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Ch.nese j.urnal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li j. Mei h. Li S. Tianj.n University China Tsingh.a Sh.nzh.n International Graduate Sch.ol China Lanzh.u j.aotong University China

Th. rapid development of clean and renewable energy tech.ologies represented by wind and solar energy,as well as th. continuous growth.of load demand,h.ve put forward h.gh.r requirements for th. safe operation of th. power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,wh.ch.cannot meet th. reliability requirements of power systems in th. new *** detection is an essential tech.ical meth.d in industrial development,wh.ch.can detect and evaluate th. defect and damage status of in-service equipment,key components,and materials with.ut damaging th. obj.ct.

关键词： service Application operation

A h.drodynamic modelling of wave-activated bodies for wavelet marine regions

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CLEAN ENERGY 2024年第2期8卷 35-47页

作者： Peh. j. S. Muh.eldeen, Moh.mmed W. Sh.aib, N. h. UCSI Univ Fac Engn Technol & Built Environm Mech Engn Dept Kuala Lumpur 56000 Malaysia MTC Engineer Sdn Bh. Shah Alam Selangor Malaysia

Recently, most wave energy research.h.s targeted sea areas with.h.gh.power density under extreme wave conditions for deployment. Th.s trend often leads to h.gh.r energy costs for wave power plants. h.wever, many marine areas with.low power density, ch.racterized by wavelet conditions and less destructive forces th.n extreme wave conditions, remain underexplored. Th.refore, th.s study aimed to propose a wave-activated body model for sea regions with.wavelet conditions. Th. wave-activated body design process encompassed site selection, parameter determination, geometry design, comparison and performance evaluation using th. ANSYS (R) AQWA model. Th. results indicated th.t th. proposed device ach.eved th. desired h.ave motion, with.an amplitude range of 1.2 to -2.5 m, validating its potential for deployment in marine regions with.wavelet conditions. Notably, wh.le th. proposed design is optimized for wavelet conditions, it was found to h.ve potential limitations in extreme wave environments. Th.s observation emph.sizes th. ch.llenge of formulating a generalized design suitable for both.conditions. Consequently, it is pivotal for wave-activated body designs to be customized based on th. specific ocean conditions th.y target, underscoring th. need for specialized designs of wave energy converters th.t consider th. unique wave ch.racteristics of th.ir deployment sites. A wave-activated body is designed for energy generation in ocean regions with.wavelet conditions. h.drodynamic modelling is carried out for two locations with.different wave ch.racteristics to determine th. optimum conditions for deployment. Graph.cal Abstract

关键词： wave energy converter South.Ch.na sea renewable and sustainable energy wavelet ANSYS AQWA h.drodynamic wave-activated bodies ENERGY IMPACT

Ch.nese Expert Consensus on th. Diagnosis and Treatment of Adult Dermatomyositis (2022)#

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International j.urnal of Dermatology and Venereology 2024年第3期7卷 163-173页

作者： Cao h. Ch.n A.-j. Cui Y. Deng D.-Q. Gao X.-h. h. Y.-L. Kang X.-j. j.n h.-Z. Li C.-X. Li F. Li h.-j. Liao W.-j. liu X.-M. Lu Q.-j. Lu Y. Pan M. Pan W.-h. Sh. X.-M. Sun Q. Tang K.-Y. Tao j. Wang Y. Xiao T. Zh.ng F.-R. Zh.ng h.-L. Department of Dermatology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatology The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatology First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China h.spital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rh.umatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology Qilu Hospital of Shandong Universit

Dermatomyositis, an idiopath.c inflammatory myopath., is ch.racterized by distinctive skin manifestations, proximal muscle weakness, and multiple organ involvement and can be accompanied by malignancies. To provide a reference for dermatologists and clinicians in oth.r relevant fields of clinical practice, experts from th. Dermatology Branch.of th. Ch.na International Exch.nge and Promotion Association for Medical and h.alth.Care and th. National Clinical Research.Center for Dermatologic and Immunologic Diseases developed th.s consensus on th. diagnosis and treatment of adult dermatomyositis using Ch.nese and international literature and expert advice. © 2024 Wolters Kluwer h.alth. All righ.s reserved.

关键词： adult clinical protocols dermatomyositis diagnosis expert consensus treatment

Th. potential of glutamine supplementation in reduced-crude protein diets for ch.cken-meat production

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ANIMAL NUTRITION 2024年第3期18卷 49-56页

作者： Selle, Peter h. Macelline, Sh.mil P. Togh.ani, Meh.i liu, Sonia Yun Univ Sydney Poultry Res Fdn Camden NSW 2570 Australia Univ Sydney Sydney Sch Vet Sci Camden NSW 2570 Australia Univ Sydney Fac Sci Sch Life & Environm Sci Camden NSW 2570 Australia

Th.s review explores th. potential of including glutamine, a so-called non-essential amino acid, in th. formulation of reduced-crude protein (CP) diets for broiler ch.ckens. Th.re is a precedent for benefits wh.n including glycine and serine in reduced-CP diets. Fundamentally th.s is due to decreases in nonessential amino acid concentrations in reduced-CP diets d an unavoidable consequence of reducing CP with.ut amino acid supplementation. Th. situation for glutamine is complicated because analysed dietary concentrations are very rarely provided as standard assays do not differentiate between glutamine and glutamate and are reported on a combined basis as glutamic acid. Th. dietary requirement for glutamic acid is approximately 36.3 g/kg but it is increasingly unlikely th.t th.s requirement will be met as dietary CP levels are progressively reduced. Glutamine is an abundant and versatile amino acid and constitutes 50.5 mg/g of wh.le-body ch.cken protein and is th. dominant free amino acid in systemic plasma wh.re it h.s been sh.wn to provide 22.6% (139.9 of 620.3 mg/mL) of th. total in birds offered 215 g/kg CP, wh.at-based diets. In addition to dietary intakes, glutamine biosynth.sis is derived mainly from th. condensation of glutamate and ammonia (Nh.) catalysed by glutamine synth.tase, a reaction th.t is pivotal to Nh. detoxification. Glutamate and Nh. are converted to glutamine by ph.sph.tedependent glutaminase in th. reciprocal reaction; th.s, glutamine and glutamate are interch.ngeable amino acids. h.wever, th. rate of glutamine biosynth.sis may not be adequate in rapidly growing broiler ch.ckens and exogenous and endogenous glutamine levels are probably insufficient in birds offered reduced-CP diets. Th. many functional roles of glutamine, including Nh. detoxification and maintenance of acid-base h.meostasis, th.n become relevant. Twenty feeding studies were identified wh.re dietary glutamine supplementation, usually 10 g/kg, was evaluated in birds kept under

关键词： Broiler ch.cken Glutamate Glutamic acid Glutamine ACID-BASE-BALANCE BROILER-Ch.CKENS AMINO-ACIDS INTESTINAL-MUCOSA SKELETAL-MUSCLE GROWTh.PERFORMANCE GLYCINE SUPPLEMENTATION ELECTROLYTE BALANCE METABOLIC-ACIDOSIS AMMONIA METABOLISM

STUDY OF Th. MICROSTRUCTURE AND PROPERTIES OF SIMULATED h.AT AFFECTED ZONE IN LASER WELDING OF ULCB 600 STEEL

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Acta Metallurgica Sinica(English.Letters) 2000年第1期13卷 151-156页

作者： Q. F. Wang j. h. liu Z. Y. Li P. h. Li G. F. Zh.u and X. Ch.n( 1) h.azh.ng University of Sci. & Tech., Wuh.n 430074, Ch.na 2) Tech.ology Center of WISCO, Wuh.n 430080, Ch.na)

Th. microstructure and properties of stmulated h.at affected zone (h.Z) of laser welded ULCB600 steel were investigate by applying th. simulation tech.ique with.gleeble - 2000 dynamic th.rmal - me - ch.nical *** influence of th. preh.at condition on th. microstructure and properties of simu- lated h.Z of laser welded plate was also studied in order to evaluate th. feasibility of reducing arisk th.t th. ductility and toedness of h.Z may be poor by using preh.at *** results indicate th.t th. grain size of laser - welded h.Z simulated is very small no matter if th.re is preh.at, th. tough.ess of simulated h.Z is th.refore improved comparing to th. base metal,and th.re is no obvious brittle - ductile transition in th. range from - 80℃ to 20℃. Th. TEM analyses of sub -microstruc- ture also discover th.t microstructure constituent of both.simulated h.Z is dominative lath.martensite. h.wever, th. sh.f of martensite is relatively coarse,and th. dislocation density is relatively h.gh.for simulated h.Z with.200℃ preh.at because of slower cooling rate. Combination of th.se tow factors is responsible for farer bardness and better tough.ess of simulated h.Z with.preh.at condition.

关键词： ph.sical simulation laser beam welding ULCB steel h.Z

“Yin-Yang ph.losoph.” for th. design of anticancer drug delivery nanoparticles

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Biomaterials Translational 2024年第2期5卷 144-156页

作者： Ai Y. Tian Y. Qiao j. Wang C. Li h. Sch.ol of Lifesciences Shanghai University Shanghai China

Understanding th. in vivo transport process provides guidelines for designing ideal nanoparticles (NPs) with.h.gh.r efficacy and fewer off-target effects. Many factors, such.as particle size, morph.logy, surface potential, structural stability, and etc., may influence th. delivering process of NPs due to th. existence of various ph.siological barriers with.n th. body. h.rein, we summarise th. distinct influences of NP ph.sicoch.mical properties on th. four consecutive in vivo transport steps: (1) navigating with.bloodstream with.n blood vessels, (2) transport across vasculature walls into tumour tissues, (3) intratumoural transport th.ough.th. interstitial space, and (4) cellular uptake & intracellular delivery by cancerous cells. We found th.t th. ph.losoph. beh.nd th. current consensus for NP design h.s certain similarities to th. “Yin-Yang” th.ory in traditional Ch.nese culture. Almost all ph.sicoch.mical properties, regardless of big or small sizes, long or sh.rt length. positive or negative zeta potentials, are double-edged swords. Th. balance of potential benefits and side effects, drug selectivity and accessibility sh.uld be fully considered wh.n optimising particle design, similar to th. “Yin-Yang h.rmony”. Th.s paper presents a compreh.nsive review of th. advancements in NPs research. focusing on th.ir distinct features in tumour targeting, drug delivery, and cell uptake. Additionally, it deliberates on future developmental trends and potential obstacles, th.reby aiming to uncover th. ways th.se ch.racteristics influence th. NPs’ biological activity and provide th.oretical guidance for th. targeted delivery of NPs. © 2024, Ch.nese Medical Multimedia Press Co Ltd. All righ.s reserved.

关键词： in vivo drug delivery nanoparticle design on-demand drug release targeting strategy “Yin-Yang h.rmony”

Vagal Nerve Stimulation May Be a Potentially Beneficial Treatment for Acute Myocardial Isch.mia

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麻醉与监护论坛 2010年第5期17卷 332-334页

作者： j. Xiong F. S. Xue Y. j. Yuan Q. Wang S. Li j. h. liu X. Liao Y. M. Zh.ng Department of Anesth.siology Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100144 China

Myocardial isch.mia reperfusion inj.ry is an inflammatory process wh.ch.is ch.racterized with.augmenting production and release of proinflammatory cytokines. Alth.ugh.isch.mia pre-and postconditioniug can protect myocardium against iscbemia reperfusion inj.ry, existence of some limitations restricts th.ir clinical application widely. Vagus nerve stimulation h.s been identified with.ability to inh.bit release of proinflammatory cytokines and to provide oth.r benefits to myocardial isch.mia reperfusion inj.ry. Moreover, vagus nerve stimulation h.s been already used clinically in patients with.neuropsych.atric disorders and ch.onic advanced h.art failure. Th.s we consider th.t vagus nerve stimulation may be an effective adj.nct treatment attenuating myocardial isch.mia reperfusion inj.ry prior to h.spital arrival or percutaneous coronary intervention.

关键词：麻醉学原理局部麻醉全身麻醉监护

Abalone sh.ll-derived Mg-doped mesoporous h.droxyapatite microsph.re drug delivery system loaded with.icariin for inducing apoptosis of osteosarcoma cells

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Biomaterials Translational 2024年第2期5卷 185-196页

作者： liu K. Ch.ng M. h.ang h. Yu h. Zh.o S. Zh.u j. Tie D. Wang j. Pan P. Ch.n j. Marine College Shandong University Shandong Province Weihai China State Key Laboratory of Mineral Processing Beijing China College of Biological Science and Tech.ology Fuzhou University Fujian Province Fuzhou China

h.droxyapatite (h.P) porous microsph.res with.very h.gh.specific surface area and drug loading capacity, as well as excellent biocompatibility, h.ve been widely used in tumour th.rapy. Mg2+ is considered to be a key factor in bone regeneration, acting as an active agent to stimulate bone and cartilage formation, and is effective in accelerating cell migration and promoting angiogenesis, wh.ch.is essential for bone tissue repair, anti-cancer, and anti-infection. In th.s study, abalone sh.lls from a variety of sources were used as raw materials, and Mg2+-doped abalone sh.ll-derived mesoporous h.P microsph.res (Mg-h.P) were prepared by h.droth.rmal synth.sis as Mg2+/icariin smart dual delivery system (ICA-Mg-h.P, IMh.). With.increasing of Mg2+ doping, th. surface morph.logy of h.P microsph.res varied from collapsed macroporous to mesoporous to smooth.and non-porous, wh.ch.may be due to Mg2+ substitution or coordination in th. h.P lattice. At 30% Mg2+ doping, th. Mg-h.P microsph.res sh.wed a more h.mogeneous mesoporous morph.logy with.a h.gh.specific surface area (186.06 m2/g). Th. IMh. microsph.res sh.wed h.gh.drug loading (7.69%) and encapsulation rate (83.29%), sustained Mg2+ release for more th.n 27 days, sustained and stable release of icariin for 60 h.urs, and good responsiveness to ph.(ph.6.4 > ph.5.6). In addition, th. IMh. delivery system stimulated th. rapid proliferation of bone marrow mesench.mal stem cells and induced apoptosis in MG63 cells by blocking th. G2 ph.se cycle of osteosarcoma cells and stimulating th. h.gh.expression of apoptotic genes (Bcl-2, caspase-3,-8,-9). Th.s suggests th.t th. abalone sh.ll-based IMh. may h.ve potential applications in drug delivery and tumour th.rapy. © 2024, Ch.nese Medical Multimedia Press Co Ltd. All righ.s reserved.

关键词： abalone sh.ll drug delivery h.droxyapatite microsph.res magnesium doping osteosarcoma

Artificial-intelligent-powered safety and efficiency improvement for controlling and sch.duling in integrated railway systems

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h.gh.speed Railway 2024年第3期2卷 172-179页

作者： liu j. liu G. Wang Y. Zh.ng W. Beij.ng National Railway Research.& Design Institute of Signal & Communication Group Co. Ltd Beijing 100070 China Engineering Research.Center of Railway Industry of Intelligent and Autonomous Train Control Beijing 100070 China

Th. multi-mode integrated railway system, anch.red by th. h.gh.speed railway, caters to th. diverse travel requirements both.with.n and between cities, offering safe, comfortable, punctual, and eco-friendly transportation services. With.th. expansion of th. railway networks, enh.ncing th. efficiency and safety of th. compreh.nsive system h.s become a crucial issue in th. advanced development of railway transportation. In ligh. of th. prevailing application of artificial intelligence tech.ologies with.n railway systems, th.s study leverages large model tech.ology ch.racterized by robust learning capabilities, efficient associative abilities, and linkage analysis to propose an Artificial-intelligent (AI)-powered railway control and dispatch.ng system. Th.s system is elaborately designed with.four core functions, including global optimum unattended dispatch.ng, synergetic transportation in multiple modes, h.gh.speed automatic control, and precise maintenance decision and execution. Th. deployment path.ay and essential tasks of th. system are furth.r delineated, alongside th. ch.llenges and obstacles encountered. Th. AI-powered system promises a significant enh.ncement in th. operational efficiency and safety of th. composite railway system, ensuring a more effective alignment between transportation services and passenger demands. © 2024 Beij.ng j.aotong University

关键词： Artificial intelligence h.gh.speed railway Large-scale mode, system framework Multi-mode railway system Safety and efficiency improvement

Compressive property and energy absorption ch.racteristic of interconnected porous Mg-Zn-Y alloys with.adj.sting Y addition

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j.urnal of Magnesium and Alloys 2024年第1期12卷 171-185页

作者： j.A.liu S.j.liu B.Wang W.B.Sun X.j.liu Z.W.h.n College of Materials Science and Engineering Key Laboratory of Automobile Materials(Ministry of Education)Jilin UniversityChangchun 130022PR China Key Laboratory of Bionic Engineering(Ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun130022PR China Weih.i Institute for Bionics-j.lin University Weihai 264205PR China

In th.s study,interconnected porous Mg-2Zn-xY alloys with.different ph.se compositions were prepared by various Y additions(x=0.4,3,and 6 wt.%)to adj.st th. compressive properties and energy absorption *** ch.racterization meth.ds were th.n applied to identify th. microstructure of th. porous Mg-Zn-Y and describe th. details of th. second *** tests were performed at room temperature(RT),200℃,and 300℃to study th. impact of th. Y addition and testing temperature on th. compressive properties of th. porous *** experimental results sh.wed th.t a h.gh.Y content promotes a microstructure refinement and increases th. volume fraction of th. second *** th. Y content increases,different Mg-Zn-Y ternary ph.ses appear:I-ph.se(Mg_(3)Zn_(6)Y),W-ph.se(Mg_(3)Zn_(3)Y_(2)),and LPSO ph.se(Mg_(12)ZnY).Wh.n th. Y content ranges between 0.4%and 6%,th. compressive strength.increases from 6.30MPa to 9.23 MPa,and th. energy absorption capacity increases from 7.33 Mj.m^(3)to 10.97 Mj.m^(3)at RT,wh.ch.is mainly attributed to th. ph.se composition and volume fraction of th. second ***,th. average energy absorption efficiency is independent of th. Y *** addition,th. compressive deformation beh.viors of th. porous Mg-Zn-Y are altered by th. testing *** compressive strength.and energy absorption capacity of th. porous Mg-Zn-Y decrease due to th. softening effect of th. h.gh.temperature on th. *** deformation beh.viors at different temperatures are finally observed to reflect th. failure mech.nisms of th. struts.

关键词： Porous magnesium Rare earth.elements Microstructure Compressive beh.vior Energy absorption ch.racteristic