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镰形红细胞的双重危险——自身氧化和铁失分隔

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国外医学（输血及血液学分册） 1990年第5期13卷 283-285页

作者： Hebbel pr 羊裔明

HbS显示一些与βb→Val有关的异常分子行为,知道最清楚的是,在低氧应激情况下,HbS有明显的多聚化倾向;其次,蛋白表面的电荷改变,影响四聚体的装配;再者,HbS不稳定带来的后果.这说明了镰形红细胞（RBC）病是氧化现象起病理作用的疾病之一... 详细信息

HbS显示一些与βb→Val有关的异常分子行为,知道最清楚的是,在低氧应激情况下,HbS有明显的多聚化倾向;其次,蛋白表面的电荷改变,影响四聚体的装配;再者,HbS不稳定带来的后果.这说明了镰形红细胞（RBC）病是氧化现象起病理作用的疾病之一.本文将对支持这种看法的资料以及对特异性镰形RBC膜成分氧化损害的资料加以综述.HbS的自身氧化脱氧Hb的生理氧合作用,涉及到一个来自Hb亚铁电子向氧的转运.氧合Hb倾向于以过氧化铁Hb方式存在.正常情况下,这一过程可以逆转.有时Hb允许氧以过氧化物形式分离,然后留下高铁Hb（metHb）.因此,生理水平的metHb生成和内源性氧窘迫（Oxidant Stress）.可因氧合HbS而加速.氧合HbS在37℃稀释液中孵育期间,自身氧化比HbA快1.7倍。

关键词：镰形红细胞 Hbs自身氧化铁失分隔

Immune Responses of Chicken Immunizedwith Marek's Disease Vaccines

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journal of Northeast Agricultural University(English Edition) 1996年第1期3卷 29-37页

作者： Liu Zhonggui, Gao Rong,Li Qingzhang,Liu Yun, Zheng Shimin,Yan Liping(Northeast Agricultural University,Harbin,150030 pr China) Northeast Agricultural University Harbin 150030 PR China

The experiment was conducted to study the dynamic changes of immune responses of chicks immunized with March's disease(MD)trivalent vaccine and turkey herpesvirus(HVT)at one day *** were found that after immunization of chicks with MD vaccines,the intcrlcukinc-2(IL-2)inductive activity and IL-2 receptor expression of T cells from thymus and spleen significantly increased,suggesting that the immunoregulativc function was markedly enhanced in the immune organs;the number of antibody-producing cells,the number and proliferative function of T cells rose markedly in Bursa Fabricius,spleen and thymus,indicating that the cellular and humoral immune responses were elevated remarkablly in the central and peripheral immune organs;the number of T and antibody-producing cells as well as the content of IgG,IgA and IgM obviously mounted in cecal tonsil, Harder tan gland mucosal lymphoid tissues of bronchus along with tears,trachea washings, bile and intestinal fluids,demonstrating that the local and mucosal immunity was raised in the respiratory and digestive tract;the levels of immune responses mentioned above in the trivalent vaccine-immuniaed chicks were apparently higher than those of HVT-immunized birds.

关键词： Marek's vaccination chick immune responses

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放射学多选题

临床放射学杂志 1989年第2期 108-112页

作者： pr Patel 孔庆德

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困难的经济预测艺术

预测 1997年第4期16卷 69-72页

作者： Masi.,pr 国际货币基金组织研究局美国

困难的经济预测艺术ＰＡＵＬＡＲ．ＤＥＭＡＳＩ经济预测是一门艺术，而不是一门科学。经济结果往往受到始料不及的事件影响，而且数据也可能不充足，在发展中国家尤其如此。１９９５—１９９６年某些工业国和发展中国家令人失望的增... 详细信息

困难的经济预测艺术ＰＡＵＬＡＲ．ＤＥＭＡＳＩ经济预测是一门艺术，而不是一门科学。经济结果往往受到始料不及的事件影响，而且数据也可能不充足，在发展中国家尤其如此。１９９５—１９９６年某些工业国和发展中国家令人失望的增长实绩，以及国际货币基金组织工作人...

关键词：发达国家发展中国家经济预测

Experimental Studies of Adaptive Conscious Systems

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journal of Systems Engineering and Electronics 1994年第1期5卷 25-35页

作者： Cai Yifa(Dept of Math & Computer SciencesDundee Institute of Technology Dundee DD1 1HGUnited Kingdom)(Division of Adaptive Neural SystemsZhejiang UniversityHangzhou 310027pr China) Dept of Math & Computer Sciences Dundee Institute of Technology Dundee DD1 1HG United Kingdom Division of Adaptive Neural Systems Zhejiang University Hangzhou 310027 PR China

Human consciousness is the most interesting and mysterious phenomenon in the *** this paper, the results of the computational studying and simulation of the conscious behaviour,such as the learning of language and image patterns, traditional conditioning, association, imagination and dream, have been presented. Based on these results, an experimental conscious systemCONSCITRON, has been developed. Further discussion on development of adaptive conscioussystems is also provided.

关键词： Adaptive conscious systems Neural networks Neural modelling

Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis

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Chinese Medical journal 2014年第4期127卷 662-668页

作者： Liu Y Li M Zhou pr Xing XP Xia WB Xu L Liu H j Zhang ZL LiaoEY Chen DC Liu j Tao TZ Wu W Department of Endocrinology Key Laboratory of EndocrinologyMinistry of HealthPeking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China Department of Endocrinology People&#39 s Hospital of Liaocheng Liaocheng Shandong 252002 China Metabolic Bone Disease and Genetics Research Unit Department of Osteoporosis and Bone Diseases Shanghai Sixth People&#39 s Hospital Affiliated with Shanghai jiao Tong University Shanghai 200233 China Osteoporosis and Bone Diseases Shanghai Sixth People's HospitalAffiliated with Shanghai Jiao Tong University Shanghai 200233China Institute of Endocrinology and Metabolism Second Xiangya Hospitalof Central South University Changsha Hunan 410011 China Department of Endocrinology Osteoporosis Education Center WestChina Hospital Sichuan University Chengdu Sichuan 610041China Department of Orthopedics Xijing Hospital Fourth Liberation ArmyUniversity Xi'an Shannxi 710032 China Department of Orthopedics Harbin Medical University AffiliatedSecond Hospital Harbin Heilongjiang 150081 China Department of Endocrinology Guangdong General HospitalGuangzhou Guangdong 510080 China

Background Genetic factors are important in the pathogenesis of osteoporosis,but less is known about the genetic determinants of osteoporosis *** aimed to explore the association between the gene polymorphisms of key enzyme farnesyl diphosphate synthase （FDPS） in mevalonate signaling pathway of osteoclast and response to alendronate therapy in osteoporotic postmenopausal women in *** The study group comprised 639 postmenopausal women aged （62.2＆#177;7.0） years with osteoporosis or osteopenia who had been randomly assigned to low dose group （70 mg/2w） or standard dose group （70 mg/w） of alendronate in this 1-year *** identified allelic variant of the FDPS gene using the polymerase chain reaction and restriction enzyme *** and after treatment,serum levels of calcium,phosphate,alkaline phosphatase （ALP）,cross linked C-telopeptide of type Ⅰ collagen （β-CTX） were *** mineral density （BMD） at lumbar spine and proximal femur was *** association was analyzed between the polymorphisms of FDPS gene and the changes of BMD,bone turnover biomarkers after the *** The FDPS rs2297480 polymorphisms were associated with baseline BMD at femoral neck,and patients with CC genotype had significantly higher baseline femoral neck BMD （（733.6＆#177;84.1） mg/cm2） than those with AC genotypes （（703.0＆#177;86.9） mg/cm2） and AA genotypes （（649.8＆#177;62.4） mg/cm2）（P 〈0.01）.No significant difference in BMD at lumbar spine was observed among different genotypes of *** percentage change of serum ALP level was significantly lower in patients with CC genotype （-22.9%） than that in those with AC genotype （-24.1%） and AA genotype （-29.8%） of FDPS after 12 months of alendronate treatment （P 〈0.05）.Neither percentage change of BMD nor β-CTX level after alendronate treatment had association with FDPS *** FDPS gene was probably a candidate gene to predict femoral neck BMD at *** gene alleles could predict chan

关键词： farnesyl diphosphate synthase polymorphism alendronate osteoporosis pharmacogenomics

腹足纲Helix pomatia β_C-血清蛋白的功能单位d,e和f中一个半胱氨酸—组氨酸之间硫醚桥键的鉴定(英文)

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药物生物技术 2007年第2期14卷 104-109页

作者：蔡皓 Gielens Constant préaux Gisele 南京中医药大学江苏省海洋药物研究开发中心江苏南京210029 Laboratoriumvoor Biochemie Katholieke Universiteit te Leuven

对腹足纲软体动物罗曼蜗牛Helix pomatia的氧运输蛋白(βC-血清蛋白)的功能单位d,e和f中的一个半胱氨酸—组氨酸之间的硫醚桥键进行了研究。以该βC—血清蛋白为载体,通过限制性胰蛋白酶水解,产生片段a-c,ef,以及功能单位d,g,和h。以片... 详细信息

对腹足纲软体动物罗曼蜗牛Helix pomatia的氧运输蛋白(βC-血清蛋白)的功能单位d,e和f中的一个半胱氨酸—组氨酸之间的硫醚桥键进行了研究。以该βC—血清蛋白为载体,通过限制性胰蛋白酶水解,产生片段a-c,ef,以及功能单位d,g,和h。以片段ef降解后的产物为研究对象,通过亲合色谱的分离纯化,得到功能单位e和f。通过对羧甲基化功能单位d的胰蛋白酶和链霉蛋白酶水解,得到一个含有硫醚桥键的4肽。同样在吡啶乙基化功能单位e和f的胰蛋白酶水解产物中也分离得到一个含有相同硫醚桥键的小肽。因此一个半胱氨酸—组氨酸之间硫醚桥键的存在似乎是腹足纲软体动物罗曼蜗牛Helix pomatia氧运输蛋白(βC-血清蛋白)功能单位的一个共有的特征。

关键词： βc-血清蛋白反相高效液相色谱氨基酸分析 DABITC-PITC双偶合法紫外吸收光谱法电喷雾质谱法

THE REACTION OF BENZOYL SUBSTITUTED HETEROCYCLIC KETENE AMINALS WITH ARYL AZIDES.A FACILE APprOACH TO SYNTHSIZE 1,5-DIARYL-4-(2-IMIDAZOLINYL)-1,2,3-TRIAZOLES

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Chinese Chemical Letters 1990年第1期1卷 5-8页

作者： Zhi Tang HUANG Mei Xiang WANG Institute of Chemistry,Academia Sinica,Beijing,pr of China

Heterocyclic ketene aminals 1 react with aryl azides 2 to give the titled compounds 3,and in some cases also with the formation of fused heterocycles 4.

关键词： IMIDAZOLINYL THE REACTION OF BENZOYL SUBSTITUTED HETEROCYCLIC KETENE AMINALS WITH ARYL AZIDES.A FACILE APprOACH TO SYNTHSIZE 1,5-DIARYL-4 TRIAZOLES

Control relevant identification and predictive control of a building

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Control relevant identification and predictive control of a ...