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the Notion of Conservation for Residual Distribution Schemes (or Fluctuation Splitting Schemes), with Some Applications

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Communications on Applied Mathematics and Computation 2020年第3期2卷 341-368页

作者： Rémi Abgrall Institüt für Mathematik Universität ZürichWinterhurerstrasse 1908057ZurichSwitzerland

In this paper,we discuss the notion of discrete conservation for hyperbolic conservation *** introduce what we call fluctuation splitting schemes(or residual distribution,also RDS)and show through several examples how these schemes lead to new *** particular,we show that most,if not all,known schemes can be rephrased in flux form and also how to satisfy additional conservation *** review paper is built on Abgrall et al.(Computers and Fluids 169:10-22,2018),Abgrall and tokareva(SIAM SISC 39(5):A2345-A2364,2017),Abgrall(j.Sci Comput 73:461-494,2017),Abgrall(Methods Appl Math 18(3):327-351,2018a)and Abgrall(j.Comput Phys 372,640--666,2018b).this paper is also a direct consequence of the work of Roe,in particular Deconinck et al.(Comput Fluids 22(2/3):215-222,1993)and Roe(j.Comput Phys 43:357-372,1981)where the notion of conservation was first ***[26],Roe mentioned the Hermes proj.ct and the role of Dassault *** Stoufflet,Vice President R&D and advanced business of this company,proposed me to have a detailed look at Deconinck et al.(Comput Fluids 22(2/3):215-222,1993).to be honest,at the time,I did not understand anything,and this was the case for several years.I was lucky to work with Katherine Mer,who at the time was a postdoc,and is now research engineer at *** helped me a lot in understanding the notion of *** present contribution can be seen as the result of my understanding after many years of playing around with the notion of residual distribution schemes(or fluctuation-splitting schemes)introduced by Roe.

关键词： Hyperbolic problems Local conservation Residual distribution

Analysis of particle dispersion and cavity formation during bulk particle water entry using fully coupled CFD-DEM-VOF approach

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Particuology 2024年第7期90卷 558-580页

作者： Utkan Çalışkan Sanj. mišković Norman B.Keevil Institute of mining Engineering University of British Columbia2329 West MallVancouverBC V6T 1Z4Canada

this paper presents the development and validation of a fully coupled computational fluid dynamics—discrete element method—volume of fluid(CFD-DEM-VOF)model to simulate the complex behavior of particle-laden flows with free *** coupling between the fluid and particle phases is established through the implemented continuity,momentum,and alpha transport *** coupled particle forces such as drag,pressure gradient,dense virtual mass,viscous,and interface forces are also integrated,with drag and dense virtual mass forces being dependent on local *** integrated conservative alpha transport equation ensures phase volume conservation during interactions between particles and ***,we have implemented a trilinear interpolation method designed to operate on unstructured hexahedral *** method has been tested for its ability to properly resolve the coupling effects in the numerical simulations,particularly in cases with a relatively low cell-size *** model is validated through three distinct test cases:single particle water entry,dam break with particles,and water entry of a group of particles *** experimental setup is built to study the dynamics of the water entry of a group of particles,where three key flow features are analyzed:the evolution of average particle velocity,cavity shape,and particle dispersion cloud profiles in *** tests involve four different scenarios,including two different water levels(16.1 and 20.1 cm)and two different particle densities(2650 and 4000 kg/m3).High-speed videometry and particle tracking velocimetry(using Imagej.trackMate)methods are employed for experimental data *** is demonstrated that numerical results are in excellent agreement with theoretical predictions and experimental *** study highlights the significance of vortices in cavity shaping and particle *** validated CFD-DEM-VOF model constitutes a robust tool for simulating particle-laden flows,cont

关键词： CFD-DEM-VOF trilinear interpolation Particle-laden flow Free-surface Particle water entry Volume conservation

Causality and Collisionless Damping in Plasma

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j.urnal of Modern Physics 2013年第4期4卷 555-558页

作者： Hee j. Lee mi Young Song Department of Physics Hanyang University Seoul Korea Plasma technology Research Center National Fusion Research Institute Gunsan Korea

We derive the collisionless Landau damping in a plasma by satisfying the causal requirement that the susceptibility function of the plasma for time t should be nil. the causality condition should be satisfied by the susceptibility function of a plasma no matter what equations we employ to describe the plasma. thus we conclude that the fundamental reason of the collisionless damping can be traced to the causality. As an example, we derive the collisionless damping of ion acoustic wave in a plasma by employing fluid equations.

关键词： Causality Landau Damping Ion Acoustic Wave

Single Crystal Growth and Magnetoresistivity of topological Semimetal CoSi

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Chinese Physics Letters 2019年第7期36卷 77-81页

作者： D.S.Wu Z.Y.mi Y.j.Li W.Wu P.L.Li Y.t.Song G.t.Liu G.Li j.L.Luo Institute of Physics and Beij.ng National Laboratory for Condensed Matter Physics Chinese Academy of Sciences Beijing 100190 School of Physical Sciences University of Chinese Academy of Sciences Beijing 100190 Songshan Lake Materials Laboratory Dongguan 523808

We report single crystal growth of CoSi, which has recently been recognized as a new type of topological semimetal hosting fourfold and sixfold degenerate nodes. the Shubnikov–de Haas quantum oscillation(QO) is observed on our crystals. there are two frequencies originating from almost isotropic bulk electron Fermi surfaces, in accordance with band structure calculations. the effective mass, scattering rate, and QO phase difference of the two frequencies are extracted and discussed.

关键词： single crystal growth been recognized as extracted and discussed

CAR t-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

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Frontiers of Medicine 2021年第6期15卷 783-804页

作者： j.an-Qing mi j.e Xu j.anfeng Zhou Weili Zhao Zhu Chen j.j.seph Melenhorst Saij.an Chen State Key Laboratory of Medical Genomics Shanghai Institute of HaematologyNational Research Centre for Translational MedicineRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Pathology&Laboratory Medicine University of PennsylvaniaPhiladelphiaPA19104USA Immunotherapy Research Centre for Hematologic Diseases of Hubei Province Department of HaematologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

the current standard of care in hematological malignancies has brought considerable clinical benefits to ***,important bottlenecks still limit optimal achievements following a current medical *** genetic complexity of the diseases and the heterogeneity of tumor clones cause difficulty in ensuring long-term efficacy of conventional treatments for most hematological ***,new treatment strategies are necessary to improve clinical *** antigen receptor t-cell(CAR t)immunotherapy opens a new path for targeted therapy of hematological *** this review,through a representative case study,we summarize the current experience of CAR t-cell therapy,the management of common side effects,the causative mechanisms of therapy resistance,and new strategies to improve the efficacy of CAR t-cell therapy.

关键词： CAR t cells hematological malignancies review

Neural Network-Based Limiter with transfer Learning

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Communications on Applied Mathematics and Computation 2023年第2期5卷 532-572页

作者： Rémi Abgrall Maria Han Veiga University of Zurich ZurichSwitzerland University of michigan Ann ArborUSA

Recent works have shown that neural networks are promising parameter-free limiters for a variety of numerical schemes(Morgan et *** A machine learning approach for detect-ing shocks with high-order hydrodynamic *** *** j.Comput Phys 367:166-191.,2018;Veiga et *** European Conference on Computational Mechanics andⅦEuropean Conference on Computational Fluid Dynamics,vol.1,***.,2018).Following this trend,we train a neural network to serve as a shock-indicator function using simulation data from a Runge-Kutta discontinuous Galer-kin(RKDG)method and a modal high-order limiter(Krivodonova in j.Comput Phys 226:879-896.,2007).With this methodology,we obtain one-and two-dimensional black-box shock-indicators which are then coupled to a standard ***,we describe a strategy to transfer the shock-indicator to a residual distribution(RD)scheme without the need for a full training cycle and large data-set,by finding a mapping between the solution feature spaces from an RD scheme to an RKDG scheme,both in one-and two-dimensional problems,and on Cartesian and unstruc-tured *** report on the quality of the numerical solutions when using the neural network shock-indicator coupled to a limiter,comparing its performance to traditional lim-iters,for both RKDG and RD schemes.

关键词： Limiters Neural networks transfer learning Domain adaptation

Ischemic and hypoxic preconditioning protect cardiac muscles via intracellular ROS signaling

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Frontiers in Biology 2013年第3期8卷 305-311页

作者： Li ZUO William j. ROBERtS Rosa C. tOLOMELLO Adam t. GOINS Molecular Physiology and Biophysics Laboratory Department of Biological Sciences Oakland University Rochester MI 48326 USA

Oxidative stress can cause extensive damage to cardiac tissue under reperfusion conditions. However, preconditioning the myocardium may diminish these negative effects and alleviate reperfusion inj.ry. there are a variety of preconditioning therapies, such as ischemic preconditioning （IPC） and hypoxie preconditioning （HPC）, each targeting specific channels, receptors, and/or intracellular molecules. Ischemic preconditioning involves brief periods of ischemia followed by brief periods of reperfusion, thus strengthening the cardiac resistance for a longer period of ischemia. IPC involves complex mechanisms, some of which are still not completely understood today. Nevertheless, many studies have already established models of IPC. In addition, similar to IPC, HPC has also been recognized as preventing reperfusion inj.ry. Reactive oxygen species （ROS） are known mediators of IPC and HPC. Particularly, mitochondria-generated ROS initiate activity of several beneficial preconditioning pathways. the role of ROS is paradoxical; low levels of ROS are key factors in signaling IPC/HPC, but high levels of ROS can contribute to increased oxidative stress on cardiomyocytes. therefore, it is important to determine the molecular mechanism of IPC and HPC to avoid excessive accumulation of ROS to prevent cardiac inj.ry. In this review, we will outline IPC and HPC, explaining the putative role of ROS in both pathways. We will also discuss preconditioning efficacy in certain conditions such as exercise and how the aging myocardium responds to preconditioning therapies.

关键词： hypoxia ischemia-reperfusion ROS cardiomyocyte preconditioning

Compressive failure analysis of unidirectional carbon/epoxy composite based on micro-mechanical models

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Chinese j.urnal of Aeronautics 2017年第6期30卷 1907-1918页

作者： Wei SUN Zhidong GUAN Zengshan LI mi ZHANG Yongj.e HUANG School of Aeronautic Science and Engineering Beihang University Beijing 100083 China

A 2D micro-mechanical model was proposed to study the compressive failure of Uni Directional（UD） carbon/epoxy composite. Considering the initial imperfection and strength distribution of the fiber, the plasticity and ductile damage of the matrix, the failure of t300/914 UD composite under longitudinal compression and in-plane combined loads was simulated by this model. Simulation results show that the longitudinal compressive failure of the UD composite is caused by the plastic yielding of the matrix in kink band, and the fiber initial imperfection is the main reason for it. Under in-plane combined loads, the stress state of the matrix in kink band is changed, which affects the longitudinal compressive failure modes and strength of UD *** failure envelope of r_1–s_（12） and r_1–r_2 are obtained by the micro-mechanical model. Meanwhile,the compressive failure mechanism of the UD composite is analyzed. Numerical results agree well with the experimental data, which verifies the validity of the micro-mechanical model.

关键词： micro-mechanical model Unidirectional composite Initial imperfection Matrix plasticity Ductile damage Kink band

Myeloid checkpoints for cancer immunotherapy

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Chinese j.urnal of Cancer Research 2022年第5期34卷 460-482页

作者： Yixin Qian ting Yang Huan Liang mi Deng Peking University International Cancer Institute Health Science CenterPeking UniversityBeijing 100191China School of Basic Medical Sciences Health Science CenterPeking UniversityBeijing 100191China Peking University Cancer Hospital&Institute Peking UniversityBeijing 100142China

Myeloid checkpoints are receptors on the myeloid cell surface which can mediate inhibitory signals to modulate anti-tumor immune *** can either inhibit cellular phagocytosis or suppress t cells and are thus involved in the pathogenesis of various *** the tumor microenvironment,besides killing tumor cells by phagocytosis or activating anti-tumor immunity by tumor antigen presentation,myeloid cells could execute protumor efficacies through myeloid checkpoints by interacting with counter-receptors on other immune cells or cancer *** summary,myeloid checkpoints may be promising therapeutic targets for cancer immunotherapy.

关键词： Cancer immune checkpoint myeloid checkpoint MDSC tAM immunotherapy