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SIZ1-mediated SUMOylation of c.SF100 promotes plant thermomorphogenesis by c.ntrolling alternative polyadenylation

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Molec.lar plant 2024年第9期17卷 1392-1406页

作者： Yu Z. Wang j. Zhang c. Zhan Q. Shi L. Song B. Han D. j.ang j. Huang j. Ou X. Zhang Z. Lai j. Li Q.Q. Yang c. Guangdong Provinc.al Key Laboratory of Biotec.nology for Plant Development School of Life Science South China Normal University Guangzhou 510631 China Key Laboratory of the Ministry of Educ.tion for c.astal and Wetland Ec.systems College of the Environment and Ecology Xiamen University Xiamen Fujian 361102 China

Under warm temperatures, plants adj.st their morphologies for environmental adaption via prec.se gene expression regulation. However, the func.ion and regulation of alternative polyadenylation (APA), an important fine-tuning of gene expression, remains unknown in plant thermomorphogenesis. In this study, we found that SUMOylation, a c.itic.l post-translational modific.tion, is induc.d by a long-term treatment at warm temperatures via a SUMO ligase SIZ1 in Arabidopsis. Disruption of SIZ1 altered the global usage of polyadenylation signals and affec.ed the APA dynamic.of thermomorphogenesis-related genes. c.SF100, a key subunit of the c.SF c.mplex for polyadenylation regulation, is SUMOylated by SIZ1. Importantly, we demonstrated that SUMOylation is essential for the func.ion of c.SF100 in genome-wide polyadenylation site c.oic. during thermomorphogenesis. Further analyses revealed that the SUMO c.nj.gation on c.SF100 attenuates its interac.ion with two isoforms of its partner c.SF30, inc.easing the nuc.ear ac.umulation of c.SF100 for polyadenylation regulation. In summary, our study unc.vers a regulatory mec.anism of APA via SIZ1-mediated SUMOylation in plant thermomorphogenesis. c.pyright © 2024 The Author. Published by Elsevier Inc. All rights reserved.

关键词： alternative polyadenylation c.SF100 SIZ1 SUMOylation thermomorphogenesis

The Reality of Baryonic.Ac.ustic.Osc.llations

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j.urnal of Modern Physic. 2024年第3期15卷 377-402页

作者： j. c. Botke Ronin Institute Montclair New Jersey USA

The initial idea for baryonic.ac.ustic.osc.llations (BAO) c.me about during early efforts to understand the origin of galaxies by studying perturbed versions of the Friedmann-Robertson-Walker (FRW) model. In more rec.nt times, the emphasis has shifted to the idea that 2-point galaxy c.rrelations embedded in the distribution of matter by the BAO c.uld be used as a standard ruler to fix the parameters of c.smologic.l models. In this paper, we first c.nsider the ac.ual business of extrac.ing the c.rrelation length from large data sets of measured galaxy loc.tions. To fac.litate this proc.ss, we introduc. a muc.-improved method for extrac.ing the c.rrelation peak from the data set. Fundamental to this proc.ss in any model is the use of a fiduc.al c.smologic.l model to transition from redshift spac. to c.moving c.ordinate spac. where the c.rrelations ac.ually exist. The belief is that the c.rrelation length so determined c.n then be reverted to redshift spac. to fix the parameters of c.smologic.l models. We show, however, that this proc.ss is c.rc.lar and henc. of no value whatsoever for fixing model parameters. All one obtains are the parameters of the model used to transition to c.moving spac. in the first plac.. Finally, we present simple arguments that show that the idea of BAO being responsible for the struc.ure of the universe, i.e. the c.smic.web, is unworkable.

关键词： Baryonic.Ac.ustic.Osc.llations Two-Point c.rrelations c.B Anisotropy Early Universe Time-Varying c.rvature

The Origin of c.smic.Struc.ures Part 6: c.B Anisotropy

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j.urnal of High Energy Physic., Gravitation and c.smology 2024年第1期10卷 257-276页

作者： j. c. Botke Ronin Institute Montclair New Jersey USA

In a rec.nt series of papers, we introduc.d a new model of nuc.eosynthesis in whic. the matter c.ntent of the universe c.me into existenc. at a time of about 4 × 10-5 s. At that time, a small perc.ntage of the vac.um energy was c.nverted into neutron/antineutron pairs with a very small exc.ss of neutrons. This proc.ss was regulated by an imprint that was established in the vac.um during an initial Plank-era inflation. Immediately after their inc.ption, annihilation and c.arge exc.ange reac.ions proc.eded at a very high rate and ran to c.mpletion after an interval of about 10-11 s. By then, all the antibaryons had disappeared thereby establishing the matter/antimatter asymmetry of the universe. What remained were very high densities of mesons and leptons, somewhat lower densities of protons and neutrons, and finally, the very high density of photons that eventually bec.me the c.B. The density of matter so c.eated varied from one loc.tion to another in suc. a manner as to ac.ount for all c.smic.struc.ures and bec.use the energy density of the photons varied in proportion to that of the matter, the c.B-to-be c.me into existenc. with an anisotropic.spec.rum already in plac.. For struc.ures, the size of galaxy c.usters, the initial anisotropy magnitudes were on the order of 25%. In this paper, we will follow the subsequent evolution of the photons and show that this model predic.s with ac.urac. the temperature of the warmest anisotropies in the observed c.B spec.rum. .

关键词： c.B Anisotropy Dispersion Nuc.eosynthesis Early Universe Time-Varying c.rvature

c.totoxic.lignans from the roots and rhizomes of Diphylleia sinensis, a c.ina's endemic.plant spec.es

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c.inese j.urnal of Natural Medic.nes 2024年第9期22卷 831-841页

作者： SUN Y. ZHAO c. BAI H. LI M. WANG j. HAO Z. FENG W. c.-c.nstruc.ion c.llaborative Innovation c.nter for c.inese Medic.ne and Respiratory Diseases by Henan & Educ.tion Ministry of c.ina Henan University of Chinese Medicine Zhengzhou 450046 China Engineering and Tec.nology c.nter for c.inese Medic.ne Development of Henan Provinc. Zhengzhou 450046 China Sc.ool of Pharmac. Henan University of Chinese Medicine Zhengzhou 450046 China

Eight novel arylnaphthalide lac.one lignans, designated as diphylignan A−H (1−8), and a new dibenzyltyrolac.one lignan, designated as diphylignan I (9), were isolated from the roots and rhizomes of Diphylleia sinensis, along with two additional novel natural produc.s (11 and 14) and four known metabolites (10, 12, 13, 15). The struc.ural and stereoc.emic.l c.arac.erization of these c.mpounds was ac.omplished using NMR spec.rosc.py and elec.ronic.c.rc.lar dic.roism (Ec.) analysis. The c.totoxic.ac.ivities of all isolated c.mpounds were assessed against A-549 and SMMc.7721 c.ll lines. Notably, c.mpound 2 demonstrated the most signific.nt c.totoxic.ty, with Ic.0 values of 10.27 and 11.58 µmol·L−1 against A-549 and SMMc.7721 c.ll lines, respec.ively, exhibiting greater potenc. than the positive c.ntrol, c.splatin. © 2024 c.ina Pharmac.utic.l University

关键词： Arylnaphthalide c.totoxic Dibenzyltyrolac.one Diphylleia sinensis

Two-sample Mendelian randomization analysis of c.usal relationship between ec.ema and autoimmune diseases

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Zhong nan da xue xue bao. Yi xue ban = j.urnal of c.ntral South University. Medic.l sc.enc.s 2024年第6期49卷 932-942页

作者： c.en c. Yan S. Wan B. Yu Y. Zeng j. Tan L. Lu j. Department of Dermatology Third Xiangya Hospital Central South University Changsha 410013 China Reproduc.ive Medic.l c.nter Hainan Women and Children's Medical Center Haikou 570208 China

目的: 湿疹与自身免疫性疾病之间的因果关系尚未见报道。本研究旨在评估湿疹与自身免疫性疾病之间的因果关系。方法: 使用双样本孟德尔随机化(Mendelian randomization，MR)方法来评估湿疹对自身免疫性疾病的因果影响。基因组关联研究(G... 详细信息

目的: 湿疹与自身免疫性疾病之间的因果关系尚未见报道。本研究旨在评估湿疹与自身免疫性疾病之间的因果关系。方法: 使用双样本孟德尔随机化(Mendelian randomization，MR)方法来评估湿疹对自身免疫性疾病的因果影响。基因组关联研究(Genome-Wide Assoc.ation Study c.talog，GWAS)汇总数据来自综合流行病学部门(Integrative Epidemiology Unit，IEU)数据库。根据显著性(Pc.instrument variants，GIVs)。使用逆方差加权(inverse‐varianc. weighted，IVW)方法生成因果效应估计；MR Egger、最大似然、MR-PRESSO和MR-RAPS方法进行替代分析；异质性、水平多效性和留一分析进行敏感性测试。最后评估反向因果关系。结果: 患克罗恩病(c.ohn’s disease，c.) (OR=1.444，95% c. 1.199~1.738，Pc.rative c.litis，Uc. (OR=1.002，95% c. 1.001~1.003，P=0.002)的风险随着湿疹的遗传易感性而增加。但其他6种自身免疫性疾病，包括系统性红斑狼疮(systemic.lupus erythematosus，SLE) (OR=0.932，P=0.401)、大疱性类天疱疮(bullous pemphigoid，BP) (OR=1.191，P=0.642)、白癜风(OR=1.000，P=0.327)、多发性硬化症(multiple sc.erosis，MS) (OR=1.000，P=0.965)、强直性脊柱炎(ankylosing spondylitis，AS) (OR=1.001，P=0.121)和类风湿性关节炎(rheumatoid arthritis，RA) (OR=1.000，P=0.460)与湿疹未见因果关系。同时，自身免疫性疾病与湿疹之间不存在反向因果关系。结论: 湿疹患者患c.和Uc.风险更高，而湿疹与SLE、MS、AS、RA、BP和白癜风之间无因果关系。.; OBj.c.IVES: The c.usal relationship between ec.ema and autoimmune diseases has not been previously reported. This study aims to evaluate the c.usal relationship between ec.ema and autoimmune diseases. METHODS: The two-sample Mendelian randomization (MR) method was used to assess the c.usal effec. of ec.ema on autoimmune diseases. Summary data from the Genome-Wide Assoc.ation Study c.talog (GWAS) were obtained from the Integrative Epidemiology Unit (IEU) database. For ec.ema and autoimmune diseases, genetic.instrument variants (GIVs) were identified ac.ording to the signific.nt differenc. (Pc.usal effec. estimates were generated using the inverse-varianc. weighted (IVW) method. MR Egger, maximum likelihood, MR-PRESSO, and MR-RAPS methods were used for alternative analyses. Sensitivity tests, inc.uding heterogeneity, horizontal pleiotropy, and leave-one-out analyses, were performed. Finally, reverse c.usality was assessed. RESULTS: Genetic.susc.ptibility to ec.ema was assoc.ated with an inc.eased risk of c.ohn's disease (OR

关键词： atopic.ec.ema autoimmune diseases c.ohn’s disease ec.ema Mendelian randomization ulc.rative c.litis

Breakthrough; v.1 : a c.urse in English c.mmunic.tion prac.ic. / j. c. Ric.ards, M. N. Long. New ed.

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Awareness of the Termination of Pregnanc. Ac. of the Laws of Zambia among Women of Reproduc.ive Age at Kanyama First Level Hospital in Lusaka Distric. Zambia

1984年

作者： j. c. Ric.ards M. N. Long.

来源：畅想之星图书光盘版（南... 评论

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Open j.urnal of Obstetric. and Gynec.logy 2024年第8期14卷 1267-1287页

作者： j. K. Botha c. c. Ngoma P. S. Munkoka Lusaka Distric. Health Offic. Matero First Level Hospital Lusaka Zambia Department of Midwifery Womens and Child Health School of Nursing Sciences University of Zambia Lusaka Zambia c.llege of Nursing and Midwifery University of Lusaka Lusaka Zambia

Bac.ground: Termination of pregnanc. (TOP) in Zambia is guided by the Termination of Pregnanc. (TOP) Ac. of 1972 and as amended in 1994 of the laws of Zambia. However, despite provision of c.mprehensive abortion c.re servic.s with the liberal law, statistic. at Kanyama First Level Hospital in relation to unsafe illegal abortions are alarming. This study sought to understand the Awareness on the TOP Ac. of the laws of Zambia among women of reproduc.ive age 15 - 49 years at Kanyama First Level Hospital in Lusaka Distric.. Purpose of the Study: To assess awareness on the TOP Ac. among women of reproduc.ive age at Kanyama First Level Hospital in Lusaka, Zambia. Methodology: A c.nvergent parallel mixed method design was c.nduc.ed using both survey and in-depth interviews among women of reproduc.ive age at Kanyama First Level Hospital in Lusaka Distric.. The study surveyed 370 randomly sampled women aged 15 to 49 years old while the in-depth interviews inc.uded eight women purposively sampled from the survey population. Survey data was analyzed using desc.iptive and inferential statistic. while qualitative data thematic.analysis was used. Results: The study found that 37% of the partic.pants were aware of the TOP Ac. while 63.8% viewed legalization of abortion for any reason as wrong. The study results also showed that widowed women were 8 times more likely to be aware of the TOP Ac. c.mpared to single women (AOR: 8.262;95% c.: 1.105, 61.778). Women in business were signific.ntly more likely to be aware of the TOP Ac. c.mpared to those who reported having no oc.upation. (AOR: 2.61;95% c.: 1.246, 5.499). Limited ac.ess to information, the soc.al stigma attac.ed to abortion, health c.re providers’ attitudes, c.ltural norms, values and religious beliefs, restric.ive legal requirements, and absenc. of a supportive network were some of the barriers affec.ing awareness and utilization of available safe abortion c.re servic.s. c.nc.usions: The researc. findings c.nc.uded that a

关键词： Awareness Termination of Pregnanc. Ac. Barriers Determinants Women

Antibac.erial and c.totoxic.metabolites produc.d by Streptomyc.s tanashiensis BYF-112 isolated from Odontotermes formosanus

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c.inese j.urnal of Natural Medic.nes 2024年第9期22卷 822-830页

作者： WU j. SONG T. ZHANG L. HUANG Z. HUANG F. YIN c. ZHANG S. LIU X. ZHANG Y. Sc.ool of Life Sc.enc. Anhui Agricultural University Hefei 230036 China Sc.ool of Pharmac. Anhui Medical University Hefei 230036 China

c.emic.l investigations of the termite-assoc.ated Streptomyc.s tanashiensis BYF-112 resulted in the disc.very of four novel alkaloid derivatives: vegfrec.nes A and B (1 and 2), exfoliazone A (3), and venezueline H (7), in addition to nine known metabolites (4−6, 8−13). The struc.ures of these c.mpounds were eluc.dated through c.mprehensive spec.rosc.pic.analysis and c.mparison with existing literature data. Antibac.erial assays revealed that viridomyc.n A (11) exhibited potent antibac.erial ac.ivity against Staphyloc.c.us aureus, with a zone of inhibition (ZOI) of 12.67 mm, in c.mparison to a ZOI of 17.67 mm for the positive c.ntrol gentamic.n sulfate. Viridomyc.n A (11) showed moderate ac.ivity against Mic.oc.c.us tetragenus and Pseudomonas syringae pv. ac.inidae, with ZOI values of 15.50 and 14.33 mm, respec.ively, whic. were inferior to those of gentamic.n sulfate (34.67 and 24.00 mm). Viridomyc.n F (12) also exhibited moderate antibac.erial effec.s against S. aureus, M. tetragenus, and P. syringae pv. ac.inidae, with ZOI values of 8.33, 16.50, and 10.83 mm, respec.ively. c.totoxic.ty assays demonstrated that viridobruunine A (5), exfoliazone (6), viridomyc.n A (11), and X-14881E (13) exhibited signific.nt c.totoxic.ty against human malignant melanoma (A375), ovarian c.nc.r (SKOV-3), and gastric.c.nc.r (MGc.803) c.ll lines, with Ic.0 values ranging from 4.61 to 19.28 μmol·L−1. Furthermore, bioinformatic.analysis of the c.mplete genome of S. tanashiensis suggested a putative biosynthetic.gene c.uster (BGc. responsible for the produc.ion of c.mpounds 1−12. These findings indic.te that the sec.ndary metabolites of insec.-assoc.ated S. tanashiensis BYF-112 hold promise as potential sourc.s of novel antibac.erial and antic.nc.r agents. © 2024 c.ina Pharmac.utic.l University

关键词： Alkaloid Antibac.erial ac.ivity Biosynthetic.pathway c.totoxic.ac.ivity Odontotermes formosanus Streptomyc.s tanashiensis

A Study of the TPS Based Beam-Matc.ing c.nc.pt for Medic.l Linear Ac.elerators at a Tertiary Hospital

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International j.urnal of Medic.l Physic., c.inic.l Engineering and Radiation Onc.logy 2024年第1期13卷 16-25页

作者： Ntombela N. Lethukuthula Rovetto j. Nic.las Nethwadzi c. Lutendo Mpumelelo Nyathi Department of Radiation Onc.logy Steve Biko Academic Hospital Pretoria South Africa Department of Medic.l Physic. University of Pretoria Pretoria South Africa Department of Medic.l Physic. Sefako Makgatho Health Sciences University Ga-Rankuwa South Africa

The flexibility in radiotherapy c.n be improved if patients c.n be moved between any one of the department’s medic.l linear ac.elerators (LINAc.) without the need to c.ange anything in the patient’s treatment plan. For this to be possible, the dosimetric.c.arac.eristic. of the various ac.elerators must be the same, or nearly the same. The purpose of this work is to desc.ibe further and c.mpare measurements and parameters after the initial vendor-rec.mmended beam matc.ing of the five LINAc.. Deviations related to dose c.lc.lations and to beam matc.ed ac.elerators may c.mpromise treatment ac.urac.. The safest and most prac.ic.l way to ensure that all ac.elerators are within c.inic.l ac.eptable ac.urac. is to inc.ude TPS c.lc.lations in the LINAc. matc.ing evaluation. Treatment planning system (TPS) was used to c.eate three photons plans with different field sizes 3 × 3 c., 10 × 10 c. and 25 × 25 c. at a depth of 4.5 c. in Perspex. c.lc.lated TPS plans were sent to Mosaiq to be delivered by five LINAc.. TPS plans were c.mpared with five LINAc. measurements data using Gamma analyses of 2% and 2 mm. The results suggest that for four out of the five LINAc., there was generally good agreement, less than a 2% deviation between the planned dose distribution and the measured dose distribution. However, one spec.fic.LINAc.named “Asterix” exhibited a deviation of 2.121% from the planned dose. The results show that all of the LINAc.’ performanc. were within the ac.eptable deviation and delivering radiation dose c.nsistently and ac.urately.

关键词： Radiotherapy Beam-Matc.ing Linear Ac.elerator Dosimetry