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国际眼科杂志 2003年第1期3卷 57-58页

作者： M.S.k.ok.S.k.m j.choi H.Hong W.k.ng Asan Medical Center University of UlsanAsan Medical Center University of UlsanAsan Medical Center University of UlsanAsan Medical Center University of UlsanUniversity of Daejon Korea

Frequency doubling perimetry (FDP) may idendtify glaucoma at a relatively early stage even before conventional perimetry does. Scanning laser polarimetry (GDx) has shown to differentiate nerve fiber layer thick.ess (N... 详细信息

关键词：青光眼双倍增频视野检查筛检算法视乳头神经纤维层厚度扫描激光旋光法

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SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct

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World j.urnal of Otorhinolaryngology 2013年第2期3卷 26-34页

作者： Tak. Ito j.lie Musk.tt Parna Chattaraj.Byung Yoon choi k.u Yup Lee Christopher k.Zalewsk. k.lly A k.ng Xiangming Li Philine Wangemann Thomas Shawk.r Carmen C Brewer Seth L Alper Andrew j.Griffith Otolaryngology Branch National Institute on Deafness and Other Communication Disorders National Institutes of Health Rockville MD 20850 United States Laboratory of Molecular Genetics National Institute on Deafness and Other Communication Disorders National Institutes of Health Rockville MD 20850 United States Anatomy and Physiology Department Kansas State University Manhattan KS 66506 United States Diagnostic Radiology Department Warren G. Magnuson Clinical Center National Institutes of Health Bethesda MD 20892 United States Renal Division Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 United States

nPendred syndrome （PS） is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct （EVA）, and mutations of the SLC26A4 gene. However, not all EVA patients have PS or SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are de-tected in the other 1/2. The presence of two mutant al-leles of SLC26A4 is associated with abnormal iodide or-ganification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The pres-ence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or in-ner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling hav-ing EVA is consistent with its segregation as an autoso-mal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 muta-tion testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling.

关键词： SLC26A4 Pendred syndrome Genetic test-ing Goiter Hearing loss Vestibular aqueduct Genotype-phenotype correlation

鉴别胰腺内副脾与小的(<3cm)实性胰腺肿瘤:MR扩散加权成像的价值

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国际医学放射学杂志 2013年第2期 163-164页

作者： k.M. j.ng S.H. k.m S. j. Lee M.j. Park.M.H. Lee D. choi 郭凌飞 Department of Radiology and Center for Imaging Science Samsung Medical Center Sungkyunkwan University School of Medicine 50 Ilwon-dong Gangnam-gu Seoul 135-710 Korea.

目的评估MR扩散加权成像在鉴别小的(<3cm)实性胰腺肿瘤与胰腺内副脾(IPAS)的应用价值。材料与方法本回顾性研究均经过机构伦理委员会的批准,免除了知情同意书。共有20例IPAS病人和22例胰腺内有小实性肿瘤的病人纳入本研究。所有病人均进... 详细信息

目的评估MR扩散加权成像在鉴别小的(<3cm)实性胰腺肿瘤与胰腺内副脾(IPAS)的应用价值。材料与方法本回顾性研究均经过机构伦理委员会的批准,免除了知情同意书。共有20例IPAS病人和22例胰腺内有小实性肿瘤的病人纳入本研究。所有病人均进行MR扩散加权成像和钆塞酸增强扫描成像。2名观察者进行定量(信号强度)和定性(信号强度和ADC值)评估。使用Fisher确切概率法和Mann-WhitneyU检验对以上两组结果进行比较。结果与脾的信号强度比较,IPAS与小的胰腺实性肿瘤相比更多地表现为等信号,在T2加权像上为95%(19/20例)和41%(9/22例);增强扫描动脉期为100%(20/20例)和18%(4/22例),门静脉期为100%(20/20例)和23%(5/22例),延迟期为100%(20/20例)和41%(9/22例);扩散加权成像b=0s/mm2为95%(19/20例)和27%(2/22例),b=100s/mm2为95%(19/20)和27%(6/22例),b=800s/mm2为100%(20/20例)和27%(6/22例),以上两组的差异均有统计学意义(P<0.01)。在扩散加权成像中,IPAS相对信号强度与ADC比率的绝对平均值较低,趋近于0,明显低于胰腺肿瘤(P<0.05)。在扩散加权成像上,对胰腺结节和脾的相似性在视觉上进行评估,观察者甲对IPAS诊断的准确度、敏感度、特异度、阳性预测值、阴性预测值分别为95%(40/42例)、100%(20/20例)、91%(20/22例)、91%(20/22例)、100%(20/20例),观察者乙为90%(38/42例)、95%(19/20例)、86%(19/22例)、86%(19/22例)、95%(19/20例)。结论除了常规形态学上的MR成像,扩散加权成像可以作为鉴别胰腺内副脾与胰腺实性肿瘤的一种方法。原文载于Radiology,2013,266(1):159-167.

关键词：胰腺肿瘤副脾消化系肿瘤实性 IPAS 加权成像 MR cm

胰腺局灶性病变体素内非相干性运动扩散加权MR成像特征

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国际医学放射学杂志 2014年第2期 173-174页

作者： k.M.k.ng j.M.Lee j.H.Yoon B.k.efer j.k.Han B.I.choi 滕泽 Department of Radiology Division of Abdominal Imaging Seoul National University College of Medicine 28 Yeongon -dongJongno-gu Seoul 110-744Korea

目的评价MR表观扩散系数(ADC)及体素内非相干性运动(IVIM)扩散衍生系数在区分常见胰腺肿瘤、慢性胰腺炎及正常胰腺组织,以及显示恶性导管内乳头状黏液性

关键词：扩散加权体素胰腺肿瘤消化系肿瘤非相干性 MR

Effect of SMAD7 gene overexpression on TGF-β1-induced profibrotic responses in fibroblasts derived from Peyronie＇s plaque

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Asian j.urnal of Andrology 2015年第3期17卷 487-492页

作者： Min j. choi k.ng-Moon Song j.n-Mi Park.Mi-Hye k.on k.-Dong k.on Soo-Hwan Park.Dong-Soo Ryu j.-k.n Ryu j.n-k.u Suh Department of Urology National Research Center for Sexual Medicine Inha University School of Medicine Incheon 400-711 Korea Department of Urology Changwon Samsung Medical Center Changwon 630-522 Korea Inha Research Institute for Medical Sciences Inha University School of Medicine Incheon 400-711 Korea

Transforming growth factor-β1 （TGF-β1） has been identified as one of the most important fibrogenic cytok.nes associated with Peyronie＇s disease （PD）. The mothers against decapentaplegic homolog 7 （SMAD7） is an inhibitory Smad protein that block. TGF-j. signaling pathway. The aim of this study was to examine the anti-fibrotic effect of the SMAD7 gene in primary fibroblasts derived from human PD plaques. PD fibroblasts were pretreated with the SMAD7 gene and then stimulated with TGF-β1. Treated fibroblasts were used for Western blotting, fluorescent immunocytochemistry, hydroxyproline determination, and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick.end labeling assays. Overexpression of the SMAD7 gene inhibited TGF-β1-induced phosphorylation and nuclear translocation of SMAD2 and SMAD3, transdifferentiation of fibroblasts into myofibroblasts, and quashed TGF-β1-induced production of extracellular matrix protein and hydroxyproline. Overexpression of the SMAD7 gene decreased the expression of cyclin D1 （a positive cell cycle regulator） and induced the expression of poly （ADP-ribose） polymerase 1, which is k.own to terminate Smad-mediated transcription, in PD fibroblasts. These findings suggest that the block.ng of the TGF-β pathway by use of SMAD7 may be a promising therapeutic strategy for the treatment of PD.

关键词： cell culture decapentaplegic homolog 7 fibrosis Peyronie's disease transforming growth factor-beta

多层螺旋CT直接CT肩关节成像时的后下盂唇裂:是一种正常变异?

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国际医学放射学杂志 2010年第1期 82-83页

作者： G.Y.Lee j.A.choi j.H.Oh j.Y.choi 徐霁 Department of Radiology Seoul National University Bundang Hospital

目的描述多层螺旋CT行直接CT肩关节成像时的后盂唇裂,并与真正的盂唇撕裂表现比较。材料与方法本研究经伦理委员会批准,免于知情同意。对126例病人的127个肩关节行16或64层螺旋CT直接CT关节成像及关节镜检查。2名肌骨系统放射科医生对C... 详细信息

目的描述多层螺旋CT行直接CT肩关节成像时的后盂唇裂,并与真正的盂唇撕裂表现比较。材料与方法本研究经伦理委员会批准,免于知情同意。对126例病人的127个肩关节行16或64层螺旋CT直接CT关节成像及关节镜检查。2名肌骨系统放射科医生对CT关节成像回顾性读片,后盂唇撕裂被定义为横断位上

关键词：盂唇定义正常变异螺旋 CT 肩关节

早期胃癌:对符合扩大标准的胃癌行治疗性内镜下黏膜切除术后的CT监测是否必要?

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国际医学放射学杂志 2017年第1期 83-84页

作者： k.S.choi S.H.k.m S.G.k.m j.k.Han 陈丽华 Department of Radiology Seoul National University Hospital

摘要目的符合扩大标准的早期胃癌(EGC)行治疗性内镜下黏膜剥离术(ESD)后,评价腹盆部CT随访对于监测胃外复发的价值。材料与方法该回顾性研究经机构伦理委

关键词：早期胃癌治疗性 EGC CT

A Study on Micromechanical Behaviors of Multi-phase steel during Uniaxial Loading

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A Study on Micromechanical Behaviors of Multi-phase steel du...

Asia Steel International Conference 2012(Asia Steel 2012)

作者： j.S.k.m E.Y.k.m Y.H.choi C.U.j.ong W.C.Woo S.-H.choi Department of Materials Science and Metallurgical Engineering Sunchon National UniversitySunchonJeonnam540-742South Korea Neutron Science Division Korea Atomic Energy Research InstituteDaejeon305-600South Korea

＜正＞The stress-strain relationship between ferrite and martensite phases in the commercial dual-phase DP980 steel was studied by using in-situ neutron diffraction and the crystal plasticity finite element method（CPFEM）.The phase identification method based on the image quality（IQ） of electron back.catter diffraction（EBSD） and a filtering process was used to obtain information concerning individual crystallographic orientations for ferrite and martensite phases in DP980 ***（200） and （211） lattice strains of ferrite and martensite phases were measured along the loading and transverse directions as a function of macroscopic stress using the in-situ neutron diffraction.A CPFEM based on representative volume elements（RVEs） was applied to determine the microscopic hardening parameters for each phase by fitting the measured macroscopic stress and measured（200） and（211） lattice strains.

关键词： Dual phase in-situ neutron diffraction Lattice strain EBSD CPFEM

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光阳厂高炉长期的高利用系数与高煤比操作

鞍钢技术 2005年第1期 42-46页

作者： j.choi 胡俊鸽

20 0 1年以来 ,光阳厂为了满足炼铁厂对铁水的需要和焦炭的平衡 ,高炉利用系数一直保持在 2 .75t/ (m3 ·d) (指工作容积利用系数 )以上 ,喷煤比大于 16 0k./t。因为高炉要保持长期高利用系数、高煤比操作 ,因而确定了几个关键因素 :(1... 详细信息

20 0 1年以来 ,光阳厂为了满足炼铁厂对铁水的需要和焦炭的平衡 ,高炉利用系数一直保持在 2 .75t/ (m3 ·d) (指工作容积利用系数 )以上 ,喷煤比大于 16 0k./t。因为高炉要保持长期高利用系数、高煤比操作 ,因而确定了几个关键因素 :(1)原料方针 ;(2 )煤气流控制 ;(3)活跃炉缸 ;(4)炉体设备维护 ;(5 )操作控制和监测系统。光阳厂相信 ,通过对这些关键因素的适当控制 ,可以在高利用系数、高煤比情况下 ,使高炉寿命超过 2 5年。

关键词：喷煤比高炉利用系数煤气流炉缸铁水炼铁厂关键因素保持焦炭

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奥曲肽治疗k.sai肝肠吻合术后的顽固性乳糜性腹水

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 52-53页

作者： Hwang j. -B. choi S. -O. Park.W. -H. 宁亮 Depts. of Pediat. Sugery and Pediat. Keimyung Univ. Dongsan Med. Center Daegu South KoreaDr.

Chylous ascites is a rare disorder with variables causes. Herein, the authors report a case of refractory chylous ascites after k.sai operation for biliary at resia, whichwas treated successfully with subcutaneous octreotide, a synthetic s omatostatin analogue. To the best of the authors’k.owledge, this is the first r eport in the English-language literature of post-k.sai chylous ascites being s uccessfully treated with subcutaneous octreotide in parallel with the continuati on of enteral feeding.

关键词：肝肠吻合术 k.sai 乳糜性腹水奥曲肽首例报道生长抑素类似物胆道闭锁持续肠内营养英文文献

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