检索结果-南通市图书馆

Des-Arg(9)bradykinin as a causal metabolite for autism spectrum disorder

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World j.urnal of Psychiatry 2024年第1期14卷 88-101页

作者： Zhong-Yu Huang Zi-Pan Lyu Hong-Gui Li Hua-Zhi You Xiang-Na Yang Cai-Hui cha Center for Medical Research on Innovation and Translation Institute of Clinical MedicineGuangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510000Guangdong ProvinceChina School of Biological Sciences Nanyang Technological UniversityNanyang Ave 639798Singapore Department of Pediatrics First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Nutrition First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Pediatric Traditional Chinese Medicine Clinic Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina Department of Psychology Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Early diagnosis and therapeutic interventions can greatly enhance the developmental traj.ctory of children with autism spectrum disorder(ASD).However,the etiology of ASD is not completely *** presence of confounding factors from environment and genetics has increased the difficulty of the identification of diagnostic biomarkers for *** To estimate and interpret the causal relationship between ASD and metabolite profile,taking into consideration both genetic and environmental *** A two-sample Mendelian randomization(MR)analysis was conducted using summarized data from large-scale genome-wide association studies(GWAS)including a metabolite GWAS dataset covering 453 metabolites from 7824 European and an ASD GWAS dataset comprising 18381 ASD cases and 27969 healthy *** in plasma were set as exposures with ASD as the main *** causal relationships were estimated using the inverse variant weight(IVW)*** also performed leave-one-out sensitivity tests to validate the robustness of the *** on the drafted metabolites,enrichment analysis was conducted to interpret the association via constructing a protein-protein interaction network with multi-scale evidence from databases including Infinome,SwissTargetPrediction,STRING,and *** Des-Arg(9)-bradykinin was identified as a causal metabolite that increases the risk of ASD(β=0.262,SE=0.064,P_(IVW)=4.64×10^(-5)).The association was robust,with no significant heterogeneity among instrument variables(P_(MR Egger)=0.663,P_(IVW)=0.906)and no evidence of pleiotropy(P=0.949).Neuroinflammation and the response to stimulus were suggested as potential biological processes mediating the association between Des-Arg(9)bradykinin and *** Through the application of MR,this study provides practical insights into the potential causal association between plasma metabolites and *** findings offer perspectives for the discovery of diagnos

关键词： Des-Arg(9)bradykinin Autism spectrum disorder Mendelian randomization Metabolite Enrichment analysis

Electricity Generation from Heatwaves

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International j.urnal of Geosciences 2024年第5期15卷 449-457页

作者： Diandong Ren Mervyn j. Lynch School of Electrical Engineering Computing and Mathematical Sciences Curtin University Perth Australia Australian Sustainable Development Institute (ASDI) Perth Australia

We chose a definition of heatwaves (HWs) that has ~4-year recurrence frequency at world hot spots. We first examined the 1940-2022 HWs climatology and trends in lifespan, severity, spatial extent, and recurrence frequency. HWs are becoming more frequent and more severe for extratropical mid- and low-latitudes. To euphemize HWs, we here propose a novel clean energy-tapping concept that utilizes the available nano-technology, micro-meteorology knowledge of temperature distribution within/without buildings, and radiative properties of earth atmosphere. The key points for a practical electricity generation scheme from HWs are defogging, insulation, and minimizing the absorption of infrared downward radiation at the cold legs of the thermoelectric generators. One sample realization is presented which, through relay with existing photovoltaic devices, provides all-day electricity supply sufficient for providing air conditioning requirement for a residence (~2000-watt throughput). The provision of power to air conditioning systems, usually imposes a significant stress on traditional city power grids during heatwaves.

关键词： Heatwaves Climate Warming Clean Energy Generation by Thermoelectric Generator Ameliorate and Transcend Heatwaves Climate Warming Mitigation and Adaptation Thermoelectric Generator (TEG) IR Interaction with Periodically Arranged Nanostructures Optical Properties of Nano Fabricating Passive Clean Energy Tapping/Generation

Recent progress on in situ characterizations of electrochemically intercalated transition metal dichalcogenides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2019年第9期12卷 2126-2139页

作者： Saj.d Yazdani Milad Yarali j.dy j. cha Department of Mechanical Engineering and Materials Science Yale UniversityNew HavenCT 06511USA Energy Sciences Institute Yale University West CampusWest HavenCT 06516USA

Layered transition metal dichalcogenides(TMDCs)have been extensively studied owing to their unique physical and chemical *** van der Waals(vdW)interact!ons betwee n the stacki ng layers of TMDCs allow intercalati on of various species including mono vale nt alkali,divale nt alkaline earth and multivale nt metal ions,zero-vale nt transiti on metals,as well as orga nic molecules,all of which can drastically alter fun dame ntal properties of the *** urge to understa nd the phe nomena and the desire to exploit them for applicati ons have inspired a great deal of investigations.A large portion of the mystery has been unveiled over the past decade of intense research;however,many questions remain open and require further *** review is concerned with investigations on structural and electronic evolution of TMDCs drive n by electrochemically con trolled in tercalati ***,we aim to survey the rece nt adva nces and experime ntal platforms for mon itoring the in tercalati on processes in situ by utilizi ng nano *** additi on,several in quiries and prospects are outlined in a broader con text for future ave nues of studies.

关键词： transition metal dichalcogenides electrochemical intercalation in situ characterizations transmission electron microscopy(TEM) magnetotransport measurements

Cluster Modulation: A Generalized Modulation Scheme Leading to NOMA or Adaptive Modulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

j.urnal of Computer and Communications 2024年第7期12卷 12-22页

作者： j.mal S. Rahhal Suliman j. Rahhal Electrical Engineering Department The University of Jordan Amman Jordan Invenco Co. Tampa USA

The need for higher data rate and higher systems capacity leads to several solutions including higher constellation size, spatial multiplexing, adaptive modulation and Non-Orthogonal Multiple Access (NOMA). Adaptive Modulation makes use of the user’s location from his base station, such that, closer users get bigger constellation size and hence higher data rate. A similar idea of adaptive modulation that makes use of the user’s locations is the NOMA technique. here the base station transmits composite signals each for a different user at a different distance from the base station. The transmitted signal is formed by summing different user’s constellations with different weights. The closer the users the less average power constellation is used. This will allow the closer user to the base station to distinguish his constellation and others constellation. The far user will only distinguish his constellation and other user’s data will appear as a small interference added to his signal. In this paper, it is shown that the Adaptive modulation and the NOMA are special cases of the more general Cluster Modulation technique. Therefore, a general frame can be set to design both modulation schemes and better understanding is achieved. This leads to designing a multi-level NOMA and/or flexible adaptive modulation with combined channel coding.

关键词： Cluster Modulation Adaptive Modulation NOMA

Are hydrides under high-pressure-high-temperature superconductors?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第7期11卷 9-12页

作者： j.E.Hirsch Department of Physics University of California

Contrary to the current consensus, I argue that the existing evidence for high-temperature superconductivity in hydrides under high pressure is not compelling. I suggest that the focus of the field should urgently shift to establish unequivocally experimentally whether or not superconductivity in pressurized hydrides exists, instead of continuing to search for new materials that might show elusive signals of unproven superconductivity at ever higher temperatures. The implications of a negative finding for the theoretical understanding of superconductivity are discussed.

关键词： Hydrides

Leader-following consensus control for networked multi-teleoperator systems with interval time-varying communication delays

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2013年第7期22卷 96-103页

作者： M. j. Park S. M. Lee j. W. Son O. M. Kwon E. j. cha School of Electrical Engineering Chungbuk National University School of Electronic Engineering Daegu University Division of IT-Convergence Daegu Gyeongbuk Institute of Science & Technology Department of Biomedical Engineering School of MedicineChungbuk National University

We study the leader-following consensus stability and stabilization of networked multi-teleoperator systems with interval time-varying communication delays. With the construction of a suitable Lyapunov–Krasovskii functional and the utilization of the reciprocally convex approach, novel delay-dependent consensus stability and stabilization conditions for the systems are established in terms of linear matrix inequalities, which can easily be solved by various effective optimization algorithms. One illustrative example is given to illustrate the effectiveness of the proposed methods.

关键词： multi-teleoperator systems interval time-varying delay leader–following consensus problem Lyapunov method

维普期刊数据库

Thermoluminescence characterization of natural and synthetic irradiated Ce-monazites

在线全文

学校读者我要写书评

暂无评论

j.urnal of Rare Earths 2024年第4期42卷 643-650页

作者： V.Correcher C.Boronat j.Garcia-Guinea j.F.Benavente T.Rivera-Montalvo CIEMAT Av.Complutense 4028040MadridSpain MNCN-CSIC J.Gutierrez Abascal 228006MadridSpain Instituto Politécnico Nacional CICATA-IPNAv.Legaria 694Mexico City11500Mexico

The thermoluminescence(TL)emission of synthetic and natural Ce-monazites was characterized here to determine the potential application in the identification of microscopic defects from a qualitative point of view trying to link each TL peak to a chemical-physical *** kinetic parameters that lead the luminescence processes were calculated by means of variable heating rate and computing glow curve deconvolution methods and allow identifying three groups of components at~90,130 and 290℃(for the mineral sample)and~90,170,220,270 and 320℃(for the synthetic CePO_(4):Nd_(0.20),La_(0.25)).The main differences appreciated in these complex TL curves are mainly due to(i)the content of impurities(natural sample contains lanthanides as well as U 0.60%and Th 5.22%)and(ii)the degree of crystallinity of the samples which is directly related to the type of impurities(synthetic monazite relies only on Nd and La).The behavior of the dose response in the range of 1-8 Gy is similar for both samples;the TL intensity increases linearly as the dose increases without changes in the position of the maxima,denoting first-order kinetic luminescence *** peak could be mostly associated with structural defects(i.e.,phase transitions),chemical reactions(i.e.,Ce3+?Ce4+redox reaction,dehydration or dehydroxylation processes)or intrinsic defects(i.e.,Frenkel defects,ODCs or NBOHCs).

关键词： Thermoluminescence Kineticparameters Phosphate Ce-monazite Defects Rare earths

维普期刊数据库

Long-term monitoring of cycles in Clethrionomys rutilus in the Yukon boreal forest

在线全文

学校读者我要写书评

暂无评论

Integrative Zoology 2024年第1期19卷 27-36页

作者： charles j.KREBS Alice j.KENNEY B.Scott GILBERT Rudy BOONSTRA Department of Zoology University of British ColumbiaVancouverBritish ColumbiaCanada Renewable Resources Management Program Yukon UniversityWhitehorseYukonCanada Department of Biological Sciences University of Toronto ScarboroughTorontoOntarioCanada

Baseline studies of small rodent populations in undisturbed ecosystems are *** report here 50 years of mon-itoring and experimentation in Yukon of a dominant rodent species in the North American boreal forest,the red-backed vole Clethrionomys *** voles breed in summer,weigh 20–25 g,and reach a maximum density of 20 to 25 per *** populations have shown consistent 3–4-year cycles for the last 50 years with the only change being that peak densities averaged 8/ha until 2000 and 18/ha since that *** the last 25 years,we have measured food resources,predator numbers,and winter weather,and for 1-year social interactions,to estimate their contribution to changes in the rate of summer increase and the rate of overwinter *** these potential limiting factors could contribute to changes in density,and we measured their relative contributions statistically with multiple *** rate of winter decline in density was related to both food supply and winter *** rate of summer increase was related to summer berry crops and white spruce cone *** measure of predator numbers was related to winter or summer changes in vole *** was a large signal of climate change effects in these *** is no density dependence in summer population growth and only a weak one in winter population *** of our results provide a clear understanding of what generates 3–4-year cycles in these voles,and the maj.r missing piece may be an understanding of social interactions at high density.

关键词： boreal forest climate change density dependence population cycles predation winter severity

H∞ synchronization of chaotic neural networks with time-varying delays

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2013年第11期22卷 244-252页

作者： O. M. Kwon M. j. Park j. H. Park S. M. Lee E. j. cha School of Electrical Engineering Chungbuk National University Department of Electrical Engineering Yeungnam University School of Electronic Engineering Daegu University Department of Biomedical Engineering School of Medicine Chungbuk National University

In this paper, we investigate the problem of H∞ synchronization for chaotic neural networks with time-varying delays. A new model of the networks with disturbances in both master and slave systems is presented. By constructing a suitable Lyapunov–Krasovskii functional and using a reciprocally convex approach, a novel H∞ synchronization criterion for the networks concerned is established in terms of linear matrix inequalities （LMIs） which can be easily solved by various effective optimization algorithms. Two numerical examples are given to illustrate the effectiveness of the proposed method.

关键词： chaotic neural networks time-varying delays H∞ synchronization Lyapunov method

维普期刊数据库