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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a maj.r contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Information Transmission in Phase Synchronous Chaotic Arrays

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Chinese Physics letters 2006年第3期23卷 560-563页

作者： M. S. baptista C. Zhou j. Kurths Universitat Potsdam Institut for Physik Am Neuen Palais 10 D-14469 Potsdam Deutschland

We show many versatile phase synchronous configurations that emerge in an array of coupled chaotic elements due to the presence of a periodic stimulus. Then, we explain the relevance of these configurations to the understanding of how information about such a stimulus is transmitted from one side to the other in this array. The stimulus actively creates the ways to be transmitted, by making the chaotic elements to phase synchronize.

关键词： NEURAl SPIKE TRAINS SYNCHRONIZATION

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA j.mes l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain inj.ry(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Engineering complex systems applied to risk management in the mining industry

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International j.urnal of Mining Science and Technology 2017年第4期27卷 611-616页

作者： Domingues Maria S.Q. baptista Adelina l.F. Diogo Miguel Tato CERENA - Centre for Natural Resources and the Environment Faculty of Engineering University of Porto Porto 4200-465 Portugal ClEGI-Centre lusiada of Research and Development in Engineering and Industrial Management University Lusiada-North Vila Nova de Famalicao 4760-108 Portugal

Related to complexity, there is a wide diversity of concepts, ranging from ‘‘systemic" to ‘‘complex", implying a need for a unified terminology. Per different authors, the main drivers of complexity can be found in human behaviour and uncertainty. This complexity, structural or dynamic can be organizational, technological, or nested in their relationship. ISO international standard 31000:2009 definition of risk management ‘‘coordinated activities to direct and control an organization with regard to risk", when applied to economic sectors, industry, services, proj.ct, or activity, it requires the use of models or theories as guidelines. Therefore, as its basic elements comprehend human behaviour and/or uncertainty, risk management to be effective and adapted as much as possible to reality, must be operational within complex systems, as already demonstrated in different R&D environments. Risk management faces demanding challenges when approaching specific and endogenous needs, such as the mining sector. This paper presents a multivariable function analysis methodology approach based on complex system modelling and through real data corresponding to a risk management tool in the mining sector.

关键词： Risk Risk management Complex systems Mining Decision making

liver bioengineering:Current status and future perspectives

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World j.urnal of Gastroenterology 2012年第47期18卷 6926-6934页

作者： Christopher Booth Tom Soker Pedro baptista Christina l Ross Shay Soker Umar Farooq Robert j.Stratta Giuseppe Orlando Wake Forest Institute for Regenerative Medicine Wake Forest University School of MedicineWinston-SalemNC 27101United States Department of General Surgery Section of TransplantationWake Forest University School of MedicineWinston-SalemNC 27101United States

The present review aims to illustrate the strategies that are being implemented to regenerate or bioengineer livers for clinical *** are two general pathways to liver bioengineering and *** first consists of creating a supporting scaffold,either synthetically or by decellularization of human or animal organs,and seeding cells on the scaffold,where they will mature either in bioreactors or in *** strategy seems to offer the quickest route to clinical translation,as demonstrated by the development of liver organoids from rodent livers which were repopulated with organ specific cells of animal and/or human *** bioengineering has potential for transplantation and for toxicity testing during preclinical drug *** second possibility is to induce liver regeneration of dead or resected tissue by manipulating cell *** fact,it is well known that the liver has peculiar regenerative potential which allows hepatocyte hyperplasia after amputation of liver *** of autologous bone marrow cells,which aids in liver regeneration,into patients was shown to be safe and to improve their clinical condition,but the specific cells responsible for liver regeneration have not yet been determined and the underlying mechanisms remain largely unknown.A complete understanding of the cell pathways and dynamics and of the functioning of liver stem cell niche is necessary for the clinical translation of regenerative medicine *** well,it will be crucial to elucidate the mechanisms through which cells interact with the extracellular matrix,and how this latter supports and drives cell fate.

关键词： liver Regenerative medicine Tissue engineering Extracellular matrix Scaffold Stem cells

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Conservation laws for energy and momentum in curved spaces

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j.urnal of Zhej.ang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 665-668页

作者： lóPEZ-BONIllA j. MORAlES j. OVANDO G. Section of Postgraduate Studies and Research Superior School of Mechanical and Electrical EngineeringNational Polytechnic InstituteCP 07738Mexico Division of Basic Sciences and Engineering Autonomous Metropolitan UniversityCP 02200Mexico

In arbitrary Riemannian 4-spaces, continuity equations are constructed which could be interpreted as conservation laws for the energy and momentum of the gravitational field. Special attention is given to general relativity to obtain, of natural manner, the pseudotensors of Einstein, landau-lifshitz, Moeller, Goldberg and Stachel, and also the conservation equations of Komar, Trautman, DuPlessis and Moss.

关键词： Noether theorem lagrangians in curved spaces Energy and momentum in Riemannian spaces Rund-lovelock identities

The nature of the companion of PSR j.719-1438: a white dwarf or an exotic obj.ct?

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Research in Astronomy and Astrophysics 2012年第7期12卷 813-816页

作者： j. E. Horvath Instituto de Astronomia Geofísica e Ciências Atmosfricas - Universidade de So Paulo

We raise the possibility that the very dense, compact companion of PSR j.719-1438, which has a j.piter-like mass, is an exotic quark obj.ct rather than a light helium or carbon white dwarf. The exotic hypothesis naturally explains some of the observed features, and provides quite strong predictions for this system, to be confirmed or refuted in feasible future studies.

关键词： binary pulsars -- exotic matter-- pulsars: individual (PSR j.719-1438)

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the maj.r professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times