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Anatomical characterization of central, apical and minima. corneal thickness

International journal of Ophthalmology(English edition) 2014年第4期7卷 668-672页

作者： Federico Saenz-Frances ma.tha Cecilia Bermúdez-Vallecilla lara Borrego-Sanz Luis jaez j osé ma.ìa.ma.tinez-de-la.ca.a.la.ra.mora.es-ferna.dez Enrique Santos-Bueso julián Garcia-Sanchez julián Garcia-Feijoo department of Ophthalmology Hospital Clínico San CarlosUniversidad Complutense de Madrid Instituto de Tecnologìa del Conocimiento Universidad Complutense de Madrid

·AIM: To anatomically locate the points of minimum corneal thickness and central corneal thickness(pupil center) in relation to the corneal apex.·METHODS: Observational, cross-sectional study, 299 healthy volunteers. Thickness at the corneal apex(AT),minimum corneal thickness(MT) and corneal thickness at the pupil center(PT) were determined using the pentacam. Distances from the corneal apex to MT(MD)and PT(PD) were calculated and their quadrant position(taking the corneal apex as the reference) determined:point of minimum thickness(MC) and point of central thickness(PC) depending on the quadrant position. Two multivariate linear regression models were constructed to examine the influence of age, gender, power of the flattest and steepest corneal axes, position of the flattest axis, corneal volume(determined using the Pentacam)and PT on MD and PD. The effects of these variables on MC and PC were also determined in two multinomial regression models.·ResULTS: MT was located at a mean distance of 0.909 mm from the apex(79.4% in the inferior-temporal quadrant). PT was located at a mean distance of 0.156 mm from the apex. The linear regression model for MD indicated it was significantly influenced by corneal volume(B =-0.024; 95% CI:-0.043 to-0.004). No significant relations were identified in the linear regression model for PD or the multinomial logisticregressions for MC and PC.·CONCLUSION: MT was typically located at the inferiortemporal quadrant of the cornea and its distance to the corneal apex tended to decrease with the increment of corneal volume.

关键词： cornealthickness anatomy glaucoma

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Ⅲ期胃癌D2根治术后辅助放化疗患者长期预后的影响因素:基于10年随访数据

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中国全科医学 2024年第17期27卷 2091-2097页

作者：马桂芬章倩刘娟孙菁林根来复旦大学附属中山医院放疗科上海市200032 复旦大学附属中山医院肿瘤防治中心上海市200032 复旦大学附属中山医院厦门分院放疗科福建省厦门市361000

背景局部进展期胃癌主要包括Ⅲ期胃癌,以综合治疗为主,患者术后复发是影响患者预后的关键因素。目的探究Ⅲ期胃癌D2根治术后辅助放化疗患者长期预后的影响因素。方法选取2009—2014年在复旦大学附属中山医院放疗科行D2根治术后辅助放化... 详细信息

背景局部进展期胃癌主要包括Ⅲ期胃癌,以综合治疗为主,患者术后复发是影响患者预后的关键因素。目的探究Ⅲ期胃癌D2根治术后辅助放化疗患者长期预后的影响因素。方法选取2009—2014年在复旦大学附属中山医院放疗科行D2根治术后辅助放化疗的胃癌患者为研究对象,病理结果根据国际癌症联合会(UICC)和美国肿瘤联合会(AjCC)第八版胃癌TNM分期系统进行分期,明确诊断Ⅲ期胃癌。术后所有患者在第1年每3个月随访1次,之后2年内每6个月随访1次,而后每年随访1次。随访截止日期为2021-12-15。采用Log-rank检验比较生存率的差异,采用Cox比例风险回归分析探究患者总生存时间(os)和无病生存时间(DFS)的影响因素,列线图预测临床病理特征对预后的影响,Kaplan-Meier法比较不同pTNM分期、年龄、转移淋巴结率(LNR)、胃切除方式患者生存差异。结果共纳入行术后辅助放疗的Ⅲ期胃癌患者135例,中位随访时间10.48年。5年内复发70例,死亡62例,5年无病生存率、总生存率分别为48.1%(65/135)、54.1%(73/135);10年内复发74例,死亡74例,10年无病生存率、总生存率均为45.2%(61/135)。Log-rank检验结果显示,不同pTNM分期、pT分期、LNR、癌结节、肿瘤位置、胃切除方式患者5年生存率比较,差异有统计学意义(Pos:HR=0.40,95%CI=0.19~0.83;DFS:HR=0.40,95%CI=0.19~0.92)、LNR(>50%,os:HR=1.74,95%CI=1.03~2.94;DFS:HR=1.73,95%CI=1.02~2.94)、胃切除方式(全胃切除术,os:HR=2.07,95%CI=1.22~3.50;DFS:HR=2.02,95%CI=1.20~3.41)是Ⅲ期胃癌D2根治术后辅助放化疗患者os和DFS的独立影响因素(Pos的独立影响因素(P<0.05)。另外,列线图表明年龄、pTNM分期、LNR、胃切除方式对Ⅲ期胃癌D2根治术后辅助放化疗患者预后有预测作用。胃癌术后患者复发情况:10例(7.4%)局部复发(放射野内吻合口和淋巴结的复发),35例(25.9%)患者出现腹、盆腔播散种植,37例(27.4%)患者出现了远处转移(包括肺、肝、骨、脑等脏器);部分患者发现了2种类型以上的复发。不同pTNM分期、年龄、LNR、胃切除方式的Ⅲ期胃癌患者术后生存曲线比较,差异有统计学意义(P<0.05)。结论大部分Ⅲ期胃癌D2根治术后辅助放化疗患者复发或死亡主要在5年内。pTNM分期、LNR和胃切除方式是这类患者预后的主要影响因素。

关键词：胃肿瘤 D2切除术辅助放化疗预后存活率无病生存时间影响因素分析

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食管癌新辅助治疗疗效评价的网状Meta分析

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中国胸心血管外科临床杂志 2024年第7期31卷 1035-1042页

作者：高鑫王铄链许帅马文文徐子昂胡尕伟李庆新中国人民解放军联勤保障部队第940医院兰州730050 宁夏医科大学研究生学院银川750004 河北北方学院研究生学院河北张家口075000

目的探讨食管癌最佳的新辅助治疗策略,为临床制定食管癌新辅助治疗方案提供理论基础。方法检索PubMed、EMbase、The Cochrane Library、Web of Science、中国知网、万方、维普,检索时限均为建库至2022年5月,由2名研究人员独立进行文... 详细信息

目的探讨食管癌最佳的新辅助治疗策略,为临床制定食管癌新辅助治疗方案提供理论基础。方法检索PubMed、EMbase、The Cochrane Library、Web of Science、中国知网、万方、维普,检索时限均为建库至2022年5月,由2名研究人员独立进行文献筛选、数据提取。采用Cochrane偏倚风险评价工具对文献质量进行评价,在RStudio环境下使用R3.6.3软件进行数据分析。结果共纳入24项研究,包括5 286例患者,治疗方法分别为单独接受手术治疗,新辅助化疗(neoadjuvant chemotherapy,NCT)、新辅助放疗(neoadjuvant radiotherapy,NRT)或新辅助放化疗(neoadjuvant chemoradiotherapy,NCRT)后联合手术治疗。纳入文献的偏倚风险较低。网状Meta分析结果显示,与单纯手术相比,NCRT[HR=0.77,95%CI(0.70,0.85)]和NCT[HR=0.89,95%CI(0.81,0.98)]后联合手术治疗可改善患者总生存期(overall survival,os)。NCRT还可显著降低食管癌患者局部复发[OR=0.43,95%CI(0.30,0.58)]和远处转移[OR=0.71,95%CI(0.52,0.93)]发生率。但NCRT[RR=1.30,95%CI(0.77,2.20)]会增加患者术后30 d死亡率。结论现有的证据表明NCRT联合手术是治疗可切除食管癌患者的最佳选择,但该治疗方法有增加术后30 d死亡率的风险。未来的研究应侧重于优化NCRT方案,以期在改善患者os的同时有效降低术后死亡率。此外受纳入研究质量的影响,该结论仍需更多高质量的随机对照试验予以佐证。

关键词：食管癌新辅助治疗化疗放疗放化疗网状Meta分析

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MECHANIcaL PROPERTIes OF LONGITUDINAL SUBMERGED ARC WELdeD STEEL PIPes USED FOR GAS PIPELINE OF OFFSHORE OIL

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Acta Metallurgica Sinica(English Letters) 2008年第2期21卷 85-93页

作者： Z.Z. Yang W. Tian Q.R. ma.Y.L. Li j.K. Li j.Z. Gao H.B. Zhang Y.H. Yang Tubular Goods Research Center of CNPC Xi＇an 710065 China Xiran Aerotechnical College Xi＇an 710077 China

Since the development of offshore oil and gas, increased subma.ine oil and gas pipelines were installed. All the early steel pipes of subma.ine pipelines depended on importing because of the strict requirements of comprehensive properties, such as, anti-corrosion, resistance to pressure and so on. To research and develop domes- tic steel pipes used for the subma.ine pipeline, the Longitudinal-seam Submerged Arc Welded （LSAW） pipes were ma.e of steel plates cut from leveled hot rolled coils by both the jCOE and UOE （the forming process in which the plate like the letter “j”, “C”, “0” or “U” shape, then expansion） forming processes. Furthermore, the mechanical properties of the pipe base metal and weld metal were tested, and the results were in accordance with the corresponding pipe specification API SPEC 5L or DNV- os-FI01, which showed that domestic LSAW pipes could be used for subma.ine oil and gas pipelines.

关键词： Mechanical properties Offshore oil and gas Longitudinal-seamsubmerged arc welded pipe (LSA W) Pipeline jCOE formingprocess UOE forming process

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Proteomic analysis of seminal plasma.from asthenozoospermia patients reveals proteins that affect oxidative stress responses and semen quality

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Asian journal of Andrology 2009年第4期11卷 484-491页

作者： jun Wang jian Wang Hua-Rong Zhang Hui-juan Shi Duan ma.Hong-Xin Zhao Biaoyang Lin Run-Sheng Li Systems Biology Division Zhejiang-California Nanosystems Institute （ZCNI） Zhejiang University Zhejiang University Huajiachi Campus Hangzhou 310029 China Key laboratory of Contraceptive Drugs and devices of National population and family planning committee （NPFPC） Shanghai Institute of Planned Parenthood Research Shanghai 200030 China Key laboratory of Molecular Medicine Ministry of Education Institute of Biomedical Sciences Shanghai Medical College Fudan University Shanghai 200030 China

Asthenozoospermia （AS） is a common cause of huma. ma.e infertility. In one study, more than 80% of the samples from infertile men had reduced sperm motility. Seminal plasma.is a mixture of secretions from the testis, epididymis and several ma.e accessory glands, including the prostate, seminal vesicles and Cowper＇s gland. Studies have shown that seminal plasma.contains proteins that are important for sperm motility. To further explore the pathophysiological character of AS, we separated the seminal plasma.proteins from AS patients and healthy donors using sodium dodecyl sulfate polyacrylamide gel electrophoresis and in-gel digestion, and then subjected the proteins to liquid chroma.ography-ma.s spectrometry （LC-MS/MS） analysis. A total of 741 proteins were identified in the seminal plasma. with a false discovery rate of 3.3%. Using spectral counting, we found that 45 proteins were threefold upregulated and 56 proteins were threefold downregulated in the AS group when compared with the control. Most of these proteins originated from the epididymis and prostate. This study identified a rich source of bioma.ker candidates for ma.e infertility and indicates that functional abnorma.ities of the epididymis and prostate can contribute to AS. We identified D j-1--a protein that has been shown elsewhere to be involved in the control of oxidative stress （os）-as a downregulated protein in AS seminal plasma. The levels of D j-1 in AS seminal plasma.were about half of those in the control samples. In addition, the levels of reactive oxygen species were 3.3-fold higher in the AS samples than in the controls. Taken together, these data suggest that downregulation of Dj-1 is involved in os in semen, and therefore affects the quality of the semen.

关键词： asthenozoospermia comparative proteomics Dj-1 seminal plasma

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Therma.-tectonic history of the Baogutu porphyry Cu deposit,West junggar as constrained from zircon U-Pb,biotite Ar/Ar and zircon/apatite(U-Th)/He dating

Thermal-tectonic history of the Baogutu porphyry Cu deposit,...

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中国科学院地质与地球物理研究所2014年度（第14届）学术年会

作者： Guang-Ming Li Ming-jian cao Ke-Zhang Qin Noreen j.Evans Brent la.McInnes Yong-Sheng Liu Key laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Sciences Graduate University of Chinese Academy of Sciences CSIRO Earth Science and Resource Engineering john de laeter Center for Isotope Research Dept. Applied Geology/Applied PhysicsCurtin University State Key laboratory of Geological Processes and Mineral Resources Faculty of Earth SciencesChina University of Geosciences

Understanding postmineralization tectonic movements in porphyry deposits,is critical to interpreting the complete therma.-tectonic *** study reports new zircon U-Pb ages,hydrotherma. biotiteAr/Ar age,and zircon and apatite(U-Th)/He ages from the Baogutu porphyry copper deposit,which,in conjunction with pre-existing geochronology and thermochronology and inverse modeling simulations,constrain the therma.-tectonic history of the *** la-ICP-MS U-Pb concordia ages indicate a late carboniferous age of 320.1 ± 2.2 ma.for the diorite complex and 309.8 ± 2.2 ma.for the mineralized granodiorite *** biotite selected from a quartz-biotite-chalcopyrite vein yields a plateau age of 311.0 ± 1.8 ma.which agrees with the age of the granodiorite porphyry and a previously reported molybdenite Re-os age,and suggests that hydrotherma. fluid circulated about310 *** and granodiorite porphyry yield weighted mean zircon(U-Th)/He ages of200.6±5.7ma.and 241.1 ±8.1 ma.respectively,with ages ranging from 221.0 ma.to 174.3 ma.and225.9 to 261.6 *** mean diorite and granodiorite porphyry apatite(U-Th)/He ages of87.4 ± 2.3 ma.and 120.0 ± 4.2 ma.were obtained with ages ranging from 68.9 ma.to 100.8 ma.and from91.0 ma.to 152.0 ma.*** wide range of zircon(U-Th)/He ages ma. be due to the combined effects of U and Th zonation and radiation dama.e,and radiation dama.e effect ma. also account for the wide range of apatite(U-Th)/He *** combined effects of depth and cooling due to meteoric water circulation contribute to an older(U-Th)/He age for the granodiorite porphyry,relative to the diorite.A five-episode cooling rate history for the diorite can be deduced by inverse model simulation:fast cooling—moderate fast cooling—relatively slow cooling—fast cooling again—very slow *** therma. and tectonic history of the wall rock indicates that it suffered significant far-field effects from the Qiangtang-Eurasia and Lhasa-Qiangta

关键词： Western junggar Baogutu porphyry copper deposit Zircon U-Pb dating Ar/Ar dating Zircon(U-Th)/He dating Apatite(U-Th)/He dating Therma.-tectonic history

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基于j2ME平台支持IPv6协议的研究与实现

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微计算机信息 2006年第4X期22卷 194-196,108页

作者：马常霞淮海工学院计算机科学系江苏连云港222006

随着无线应用与嵌入式系统愈来愈受到人们的重视,SUN推出了java2PlatformMicroEdition(j2ME),它用来为接入互联网的设备提供应用开发平台和执行环境。本文阐述了基于IPv6的socket编程,详细讨论了MIDP/CLDC的网络接口的调用,在Linux操作... 详细信息

随着无线应用与嵌入式系统愈来愈受到人们的重视,SUN推出了java2PlatformMicroEdition(j2ME),它用来为接入互联网的设备提供应用开发平台和执行环境。本文阐述了基于IPv6的socket编程,详细讨论了MIDP/CLDC的网络接口的调用,在Linux操作系统下,用扩展接口的方法添加了一套新的网络接口来支持IPv6协议,且编译通过该参考实现(RI)。编写的基于IPv6技术的MIDlets可以在该平台上运行成功,验证了该平台的可用性。

关键词：移动信息设备子集网际协议网络接口 IPv6协议 j2ME平台

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ART1 and putrescine contribute to rice aluminum resistance via osMYB30 in cell wall modification

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journal of Integrative Plant Biology 2023年第4期65卷 934-949页

作者： Li jun Gao Xiang Pei Liu Ke Ke Gao Meng Qi Cui Hui Hui Zhu Gui Xin Li jing Ying Yan Yun Rong Wu Zhong jie Ding Xue Wei Chen jian Feng ma.Nicholas PHarberd Shao jian Zheng State Key laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China Guangdong laboratory for Lingnan Modern Agriculture College of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 5100642China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China College of Agronomy and Biotechnology Zhejiang UniversityHangzhou 310058China Agricultural Experimental Station Zhejiang UniversityHangzhou 310058China Rice Research Institute Sichuan Agricultural University at WenjiangChengdu 611130China Institute of Plant Science and Resources Okayama UniversityKurashiki 710‐0046Japan department of Plant Science University of OxfordOxford OX13RBUnited Kingdom

Cell wall is the first physical barrier to aluminum(Al)*** of cell wall properties to change its binding capacity to Al is one of the ma.or strategies for plant Al resistance;nevertheless,how it is regulated in rice rema.ns largely *** this study,we show that exogenous application of putrescines(Put)could significantly restore the Al resistance of art1,a rice mutant lacking the central regulator Al ResISTANCE TraNSCRIPTION FACTOR 1(ART1),and reduce its Al accumulation particularly in the cell wall of root *** on RNA-sequencing,yeast-onehybrid and electrophoresis mobility shift assays,we identified an R2R3 MYB transcription factor osMYB30 as the novel target in both ART1-dependent and Put-promoted Al ***,transient dual-luciferase assay showed that ART1 directly inhibited the expression of osMYB30,and in turn repressed os4CL5-dependent 4-couma.ic acid accumulation,hence reducing the Al-binding capacity of cell wall and enhancing Al ***,Put repressed osMYB30 expression by eliminating Alinduced H2O2accumulation,while exogenous H2O2promoted osMYB30 *** concluded that ART1 confers Put-promoted Al resistance via repression of osMYB30-regulated modification of cell wall properties in rice.

关键词： ART1 cell wall 4‐couma.ic acid osMYB30 os4CL5 putrescine

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黑龙江中游浮游植物多样性动态变化及水质评价

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中国水产科学 2012年第4期19卷 671-678页

作者：李喆姜作发霍堂斌马波中国水产科学研究院黑龙江水产研究所农业部黑龙江流域渔业资源环境科学观测实验站

运用灰关联分析、单因子评价与生物多样性指数相结合的方法,于2010年5月、7月、9月通过对黑龙江浮游植物的多样性及其季节变动的研究,评价黑龙江中游(黑河?抚远江段)水质现状。结果表明:黑龙江中游浮游植物共计8门115种属,种类组成以硅... 详细信息

运用灰关联分析、单因子评价与生物多样性指数相结合的方法,于2010年5月、7月、9月通过对黑龙江浮游植物的多样性及其季节变动的研究,评价黑龙江中游(黑河?抚远江段)水质现状。结果表明:黑龙江中游浮游植物共计8门115种属,种类组成以硅藻为主。浮游植物的多样性丰富(H’、j三季均值分别在3.66～3.86、0.83～0.88之间);多样性指数的最大值和最小值分别出现在绥滨、黑河、三江口江段;黑龙江中游浮游植物的多样性表现出明显的季节变化规律,夏季较春、秋季丰富。应用灰关联分析评价黑龙江中游水质类别,呈现黑河、逊克、嘉荫、萝北、绥滨、三江口、抚远采样点水质与《地表水环境质量标准》(GB3838-2002)中的Ⅰ类水质的关联度最大,分别为0.788、0.903、0.851、0.856、0.864、0.791和0.879。结合生物多样性指数及灰关联分析、单因子评价法综合分析,黑龙江中游(黑河-抚远江段)水质现状良好,属于寡污-清洁型河流,水质类别为Ⅰ-Ⅱ类,能够满足珍稀水生生物栖息地、鱼虾类产卵场、仔稚幼鱼索饵场的水质要求。同时,黑龙江中游江段浮游植物多样性丰富,水质现状良好,也为恢复渔业资源,保护水生生物提供了条件。本研究旨在为黑龙江中游生态环境评价以及合理制定资源恢复策略提供科学依据。

关键词：黑龙江中游浮游植物多样性水质评价灰关联分析

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Correlation of circulating tumor DNA EGFR mutation levels with clinical outcomes in patients with advanced lung adenocarcinoma

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Chinese Medical journal 2021年第20期134卷 2430-2437页

作者： Xiang-Liang Liu Ri-lan Bai Xiao Chen Yu-Guang Zhao Xu Wang Ke-Wei ma.Hui-Min Tian Fu-jun Han Zi-Ling Liu Lei Yang Wei Li Fei Gai jiu-Wei Cui cancer Center The First Hospital of Jilin UniversityChangchunJilin 130021China Institute of Translational Medicine The First Hospital of Jilin UniversityChangchunJilin 130021China Amoy Diagnostics Co. LtdXiamenFujian 361000China

Background:Circulating tumor DNA(ctDNA)is a promising bioma.ker for non-invasive epiderma. growth factor receptor mutations(EGFRm)detection in lung cancer patients,but existing methods have limitations in sensitivity and *** this study,we used theΔCt value(mutant cycle threshold[Ct]value-internal control Ct value)generated during the polymerase chain reaction(PCR)assay to convert super-amplification-refractory mutation system(superaRMS)from a qualitative method to a semi-quantitative method named reformed-superaRMS(R-superaRMS),and evaluated its performa.ce in detectingEGFRm in plasma.ctDNA in patients with advanced lung ***:A total of 41 pairs of tissues and plasma.samples were obtained from lung adenocarcinoma.patients who had knownEGFRm in tumor tissue and were previously *** in ctDNA was identified by using *** ma.ing use ofΔCt value generated during the detection process of superaRMS,we indirectly transform this qualitative detection method into a semi-quantitative PCR detection method,named *** qualitative and quantitative analyses of the data were ***-Meier analysis was performed to estima.e the progression-free survival(PFS)and overall survival(os).Fisher exact test was used for categorical ***:The concordance rate ofEGFRm in tumor tissues and ma.ched plasma.samples was 68.3%(28/41).At baseline,EGFRm-positive patients were divided into two groups according to the cut-offΔCt value ofEGFRm set at 8.11.A significant difference in the median os(mos)between the two groups was observed(EGFRmΔCt≤8.11vs.>8.11:not reachedvs.11.0 months;log-rankP=0.024).Patients were divided into mutation clearance(MC)group and mutation incomplete clearance(MIC)group according to whether theΔCt value ofEGFRm test turned negative after 1 month of *** found that there was also a significant difference in mos(not reachedvs.10.4 months;log-rankP=0.021)between MC group and MIC ***

关键词： Lung adenocarcinoma Non-sma.l cell lung adenocarcinoma Liquid biopsy Super-amplification-refractory mutation system EGFR mutation

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