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河南外科学杂志 2017年第6期23卷 50-51页

作者：王玉波葛波涌 j mulenga 郑州大学第二附属医院急诊科郑州450014 赞比亚基特韦市中心医院

目的探讨低分子肝素预防非洲脊柱结核术后深静脉血栓形成(DVT)的效果。方法随机将60例接受手术治疗的脊柱结核患者分为2组,各30例。对照组术后给予间歇气压疗法,治疗组在对照组基础上皮下注射低分子肝素钙,比较2组的疗效。结果治疗组DV... 详细信息

目的探讨低分子肝素预防非洲脊柱结核术后深静脉血栓形成(DVT)的效果。方法随机将60例接受手术治疗的脊柱结核患者分为2组,各30例。对照组术后给予间歇气压疗法,治疗组在对照组基础上皮下注射低分子肝素钙,比较2组的疗效。结果治疗组DVT总发生率低于对照组,差异有统计学意义(P0.05);预防治疗后2组下肢周径明显改善,且治疗组改善幅度优于对照组,差异均有统计学意义(P<0.001)。结论低分子肝素钙可有效预防非洲脊柱结核术后DVT,并改善患者下肢周径。

关键词：低分子肝素钙非洲脊柱结核手术

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Chronic hepatitis B virus monoinfection at a university hospital in Zambia

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World journal of Hepatology 2018年第9期10卷 622-628页

作者： Michael j Vinikoor Edford Sinkala Annie Kanunga Mutinta Muchimba Bright Nsokolo Roma Chilengi Gilles Wandeler joseph mulenga Tina Chisenga Debika Bhattacharya Michael S Saag Graham Foster Michael W Fried Paul Kelly Tropical Gastroenterology and Nutrition Group School of MedicineUniversity of ZambiaLusaka 50110Zambia Centre for Infectious Disease Research in Zambia Lusaka 34681Zambia Department of Medicine University of Alabama at BirminghamBirminghamAL 35294United States Department of Infectious Diseases Bern University HospitalUniversity of BernBern 3012Switzerland Institute of Social and Preventive Medicine University of BernBern 3012Switzerland Zambia National Blood Transfusion Service Private Bag RW1X RidgewayLusaka 50110Zambia Zambian Ministry of Health Ndeke HouseLusaka 30205Zambia Department of Medicine University of California at Los AngelesLos AngelesCA 90035United States Blizard Institute Barts and The London School of MedicineQueen Mary University of LondonLondon E1 2ATUnited Kingdom Department of Medicine University of North Carolina at Chapel HillChapel HillNC 27514United States

AIM To characterize antiviral therapy eligibility among hepatitis B virus(HBV)-infected adults at a university hospital in *** Hepatitis B surface antigen-positive adults(n = 160) who were h IV-negative and referred to the hospital after a routine or clinically-driven HBV test were enrolled. Alanine Aminotransferase(ALT),Aspartate Aminotransferase(AST),platelet count,hepatitis B e-antigen,and HBV DNA were measured. Liver fibrosis/cirrhosis was assessed by physical examination,AST-to-platelet ratio index,and transient elastography. In antiviral therapy-na?ve individuals,we described hBV stages and antiviral therapy eligibility per World health Organization(WhO) and by hBV test(routine vs clinical). Elevated ALT was > 19 in women and > 30 U/L in men. Among treatmentexperienced individuals,we described medication side effects,adherence,and viral *** The median age was 33 years,71.9% were men,and 30.9% were diagnosed with HBV through a clinicallydriven test with the remainder identified via routine testing(at the blood bank,community events,etc.). Among 120 treatment-na?ve individuals,2.5% were categorized as immune tolerant,11.7% were immune active,35.6% were inactive carriers,and 46.7% had an indeterminate phenotype. Per WhO guidelines,13(10.8%) were eligible for immediate antiviral therapy. The odds of eligibility were eight times higher for those diagnosed at clinical vs routine settings(adjusted odds ratio,8.33; 95%CI: 2.26-29.41). Among 40 treatmentexperienced hBV patients,virtually all took tenofovir,and a history of mild side effects was reported in 20%. Though reported adherence was good,12 of 29(41.4%) had HBV DNA > 20 IU/m L. CONCLUSION Approximately one in ten HBV-monoinfected Zambians were eligible for antivirals. Many had indeterminate phenotype and needed clinical follow-up.

关键词： Hepatitis B virus Liver fibrosis Treatment Tenofovir Africa

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<i>In Vivo</i>Evaluation of Anti-Mycobacterial Activity of a Phytomedicine “MATHESIA” on <i>Mycobacterium ulcerans</i>: Influence of Alkalinity on the Activity of Antibiotics Used in the Treatment of Buruli Ulcer

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Open journal of Medical Microbiology 2021年第1期11卷 47-57页

作者： L. H. Nkasa K. j. Kadinekene O. Kiabanzawoko B. Tchey S. Kimbonza M. O. Lunguya S. S. Karhemere Bin M. C. mulenga T. j. j. Muyembe S. j. Kayembe K. M. Taba Department of Chemistry Faculty of Sciences University of Kinshasa Kinshasa DR Congo Department of Surgery Faculty of Medicine University of Kinshasa Kinshasa DR Congo BU Project of the Evangelic Medical Institute of Kimpese Kongo Central DR Congo National Program for Tuberculosis Control Kinshasa DR Congo National Institute of Biomedical Research Kinshasa DR Congo Department of Medical Biology Faculty of Medicine University of Kinshasa Kinshasa DR Congo

The present study reports the in vivo anti-Mycobacterial Activity of a Phytomedicine “MATHESIA” on Mycobacterium ulcerans. It also explores the influence of ethanolamine (alkali agent) on the in vivo activity of some antibiotics (Isoniazid, Rifampicin, Ethambutol) used in the treatment of Buruli ulcers in DR Congo. Experiments were conducted on adult white Wistar rats of both sexes with the weights comprising between 110 - 165 g. The result obtained have shown that the phytomedicine MATHESIA (pH 10) has a good in vivo activity on M. ulcerans and the duration for wounds healing and total cicatrization was 6 days;whereas this duration was 10, 12, 14, and 16 days respectively for Rifampicin (I

关键词： Buruli Ulcer Mycobacterium ulcerans Mathesia Ethanolamine Rifampicin Ethambutol Isoniazid Kibadi Solution

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