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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili patricia Graham Adriana Brooks Risset Silvera Alexander j.p.Goldschmidt Damien D.pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami project to Cure paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António j.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Exploring the concept of castability in magnesium die-casting alloys

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journal of Magnesium and Alloys 2021年第1期9卷 102-111页

作者： j.p.Weiler Meridian Lightweight Technologies Canada

This paper provides a summary of the recent work completed and history of the measure of manufacturability in the magnesium diecasting *** most popular die-casting alloys utilized in this industry are based on the Mg-Al system,including AZ91,AM60 and *** are well-established alloys,and are generally considered to be highly ***,the concept of castability in magnesium die-casting is not a well-defined characteristic or quantitative material *** a result,the author investigates the subject of castability for magnesium die-cast alloys and how it relates to the development of alloys for innovative applications or improved *** paper provides a summary of some key findings in literature on the castability of magnesium die-cast alloys,how castability is defined and evaluated,the impact of different alloying elements on the castability of magnesium alloys,and suggestions for future work.©2020 published by Elsevier *** behalf of Chongqing University.

关键词： casting alloys property.

The role of the Mg_(17)Al_(12)-phase in the high-pressure die-cast magnesium-aluminum alloy system

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journal of Magnesium and Alloys 2023年第11期11卷 4235-4246页

作者： j.p.Weiler Meridian Lightweight Technologies Canada

The Mg_(17)Al_(12)β-phase is highly influential to the performance of magnesium-aluminum high-pressure die-casting alloys. Numerous studies have investigated the effect of this phase on the room temperature and elevated-temperature mechanical properties as well as the corrosion,flammability, thermal conductivity and castability performance. This work summarizes the results of these works, as well as the studies that describe control of the Mg_(17)Al_(12)-phase through alloying additions that modify the microstructure and resulting alloy performance. The results of this work can be used as a basis for the development of alloying additions that enable modifications to the performance of high-pressure die-cast magnesium-aluminum-based alloys.

关键词： Magnesium alloys HpDC Alloy development properties

An accurately fast algorithm of calculating reflection/transmission coefficients

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Science China(physics,Mechanics & Astronomy) 2008年第7期51卷 823-846页

作者： CASTAGNA j p Department of Earth and Atmospheric Sciences University of Houston

For the boundary between transversely isotropic media with a vertical axis of symmetry (VTI media), the interface between a liquid and a VTI medium, and the free-surface of an elastic half-space of a VTI medium, an accurately fast algorithm was presented for calculating reflection/transmission (R/T) coefficients. Specially, the case of post-critical angle incidence was considered. Although we only performed the numerical calculation for the models of the VTI media, the calculated results can be extended to the models of transversely isotropic media with a horizontal axis of rotation symmetry (HTI media). Compared to previous work, this algorithm can be used not only for the calculation of R/T coefficients of the boundary between ellipsoidally anisotropic media, but also for that between generally anisotropic media, and the speed and accuracy of this algorithm are faster and higher. According to the anisotropic parameters of some rocks given by the published literature, we performed the calculation of R/T coefficients by using this algorithm and analyzed the effect of the rock anisotropy on R/T coefficients. We used Snell's law and the energy balance principle to perform verification for the calculated results.

关键词： reflection/transmission coefficient AVO analysis anisotropy VTI medium HTI medium

Isothermal study of effusion cooling flows using a large eddy simulation approach

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航空动力学报 2009年第4期24卷 729-739页

作者： W.p.Bennett j.j.Mc Guirk Aeronautical and Automotive Engineering Department Loughborough University

An isothermal numerical study of effusion cooling flow is conducted using a large eddy simulation(LES) *** main types of cooling are considered,namely tangential film cooling and oblique patch effusion *** represent tangential film cooling,a simplified model of a plane turbulent wall jet along a flat plate in quiescent surrounding fluid is *** contrast to a classic turbulent boundary layer flow,the plane turbulent wall jet possesses an outer free shear flow region,an inner near wall region and an interaction region,characterised by substantial levels of turbulent shear stress *** shear stress characteristics hold significant implications for RANS modelling,implications that also apply to more complex tangential film cooling flows with non-zero free stream *** LES technique used in the current study provides a satisfactory overall prediction of the plane turbulent wall jet flow,including the initial transition region,and the characteristic separation of the zero turbulent shear stress and zero shear strain *** effusion patch cooling is modelled using a staggered array of 12 rows of effusion holes,drilled at 30° to the flat plate *** effusion holes connect two channels separated by the flat ***,these comprise of a channel representing the combustion chamber flow and a cooling air supply channel.A difference in pressure between the two channels forces air from the cooling supply side,through the effusion holes,and into the combustion chamber *** from successive effusion rows coalesces to form an aerodynamic film between the combustion chamber main flow and the flat *** practical applications,this film is used to separate the hot combustion gases from the combustion chamber *** numerical model is shown to be capable of accurately predicting the injection,penetration,downstream decay,and coalescence of the effusion *** addition,the numerical model captures entrainmen

关键词： effusion cooling large eddy simulation isothermal analysis film cooling turbulent wall jet

proteins as nanomagnets and magnetoreceptors

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Zoological Research 2024年第4期45卷 831-832页

作者： p.j.Hore Department of Chemistry University of OxfordUK

It is an appealing notion that a protein molecule could act as a nanomagnet.A genetically encodable biomolecule with a permanent magnetic moment at room temperature could have a range of applications:a magnetogenetic actuator,a magnetic tag for purifying and immobilizing enzymes,a contrast agent for magnetic resonance imaging,and a basis for a biomimetic magnetic sensing device,to name just a few.A magnetic protein could perhaps also function as the sensor in the magnetic compass that enables small songbirds to navigate the huge distances between their breeding and wintering *** though such possibilities may be,how realistic are they?

关键词： magnetic magnets enable

The Dirichlet Form of a Gradient-type Drift Transformation of a Symmetric Diffusion

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Acta Mathematica Sinica,English Series 2008年第7期24卷 1057-1066页

作者： p.j.FITZSIMMONS Department of Mathematics University of CaliforniaSan Diego9500 Gilman DriveLa JollaCA 92093-0112USA

In the context of a symmetric diffusion process X, we give a precise description of the Dirichlet form of the process obtained by subjecting X to a drift transformation of gradient type. This description relies on bou... 详细信息

关键词： diffusion Dirichlet form Girsanov theorem drift perturbation Markovian extension umqueness

A review of magnesium die-castings for closure applications

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journal of Magnesium and Alloys 2019年第2期7卷 297-304页

作者： j.p.Weiler Meridian Lightweight Technologies Canada

Vehicle mass reduction in the automotive industry has become an industry-wide *** fuel efficiency and greenhouse gas emission targets for engine-powered vehicles,and ambitions for extended range electric vehicles have motivated these reductions in vehicle *** reduction opportunities in structural automotive applications are increasingly realized through lightweight alloy castings,such as magnesium,primarily due to the ease of component *** traditional benefits of magnesium die-castings including lightweighting and associated compounded mass savings,excellent strength-to-weight ratio,part consolidation,near net-shape forming,dimensional repeatability,and integration of additional components can be realized in closure *** recent example is the application of a magnesium die-casting for the structural inner of the liftgate in the 2017 Chrysler pacifica,replacing nine parts in the previous generation and resulting in a liftgate assembly weight reduction of nearly 50%.The work presented here reviews past and current developments of magnesium die-castings in closure applications and discusses the benefits and challenges of magnesium alloys for these applications,including casting design,corrosion and fastening strategies,and the manufacturing design and assembly methodologies.

关键词： Die-casting Automotive applications Closures Lightweighting