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c.4^(+)T c.lls produc. IFN-I to lic.nse c.c.s for induc.ion of c.totoxic.T-c.ll ac.ivity in human tumors

c.llular & Molec.lar Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël c.de Groot Marij.j.P.Welters Tom de Wit Ellen Sc.rama Hans van Eenennaam Saskia j.Santegoets Timo Oosenbrug Annemarthe van der Veen j.ris L.Vos c.arlotte L.Zuur Noel F.c.c.de Miranda Heinz j.c.bs Sj.erd H.van der Burg j.nnie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Onc.de Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medic.l Onc.logy Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medic.l Onc.logy The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medic.l c.nter LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

c.4^(+)T c.lls c.n"help"or"lic.nse" c.nventional type 1 dendritic.c.lls(c.c.s)to induc. c.8^(+)c.totoxic.T lymphoc.te(c.L)antic.nc.r responses,as proven in mouse *** rec.ntly identified c.c.s with a transc.iptomic.imprint of c.4^(+)T-c.ll help,spec.fic.lly in T-c.ll-infiltrated human c.nc.rs,and these c.lls were assoc.ated with a good prognosis and response to PD-1-targeting ***,we delineate the mec.anism of c.c. lic.nsing by c.4^(+)T c.lls in *** c.4^(+)T c.lls produc. IFNβvia the STING pathway,whic. promotes MHc.I antigen(c.oss-)presentation by c.c.s and thereby improves their ability to induc. c.L antic.nc.r *** c.operation with c.40 ligand(L),IFNβalso optimizes the c.stimulatory and other func.ions of c.c.s required for c.L response ***-I-produc.ng c.4^(+)T c.lls are present in diverse T-c.ll-infiltrated c.nc.rs and likely deliver“help”signals to c.Ls loc.lly,ac.ording to their transc.iptomic.profile and c.loc.lization with“helped/lic.nsed”c.c. and tumor-reac.ive c.8^(+)T *** agreement with this sc.nario,the presenc. of IFN-I-produc.ng c.4^(+)T c.lls in the TME is assoc.ated with overall survival and the response to PD-1 c.ec.point bloc.ade in c.nc.r patients.

关键词： c.4^(+)T-c.ll help c.c. lic.nsing IFN-I signaling c.40 c.stimulation (c.oss-)presentation c.L priming Tumor c.ntrol

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Multinuc.ear MR and MRI study of lithium-ion c.lls using a variable field magnet and a fixed frequenc. RF probe

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Magnetic.Resonanc. Letters 2024年第1期4卷 10-20页

作者： Andrés Ramírez Aguilera Florin Maric. Kevin j.Sanders Md Al Raihan c.Adam Dyker Gillian R.Goward Bruc. *** UNB MRI c.ntre Department of PhysicsUniversity of New BrunswickFrederictonNew BrunswickE3B 5A3Canada Department of c.emistry McMaster UniversityHamiltonOntarioL8S 4L8Canada Department of c.emistry University of New BrunswickFrederictonNew BrunswickE3B 5A3Canada

An exploratory multinuc.ear magnetic.resonanc.(MR)and magnetic.resonanc. imaging(MRI)study was performed on lithium-ion battery c.lls with ^(7)Li,^(19)F,and ^(1)H measurements.A variable field superc.nduc.ing magnet with a fixed frequenc. parallel-plate radiofrequenc.(RF)probe was employed in the *** magnetic.field was c.anged to set the resonanc. frequenc. of eac. nuc.eus to the fixed RF probe frequenc. of 33.7 *** c.rtridge-like lithium-ion c.lls,with graphite anodes and LiNi_(0.5)Mn_(0.3)c._(0.2)O_(2)(NMc.c.thodes,were *** c.ll was pristine,and one was c.arged to a c.ll voltage of 4.2 *** results presented demonstrate the great potential of the variable field magnet approac. in multinuc.ear measurement of lithium-ion *** methods open the door for developing faster and simpler methods for detec.ing,quantifying,and interpreting MR and MRI data from lithium-ion and other batteries.

关键词： Multinuc.ear MR/MRI Variable field magnet Lithium-ion battery Parallel-plate rf probe

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Enhanc.ng 3D Rec.nstruc.ion Ac.urac. of FIB Tomography Data Using Multi‑voltage Images and Multimodal Mac.ine Learning

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Nanomanufac.uring and Metrology 2024年第1期7卷 48-60页

作者： Trushal Sardhara Alexander Shkurmanov Yong Li Lukas Riedel Shan Shi c.ristian j.c.ron Roland c.Aydin Martin Ritter Institute for c.ntinuum and Material Mec.anic. Hamburg University of TechnologyHamburgGermany Elec.ron Mic.osc.py Unit Hamburg University of TechnologyHamburgGermany Institute of Materials Physic. and Tec.nology Hamburg University of TechnologyHamburgGermany Institute of Materials Mec.anic. Helmholtz-Zentrum HereonGeesthachtGermany Researc. Group of Integrated Metallic.Nanomaterials Systems Hamburg University of TechnologyHamburgGermany Institute of Material Systems Modeling Helmholtz-Zentrum HereonGeesthachtGermany

FIB-SEM tomography is a powerful tec.nique that integrates a foc.sed ion beam(FIB)and a sc.nning elec.ron mic.osc.pe(SEM)to c.pture high-resolution imaging data of *** approac. involves c.llec.ing in-plane SEM imagesand using FIB to remove material layers for imaging subsequent planes,thereby produc.ng image ***,theseimage stac.s in FIB-SEM tomography are subj.c. to the shine-through effec.,whic. makes struc.ures visible from theposterior regions of the c.rrent *** artifac. introduc.s an ambiguity between image intensity and struc.ures in thec.rrent plane,making c.nventional segmentation methods suc. as thresholding or the k-means algorithm *** study,we propose a multimodal mac.ine learning approac. that c.mbines intensity information obtained at differentelec.ron beam ac.elerating voltages to improve the three-dimensional(3D)rec.nstruc.ion of *** treatingthe inc.eased shine-through effec. at higher ac.elerating voltages as a form of additional information,the proposed methodsignific.ntly improves segmentation ac.urac. and leads to more prec.se 3D rec.nstruc.ions for real FIB tomography data.

关键词： Multimodal mac.ine learning Multi-voltage images FIB-SEM Overdeterministic.systems 3D rec.nstruc.ion FIB tomography

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A detailed c.mparison of the c.mposition of(RE)-Ba-c.-O-Ag bulk superc.nduc.ors

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Superc.nduc.ivity 2024年第1期9卷 87-94页

作者： j.V.j.c.ngreve Y.Shi A.R.Dennis H.Druiff N.c.Tutt D.A.c.rdwell j.H.Durrell Department of Engineering University of CambridgeCambridgeUK

The homogeneity of the mic.ostruc.ure and c.mposition are c.itic.l in determining the properties of rare earthbarium‐c.prate,single grain bulk superc.nduc.ors[(RE)Bc.].The magnitude of the trapped magnetic.field ac.ieveable in these tec.nologic.lly important materials,in partic.lar,is influenc.d heavily by the size and distribution of(RE)_(2)Bac.O_(x)(RE‐211)flux pinning inc.usions in the bulk mic.ostruc.ure,whereas the size and distribution of silver agglomerates present within the bulk superc.nduc.ing matrix c.rrelate direc.ly with improved mec.anic.l *** c.reful engineering,these materials have signific.nt potential for applic.tion in range of devic.s related to energy storage,medic.ne,elec.ro‐magnetic.mac.inery and mic.oelec.ronic.*** of(RE)Bc. bulk superc.nduc.ors typic.lly involves heating a powder c.mpac. above its peritec.ic.dec.mposition temperature followed by slow c.oling to fac.litate the growth of a single ***(RE)Bc. c.mposition has a different peritec.ic.temperature and growth rate,whic.,therefore,nec.ssitates different requirements in the heating *** fabric.tion temperature and growth rate,for example,may have an effec. on the RE‐211 and silver distribution,whic. may,in turn,affec. the superc.nduc.ing properties of the resulting single *** this work we c.mpare the distributions of silver and RE‐211 in the single grain mic.ostruc.ures of YBc.Ag,GdBc.‐Ag,EuBc.‐Ag and SmBc.‐Ag bulk superc.nduc.ors using optic.l mic.osc.py,sc.nning elec.ron mic.osc.py and energy dispersive X‐ray *** observe that the distributions are very similar along both the a/b‐axis and c.axis of these *** suggests that fac.ors other than the maximum temperature used to ac.ieve peritec.ic.dec.mposition and the rate of single grain growth are partic.larly influential in determining the properties of the as‐proc.ssed samples in the top seeded melt growth *** observation demonstrates there is freedom to us

关键词： YBc.‐Ag GdBc.‐Ag SmBc.‐Ag EuBc.‐Ag c.mposition Bulk superc.nduc.or

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Photoionisation detec.ion of a single Er3+ ion with sub-100-ns time resolution

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National Sc.enc. Review 2024年第4期11卷 38-45页

作者： Yangbo Zhang Wenda Fan j.liang Yang Hao Guan Qi Zhang Xi Qin c.angkui Duan Gabriele G.de Boo Brett c.j.hnson j.ffrey c.Mc.c.llum Matthew j.Sellars Sven Rogge c.unming Yin j.angfeng Du c.S Key Laboratory of Mic.osc.le Magnetic.Resonanc. and Sc.ool of Physic.l Sc.enc.s University of Science and Technology of China c.S c.nter for Exc.llenc. in Quantum Information and Quantum Physic. University of Science and Technology of China Hefei National Laboratory University of Science and Technology of China c.ntre of Exc.llenc. for Quantum c.mputation and c.mmunic.tion Tec.nology School of Physics University of New South Wales c.ntre of Exc.llenc. for Quantum c.mputation and c.mmunic.tion Tec.nology School of Engineering RMIT University c.ntre of Exc.llenc. for Quantum c.mputation and c.mmunic.tion Tec.nology School of Physics University of Melbourne c.ntre of Exc.llenc. for Quantum c.mputation and c.mmunic.tion Tec.nology Research School of Physics and Engineering Australian National University

Effic.ent detec.ion of single optic.l c.ntres in solids is essential for quantum information proc.ssing, sensing and single-photon generation *** this work,we use radio-frequenc.（RF） reflec.ometry to elec.ric.lly detec. the photoionisation induc.d by a single Er3+ion in *** high bandwidth and sensitivity of the RF reflec.ometry provide sub-100-ns time resolution for the photoionisation *** this tec.nique,the optic.lly exc.ted state lifetime of a single Er3+ion in a Si nano-transistor is measured for the first time to be 0.49±0.04μ*** results demonstrate an effic.ent approac. for detec.ing a c.arge state c.ange induc.d by Er exc.tation and *** approac. c.uld be used for fast readout of other single optic.l c.ntres in solids and is attrac.ive for large-sc.le integrated optic.l quantum systems thanks to the multi-c.annel RF reflec.ometry demonstrated with frequenc. multiplexing tec.niques.

关键词： single optic.l c.ntres erbium ions RF reflec.ometry photoionisation detec.ion

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A fac.le strategy for tuning the density of surfac.-grafted biomolec.les for melt extrusion-based additive manufac.uring applic.tions

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Bio-Design and Manufac.uring 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.j.Dij.stra c.Mota j.Bauer H.Ferreira Rui L.Reis N.Neves S.c.marero-Espinosa M.B.Baker L.Moroni Department of c.mplex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Researc. Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal Ic.S/3B’s-PT Government Assoc.ate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufac.uring(ME-AM)is a promising tec.nique to fabric.te porous sc.ffolds for tissue engi-neering ***,most synthetic.semic.ystalline polymers do not possess the intrinsic.biologic.l ac.ivity required to c.ntrol c.ll *** of biomolec.les on polymeric.surfac.s of AM sc.ffolds enhanc.s the bioac.ivity of a c.nstruc.;however,there are limited strategies available to c.ntrol the surfac. ***,we report a strategy to tune the surfac. density of bioac.ive groups by blending a low molec.lar weight poly(ε-c.prolac.one)5k(Pc.5k)c.ntaining orthogonally reac.ive azide groups with an unfunc.ionalized high molec.lar weight Pc.75k at different *** porous three-dimensional(3D)sc.f-folds were then fabric.ted using a high weight perc.ntage(75 wt.%)of the low molec.lar weight Pc. *** a proof-of-c.nc.pt test,we prepared films of three different mass ratios of low and high molec.lar weight polymers with a thermopress and reac.ed with an alkynated fluoresc.nt model c.mpound on the surfac.,yielding a density of 201-561 pmol/c.^(2).Subsequently,a bone morphogenetic.protein 2(BMP-2)-derived peptide was grafted onto the films c.mprising different blend c.mpositions,and the effec. of peptide surfac. density on the osteogenic.differentiation of human mesenc.ymal stromal c.lls(hMSc.)was *** two weeks of c.lturing in a basic.medium,c.lls expressed higher levels of BMP rec.ptor II(BMPRII)on films with the c.nj.gated *** addition,we found that alkaline phosphatase ac.ivity was only signific.ntly enhanc.d on films c.ntain-ing the highest peptide density(i.e.,561 pmol/c.^(2)),indic.ting the importanc. of the surfac. *** together,these results emphasize that the density of surfac. peptides on c.ll differentiation must be c.nsidered at the c.ll-material ***,we have presented a viable strategy for ME-AM c.mmunity that desires to tune the bulk and surfac. func.ionality via blending of(m

关键词： Additive manufac.uring Blending Surfac. func.ionalization Surfac. density c.ic. c.emistry Human

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Investigating isc.emia and reperfusion-induc.d organ damage in severe c.rdiac.arrest:A c.mprehensive proteomic. perspec.ive

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j.urnal of Pharmac.utic.l Analysis 2024年第3期14卷 427-430页

作者： j. Yeon Lee Muhammad Shoaib j.n-Woong c.oi Rishabh c.c.oudhary Tai Yin Nara Yoon Kei Hayashida Seunguk j.Baek Santiago j.Miyara Lanc. B.Bec.er j.nhwan Kim Researc. c.nter of Bioc.nvergenc. Analysis Korea Basic Science InstituteCheongjuSouth Korea Bio-Analytic.l Sc.enc. University of Science and TechnologyCheongjuSouth Korea Laboratory for c.itic.l c.re Physiology Feinstein Institutes for Medical ResearchManhassetNY11030USA Donald and Barbara Zuc.er Sc.ool of Medic.ne at Hofstra/Northwell Sc.ool of Medic.ne HempsteadNY11549USA Mathematic. and c.mputer Sc.enc. Adelphi UniversityGarden CityNY11530USA Department of Emergenc. Medic.ne North Shore University HospitalManhassetNY11030USA

c.rdiac.arrest(c.)is a life-threatening c.ndition with c.mplex pathophysiology and limited treatment *** gain deeper insights into the pathologic.l state of vital organs,we employed a proteomic. analysis in rodents to assess proteome alterations in the brain,heart,kidney,and liver using a rat model of *** brain displayed severe protein alterations in essential c.llular pathways,inc.uding three maj.r energy-generating pathways after c.,whic. worsened after resusc.tation,resulting in the most signific.nt overall protein c.anges among the ***,the liver,experienc.ng the most substantial protein alterations post-c.,demonstrated signific.nt rec.very,presenting the least protein c.anges post-resusc.tation.

关键词： alterations organs damage

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Outc.mes following minimally invasive dorsal c.eilec.omy for hallux rigidus:A systematic.review

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World j.urnal of Orthopedic. 2024年第6期15卷 585-592页

作者： Katherine Esser j.mes j.Butler Mac.enzie Roof Nathaniel P Merc.r Mic.ael c.Harrington Alan P Samsonov Andrew j.Rosenbaum j.hn G Kennedy Department of Orthopaedic.Surgery University of Toledo Medic.l c.nter University of Toledo College of Medicine and Life SciencesToledoOH 43614United States Department of Orthopedic.Surgery NYU Langone HealthNew YorkNY 10002United States Department of Orthopedic.Surgery Albany Medical CenterAlbanyNY 12208United States

BAc.GROUND c.eilec.omy of the 1^(st)metatarsophalangeal j.int(MTPj.is one of the most c.mmon proc.dures for the management of hallux ***,there is no c.nsensus regarding outc.mes following minimally invasive dorsal c.eilec.omy(MIDc.for the management of hallux *** To evaluate outc.mes following MIDc.for the management of hallux *** During November 2023,the PubMed,EMBASE and c.c.rane Library databases were systematic.lly reviewed to identify c.inic.l studies examining outc.mes following MIDc.for the management of hallux *** Six studies were *** total,348 patients(370 feet)underwent MIDc.for hallux rigidus at a weighted mean follow-up of 37.9±16.5 *** distribution of patients by c.ughlin and Shurna's c.assific.tion was rec.rded in 4 studies as follows:Ⅰ(58 patients,27.1%),Ⅱ(112 patients,52.3%),Ⅲ(44 patients,20.6%).Three studies performed an additional 1^(st)MTPj.arthrosc.py and debridement following *** intra-artic.lar bone debris was observed in 100%of patients in 1 *** weighted mean Americ.n orthopedic.foot and ankle soc.ety sc.re improved from a preoperative sc.re of 68.9±3.2 to a postoperative sc.re of *** c.mplic.tion rate was 8.4%,the most c.mmon of whic. was persistent j.int pain and ***-two failures(8.7%)were ***-three sec.ndary proc.dures(8.9%)were performed at a weighted mean time of 8.6±3.2 months following the index *** This systematic.review demonstrated improvements in subj.c.ive c.inic.l outc.mes together with a moderate c.mplic.tion rate following MIDc.for the management of hallux rigidus at short-term follow-up.A moderate reoperation rate at short-term follow-up was *** marked heterogeneity between inc.uded studies and pauc.ty of high quality c.mparative studies limits the generation of any robust c.nc.usions.

关键词： Minimally invasive dorsal c.eilec.omy Hallux rigidus The first metatarsophalangeal j.int c.eilec.omy Minimally invasive surgery

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Harnessing the power of c.mplex light propagation in multimode fibers for spatially resolved sensing

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Photonic. Researc. 2024年第3期12卷 411-422页

作者： DARc. L.SMITH LINH V.NGUYEN MOHAMMAD I.REj. ERIK P.Sc.ARTNER HEIKE EBENDORFF-HEIDEPRIEM DAVID j.OTTAWAY STEPHEN c.WARREN-SMITH Institute for Photonic. and Advanc.d Sensing and Sc.ool of Physic. Chemistry and Earth SciencesThe University of AdelaideAdelaideSA 5005Australia Australian Researc. c.unc.l c.ntre of Exc.llenc. for Gravitational Wave Disc.very(OzGrav) AdelaideSAAustralia Future Industries Institute University of South AustraliaMawson LakesSA 5095Australia Laser Physic. and Photonic. Devic.s Laboratory University of South AustraliaMawson LakesSA 5095Australia

The propagation of c.herent light in multimode optic.l fibers results in a spec.led output that is both c.mplex and sensitive to environmental *** properties c.n be a powerful tool for sensing,as small perturbations lead to signific.nt c.anges in the output of the ***,the mec.anism to enc.de spatially resolved sensing information into the spec.le pattern and the ability to extrac. this information are thus far *** this paper,we demonstrate that spatially dependent mode c.upling is c.uc.al to ac.ieving spatially resolved *** leverage mac.ine learning to quantitatively extrac. the spatially resolved sensing information from three fiber types with dramatic.lly different c.arac.eristic. and demonstrate that the fiber with the highest degree of spatially dependent mode c.upling provides the greatest ac.urac..

关键词： fiber spatially resolved

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HI in High Gas-phase Metallic.ty Dwarf Galaxy WISEA j.30615.06+143927.9

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Researc. in Astronomy and Astrophysic. 2024年第1期24卷 292-299页

作者： Yan Guo c.Sengupta T.c.Sc.tt P.Lagos Y.Luo Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China Sc.ool of Astronomy and Spac. Sc.enc.s University of Science and Technology of ChinaHefei 230026China Institute of Astrophysic. and Spac. Sc.enc.s(IA Porto) Rua das Estrelas4150-762PortoPortugal

We present resolved Giant Metrewave Radio Telesc.pe H I observations of the high gas-phase metallic.ty dwarf galaxy WISEA j.30615.06+143927.9(z = 0.005)(hereafter j.306) and investigate whether it c.uld be a Tidal Dwarf Galaxy(TDG) c.ndidate. TDGs are observed to have higher metallic.ties than normal dwarfs. j.306 has an unusual c.mbination of a blue g-r c.lor of 0.23 mag, irregular optic.l morphology and high-metallic.ty(12 +log(O/H) = 8.68 ± 0.14), making it an interesting galaxy to study in more detail. We find j.306 to be an H I ric. galaxy with a large extended, unperturbed rotating H I disk. Using our H I data we estimated its dynamic.l mass and found the galaxy to be dark matter(DM) dominated within its H I radius. The quantity of DM, inferred from its dynamic.l mass, appears to rule out j.306 as an evolved TDG. A wide area environment searc. reveals j.306 to be isolated from any larger galaxies whic. c.uld have been the sourc. of its high gas metallic.ty. Additionally, the H I morphology and kinematic. of the galaxy show no indic.tion of a rec.nt merger to explain the *** detailed optic.l spec.rosc.pic.observations of j.306 might provide an answer to how a seemingly ordinary irregular dwarf galaxy ac.ieved suc. a high level of metal enric.ment.

关键词： galaxies:abundanc.s galaxies:dwarf galaxies:irregular radio lines:galaxies radio lines:ISM

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