemena Richel j.Felt-Bersma Chris j.mulder Stephan GM Meuwissen Amado Salvador Pea Adriaan A van Bodegraven Department of Gastroenterology VUmcUniversity Medical Center Department of Pathology VUmc University MedicalCenter

AIM： To describe the characteristics of Dutch patients with *** bowel disease （IBD） first diagnosed above 60 years of age-a disease also known as old-age colitis （OAC） and to highlight a condition that has a similar appearance to IBD, namely segmen- tal colitis associated with diverticular disease （SCAD）. METHODS： A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years. RESULTS： Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 （50） [median age 82 years （range 64-101）; 25 male （42%）] were identified. These patients were diagnosed with ulcerative colitis （n = 37, 61%）, Crohn＇s disease （n = 14, 24%）, and indeterminate colitis （n = 8, 15%）. Remission was induced in 40 （68%） patients within a median interval of 6 mo （range 1-21） and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five （8%） patients. CONCLUSION： OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical features suggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli.

关键词： Inflammatory bowel disease Old-age colitis Segmental colitis