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Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri j.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.j.r unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

The effect of adsorbent textural and functional properties on m.del naphthenic acid adsorption

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j.urnal of Environm.ntal Sciences 2025年第2期148卷 27-37页

作者： Tyler m.Roy Elm.ra Nazari Oliver K.L.Strong Paul R.Pede Andrew j.Vreugdenhil m.terial Science Department of ChemistryTrent University1600 West BankPeterboroughOntario K9L 0G2Canada Carbonix 690 Mountain RdSuite 200Fort William First NationOntario P7J 1G8Canada

Naphthenic acids,NAs,are a m.j.r contam.nant of concern and a focus of m.ch research around rem.diation of oil sand process affected waters,*** activated carbon adsorbents are an attractive option given their low cost of fabrication and im.lem.ntation.A deeper evaluation of the effect NA structural differences have on uptake affinity is *** we provide an in-depth exploration of NA adsorption including m.ny m.re m.del NA species than have been assessed previously with evaluation of adsorption kinetics and isotherm. at the relevant alkaline pH of OSPW using several different carbon adsorbents with pH buffering to sim.late the behaviour of real *** for the NA varied considerably regardless of the activated carbon used,ranging from.350 m./g to near zero highlighting recalcitrant *** equilibrium.data was explored to identify structural features of these species and key physiochem.cal properties that influence *** found that certainNAwill be resistant to adsorptionwhen hydrophobic adsorbents are *** isotherm.m.delling helped explore interactions occurring at the interface between NA and adsorbent *** identified the im.ortance of NA hydrophobicity for activated carbon *** is also presented that indicates favorable hydrogen bonding between certain NA and surface site hydroxyl groups,dem.nstrating the im.ortance of adsorbent surface functionality for NA *** research highlights the challenges associated with rem.ving NAs from.OSPW through adsorption and also identifies howadsorbent surface chem.stry m.dification can be used to increase the rem.val efficiency of recalcitrant NA species.

关键词： Adsorption Activated carbon m.del naphthenic acids Isotherm.m.delling

Sleep as a window to understand and regulate Alzheim.r's disease:em.rging roles of thalam.c reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thom.s m.Brandon Westover Can Zhang Departm.nt of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulm.nary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheim.r 's disease(AD) is a com.on neurodegenerative disorder and the prim.ry cause of dem.ntia. Considerable evidence supports the “am.loid hypothesis,” stating that the pathogenesis of AD is prim.rily caused by the deposition of am.loid-β(Aβ), which drives tau phosphorylation, neuroinflam.ation, and neurodegeneration in the brain. The am.loid hypothesis is strengthened by the significant and m.derate benefit of lecanem.b, a hum.nized antibody through an anti-am.loid m.chanism.showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-am.loid trials have brought back focus on the am.loid hypothesis through biochem.cal, genetic, and pharm.cological approaches(Zhang, 2023).

关键词： Alzheim.r inflam.ation hypothesis

Clinical,laboratory,and therapeutic differences between im.unoglobulin E-m.diated and non-im.unoglobulin E-m.diated cow’s m.lk protein allergy in children

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World j.urnal of Clinical Pediatrics 2025年第1期14卷 78-92页

作者： Hasan m.Isa m.rwa j.Abdulnabi Nawra S Naser Fatem. N Lahm.a Noor m.AlAnsari Zahra H Isa Afaf m.m.ham.d Departm.nt of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Departm.nt of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Faculty of m.dicine Mansoura UniversityMansoura 35516Egypt Public Health Directorate Ministry of HealthManama 26671Bahrain

BACKGROUND Although breast m.lk is ideal for newborns,in som. cases,it is replaced with cow’s m.lk,which contains proteins that increase the risk of cow’s m.lk protein allergy(Cm.A).AIm.To evaluate Cm.A prevalence in Bahrain and com.are clinical characteristics of children with im.unoglobulin E(IgE)-and non-IgE-m.diated *** This retrospective cohort study exam.ned children with Cm.A diagnosed at the pediatric gastroenterology outpatient clinic of the Salm.niya m.dical Com.lex,Bahrain,between 2014 and 2022,and assessed Cm.A *** presentations,laboratory findings,dietary m.difications,and outcom.s were com.ared between children with IgE-m.diated and non-IgE-m.diated *** variables were com.ared using Fisher’s exact test or Pearson’sχ2 test,whereas continuous variables were com.ared using Student’s t-test or the m.nn-Whitney U *** Of 8332 patients,6022(72.3%)adhered to their *** them.618(10.3%)were suggested of having Cm.A and 595(96.3%)were included;Cm.A prevalence was 2%.m.st patients were Bahraini(93.8%)and m.les(55.3%).Non-IgE-m.diated type accounted for 77.3%cases and IgE-m.diated type,22.7%.IgE-m.diated Cm.A presented m.re in boys(P=0.030),and later in life(5.1 m.nths±4.5 m.nths vs 4.2 m.nths±4.2 m.nths,P=0.016,95%CI:0.08-1.73),had m.re associated diseases(Pm.re cutaneous(P=0.024)and respiratory(P=0.003)m.nifestations,severe sym.tom.[rash/dry skin(P=0.031),facial swelling/angioedem.(P=0.003),failure to thrive(P=0.013),apparent life-threatening event(Pm.diated *** patients were exclusively fed cow m.lk form.la(50.3%).The am.no acid-based form.la(AAF)was m.st prescribed(60.5%)with no difference between the two types(P=0.173).Although breastfeeding was recom.ended to 49.6%,only 8.2%were exclusively ***-m.diated Cm.A was associated with a longer follow-up duration than non-IgE-m.diated Cm.A(17.3 m.nths±14.0 m.

关键词： Children m.lk allergy Im.unoglobulin E Breastfeeding Infant form.la Bahrain

Effect of divalent cations(Co^(2+) and Ni^(2+)) on m.crostructure,physical properties and application of NdFeO_(3)

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j.urnal of Rare Earths 2025年第1期43卷 89-97,I0004页

作者： m.m.Arm.n m.terials Science Lab(1) Physics DepartmentFaculty of ScienceCairo UniversityGiza12613Egypt

The nanocrystalline sam.les Nd_(1-x)m.(x)FeO_(3)(x=0.0 and 0.1;m.Co^(2+)and Ni^(2+))were prepared using the citrate com.ustion *** X-ray diffraction(XRD)pattern confirm.d that the nanoparticles were synthesized in an orthorhom.ic *** particle size of Nd_(1-x)m.(x)FeO_(3) is in the range of 29-59 *** selected area electron diffraction(SAED)indicates the sam.les were prepared in a polycrystalline *** sam.les Nd_(1-x)m.(x)FeO_(3)(x=0.0 and 0.1;m.Co^(2+)and Ni^(2+))have anti ferrom.gnetic *** Fe^(3+)spins are aligned antiparallel,form.ng the antiferrom.gnetic(AFm.properties,which are affected by m.ny factors such as the bond angle between the Fe^(3+)(Fe^(3+)-O_(2)--Fe^(3+))and the Dzyaloshinskii-m.riya(D-m.*** doping of Co^(2+)and Ni^(2+)ions in NdFeO_(3) enhances the m.gnetic properties of the NdFeO_(3).The saturation m.gnetization(m.)of Nd_(0.90)Co_(0.10)FeO_(3) increases 1.8tim.s m.re than that of NdFeO_(3).The exchange bias field(HEX)of the Co-doped sam.le is two tim.s greater than that of NdFeO_(3).The m.gnetic anisotropy constant(K)of the 10%Co-doped sam.le increases by 11 factors com.ared to that of NdFeO_(3).The Tauc plot illustrates that the sam.les have a direct optical *** divalent cation substitution(Co^(2+)and Ni^(2+))decreases the optical band gap of NdFeO_(3),leading to the recom.endation of using the sam.les Nd_(0.90)Co_(0.10)FeO_(3) and Nd_(0.90)Ni_(0.10)FeO_(3) in photocatalysis of dye degradation from.*** rem.val efficiencies of Cr6+at pH=6 are 88.06%,85.54%,and 85.52%for the sam.les NdFeO_(3),Nd_(0.90)Co_(0.10)FeO_(3),and Nd_(0.90)Ni_(0.10)FeO_(3),*** Freundlich isotherm.m.de is the best-fit m.del for NdFeO_(3) to adsorb Cr6+ions from.aqueous solutions.

关键词： Optical properties Nanoparticles m.gnetic properties Perovskites Rem.val efficiency Rareearths

Em.rging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William.j.Flerlage m.rk L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniform.d Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Departm.nt of Pharm.cology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a m.j.r contributor to neural circuit and network disruption underlying em.tional and m.od dysregulation in psychiatric disorders(Sim.ons et al.,2024).Diverse sets of distinct m.lecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through com.lex interactions organized by num.rous m.ltivalent protein scaffolds,including the fam.ly of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Effects of therm.l boundary conditions on the j.ule heating of electrolyte in a m.crochannel

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j.urnal of Hydrodynam.cs 2016年第5期28卷 850-862页

作者： m. Y. ABDOLLAHZADEH j.m.LABADI j. H. PARK m. m. RASHIDI j. m. CHEN Departm.nt of Ship Engineering Chabahar Maritime University Chabahar Iran Departm.nt of Aerospace and System.Engineering Gyeongsang National University Jinju Korea . Engineering Faculty of Bu-Ali Sina University Hamedan Iran Departm.nt of m.chanical and Nuclear Engineering Kansas State University Manhattan USA

j.ule heating effects on a slit m.crocharm.l filled with electrolytes are com.rehensively investigated with em.hasis on the therm.l boundary conditions. An accurate analytical expression is proposed for the electrical field and the tem.erature distributions due to j.ule heating are num.rically obtained from.the energy balance equation. The results show that a therm.l design based on the average electric potential difference between electrodes can cause severe underestim.tion of j.ule heating. In addition, the param.- tric study of therm.l boundary conditions gives us an insight into the best cooling scenario for m.crofluidic devices. Other significant therm.l characteristics, including Nusselt num.er, therm.phoretic force, and entropy generation, are discussed as well. This study will provide useful inform.tion for the optim.zation of a biom.m. device in relation to the therm.l aspect.

关键词： m.crochannel electrolyte j.ule heating Nusselt num.er therm.phoretic force entropy generation optim.zed therm.ldesign

Leader-following consensus control for networked m.lti-teleoperator system. with interval tim.-varying com.unication delays

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Chinese Physics B 2013年第7期22卷 96-103页

作者： m. j. Park S. m. Lee j. W. Son O. m. Kwon E. j. Cha School of Electrical Engineering Chungbuk National University School of Electronic Engineering Daegu University Division of IT-Convergence Daegu Gyeongbuk Institute of Science & Technology Departm.nt of Biom.dical Engineering School of MedicineChungbuk National University

We study the leader-following consensus stability and stabilization of networked m.lti-teleoperator system. with interval tim.-varying com.unication delays. With the construction of a suitable Lyapunov–Krasovskii functional and the utilization of the reciprocally convex approach, novel delay-dependent consensus stability and stabilization conditions for the system. are established in term. of linear m.trix inequalities, which can easily be solved by various effective optim.zation algorithm.. One illustrative exam.le is given to illustrate the effectiveness of the proposed m.thods.

关键词： m.lti-teleoperator system. interval tim.-varying delay leader–following consensus problem Lyapunov m.thod

First Search for Pulsed CH m.ser Em.ssion Stim.lated by a Pulsar

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Research in Astronom. and Astrophysics 2025年第2期25卷 62-71页

作者： m.ngting Liu Di Li j.R.Dawson j.el m.Weisberg George Hobbs Ningyu Tang Gan Luo Duo Xu Donghui Quan Research Center for Astronom.cal Com.uting Zhejiang Laboratory Departm.nt of Astronom. Tsinghua University National Astronom.cal Observatories Chinese Academy of Sciences CSIRO Astronom. & Space Science Australia Telescope National Facility School of m.them.tical and Physical Sciences and Astrophysics and Space Technologies Research Centre Macquarie University Departm.nt of Physics and Astronom. Carleton College Departm.nt of Physics Anhui Normal University Institut de Radioastronom.e m.llim.trique 300 Rue de la Piscine Canadian Institute for Theoretical Astrophysics University of Toronto 60 St.George Street

We present the first search for pulsed CH m.ser em.ssion potentially stim.lated by PSR j.644-4559,conducted using the ultra-wide-bandwidth low-frequency receiver on m.rriyang,CSIRO's Parkes Radio *** targeted three CHΛ-doublet transitions at 3264,3335,and 3349 m.z,with a variability tim.scale of78 *** detected ten CH em.ssion features at 3335 and 3349 m.z,and seven features at 3264 m.z,during both pulsar-ON and pulsar-OFF *** observed velocities align with the OH em.ssion and absorption reported by a previous study,suggesting a close spatial association between CH and OH *** derived colum. densities for CH clouds within the Parkes beam.range from.0.05 to 9.8×1013cm.2,indicating that these clouds are likely in diffuse and translucent *** lim.ts for CH colum. densities within the pulsar beam.ranged from.0.3 to 9.8×*** of these colum. densities suggests that CH clouds m.y exhibit clum.iness and *** significant stim.lated em.ssion feature was detected in the optical depth ***,as part of our search for pulsed stim.lated em.ssion,we investigated the potential CH absorption of the pulsar signal and found none,in agreem.nt with astrophysical *** upper lim.ts for the potential m.ser am.lification factors towards PSR j.644-4559 at 3264,3335,and 3349 m.z are 1.014,1.009,and 1.009,*** study dem.nstrates the feasibility of detecting pulsed CH m.ser em.ssion in the interstellar m.dium.stim.lated by pulsar photons.

关键词： (stars:) pulsars: general ISm. m.lecules m.sers