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Pre-osteoblastic MC3T3-E1 cells promote breast cancer growth in bone in a murine xenograft model

Chinese j.urnal of Cancer 2011年第3期30卷 189-196页

作者： Thomas M. Bodenstine Benj.min H. Beck Xuemei Cao Leah M. Cook Aimen Ismail j. kent powers Andrea M. Mastro Danny R. Welch Department of Pathology University of Alabama at Birmingham Birmingham AL 35294 USA National Foundation for Cancer Research-Center for Metastasis Research University of Alabama at Birmingham Birmingham AL 35294 USA Department of Biochemistry and Molecular Biology Pennsylvania State University University Park PA 16802 USA Department of Pharmacology/ Toxicology University of Alabama at Birmingham Birmingham AL 35294 USA Cell Biology University of Alabama at Birmingham Birmingham AL 35294 USA Comprehensive Cancer Center University of Alabama at Birmingham Birmingham AL 35294 USA Center for Metabolic Bone Disease University of Alabama at Birmingham Birmingham AL 35294 USA.

The bones are the most common sites of breast cancer metastasis. Upon arrival within the bone microenvironment, breast cancer cells coordinate the activities of stromal cells, resulting in an increase in osteoclast activity and bone matrix degradation. In late stages of bone metastasis, breast cancer cells induce apoptosis in osteoblasts, which further exacerbates bone loss. However, in early stages, breast cancer cells induce osteoblasts to secrete inflammatory cytokines purported to drive tumor progression. To more thoroughly evaluate the role of osteoblasts in early stages of breast cancer metastasis to the bones, we used green fluorescent protein-labeled human breast cancer cell lines MDA-MB-231 and MDA-MB-435, which both induce osteolysis after intra-femoral inj.ction in athymic mice, and the murine pre-osteoblastic cell line MC3T3-E1 to modulate osteoblast populations at the sites of breast cancer metastasis. Breast cancer cells were inj.cted directly into the femur with or without equal numbers of MC3T3-E1 cells. Tumors grew significantly larger when co-inj.cted with breast cancer cells and MC3T3-E1 cells than inj.cted with breast cancer cells alone. Osteolysis was induced in both groups, indicating that MC3T3-E1 cells did not block the ability of breast cancer cells to cause bone destruction. MC3T3-E1 cells promoted tumor growth out of the bone into the extraosseous stroma. These data suggest that breast cancer cells and osteoblasts communicate during early stages of bone metastasis and promote tumor growth.

关键词：乳腺癌细胞成骨细胞肿瘤生长小鼠绿色荧光蛋白标记模型移植早期阶段

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Time series analysis of mantle cycles Part Ⅰ:Periodicities and correlations among seven global isotopic databases

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Geoscience Frontiers 2019年第4期10卷 1305-1326页

作者： Stephen j. Puetz kent C. Condie Progressive Science Institute HonoluluHI96815USA New Mexico Institute of Mining and Technology SocorroNM87801USA

In this study,seven isotopic databases are presented and analyzed to identify mantle and crustal episodes on a global scale by focusing on periodicity ranging from 70 to 200 million years(Myr).The databases are the largest,or among the largest,compiled for each type of data-with an obj.ctive of finding some samples from every region of every continent,to make each database as global as conceivably *** databases contain zircon Lu/Hf isotopic data,whole-rock Sm/Nd isotopic data,U/Pb detrital zircon ages,U/Pb igneous zircon ages,U/Pb non-zircon ages,whole-rock Re/Os isotopic data,and large igneous province *** I of this study focuses on the periodicities of age histograms and geochemical averages developed from the seven databases,via spectral and cross-correlation *** physical cycles often propagate in exact integer multiples of a fundamental cycle,referred to as *** tests show that harmonic geological cycles of^93.5 and^187 Myr have persisted throughout terrestrial history,and the cyclicities are statistically significant for U/Pb igneous zircon ages,U/Pb detrital zircon ages,U/Pb zircon-rim ages,large igneous province ages,meanεHf(t)for all samples,meanεHf(t)values for igneous-only samples,and relative abundance of mafic *** important,cross-correlation analyses show these seven time-series are nearly synchronous(±7 Myr)with a model consisting of periodicities of 93.5 and 187 ***,the similarities between peaks in the 93.5 and 187 Myr mantle cycles and terminal ages of established and suspected superchrons provide a framework for predicting and testing superchron periodicity.

关键词： Zircon Database Isotope Statistical analysis Spectral analysis Cross correlation

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Time series analysis of mantle cycles Part Ⅱ:The geologic record in zircons, large igneous provinces and mantle lithosphere

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Geoscience Frontiers 2019年第4期10卷 1327-1336页

作者： kent C. Condie Stephen j. Puetz Department of Earth & Environmental Science New Mexico Institute of Mining and TechnologySocorroNM87801USA Progressive Science Institute HonoluluHI96815USA

Igneous and detrital zircons have six maj.r U/Pb isotopic age peaks in common(2700 Ma,1875 Ma.1045 Ma,625 Ma,265 Ma and 90 Ma).For igneous rocks,each age peak is comprised of subpeaks with distinct geographic distributions and a subpeak age range per age peak≤100 *** are eight maj.r LIP age peaks(found on≥10 crustal provinces)of which only four are in common to maj.r detrital zircon age peaks(2715 Ma,1875 Ma,825 Ma,90 Ma).Of the whole-rock Re depletion ages,58%have correspo nding detrital zircon age peaks and 55%have corresponding LIP age *** age pea ks are fou nd in common to igneous zircon,detrital zircon,LIP,and Re depletion age time series(3225 Ma,2875 Ma,2145 Ma,2085 Ma,1985 Ma,1785 Ma,1455 Ma,1175 Ma,825 Ma,and 90 Ma).and these are very robust peaks on a global scale as recorded in both crustal and mantle *** 50%of the age peaks in each of these time series correspond to predicted peaks in a 94-Myr mantle cycle,including four of the ten peaks in common to all four time series(2875 Ma,1785 Ma,825 Ma and 90 Ma).Age peak widths and subpeak ranges per age peak suggest that mantle events responsible for age peaks are2500 Ma),with the number of new provinces in which age peaks are represented decreasing with time within each *** breaks between the populations(at 2.5 Ga and 1 Ga)fall near the onsets of two transitions in Earth *** First Transition may represent a change from stagnant-lid tectonics into plate tectonics and the Second Transition,the onset of subduction of continental *** maj.r factor controlling geographic distribution of age peaks is the changing locations of ***^2 Ga,age subpeaks and peaks are housed in orogens within or around the edges of crustal provinces,mostly in accretionary *** beginning at 1.9 Ga,collisional orogens become more *** coincidence in duration

关键词： Isotopic age peaks U/Pb zircon ages Re depletion ages Large igneous provinces Age peak correlation Mantle cycles

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Elucidating regulatory processes of intense physical activity by multi-omics analysis

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Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim j.nnifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie Munoz Kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus kent j.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes Kathleen A.Clark Grant Tietj. j.stin Teeguarden Kristin E.Burnum-j.hnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding j.bs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

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Measuring user preferences and behaviour in a topographic immersive virtual environment(TopoIVE)of 2D and 3D urban topographic data

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International j.urnal of Digital Earth 2021年第12期14卷 1835-1867页

作者： Łukasz Halik Alexander j.kent Department of Cartography and Geomatics Adam Mickiewicz UniversityPoznańPoland School of Psychology and Life Sciences Canterbury Christ Church UniversityCanterburyUK

This paper investigates user preferences and behaviour associated with 2D and 3D modes of urban representation within a novel Topographic Immersive Virtual Environment(TopoIVE)created from official 1:10,000 *** participants were divided into two groups:the first were given a navigational task within a simulated city and the second were given the freedom to explore it.A Head-Mounted Display(HMD)Virtual Reality(VR)app allowed participants to switch between 2D and 3D representations of buildings with a remote controller and their use of these modes during the experiment was *** performed mental rotation tests before entering the TopoIVE and were interviewed afterwards about their experiences using the *** results indicate that participants preferred the 3D mode of representation overall,although preference for the 2D mode was slightly higher amongst those undertaking the navigational task,and reveal that different wayfinding solutions were adopted by participants according to their ***,the findings suggest that users exploit different aspects of 2D and 3D modes of visualization in their wayfinding strategy,regardless of their *** potential to combine the functionality of 2D and 3D modes therefore offers substantial opportunities for the development of immersive virtual reality products derived from topographic datasets.

关键词： Virtual reality(VR) immersive virtual environment(IVE) 2D versus 3D wayfinding topographic data

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Radial Basis Function Networks Applied in Bacterial Classification Based on MALDI-TOF-MS

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Chemical Research in Chinese Universities 2002年第4期18卷 453-457页

作者： HARRINGTON Peter de B. VOORHEES kent j. REES j.n Ohio University Center for Intelligent Chemical Instrumentation Department of Chemistry and Biochemistry Ohio UniversityDepartment of Chemistry and Geochemistry Colorado School of MinesDepartment of Chemistry and Geochemistry Colorado School of Mines Athens Ohio 45701-2979 USA Golden CO 80401 USAGolden CO 80401 USA

The radial basis function networks were applied to bacterial classification based on the matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF-MS) data. The classification of bacteria cultured at different time was discussed and the effect of the network parameters on the classification was investigated. The cross-validation method was used to test the trained networks. The correctness of the classification of different bacteria investigated changes in a wide range from 61.5% to 92.8%. Owing to the complexity of biological effects in bacterial growth, the more rigid control of bacterial culture conditions seems to be a critical factor for improving the rate of correctness for bacterial classification.

关键词： Radial basis function network Matrix-assisted laser desorption/ionization Time-of-flight mass spectrometry Bacterium Classification

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Ophiolites:Identification and tectonic significance in space and time

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Geoscience Frontiers 2023年第6期14卷 380-385页

作者： kent C.Condie Robert j.Stern Department of Earth&Environmental Science New Mexico Institute of Mining and TechnologySocorroNM 87801USA Geosciences Department University of Texas at DallasRichardsonTX 75080USA

Ophiolites are fragments of oceanic lithosphere that are produced at spreading centers at ocean ridges,back arc basins,or forearcs during subduction initiation,and are key indicators of plate *** it is widely agreed that ophiolites are remnants of oceanic crust and associated depleted mantle preserved in orogens,the recognition of ophiolites and their tectonic significance is still a topic of discussion and *** propose that ophiolites can be recognized in the geologic record by some combination of genetically related pillow basalt,layered gabbro,sheeted dykes,podiform chromite,harzburgite or/and *** igneous rocks have either ocean-ridge basalt or immature oceanic arc basalt chemical *** a scoring system of 1–11 for ophiolite confidence level,scores of8 are considered confident,6–8 probable,andj.rmua and Purtuniq ophiolites at 2000–1950 *** do not become geographically widespread until after 900 Ma,and most ophiolites of all ages formed in a forearc(subduction initiation)tectonic *** ophiolite production requires plate tectonics,subduction must have begun at least locally by 2700 Ma but did not become widespread until after 2000 *** abundance of ophiolites after 900 Ma may reflect better preservation of subduction-related ophiolites,or to an increasing global network of interconnected *** frequency peaks in the geologic record partially reflect geographic regions where ophiolites have been extensively studied rather than monitoring the production rate of ophiolites,but the scarcity of>900 Ma ophiolites is probably real.

关键词： Ophiolite Plate tectonics Subduction initiation Forearc Ocean ridge Tectonic setting Supercontinent

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Innovative methods of marine ecosystem restoration /

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2013年

作者： Thomas j. Goreau Robert kent Trench

来源：畅想之星图书光盘版（南... 评论

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Effect of moisture and fungal exposure on the mechanical properties of hem-fir plywood

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j.urnal of Forestry Research 2005年第4期16卷 299-300页

作者： WANG Wei-hong Scott kent Camille Freitag Rorbert j. leichti j.ffrey j. Morrell Key Lab. of Bio-based Material Science and Technology of Ministry of Education Northeast Forestry University Harbin 150040 P. R. China Department of Wood Science and Engineering Oregon State University USA

Hem-fir plywood were exposed to two brown rot fungi, Gloeophyllum trabeum and Postia placenta, and one white rot fungus, Trametes versicolor, to investigate the effect of fungal decay on mechanical properties of plywood. Results showed that modulus of rupture （MOR） and modulus of elasticity （MOE） of hem-fir plywood declined significantly by inoculating fungi, and weight loss of sample had a modest decrease. The fungi also made a greater effect on MOR than on MOE. Of three fungi, Postia placenta caused a most significant weight loss, and Gloeophyllum trabeum resulted in a largest flexural properties loss. Substantial declines in MOR and MOE of hem-fir plywood were also observed when the plywood samples were stored under wet conditions over 15 weeks, even in the absence of fungal attack.

关键词： Fungus decay Weight loss Flexural properties Moist condition Plywood MOR, MOE

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Variation of Quantum Efficiency in CZTSSe Solar Cells with Temperature and Bias Dependence by SCAPS Simulation

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j.urnal of Energy and Power Engineering 2017年第2期11卷 69-77页

作者： Sanghyun Lee kent j. Price School of Engineering and lnformation Systems Morehead State University Morehead KY 40351 USA Department of Math and Physics Morehead State University Morehead KY 40351 USA

The quantum efficiency of CZTSSe （copper zinc tin sulphur selenium） thin film solar cells is numerically simulated at different temperatures and under a set of bias conditions about the efficiency limiting factors. A systematic methodology is developed and integrated into the proposed model to simulate the characteristics in the quantum efficiency. The proposed model is demonstrated with respect to an ideal device model under a set of bias conditions to selectively deactivate performance limiting parameters under light and voltage biased conditions. Under particular wavelength regions and bias conditions, a particular type of defects near the heteroj.nction interface significantly impact the carrier collection of devices. This deep acceptor type defect distribution is located in the band of ＋/- 0.3 eV from the midgap. These defect states influence CZTSSe spectral responses of red and IR light wavelength regions in quantum efficiency caused by affected depletion width toward the back contact. Therefore, the quantum efficiency of CZTSSe devices is altered disproportionally at biased conditions.

关键词： Degradation thin film solar cells defects modeling.

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