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Chronic hepatitis C infection in a patient with bone marrow hypoplasia

World journal of Gastroenterology 2008年第26期14卷 4238-4240页

作者： S Bethlen K Chandrikakumari L de Leval jB Giot D Mukeba P Leonard F Frippiat C Meuris j delwaide M Moutschen Centre Hospitalier Universitaire de Liege Liege 4000Belgium Medical Student Department of Infectious Diseases and Internal Medicine Centre Hospitalier Universitaire de LiegeLiege 4000Belgium Department of Pathology Centre Hospitalier Universitaire de LiegeLiege 4000Belgium Department of Gastroenterology and Hepatology Centre Hospitalier Universitaire de LiegeLiege 4000Belgium

Chronic hepatitis C virus(HCV) infection is associated with multifarious extra-hepatic manifestations;the most described and discussed being mixed cryoglob-ulinemia which is strongly related to B-cell lympho-proliferative disorders(LPDs).We present a case of chronic HCV infection and mixed cryoglobulinemia,with minimal liver *** case is a 53-year-old patient who was diagnosed as having bone marrow hypoplasia at the age of *** received several blood transfusions to normalize her *** the age of 31,she was diagnosed with rheumatoid ar-thritis on account of her diffuse joint pain and inflam-mation,elevated rheumatoid factor(RF) and Raynaud's *** years later,monoclonal gam-mopathy of IgG Lambda(one year later,changed to IgM Kappa) was detected during a routine examina-tion.A bone marrow biopsy showed hypoplasia,Kappa positive B-lymphocytes and low-grade malignant lym-phoma *** of the bone marrow aspirate was not *** treatment was initiated owing to herpoor bone marrow function and she is under regular follow-up.

关键词： Chronic hepatitis C infection Mixed cryoglobulinemia Prognosis

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比利时南部基因5型丙型肝炎病毒患者:流行病学特征和治疗应答

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世界核心医学期刊文摘（胃肠病学分册） 2006年第5期2卷 14-14页

作者： delwaide j. Gerard C. Reenaers C. 李宏宇 Department of Hepato-Gastroenterology CHU Sart Tilman 4000 Liège Belgium Dr.

Data are scarce on patients infected with hepatitis C virus of genotype 5, due to the low prevalence of this genotype around the world. To better define the characteristics of these patients, we reviewed the files of 16 genotype 5 patients. Mean age was 38 ± 14. All patients were of European origin. Most of them (75% ) had been contaminated by transfusion within a short time period (between 1980 and 1991). There were no intravenous drug addicts. Seven patients received treatment. One patient did not respond to interferon (IFN) monotherapy. Of four patients treated with IFN and ribavirin, three became sustained viral responders. Two patients treated with pegylated IFN and ribavirin became sustained viral responders. In our region, genotype 5 patients seem to have been contaminated within a relatively short time period. Treatment with IFN or pegylated IFN and ribavirin gave a high rate (83% ) of sustained viral responses.

关键词：丙型肝炎病毒患者档案治疗应答部基因流行病学特征比利时聚乙二醇干扰素利巴韦林单一疗法病毒应答

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