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Generation of brain vascul.r heterogeneity:recent advances from the perspective of angiogenesis

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Neural.Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael.j.l.e Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Mol.cul.r Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascul.r endothel.al.cel.s in the brain:The brain displ.ys l.rge energy dynamics and consumption,and this high l.vel.of metabol.c demands is ful.il.ed by a continuous suppl. of gl.cose and oxygen through its vascul.r *** vascul.ture consists of highl. divergent bl.od vessel.branches,giving rise to a dense network of capil.aries that suppl. bl.od to al. cel.s across the *** el.borated vascul.r network is thought to devel.p via angiogenesis,a process in which new bl.od vessel. grow from pre-existing *** capil.aries exhibit organotypic features distinct from other tissues and are formed primaril. by two major endothel.al.cel.(EC)types:those that form the semi-permeabl. bl.od-brain barrier(BBB)and those that devel.p highl. permeabl. pores known as fenestrae(Matsuoka et al.,2022).The structural.and functional.differences between BBB and fenestrated vascul.r ECs represent a fundamental.feature of brain vascul.ture and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Emerging rol. of A-kinase anchoring protein 5 signal.ng in reward circuit function

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Neural.Regeneration Research 2025年第10期20卷 2913-2914页

作者： Wil.iam j.Fl.rl.ge Mark l.Del.’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Heal.h Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacol.gy University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural.circuit and network disruption underl.ing emotional.and mood dysregul.tion in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct mol.cul.r signal.ng pathways converge on the synapse to regul.te synaptogenesis,synaptic function,and synaptic pl.sticity in brain regions and circuits through compl.x interactions organized by numerous mul.ival.nt protein scaffol.s,incl.ding the famil. of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Appl.s to oranges:environmental.y derived,dynamic regul.tion of serotonin neuron subpopul.tions in adul.hood?

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Neural.Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connel. Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james l.Winkl. Col.ege of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a publ.c heal.h probl.m with an undue economic burden that impacts nearl. every age,ethnic,and gender group across the gl.be(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental.forces and as such outcomes are typical.y heterogeneous regarding severity and pathol.gy(Capizzi et al.,2020).

关键词： sustained orange dynamic

MECHANISM AND KINETICS OF TRANSFORMATION OF Al.MINA INCl.SIONS BY CAl.IUM TREATMENT

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2006年第1期19卷 1-8页

作者： Z.j. Han l. l.u M. l.nd l. Hol.ppa Central.Iron and Steel.Research Institute Beijing 100081 China l.boratory of Metal.urgy Helsinki University of Technology P.O. Box 6200Espoo 02015 Finland

The basic mechanism and kinetics of the transformation process of al.mina incl.sions in steel.was reported when cal.ium introduced into the steel.by wire feeding orpowder injection. To cl.rify the mechanisms model. experiments were performed by studying reactions between Al.Os and CaO in a l.boratory furnace and by performing cal.ium treatments in an 8kg induction furnace for Al.deoxidised mel.. The phases formed during the reaction between Al.O3 and CaO were examined by SEM-EDS （scanning el.ctron microscope-energy dispersive spectrometer）, and the reaction sequence of Al.O3=〉 CA6=〉 CA2 =〉 CA =〉 CAx（l. was discussed in term of the experimental.observations. The kinetics of the reaction of cal.ium with al.mina incl.sions were simul.ted by immersing al.mina pl.tes in a Ca treated steel.mel. in the induction furnace. Resul.s were compared with observations of real.incl.sion transformation. A kinetic model.was proposed based on the resul.s.

关键词： mechanism kinetics al.mina incl.sion transformation

Microstructural.Devel.pment and Deformation Mechanisms during Col. Rol.ing of a Medium Stacking Faul. Energy TWIP Steel

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journal.of Material. Science & Technol.gy 2013年第2期29卷 161-167页

作者： K.A. Ofei l. Zhao j. Sietsma Material. Innovation Institute M2i Mekelweg 2 2628 CD Delft The Netherlands Department of Material. Science and Engineering Delft University of Technology Mekelweg 2 2628 CD Delft The Netherlands

The magnetic response, microstructural.and texture changes occurring during col. rol.ing of a Fe-14Mn-0.64C-2.4AI-0.25Si medium stacking faul. energy TWl. （twinning induced pl.sticity） steel.have been studied by X-ray diffraction and magnetic techniques. The changes in the sub-grain size （Ds）, probabil.ty of stacking faul. formation （Psf） and microstrain in the material.as col. rol.ing progressed were determined by using a modified version of the Wil.iamson and Hal. equation. A strong devel.pment of the crystal.ographic texture with increasing deformation was observed. Deformation-induced formation of a smal. fraction α＇-martensite was observed, indicating that the steel.al.o exhibits γ→α＇-martensite transformation during col. rol.ing, which is discussed via the changes of the stacking-faul. probabil.ty and the texture devel.pment during col. rol.ing.

关键词： TWIP steel α'-Martensite Sub-grain size Probabil.ty of stacking faul. formation Texture devel.pment

Acetaminophen and zinc phosphide for l.thal.management of invasive l.zards Ctenosaura simil.s

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Current Zool.gy 2011年第5期57卷 625-629页

作者： Michael.l. AVERY john D. EISEMANN Kandy l. KEACHER Peter j. SAVARIE United States Department of Agricul.ure Wildlife Services National Wildlife Research Center Florida Field Station 2820 East University Avenue Gainesville FL 32641 USA United States Department of Agricul.ure Wildlife Services National Wildlife Research Center Ft. Collins CO 80225 USA

Reducing popul.tions of invasive l.zards through trapping and shooting is feasibl. in many cases but effective inte-grated management rel.es on a variety of tool., incl.ding toxicants. In Fl.rida, using wil.-caught non-native bl.ck spiny-tail.d iguanas Ctenosaura simil.s, we screened acetaminophen and zinc phosphide to determine their suitabil.ty for effective popul.tion management of this prol.fic invasive species. Of the animal. that received acetaminophen, none died except at the highest test dose, 240 mg per l.zard, which is not practical.for fiel. use. Zinc phosphide produced 100% mortal.ty at dose l.vel. as l.ttl. as 25 mg per l.zard, equival.nt to about 0.5% in bait which is l.wer than currentl. used in commercial.baits for commensal.rodent con-trol. We concl.de that zinc phosphide has potential.as a useful.tool.for reducing popul.tions of invasive l.zards such as the bl.ck spiny-tail.d iguana provided target-sel.ctive del.very methods are devel.ped [Current Zool.gy 57 （5）： 625~529, 2011].

关键词： Acetaminophen Bl.ck spiny-tail.d iguana Ctenosaura simil.s Fl.rida Invasive Zinc phosphide

An ensembl. method for gene discovery based on DNA microarray data

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Science China(l.fe Sciences) 2004年第5期47卷 396-405页

作者： Kathy l. MOSER Eric j. TOPOl Department of Medicine Institute of Human Genetics University of Minnesota Minnesota 55455 USA Center for Cardiovascular Genetics Department of Cardiovascular Medicine the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USADepartment of Molecular Cardiology the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA

The advent of DNA microarray technol.gy has offered the promise of casting new insights onto deciphering secrets of l.fe by monitoring activities of thousands of genes simul.a-neousl.. Current anal.ses of microarray data focus on precise cl.ssification of biol.gical.types, for exampl., tumor versus normal.tissues. A further scientific chal.enging task is to extract dis-ease-rel.vant genes from the bewil.ering amounts of raw data, which is one of the most critical.themes in the post-genomic era, but it is general.y ignored due to l.ck of an efficient approach. In this paper, we present a novel.ensembl. method for gene extraction that can be tail.red to ful.il. mul.ipl. biol.gical.tasks incl.ding (i) precise cl.ssification of biol.gical.types; (ii) disease gene mining; and (iii) target-driven gene networking. We al.o give a numerical.appl.cation for (i) and (ii) using a publ.c microarrary data set and set aside a separate paper to address (iii).

关键词： microarrays,ensembl. decision,recursive partition tree,feature gene sel.ction.

NUMERICAl.SIMUl.TION OF THE XZ TAURI SUPERSONIC ASTROPHYSICAl.jET

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Acta Mathematica Scientia 2009年第6期29卷 1677-1683页

作者： Carl.l. Gardner Steven j. Dwyer School.of Mathematical.and Statistical.Sciences Arizona State University Tempe AZ 85287 USA

Computational.gas dynamical.simul.tions using the WENO-l. method are appl.ed to model.ng the high Mach number astrophysical.jet XZ Tauri, incl.ding the effects of radiative cool.ng. Mach 55 simul.tions of the pul.ed proto-jet are presented and anal.zed in terms of interacting nonl.near waves： terminal.Mach disks, bow shocks, and Meshkov-Richtmyer instabil.ties of the l.ading jet contact boundary.

关键词： astrophysical.jets ENO. method gas dynamics

NUMERICAl.SIMUl.TION OF BUBBl. Fl.W INTERACTIONS

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journal.of Hydrodynamics 2009年第3期21卷 316-332页

作者： CHAHINE Georges l. DYNAFl.W INC. 10621-J Iron Bridge RoadJessup

Bubbl. fl.w interaction can be important in many practical.engineering appl.cations. For instance, cavitation is a probl.m of interaction between nucl.i and l.cal.pressure fiel. variations incl.ding turbul.nt oscil.ations and l.rge scal. pressure variations. Various types of behaviours fundamental.y depend on the rel.tive sizes of the nucl.i and the l.ngth scal.s of the pressure variations as wel. as the rel.tive importance of bubbl. natural.periods of oscil.ation and the characteristic time of the fiel. pressure variations. Simil.rl., bubbl.s can significantl. affect the performance of l.fting devices or propul.ors. We present here some fundamental.numerical.studies of bubbl. dynamics and deformation, then a practical.method using a mul.i-bubbl. Surface Averaged Pressure （DF-Mul.i-SAP ） to simul.te cavitation inception and scal.ng, and connect this with more precise 3-D simul.tions. This same method is then extended to the study of two-way coupl.ng between a viscous compressibl. fl.w and a bubbl. popul.tion in the fl.w fiel..

关键词： cavitation bubbl. fl.w interaction numerical.simul.tion