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Advances in Manufacturing 2018年第3期6卷 301-307页

作者： P. Wiederkehr T. Siebrecht j. baumann D. Biermann Institute of Machining Technology TU Dortmund University Dortmund Germany Virtual Machining Department of Computer Science TU Dortmund University Dortmund Germany

Geometric physically-based simulation systemscan be used for analyzing and optimizing complex millingprocesses, for example in the automotive or aerospaceindustry, where the surface quality and process efficiencyare limited due to chatter vibrations. Process simulationsusing tool models based on the constructive solid geometry（CSG） technique allow the analysis of process forces, tooldeflections, and surface location errors resulting from five-axis machining operations. However, modeling complextool shapes and effects like runout is difficult using CSGmodels due to the increasing complexity of the shapedescriptions. Therefore, a point-based method for modelingthe rotating tool considering its deflections is presented inthis paper. With this method, tools with complex shapesand runout can be simulated in an efficient and flexibleway. The new modeling approach is applied to exemplarymilling processes and the simulation results are validatedbased on machining experiments.

关键词： Modeling Tool geometry Milling

Academic productivity correlates with industry earnings in foot and ankle fellowship programs in the United States:A retrospective analysis

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World j.urnal of Orthopedics 2024年第2期15卷 129-138页

作者： Albert T Anastasio Anthony N baumann Kempland C Walley Kyle j.Hitchman Conor O’Neill j.nathan Kaplan Samuel B Adams Department of Orthopedic Surgery Duke University HospitalDurhamNC 27710United States College of Medicine Northeast Ohio Medical UniversityRootstownOH 44272United States Department of Orthopedic Surgery University of MichiganAnn ArborMI 48109United States School of Osteopathic Medicine Campbell UniversityLillingtonNC 27546United States

BACKGROUND The study investigates the connection between academic productivity and industry earnings in foot and ankle orthopedic surgery *** metrics like the H-index and Open Payments Database(OPD)data,it addresses a gap in understanding the relationship between scholarly achievements and financial outcomes,providing a basis for further exploration in this specialized medical *** To elucidate the trends between academic productivity and industry earnings across foot and ankle orthopedic surgery fellowship programs in the United *** This study is a retrospective analysis of the relationship between academic productivity and industry earnings of foot and ankle orthopedic surgery fellowships at an individual faculty and fellowship *** productivity was defined via H-index and recorded from the Scopus *** earnings were recorded from the *** Forty-eight foot and ankle orthopedic surgery fellowships(100%of fellowships)in the United States with a combined total of 165 physicians(95.9%of physicians)were *** individual physician(n=165)total life-time earnings reported on the OPD website was United States Dollar(USD)451430.30±1851084.89(range:USD 25.16-21269249.85;median:USD 27839.80).Mean physician(n=165)H-index as reported on Scopus is 14.24±12.39(range:0-63;median:11).There was a significant but weak correlation between individual physician H-index and individual physician total life-time earnings(P<0.001;Spearman’s rho=0.334)and a significant and moderate positive correlation between combined fellowship H-index and total life-time earnings per fellowship(P=0.004,Spearman’s rho=0.409).CONCLUSION There is a significant and positive correlation between academic productivity and industry earnings at foot and ankle orthopedic surgery fellowships in the United *** observation is true on an individual physician level as well as on a fellowship level.

关键词： Sunshine act Foot and ankle Orthopedic surgery Orthopedic fellowship Industry earnings

Root-Specific Transcript Profiling of Contrasting Rice Genotypes in Response to Salinity Stress

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Molecular Plant 2011年第1期4卷 25-41页

作者： Olivier Cotsaftis Darren Plett Alexander A.T. j.hnson Harkamal Walia Clyde Wilson Abdelbagi M. Ismail Timothy j. Close Mark Tester Ute baumann Australian Centre for Plant Functional Genomics Private Mail Bag 1 Glen Osmond SA 5064 Australia Present address: School of Botany University of Melbourne Parkville Vic 3010 Australia Department of Botany and Plant Sciences University of California Riverside CA 92521 USA Present address: Department of Agronomy and Horticulture University of Nebraska Lincoln NE 68588 USA United States Department of Agriculture Agricultural Research Service George E. Brown Jr Salinity Laboratory Riverside CA 92507 USA International Rice Research Institute Manila The Philippines

Elevated salinity imposes osmotic and ion toxicity stresses on living cells and requires a multitude of responses in order to enable plant survival. Building on earlier work profiling transcript levels in rice （Oryza sativa） shoots of FL478, a salt-tolerant indica recombinant inbred line, and IR29, a salt-sensitive cultivar, transcript levels were compared in roots of these two accessions as well as in the roots of two additional salt-tolerant indica genotypes, the landrace Pokkali and the recombinant inbred line IR63731. The aim of this study was to compare transcripts in the sensitive and the tolerant lines in order to identify genes likely to be involved in plant salinity tolerance, rather than in responses to salinity perse. Transcript profiles of several gene families with known links to salinity tolerance are described （e.g. HKTs, NHXs）. The putative function of a set of genes identified through their salt responsiveness, transcript levels, and/or chro- mosomal location （i.e. underneath QTLs for salinity tolerance） is also discussed. Finally, the parental origin of the Saltol region in FL478 is further investigated. Overall, the dataset presented appears to be robust and it seems likely that this system could provide a reliable strategy for the discovery of novel genes involved in salinity tolerance.

关键词： Rice root salinity tolerance microarray HKT Saltol.

Rhizosphere microbial communities associated to rose replant disease:links to plant growth and root metabolites

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Horticulture Research 2020年第1期7卷 1031-1046页

作者： B.Yim A.baumann G.Grunewaldt-Stöcker B.Liu L.Beerhues S.Zühlke M.Sapp j.Nesme S.j.Sørensen K.Smalla T.Winkelmann Institute of Horticultural Production Systems Leibniz Universität Hannover30419 HannoverGermany j.lius Kühn-Institut(j.I) Institute for Epidemiology and Pathogen Diagnostics38104 BraunschweigGermany Institute of Pharmaceutical Biology Technische Universität Braunschweig38106 BraunschweigGermany Faculty of Chemistry and Chemical Biology(CCB) Technische Universität Dortmund44227 DortmundGermany Cluster of Excellence on Plant Sciences(CEPLAS) Institute for Population GeneticsHeinrich Heine University40225 DüsseldorfGermany Section of Microbiology Department of BiologyUniversity of Copenhagen2100 CopenhagenDenmark

Growth depression of Rosa plants at sites previously used to cultivate the same or closely related species is a typical symptom of rose replant disease(RRD).Currently,limited information is available on the causes and the etiology of RRD compared to apple replant disease(ARD).Thus,this study aimed at analyzing growth characteristics,root morphology,and root metabolites,as well as microbial communities in the rhizosphere of the susceptible rootstock Rosa corymbifera‘Laxa’grown in RRD-affected soil from two sites(Heidgraben and Sangerhausen),either untreated or disinfected byγ-*** a greenhouse bioassay,plants developed significantly more biomass in theγ-irradiated than in the untreated soils of both *** plant metabolites detected in ***‘Laxa’roots were site-and *** aloesin was recorded in significantly higher concentrations in untreated than inγ-irradiated soils from Heidgraben,the concentrations of phenylalanine were significantly lower in roots from untreated soil of both *** microbial communities of 8-week-old plants were studied by sequencing of 16S rRNA,ITS,and cox gene fragments amplified from total community *** by microscopic observations,sequences affiliated to the bacterial genus Streptomyces and the fungal genus Nectria were identified as potential causal agents of RRD in the soils *** relative abundance of oomycetes belonging to the genus Pythiogeton showed a negative correlation to the growth of the ***,the RRD symptoms,the effects of soil treatments on the composition of the rhizosphere microbial community revealed striking similarities to findings related to ARD.

关键词： soil roots plant

Sciatic Nerve Block with Ropivacaine and Prilocaine in a Patient with Chronic Progressive External Ophthalmoplegia(CPEO)

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Open j.urnal of Anesthesiology 2012年第4期2卷 117-119页

作者： Heiko baumann Eduard Schlegel Fabian Wagner j.rgen Biscoping Department of Anesthesia and Intensive Care St.Vincentius-Kliniken gAGKarlsruheGermany

The anesthetic implications of caring for patients with mitochondrial myopathies (MM) are not well defined, and the few case reports that have been published are contradictory. Local anesthetics particularly have the potential to worsen neuromuscular manifestations via direct effects on mitochondrial bioenergetics. Here we describe the anesthetic management of a patient with chronic progressive external ophthalmoplegia (CPEO) in which a sciatic nerve block with ropivacaine and prilocaine was performed and review the available related literature.

关键词： Local Anesthetics Mitochondrial Myopathy Sciatic Nerve Block Pharmacology Anesthetic Management

Expression of O<sup>6</sup>-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue

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j.urnal of Cancer Therapy 2013年第4期4卷 919-931页

作者： Kimiko Ishiguro Krishnamurthy Shyam Philip G. Penketh Raymond P. baumann Alan C. Sartorelli Thomas j. Rutherford Elena S. Ratner Department of Pharmacology and Developmental Therapeutics Program Cancer Center Yale University School of Medicine New Haven USA Division of Gynecologic Oncology Department of Obstetrics and Gynecology Yale University School of Medicine New Haven USA

The tumor selectivity of alkylating agents that produce guanine O6-chloroethyl (laromustine and carmustine) and O6-methyl (temozolomide) lesions depends upon O6-methylguanine-DNA methyltransferase (MGMT) activity being lower in tumor than in host tissue. Despite the established role of MGMT as a tumor resistance factor, consensus on how to assess MGMT expression in clinical samples is unsettled. The aim of this study is to examine the relationship between the values derived from distinctive MGMT measurements in 13, 12, 6 and 2 pairs of human tumors and matched normal adj.cent tissue from the colon, kidney, lung and liver, respectively, and in human cell lines. The MGMT measurements included 1) alkyl-transfer assays using [benzene-3H]O6-benzylguanine as a substrate to assess functional MGMT activity, 2) methylation-specific PCR (MSP) to probe MGMT gene promoter CpG methylations as a measure of gene silencing, and 3) western immunoblots to analyze the MGMT protein. In human cell lines, a strict negative correlation existed between MGMT activity and the extent of promoter methylation. In tissue specimens, by contrast, the correlation between these two variables was low. Moreover, alkyl-transfer assays identified 3 pairs of tumors and normal tissue with tumor-selective reduction in MGMT activity in the absence of promoter methylation. Cell line MGMT migrated as a single band in western analyses, whereas tissue MGMT was heterogeneous around its molecular size and at much higher molecular masses, indicative of multi-layered post-translational modifications. Malignancy is occasionally associated with a mobility shift in MGMT. Contrary to the prevalent expectation that MGMT expression is governed at the level of gene silencing, these data suggest that other mechanisms that can lead to tumorselective reduction in MGMT activity exist in human tissue.

关键词： O6-Methylguanine-DNA Methyltransferase (MGMT O6-Alkylguanine-DNA Alkyltransferase AGT) [Benzene-3H]O6-Benzylguanine Methylation-Specific PCR (MSP) Laromustine (Onrigin Cloretazine VNP40101M 101M) Temozolomide

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高压水射流助切隧洞掘进机

发电技术 1981年第1期 22-26+19页

作者： Lothar baumann j.Heneke 费刚

两年多来,矿山研究公司(BergbauForschung)以高压水射流结合硬岩挖进的全断面挖进机,在烟煤开采中进行了商业性试验。试验是在开挖直径为2.6米的维尔特TBI/260型掘进机上于多特蒙德—霍恩西堡(Dortmund—Hohensyburg)附近的上石灰纪石... 详细信息

两年多来,矿山研究公司(BergbauForschung)以高压水射流结合硬岩挖进的全断面挖进机,在烟煤开采中进行了商业性试验。试验是在开挖直径为2.6米的维尔特TBI/260型掘进机上于多特蒙德—霍恩西堡(Dortmund—Hohensyburg)附近的上石灰纪石灰岩坑道中进行的(见图1)。

关键词：水射流盘刀最佳化破岩刀片高压水刀盘

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异型坯连铸技术基础及操作结果

钢铁 2002年第6期37卷 15-19,14页

作者： H.Hoedl F.Wimmer K.Mayrhofer G.Hartmann j.Dengler H.baumann 奥钢联工程技术公司德国图林根钢铁公司

近终形异型坯连铸对大、中型材和轨梁生产的优点与薄板坯连铸对板带生产的优点相似 ,可降低轧制成本、提高生产率以及降低能耗 ,因而是常规大方坯连铸工艺的一个理想的替代方案。

关键词：异型坯连铸操作结果工艺方案轨梁型钢

Composition Changes and Movements in Mixed-Species Groups of Algae Grazing Fish in j.maica and Grand Cayman Island. Part II

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Open j.urnal of Marine Science 2021年第1期11卷 41-54页

作者： Andrew Bloch Layla Al-Shaer Brandon baumann Matthew Draud M. Itzkowitz Department of Biological Sciences Lehigh University Bethlehem PA USA Office of the Vice President McMurry University Abilene TX USA

Although Caribbean mixed-species herbivorous fish groups are an important component to the reef community by helping to crop algae that often overgrow and kill corals, little is known of how they organize their foraging groups. In spite of a highly flexible membership, the basic structure of these groups consists of a “core species,” that leads the group and often is either the striped parrotfish (Scarus iserti) or the ocean surgeon (Acanthurus tractus). These species lead their groups to open areas where they feed largely on low profile turf algae. Other members prefer macro algae and are termed “associate species,” of which the two common species we studied were the stoplight parrotfish (Sparisoma viride) and the redband parrotfish (Sparisoma aurofrenatum). In spite of the large difference in group sizes between j.maica and Grand Cayman Islands, the relationships between movement patterns and compositional changes were largely consistent. There was no support for the hypothesis that these dramatic and continuous group changes were related to foraging success. Instead, we speculated that these group changes perhaps were designed to maintain cohesion among a membership that was spread over a wide area. We also examined if associates species may be more than j.st passive followers of core species but rather instigated the attracting or the building of core groups. Both associate species do attract striped parrotfish in open areas and thus appear active in initiating mixed-species groups. Finally, given that associate species seem to derive little foraging benefit from following core species, we tested the hypothesis that associate species j.ined core groups to gain protection against predators. Associate species do not selectively j.in the larger groups of striped parrotfish but appear to j.in core species randomly and the groups they j.ined resembled the wide assortment of core groups available in the area. Thus, while associates may be j

关键词： Caribbean Parrotfish Scarus Sparisoma Surgeonfish Acanthurus

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小型科学卫星的结构设计技术(一)

中国空间科学技术(中英文) 1980年第5期 75-82页

作者： j.M.Madey R.C baumann

本文叙述了小型科学卫星从方案设计到发射以及飞行后分析的许多设计原则和方法。它包括下列内容:卫星外形的确定、结构部件和附件的设计载荷、设计技术和材料使用、自旋稳定卫星的动态稳定准则、卫星的力学试验及组装、各类卫星及其功... 详细信息

本文叙述了小型科学卫星从方案设计到发射以及飞行后分析的许多设计原则和方法。它包括下列内容:卫星外形的确定、结构部件和附件的设计载荷、设计技术和材料使用、自旋稳定卫星的动态稳定准则、卫星的力学试验及组装、各类卫星及其功用、飞行星的管理和运输、发射现场的工作和发射后的分析等。文中的一些计算范例可以帮助结构设计人员设计和试验附件、转动惯量试验装置、哟-哟消旋系统、动载荷计算和断面系数的确定等等,本文还推荐了一些卫星管理及运输方面的知识.

关键词：卫星惯性矩转动惯量结构部件质量自旋轴飞行后分析结构设计