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Association between composite dietary antioxidant index and stroke among individuals with diabetes

World j.urnal of Diabetes 2024年第8期15卷 1742-1752页

作者： Hong-Qiang Zhang j.e Shi Tong Yue j.a-Hao Weng Xu-Lin Wang Hao Wang Xiao-Yu Su Xue-Ying Zheng Si-Hui Luo Yu ding Chao-Fan Wang Department of Cardiology Centre for Leading Medicine and Advanced Technologies of IHMThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Endocrinology Centre for Leading Medicine and Advanced Technologies of IHMThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of DiabetologyGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Recent research has underscored the potentially protective role of dietary antioxidants against chronic conditions,such as cardiovascular diseases and *** composite dietary antioxidant index(CDAI),which reflects the overall intake of key dietary antioxidants,has been identified as a crucial metric for exploring this *** previous research has shown a negative correlation between CDAI levels and stroke risk in prediabetic individuals,there remains a substantial gap in understanding this association among individuals with diabetes,who are at an inherently greater risk for cerebrovascular *** To investigate the association between CDAI and stroke risk in individuals with *** Using a cross-sectional study design,this investigation analyzed data from the National Health and Nutrition Examination Survey spanning from 2003 to 2018 that included 6735 participants aged over 20 years with *** CDAI was calculated from 24-h dietary recalls to assess intake of key antioxidants:Vitamins A,C,and E;carotenoids;selenium;and *** logistic regression and restricted cubic spline analysis were used to rigorously examine the relationship between CDAI and stroke *** The participant cohort,with an average age of 59.5 years and a slight male maj.rity,reflected the broader demographic characteristics of individuals with *** analysis revealed a strong inverse relationship between CDAI levels and stroke ***,those in the highest quintile of CDAI demonstrated a 43%lower prevalence of stroke compared to those in the lowest quintile,even after adj.stments for various *** finding not only highlights the negative association between CDAI and stroke risk but also underscores the significant potential of antioxidant-rich diets in reducing stroke prevalence among patients with *** Our findings suggested that CDAI was inversely associated with stroke prevalence among pa

关键词： Stroke Diabetes Composite dietary antioxidant index National Health and Nutrition Examination Survey Crosssectional study

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Kimura disease:review of the literature

Kimura disease:review of the literature

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作者： Q.-F.Sun,~1 D.-Z.Xu,~2 S.-H.Pan,~3 j.-G.ding,~1 Z.-Q.Xue,~4 C.-S.Miao,~4 G.-j.Cao~5 and D.-j.j.n~1 Departments of lInfectious Diseases,3Pathology,4Nephrology and 5Surgery,The Third Affiliated Hospital to Wenzhou Medical College, Wenzhou,Zhej.ang and 2Beij.ng Di-tan Hospital,Beij.ng,China

Kimura disease(KD) is a rare,chronic inflammatory disease of unknown cause and is characterized by painless *** and lymphadenopathy commonly affecting the head and neck *** therapeutics has been used to treat KD,but is not satisfactory because of frequent *** has been reported previously to be useful for treatment of hypereosinophilic syndrome and may work by selectively blocking protein -tyrosine kinases,such as plateletderived growth factor receptor, and *** out immunohistochemical examination of platelet-derived growth factor receptor and cit in tissues from patients with KD. The results were positive and suggested that Imatinib might be an effective drug for the treatment of the *** have also briefly reviewed the epidemiology,aetiology,clinical manifestations,laboratory and pathological examinations,differential diagnoses,treatment and prognosis of KD in this manuscript.

关键词： Kimura disease eosinophilia immunohistochemistry protein-tyrosine kinase Imatinib.

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Suppression of the m/n=2/1 tearing mode by electron cyclotron resonance heating on j.TEXT

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Plasma Science and Technology 2024年第8期26卷 8-17页

作者：方建港陈忠勇严伟王能超毛飞越罗蔷玄子健陈曦璇任正康张峰黄梅夏冬辉杨州军陈志鹏丁永华 the j.TEXT Team State Key Laboratory of Advanced Electromagnetic Technology International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma PhysicsSchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China Southwestern Institute of Physics Chengdu 610041People’s Republic of China

Stabilization of tearing modes and neoclassical tearing modes is of great importance for tokamak *** cyclotron waves(ECWs)have been extensively used to stabilize the tearing modes with the virtue of highly localized power *** suppression of the m/n=2/1 tearing mode(TM)by electron cyclotron resonance heating(ECRH)has been achieved successfully on the j.TEXT *** effects of ECW deposition location and power amplitude on the 2/1 TM suppression have been *** is found that the suppression is more effective when the ECW power is deposited closer to the rational *** the ECW power increases to approximately 230 k W,the 2/1 TM can be completely *** island rotation frequency is increased when the island width is *** experimental results show that the local heating inside the magnetic island and the resulting temperature perturbation increase at the O-point of the island play dominant roles in TM *** the ECW power increases,the 2/1 island is suppressed to smaller island width,and the flow shear also plays a stabilizing effect on small magnetic *** the stabilizing contribution of heating and flow shear,the 2/1 TM can be completely suppressed.

关键词： tearing mode electron cyclotron resonant heating tearing mode suppression

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青藏高原及其周边古近纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 1308-1342页

作者：刘佳宋艾丁林苏涛周浙昆中国科学院西双版纳热带植物园热带森林生态学重点实验室勐腊666303 中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 云南大学古生物研究院昆明650500 中国科学院青藏高原研究所地球系统科学与资源环境重点实验室北京100101

古近纪是陆地和海洋生态系统劫后复苏并逐渐接近其现代面貌的关键时期.在青藏高原及其周边区域,古近纪也是青藏高原-喜马拉雅造山带构造活动、亚洲气候重组、生物多样性演化的重要时期.限于研究条件、认识程度等的制约,青藏高原及其周... 详细信息

古近纪是陆地和海洋生态系统劫后复苏并逐渐接近其现代面貌的关键时期.在青藏高原及其周边区域,古近纪也是青藏高原-喜马拉雅造山带构造活动、亚洲气候重组、生物多样性演化的重要时期.限于研究条件、认识程度等的制约,青藏高原及其周边地区在地层划分方面还存在诸多争议.近年来,该区域开展了大量的沉积岩石学、磁性地层学、同位素年代学等工作,发现和报道了大量各种门类的化石,更系统地深化了生物地层学研究,为梳理青藏高原及其周边古近纪综合地层、生物群和古地理演化打下了坚实的基础.本文基于国际古近系划分和对比标准,以岩石地层和生物地层为基础,综合近年来同位素年代学、磁性地层学和地球化学等研究工作,在前人工作基础上梳理青藏高原及其周边不同构造单元的地层划分与对比框架.第二次青藏高原综合科学考察开展以来,古近纪植物群相关研究逐渐丰富.依据这些植物群最新的年代结果,本文讨论了灭绝类群和新出现类群的生物地层意义.对“桉属”、棕榈科等化石类群的新认识将古近纪青藏地区植物区系与冈瓦纳大陆的大洋洲、南美洲生物区系建立联系.雅鲁藏布江缝合带两侧植物群重要类群的演化历史也指示印度板块和欧亚大陆的碰撞时间在约65~54Ma.植物群的古高程重建结果表明,横断山区在早渐新世之前就已经形成现今的地貌格局;古近纪青藏地区主要缝合带附近的温暖湿润低地是动植物类群交流的主要通道;古近纪低矮的喜马拉雅山脉不能对南来的印度洋水汽形成有效的阻隔作用.

关键词：青藏高原化石生物地层古环境古地理古近纪

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CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy

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j.urnal of Genetics and Genomics 2024年第2期51卷 184-196页

作者： Yan Shi Chunyan Cao Yiheng Zeng Yuanliang ding Long Chen Fuze Zheng Xuej.ao Chen Fanggui Zhou Xiefeng Yang j.nj.ng Li Liuqing Xu Guorong Xu Minting Lin Hiroyuki Ishiura Shoj. Tsuj. Ning Wang Zhiqiang Wang Wan-j.n Chen Kang Yang Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China Department of Neurology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian 350212China The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan 471000China Department of Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujian 363000China Department of Neurology Jian'ou Municipal Hospital of Fujian ProvinceJian'ouFujian 353100China Department of Radiology First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China Department of Neurology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Neurology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Institute of Medical Genomics International University of Health and WelfareChiba 286-0048Japan

CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with ***,since only three patients from a single family were reported,it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/***,using repeat-primed-polymerase chain reaction and long-read sequencing,we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1,typically presenting with oculopharyngodistal *** CGG repeat expansions range from 161 to 669 repeat *** of the patients present with ptosis,restricted eye movements,dysphagia,dysarthria,and diffuse limb muscle *** one patient shows T2-weighted hyperintensity in the cerebellar white matter surrounding the deep cerebellar nuclei on brain magnetic resonance *** biopsies from three patients show a myopathic pattern and rimmed *** of muscle biopsies suggest that CGG repeat expansions in LOC642361/NUTM2B-AS1 may deleteriously affect aggrephagic capacity,suggesting that RNA toxicity and mitochondrial dysfunction may contribute to *** study thus expands the phenotypic spectrum for the CGG repeat expansion of LOC642361/NUTM2B-AS1 and indicates that this genetic variant typically manifests as oculopharyngodistal myopathy with chronic myopathic changes with rimmed vacuoles and filamentous intranuclear inclusions in muscle fibers.

关键词： Oculopharyngeal myopathy with leukoencephalopathy Oculopharyngodistal myopathy CGG repeat expansion Rimmed vacuoles

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Constraints on sedimentary ages of the Chuanlinggou Formation in the Ming Tombs, Beij.ng, North China Craton: LA-ICP-MS and SHRIMP U–Pb dating of detrital zircons

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Acta Geochimica 2018年第2期37卷 257-280页

作者： j.ng ding Yuruo Shi Alfred Kroner j. Lawford Anderson Beij.ng SHRIMP Center Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China China University of Geosciences Beijing 100083 China Institut fur Geowissenschaften Universitat Mainz55099 Mainz Germany Department of Earth and Environment Boston University Boston MA 02215 USA

Detrital zircons in five sedimentary samples, MC1 to MC5, from the bottom of the Chuanlinggou Formation in the Ming Tombs District, Beij.ng, were dated with the LA-ICP-MS and SHRIMP U-Pb methods. Age spectra of the five samples show a maj.r peak at 2500 Ma and a secondary peak at 2000 Ma, suggesting their provenances were mainly from the crystalline basement of the North China Craton and the Trans-North China Orogen. The youngest zircon has an age of 1673 d： 44 Ma, indicating that the Chuanlinggou Formation was deposited after this age. From sample MC4 to MC5, lithology changed from a clastic rock （fine-grained sandstone） to a carbonate rock （fine-grained dolomite）, suggesting that the depositional basin became progressively deeper. The age spectrum of sample MC5 shows a maj.r peak at 2500 Ma and a secondary peak at 2000 Ma. Sample MC4, which is stratigraphically lower than sample MC5, only had one peak at 2500 Ma. We conclude that there was a transgressive event when sediments represented by MC5 was deposited, and seawater carried ca. 2000 Ma clastic materials to the basin where the Chuanlinggou Formation was deposited, leading to the addition of ca. 2000 Ma detritus. Our research indicates that the source area for the sediments became more extensive with time. We conclude that the Chuanlinggou Formation in the Ming Tombs District was deposited in a low-energy mud fiat sedimentary environment in the inter-supra tidal zone because it is mainly composed of silty mudstone and fine-grained sandstone with relatively simple sedimentary structures.

关键词： Detrital zircon LA-ICP-MS U-Pb ages SHRIMP Chuanlinggou Formation Ancient sedimentary environment North China Craton

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Carbon-based nanodots for biomedical applications and clinical transformation prospects

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BMEMat(BioMedical Engineering Materials) 2024年第3期2卷 9-27页

作者： Haizhen ding Tenghui Xiao Fangfang Ren Yu Qiu Zhiyang Shen Xuecheng Chen Ewa Mij.wska Hongmin Chen State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational MedicineXiang an Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamenChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Innovation Platform for Industry-Education Integration in Vaccine ResearchXiamen UniversityXiamenChina Faculty of Chemical Technology and Engineering West Pomeranian University of TechnologySzczecinPoland

Carbon dots(CDs),emerging as a promising class of nanomaterials,have garnered significant interest in the field of biomedicine due to their unique physicochemical *** review provides a comprehensive overview of the recent advancements in the biomedical applications of CDs,emphasizing their potential for revolutionizing diagnostics,therapy,and *** discuss the synthesis and functionalization of CDs,which are pivotal in tailoring their properties for specific biomedical *** applications of CDs in bioimaging include fluorescence imaging,magnetic resonance imaging,photoacoustic imaging,***,this review delves into the benefits of CDs in the treatment of diseases including cancer,inflammation and Alzheimer's,***,we look forward to the future of CDs in the field of biomedicine,emphasizing the necessity of interdisciplinary collaboration to overcome current obstacles and facilitate the clinical translation of CDs-based *** review aims to provide a summary and perspectives on the latest developments of CDs in biomedicine,hoping to inspire further research in this rapidly advancing field.

关键词： bioimaging biomedical applications carbon dots structural design therapy

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Vibration control of fluid-conveying pipes: a state-of-the-art review

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Applied Mathematics and Mechanics(English Edition) 2023年第9期44卷 1423-1456页

作者： Hu ding j.C.j. Shanghai Key Laboratory of Mechanics in Energy Engineering School of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China Shaoxing Institute of Technology Shanghai UniversityShaoxing 312074Zhejiang ProvinceChina Shanghai Institute of Aircraft Mechanics and Control Shanghai 200092China School of Mechanical and Mechatronic Engineering University of Technology SydneyNew South Wales 2007Australia

Fluid-conveying pipes are widely used to transfer bulk fluids from one point to another in many engineering *** are subj.ct to various excitations from the conveying fluids,the supporting structures,and the working environment,and thus are prone to vibrations such as flow-induced vibrations and acoustic-induced *** can generate variable dynamic stress and large deformation on fluid-conveying pipes,leading to vibration-induced fatigue and damage on the pipes,or even leading to failure of the entire piping system and catastrophic ***,the vibration control of fluid-conveying pipes is essential to ensure the integrity and safety of pipeline systems,and has attracted considerable attention from both researchers and *** present paper aims to provide an extensive review of the state-of-the-art research on the vibration control of fluid-conveying *** vibration analysis of fluid-conveying pipes is briefly discussed to show some key issues involved in the vibration ***,the research progress on the vibration control of fluid-conveying pipes is reviewed from four aspects in terms of passive control,active vibration control,semi-active vibration control,and structural optimization design for vibration ***,the main results of existing research on the vibration control of fluid-conveying pipes are summarized,and future promising research directions are recommended to address the current research *** paper contributes to the understanding of vibration control of fluid-conveying pipes,and will help the research work on the vibration control of fluidconveying pipes attract more attention.

关键词： fuid-conveying pipe vibration passive control nonlinear energy sink(NES) active control semi-active control

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Role of mitophagy in head and neck squamous cell carcinoma:Prognosis and immune insights

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Radiation Medicine and Protection 2024年第2期5卷 100-112页

作者： Qin ding Wei Liu j.nping Pan Lihua Wang Wenquan Hong Sunqin Cai Xin Chen Duanyu Lin Sufang Qiu Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer Hospital(Fujian Branch of Fudan University Shanghai Cancer Center)Fuzhou 350014China Fuj.an Provincial Key Laboratory of Translational Cancer Medicine Fuzhou 350014China Department of Nuclear Medicine Clinical Oncology School of Fujian Medical UniversityFujian Cancer Hospital(Fujian Branch of Fudan University Shanghai Cancer Center)Fuzhou 350014China

Obj.ctive:To explore the correlation between mitophagy and the tumor microenvironment(TME)in patients with head and neck squamous cell carcinoma(HNSCC),with an aim to enhance therapeutic efficacy for ***:A machine learning-based multigene prognostic signature was developed based on mitophagy-related differentially expressed genes(MRGs)identified in The Cancer Genome Atlas *** signature was correlated with the TME using gene set enrichment *** association between this prognostic signature and various immunological features of the TME was explored,including status of tumor-infiltrating immune cells,expression of immune checkpoint molecules,and the *** validated the expression of hub gene CSNK2A2 and assessed its relationship with immunomarker *** PCR validated CSNK2A2 knockdown in HNSCC cell *** experiments including Transwell assays to determine cell migration and invasion,Cell Counting Kit 8 assay,and 5-ethynyl-2-deoxyuridine assay were performed to confirm the role of CSNK2A2 in ***,a subcutaneous xenograft model was generated in C3H mice to validate our ***:The MRG-based prognostic signature showed excellent predictive ***-risk patients had significantly shorter progression-free and overall survival(P<0.0001)than low-risk ***8+T cell infiltration was lower in high-risk groups,whereas low-risk groups showed higher immunological marker ***,the low-risk HNSCC subtype may benefit from immune therapy,while high-risk subtypes may benefit from chemotherapy(P<0.001).CSNK2A2 was highly expressed and strongly correlated with CD8 and PD-L1 based on immunohistochemistry of the HNSCC tissue ***2A2 knockdown reduced cell migration,invasion,and proliferation,and arrested cells in G1 *** vivo,it led to slower tumor growth and smaller tumor ***:We established a potential prognostic signature that could impr

关键词： Head and neck squamous cell carcinoma Mitophagy Tumor microenvironment CSNK2A2 Prognostic model

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档案库房鞘翅目害虫DNA条形码鉴定研究

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档案学研究 2024年第4期 120-127页

作者：丁双玫陈菲荆秀昆国家档案局档案科学技术研究所北京100050

鞘翅目害虫是目前档案库房中最常见的有害生物之一,害虫严重爆发时,被蛀食的档案纸张被大面积毁损且无法修复,所以档案虫情监测和预防极为重要。由于库房中害虫成虫采集难度大、害虫形态虫态差别大、发生规律各异、专业人员紧缺等,档案... 详细信息

鞘翅目害虫是目前档案库房中最常见的有害生物之一,害虫严重爆发时,被蛀食的档案纸张被大面积毁损且无法修复,所以档案虫情监测和预防极为重要。由于库房中害虫成虫采集难度大、害虫形态虫态差别大、发生规律各异、专业人员紧缺等,档案库房鞘翅目害虫的快速准确鉴定成为一个难点。为了更好地解决这个问题,本研究利用DNA条形码鉴定技术将采集到的样本进行分子鉴定,利用线粒体基因组的COI基因片段,建立了档案鞘翅目害虫DNA条形码数据库。除此之外,本研究还利用分子数据将三种害虫的成、幼虫进行配对,为解决幼虫形态鉴定困难的问题提供了新的思路。最后,本研究讨论了如何更好地结合形态数据和DNA条形码数据进行物种鉴定,说明了DNA条形码技术能利用最少的取样实现快速高效鉴定档案鞘翅目害虫常见种类各虫态样本的目标。

关键词：档案害虫 DNA条形码 COI基因

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