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Tra.sla.ing Pa.hologica. Bra.n a.tivity Primers in Pa.kinson’s Disea.e Resea.ch

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Resea.ch 2024年第1期2023卷 735-752页

作者： Da.iela.Mirza. Svenj. L.Kreis Heiko j.Luhma.n Ga.riel gonzalez-Esca.illa.Sergiu Groppa Movement Disorders a.d Neurostimula.ion Department of NeurologyFocus Program Translational NeuroscienceRhine Main Neuroscience NetworkUniversity Medical Center of the Johannes Gutenberg University Mainz55131 MainzGermany Institute of Physiology University Medical Center of the Johannes Gutenberg University Mainz55131 MainzGermany

Tra.sla.iona. experimenta. a.proa.hes tha. help us better tra.e Pa.kinson’s disea.e(PD)pa.hophysiologica. mecha.isms lea.ing to new thera.eutic ta.gets a.e urgently *** this a.ticle,we review recent experimenta. a.d clinica. studies a.dressing a.norma. neurona. a.tivity a.d pa.hologica. network oscilla.ions,a. well a. their underlying mecha.isms a.d *** a.m is to enha.ce our knowledge a.out the progression of Pa.kinson's disea.e pa.hology a.d the timing of its symptom’s ***,we present mecha.istic insights releva.t for the genera.ion of a.erra.t oscilla.ory a.tivity within the cortico-ba.a. ga.glia.*** summa.ize recent a.hievements extra.ola.ed from a.a.la.le PD a.ima. models,discuss their a.va.ta.es a.d limita.ions,deba.e on their differentia. a.plica.ility,a.d suggest a.proa.hes for tra.sferring knowledge on disea.e pa.hology into future resea.ch a.d clinica. a.plica.ions.

关键词： clinica. knowledge insight

La.er-induced pla.ma.forma.ion in wa.er with up to 400 mj.double-pulse LIBS

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Pla.ma.Science a.d Technology 2024年第1期26卷 93-100页

作者： Ma.ion HENKEL Michelle SIEMENS Ra.f METHLING Benj.min EMDE j.rg HERMSDORF Steffen FRa.KE Diego gonzalez Leibniz Institute for Pla.ma.Science a.d Technology(INP) Felix-Hausdorff-Straße 2Greifswald 17489Germany La.er Zentrum Ha.nover e.V.(LZH) Hollerithallee 8Hannover 30419Germany

Double-pulse LIBS is a.promising technique for deep-sea.*** mea.urements in sha.low wa.er with up to 400 mj.ea.h pulse were done to select la.er pa.a.eters which promote optimized spectra. line emission from pla.ma.even a. eleva.ed pressures,where line broa.ening until loss of most of the spectra. informa.ion ca. *** emission spectroscopy,using a.Czerny-Turner spectrometer,ha. been a.plied to investiga.e the dependence of the emitted ra.ia.ion on la.er pa.a.eters a.d hydrosta.ic *** ha. been found,tha. higher la.er pulse energies,especia.ly with short pulse dela. a. required in high wa.er pressure,ca. a.so ha.e a. a.verse effect on the mea.ured spectrum.

关键词： double-pulse LIBS underwa.er pla.ma.forma.ion emission spectrosocpy

Mea.urement of cryoelectronics hea.ing using a.loca. qua.tum dot thermometer in silicon

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Chip 2024年第3期3卷 1-7页

作者： Ma.hieu de Kruij. Gra.son M.Noa. a.berto Gomez-Sa.z j.hn j.L.Morton M.Ferna.do gonzalez-Za.ba Qua.tum Motion 9 Sterling WayLondon N79HJUnited Kingdom London Centre for Na.otechnology University College London17-19 Gordon StreetLondon WC1H 0AHUnited Kingdom

Silicon technology offers the enticing opportunity for monolithic integra.ion of qua.tum a.d cla.sica. electronic ***,the power consumption levels of cla.sica. electronics ma. compromise the loca. chip tempera.ure a.d hence a.fect the fidelity of qubit *** the current work,a.qua.tum-dot-ba.ed thermometer embedded in a. industry-sta.da.d silicon fieldeffect tra.sistor(FET)wa. a.opted to a.sess the loca. tempera.ure increa.e produced by a. a.tive FET pla.ed in close *** impa.t of both sta.ic a.d dyna.ic opera.ion regimes wa. thoroughly *** the FET wa. opera.ed sta.ica.ly,a.power budget of 45 nW a. 100-nm sepa.a.ion wa. found,wherea. a. 216μm,the power budget wa. ra.sed to 150μ*** tempera.ure increa.e for the switch frequencies tested up to 10 MHz wa. observed when opera.ing *** current work introduced a.method to a.cura.ely ma. out the a.a.la.le power budget a. a.dista.ce from a.solid-sta.e qua.tum processor,a.d indica.ed the possible conditions under which cryoelectronics circuits ma. a.low the opera.ion of hybrid qua.tum-cla.sica. systems.

关键词： Qua.tum dot Cryogenic electronics Thermometry Spin qubit Hea. ma.a.ement

Susta.ned a.enosine relea.e:Revea.ing its impa.t on osteogenic signa.ling pa.hwa.s of huma. mesenchyma. stroma. cells

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Engineered Regenera.ion 2024年第2期5卷 255-268页

作者： Ha.i Ha.0}a.i j.ne McLa.en Cristina.gonzalez-Ga.cía.Sa.a. a.delra.ig Dong-Hyun Kim Ma.thew j.Da.by Ma.uel Sa.merón-Sánchez Felicity R.a.j.Rose School of Pha.ma.y Nottingham Biodiscovery InstituteUniversity of NottinghamNottinghamUK Hea.thca.e Technologies Institute School of Chemical EngineeringUniversity of BirminghamBirminghamUK Centre for the Cellula. Microenvironment University of GlasgowGlasgowUK Centre for a.a.ytica. Bioscience Advanced Materials&Healthcare Technologies DivisionSchool of PharmacyUniversity of NottinghamNottinghamUK Ma.ine Microbiomics Program in BiologyDivision of Science and MathematicsNew York University Abu Dhabi(NYUAD)P.O.Box 129188Abu DhabiUnited Arab Emirates

Non-hea.ing fra.tures,a.globa. hea.th concern a.ising from tra.ma.osteoporosis,a.d tumours,ca. lea. to severe ***,integra. to cellula. energy meta.olism,ga.ns prominence in bone regenera.ion via.a.eno-sine a. B receptor *** study introduces a.controlled-relea.e system for loca.ized a.enosine delivery,fostering huma. mesenchyma. stroma. cell(hMSC)differentia.ion into functiona. bone *** study investi-ga.es how the ra.io of la.tic a.id to glycolic a.id in micropa.ticles ca. influence a.enosine relea.e a.d explores the downstrea. effects on gene expression a.d meta.olic profiles of osteogenic differentia.ion in hMSCs cultured in growth a.d osteoinductive *** into a.enosine-modula.ed signa.ling pa.hwa.s during MSC differenti-a.ion,with osteogenic fa.tors,provide a.comprehensive understa.ding of the pa.hwa.s *** gene expression a.d meta.olic profiles unra.els a.enosine’s regula.ory mecha.isms in MSC *** a.enosine relea.e from micropa.ticles induces minera.iza.ion,synergizing with osteogenic media.supplements,showca.ing the potentia. of a.enosine for trea.ing critica. bone defects a.d meta.olic *** study high-lights the effica.y of a.polymeric micropa.ticle-ba.ed delivery system,offering novel stra.egies for bone *** a.enosine’s roles a.d a.socia.ed signa.ling pa.hwa.s a.va.ces our comprehension of molecula. mech-a.isms steering bone regenera.ion,propelling innova.ive bioma.eria.,combined with meta.olites,a.proa.hes for clinica. use.

关键词： a.enosine relea.e Osteogenic signa.ling pa.hwa.s Huma. mesenchyma. stroma. cells Bone regenera.ion

Tempora. sta.ility a.d directiona. cha.ge in a.color cline of a.ma.ine sna.l from NW Spa.n

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Current Zoology 2024年第2期70卷 163-173页

作者： j.a. Gefa.ll Ra.on Vigo a.Honora.o gonzalez-Va.quez j.a. Ga.indo Emilio Rola.-a.va.ez Centro de Investiga.ion Ma.ina Universidade de VigoDepartamento de BioquimicaGenetica e Inmunologia36310 VigoSpain

The evolution a.d ma.ntena.ce of color clines is a.cla.sic topic of resea.ch in evolutiona.y ***,studies a.a.yzing the tempora. dyna.ics of such clines a.e much less frequent,due to the difficulty of obta.ning relia.le da.a.a.out pa.t color distributions a.ong environmen-ta. *** this a.ticle,we describe a.ca.e of deca.es-long tempora. sta.ility a.d directiona. cha.ge in a.color cline of the ma.ine sna.l Littorina.sa.a.ilis a.ong the coa.ta. inlet of the Ria.de Vigo(NW Spa.n).*** from this a.ea.shows a.clea. color cline with 3 distinct a.ea. from the innermost to the more wa.e-exposed loca.ities of the Ria.the inner,protected loca.ities show a. a.unda.ce of fa.n-like individua.s;the intermedia.e loca.ities show a.high diversity of colors;a.d the outer,wa.e-exposed loca.ities show popula.ions with a.high frequency of a.bla.k a.d linea.ed *** compa.e da.a.from the 1970s a.d 2022 in the sa.e loca.ities,showing tha. the cline ha. kept rela.ively sta.le for a. lea.t over ha.f a.century,except for some directiona. cha.ge a.d loca. va.ia.ility in the frequency of certa.n *** regression a.a.yses a.d biodiversity mea.ures a.e presented to provide clues into the selective pressures tha. might be involved in the ma.ntena.ce of this color *** resea.ch a.enues to properly test the expla.a.ory power of these selective a.ents a. well a. the possible origins of the cline a.e discussed.

关键词： clina. va.ia.ion color polymorphism ecologica. gra.ient Littorina.sa.a.ilis na.ura. selection wa.e exposure.

Beyond cotton a.d polyester: a. eva.ua.ion of emerging feedstocks a.d conversion methods for the future of fa.hion industry

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j.urna. of Bioresources a.d Bioproducts 2024年第2期9卷 130-159页

作者： Ryen M.Fra.ier Keren a.Viva. Iva.a.a.ua.0} Ra.on Vera.a.onzo Pifa.o Na.ca.i Forfora.Ha.a. j.meel Ericka.Ford j.el j.Pa.la. Richa.d Venditti Rona.ds gonzalez Depa.tment of Forest Bioma.eria.s North Carolina State UniversityRaleighNC 27695USA Depa.tment of Textile Engineering Chemistry and ScienceThe Nonwovens InstituteNorth Carolina State UniversityRaleighNC 27695USA

a. the globa. popula.ion grows,the dema.d for textiles is increa.ing ***,this puts immense pressure on ma.ufa.turers to produce more *** synthetic fibers ca. be pro-duced chea.ly,they ha.e a.nega.ive impa.t on the *** the other ha.d,fibers from wool,sisa.,fique,wood pulp(viscose),a.d ma.-ma.e cellulose fibers(MMCFs)from cotton ca.-not a.one meet the growing fiber dema.d without ma.0}r stresses on la.d,wa.er,a.d existing ma.kets using these *** a.grea.er empha.is on tra.spa.ency a.d circula. economy pra.tices,there is a.need to consider na.ura. non-wood a.terna.ive sources for MMCFs to supple-ment other fiber ***,introducing new feedstocks with different compositions ma. require different bioma.s conversion ***,ba.ed on existing work,this review a.-dresses the technica. fea.ibility of va.ious a.terna.ive feedstocks for conversion to textile-gra.e ***,a.terna.ive feedstocks a.e introduced,a.d then conventiona.(dissolving pulp)a.d emerging(fibrilla.ed cellulose a.d recycled ma.eria.)conversion technologies a.e eva.ua.ed to help select the most suita.le a.d promising processes for these emerging a.terna.ive sources of *** is importa.t to note tha. for a.terna.ive feedstocks to be a.opted on a.mea.ingful sca.e,high bioma.s a.a.la.ility a.d proximity of conversion fa.ilities a.e critica. *** North a.erica.soybea.,whea.,rice,sorghum,a.d suga.ca.e residues a.e widely a.a.la.le a.d most suita.le for conventiona. conversion through va.ious dissolving pulp production methods(pre-hydrolysis kra.t,a.id sulfite,soda.SO2-etha.ol-wa.er,a.d pota.sium hydroxide)or by emerging cellulose fibrilla.ion *** dissolving pulp conversion is well-esta.lished,fibrilla.ed cel-lulose methods could be beneficia. from cost,efficiency,a.d environmenta. ***,the a.thors strongly encoura.e more work in this growing resea.ch ***,conducting thorough cost a.d susta.na.ility a.sessment

关键词： Non-wood Residue Regenera.ed cellulose Dissolving pulp Ma.-ma.e cellulose fiber a.pa.el textile

Vertica. Displa.ement Mea.urement in a.Slow-Moving Sinkhole Using BOTDA

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Photonic Sensors 2024年第1期14卷 23-39页

作者： Pa.cua. SEVILLa.O j.vier PRECIa.O-Ga.Ba.O j.rge SEVIL Fra.cisco GUTIERREZ j.a. j.a.TiNEZ Sonia.Ma.TiN-LOPEZ Miguel gonzalez-HERRa.Z a.a.on Institute of Engineering Resea.ch(I3a. Universidad de ZaragozaZaragoza 50018Spain Electronic Enginering a.d Communica.on Dpa.tment EINAUniversidad de ZaragzaZaragza 50018Spain a.a.on Photonics La.s. Zaragoza 50009Spain Depa.tment of Ea.th Sciences Universidad de ZaragozaZaragoza 50009Spain Depa.tment of Electronics Escuela Politecnica SuperiorUniversidad de AlcalaMadrid 28805Spain

The effectiveness of monitoring a.d ea.ly-wa.ning systems for ground deforma.ion phenomena.such a. sinkholes,depends on their a.ility to a.cura.ely resolve the ongoing ground displa.ement a.d detect the subtle deforma.ion preceding ca.a.trophic *** sinkholes with a.slow subsidence ra.e a.d diffuse edges pose a.significa.t cha.lenge for subsidence monitoring due to the low deforma.ion ra.es a.d limited la.era. stra.n *** this work,we sa.isfa.torily illustra.e the pra.tica.ity of the Brillouin optica. time doma.n a.a.ysis(BOTDa.to mea.ure the spa.ia.-tempora. pa.terns of the vertica. displa.ement in such cha.lenging slow-moving sa.ging *** a.sess the performa.ce of the a.proa.h,we compa.e the stra.n recorded by the distributed optica. fiber sensor with the vertica. displa.ement mea.ured by high-precision *** results show a.good spa.ia. correla.ion with the a.ility to identify the ma.imum subsidence *** is a.so a.good tempora. correla.ion with the detection of a. a.celera.ion pha.e in the subsidence a.socia.ed with a.flood event.

关键词： Distributed fiber optic sensing(DFOS) vertica. displa.ement mea.urement slow subsidence ra.e sinkhole ha.a.d ea.ly-wa.ning system

Multi-obj.ctive optimiza.ion design of bridge piers with hybrid heuristic a.gorithms

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j.urna. of Zhej.a.g University-Science a.a.plied Physics & Engineering) 2012年第6期13卷 420-432页

作者： Fra.cisco j. Ma.TINEZ-Ma.TIN Ferna.do gonzalez-VIDOSa.a.tonio HOSPITa.ER Víctor YEPES Depa.tment of Geotechnica. Engineering Universitat Politècnica de València 46022 Valencia Spain Depa.tment of Construction Engineering ICITECH Universitat Politècnica de València 46022 Valencia Spain

This pa.er describes one a.proa.h to the design of reinforced concrete (RC) bridge piers, using a.three-hybrid multi- obj.ctive simula.ed a.nea.ing (Sa. a.gorithm with a.neighborhood move ba.ed on the muta.ion opera.or from the genetic a.gorithms (Ga.), na.ely MOSa.O1, MOSa.O2 a.d MOSa.O3. The procedure is a.plied to three obj.ctive functions: the economic cost, the reinforcing steel congestion a.d the embedded CO 2 emissions. a.ditiona. results for a.ra.dom wa.k a.d a.descent loca. sea.ch multi-obj.ctive a.gorithm a.e presented. The eva.ua.ion of solutions follows the Spa.ish Code for structura. concrete. The methodology wa. a.plied to a.typica. bridge pier of 23.97 m in height. This exa.ple involved 110 design va.ia.les. Results indica.e tha. a.gorithm MOSa.O2 outperforms other a.gorithms rega.ding the definition of Pa.eto fronts. Further, the proposed procedure will help structura. engineers to enha.ce their bridge pier designs.

关键词： Bridge piers Concrete structures Multi-obj.ctive optimiza.ion Simula.ed a.nea.ing (Sa. Structura. design

Va.ia.ion in sexua. dimorphism a.d a.sorta.ive ma.ing do not predict genetic divergence in the sexua.ly dimorphic Goodeid fish Gira.dinichthys multira.ia.us

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Current Zoology 2012年第3期58卷 440-452页

作者： C. Ma.Ia. Ga.CIa.G SMITH C. gonzalez ZUa.TH j. a. GRa.ES M. G. RITCHIE Depa.ta.ento de Ecologia.Evolutiva Instituto de Ecologia UNAM A. E 70-275 C. E 04510 M6xico DE M6xico School of Biology University of St Andrews St Andrews Fife KY16 9TH Scotland UK

Sexua. dimorphism is often used a. a.proxy for the intensity of sexua. selection in compa.a.ive studies of sexua. selection a.d diversifica.ion. The Mexica. Goodeina. a.e a.group of livebea.ing freshwa.er fishes with la.ge va.ia.ion between species in sexua. dimorphism in body sha.e. Previously we found a. a.socia.ion between va.ia.ion in morphologica. sexua. dimorphism between species a.d the a.ount of gene flow within popula.ions in the Goodeina.. Here we ha.e exa.ined if mor- phologica. differentia.ion within a.single dimorphic species is rela.ed to a.sorta.ive ma.ing or gene flow between popula.ions. In the a.a.illo fish Gira.dinichthys multira.ia.us studies ha.e shown tha. exa.gera.ed ma.e fins a.e ta.gets of fema.e preferences. We find tha. popula.ions of the species differ in the level of sexua. dimorphism displa.ed due to fa.ter evolution of differences in ma.e tha. fema.e morphology. However, this does not predict va.ia.ion in a.sorta.ive ma.ing tests in the la.ora.ory; in fa.t dif- ferences in ma.e morphology a.e nega.ively correla.ed with a.sorta.ive ma.ing. Microsa.ellite ma.kers revea. significa.t genetic differences between popula.ions. However, gene flow is not predicted by either morphologica. differences or a.sorta.ive ma.ing. Ra.her, it demonstra.es a.pa.tern of isola.ion by dista.ce with grea.er differentia.ion between wa.ersheds. We discuss the ca.ea.s of predicting beha.ioura. a.d genetic divergence from so-ca.led proxies of sexua. selection [Current Zoology 58 （3）： 440-452, 2012].

关键词： Sexua. dimorphism a.sorta.ive ma.ing Genetic dista.ce Specia.ion Vivipa.ous fish