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女性寻常性痤疮与性激素的研究

中国医学创新 2025年第1期22卷 164-170页

作者：梁兮宇赵永要薛燕宁南京中医药大学附属医院皮肤科江苏南京210004

痤疮是皮肤科常见的一种疾病,其发病机制非常复杂,包括环境因素、遗传因素、性激素水平异常、毛囊皮脂腺导管角化异常及其他多种相关因素。随着对该疾病的深入探究,性激素逐渐成为主要关注点之一,皮肤是一个内分泌器官,能够表达多种激... 详细信息

痤疮是皮肤科常见的一种疾病,其发病机制非常复杂,包括环境因素、遗传因素、性激素水平异常、毛囊皮脂腺导管角化异常及其他多种相关因素。随着对该疾病的深入探究,性激素逐渐成为主要关注点之一,皮肤是一个内分泌器官,能够表达多种激素的代谢酶和激素受体。皮脂腺是激素尤其是雄激素生物合成的主要场所,痤疮是经典的雄激素介导的皮肤病。本文将对痤疮的主要发病机制及影响因素、性激素水平的异常与女性痤疮的发生、女性痤疮的激素疗法展开综述,探讨相关性激素和激素受体在痤疮发病机制中的作用。

关键词：女性痤疮发病机制性激素

NRf2 participates in the suppressive tumor immune microenvironment of KRAS/KEAP1 co-mutant non-small cell lung cancer by inhibiting the STING

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Genes & Diseases 2023年第5期10卷 1727-1730页

作者： Sun Xiaodan zhao Peiyan Li Hui Liu Yan Cheng Ying Postdoctoral Research Workstation Jilin Cancer HospitalChangchunJilin 130012China Translational Cancer Research Jilin Cancer HospitalChangchunJilin 130012China Department of Medical Thoracic Oncology Jilin Cancer HospitalChangchunJilin 130012China

Kirsten rat sarcoma(KRAS)mutant non-small cell lung cancer(NSCLC)has distinct co-mutational *** 20%of KRAS mutant NSCLC cases underwent loss-of-function mutation of Kelch-like ECH-associated protein 1(KEAP1)gene,namely KRAS-KEAP1 comutation(KK)type,which exhibited a poorer immune checkpoint inhibitor(ICl)response compared with individual KRAS mutation(K)type tumors.i Recent studies suggest that K-type tumors are referred to as"hot tumors"while KK-type tumors are as"cold tumors".Therefore,clarifying the molecular mechanism of the poor IClresponsive phenotype of KK-type tumors is the key to improving the clinical efficacy and breaking through the therapy ***-mutations could regulate the immune contexture to reshape the tumor immune microenvironment(TIME)。

关键词： KRAS inhibiting cancer

The theoretical study of the efficiency of diffusion deposition of nanoaerosols in the extended range of the Peclet numbers

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Particuology 2023年第6期77卷 47-55页

作者： R.f.Mardanov S.K.Zaripov V.f.Sharafutdinov N.I.Lobachevskii Institute of Mathematics and Mechanics Kazan(Volga Region)Federal UniversityKremlevskaya ul.18KazanTatarstan420008Russia

The efficiencies of the diffusion deposition of nanoaerosols for a single fiber for the models of aerosol filter and wire mesh screen are studied numerically in the extended range of the Peclet number *** rectangular periodic cell model for fluid flow and convective-diffusive transport of small aerosol particles is *** of the previous theoretical and experimental studies of single fiber diffusion deposition efficiency were for the case of Pe>*** array with uniform square or chess grid of fibers and of a row of circular cylindrical fibers are considered as the filter and wire mesh screen *** flow and particles transport equations are solved numerically using the Boundary Element *** obtained numerical data are used to derive the approximate formulas for the deposition efficiency in the entire range of the Peclet number for the various porosities of the filter medium or distances between fibers in a wire mesh *** derived dependencies take into account nonlinearity of the deposition efficiency at the low Peclet *** obtained analytical dependencies compare well with the numerical and experimental data.

关键词： Arrayof fibers Row of fibers Periodic cell model Convection-diffusion equation Single fiber efficiency

How water molecules occupying the active site of a single-atom catalyst affect the electrochemical reduction of carbon dioxide

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Nano Research 2023年第7期16卷 9091-9098页

作者： jia zhao Di Liu fenfei Wei Weng fai Ip Hui Pan Sen Lin State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350002China Institute of Applied Physics and Materials Engineering University of MacaoTaipa 999078MacaoChina Department of Physics and Chemistry Faculty of Science and TechnologyUniversity of MacaoTaipa 999078MacaoChina

In single-atom catalysts(SACs),the single atoms are often exposed as protrusions above the *** solvent molecules in the electrocatalytic environment can interact or even bind to these coordination-unsaturated single atoms and thus influence the reaction process,but this has not been studied in *** this work,we systematically investigate the thermodynamics of CO_(2)reduction reaction(CO_(2)RR)to CO over MoS_(2)-supported single metal atom catalysts(TM@MoS_(2),TM=transition metal)under vacuum and explicit solvent environments using density functional *** addition,the ab initio molecular dynamics results show that explicit H_(2)O molecules can coordinate to the TM site and undergo competitive adsorption with the CO_(2)RR intermediates,which significantly affects the energy and conformation of the CO_(2)RR *** structure analysis reveals that the occupying H_(2)O molecules change the electronic state of single atom and further influence the adsorption strength of different CO_(2)RR *** work shows that water molecules can not only act as ligands to influence the electronic state of TM,but also affect the energy and conformation of CO_(2)RR intermediates,which highlights the important role of occupying H_(2)O molecules at the single-atom sites in CO_(2)RR and provides useful insights for the design of SACs for efficient CO_(2)RR.

关键词： electrocatalytic CO_(2)reduction solvent effect single-atom catalysis density functional theory ab initio molecular dynamics

One-step synthesis of cyclic polypyrazole and the self-assembly vesicles driven by hydrogen bond

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Chinese Chemical Letters 2022年第2期33卷 825-829页

作者： Zhen Lu Bogeng Guo Yulai zhao Linxi Hou Longqiang Xiao Department of Materials-Oriented Chemical Engineering College of Chemical EngineeringFuzhou UniversityFuzhou 350116China fujian Key Laboratory of Advanced Manufacturing Technology of Specialty Chemicals Fuzhou UniversityFuzhou 350116China

The synthesis of cyclic polymer is an important topic in polymer chemistry. Herein, we report a one-step method to prepare cyclic polypyrazoles. Monomers with two functional groups, diazo and alkyne, were synthesized and polymerized via 1,3-diploar cycloaddition in bulk under heating without any *** with molecular weights in the range of 3800-4400 g/mol and yields in the range of 78.8-98.7% were successfully synthesized. No chain end group was detected by LC-QTOf-MS and fTIR, which proves the cyclic structure of polypyrazoles. What is noteworthy is that the cyclic polypyrazoles can selfassemble into vesicles during the reprecipitation process, which was proved by the results of SEM and TEM. The reason for that is the formation of intermolecular hydrogen bond between NH and ester groups.

关键词： 1,3-Dipolar cycloaddition Polypyrazole Self-assembly Cyclic polymers

Improving the electrochemical performance of α-MoO_(3) electrode using aluminium trifluoromethanesulfonate water-in-salt electrolyte

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journal of Energy Chemistry 2023年第3期78卷 123-134,I0004页

作者： Ayman E.Elkholy Timothy T.Duignan Ruth Knibbe Xiu Song zhao School of Chemical Engineering The University of QueenslandSt Lucia CampusBrisbane 4072Australia School of Mechanical and Mining Engineering The University of QueenslandSt Lucia CampusBrisbane 4072Australia

Orthorhombic molybdenum trioxide(α-MoO_(3)) electrode material experiences severe capacity fading and poor cycling stability in aqueous *** investigated the charge-storage performance of α-MoO_(3) electrode in aluminium trifluoromethanesulfonate(Al(OTf)_(3))-based salt-in-water electrolyte(SiWE) and water-in-salt electrolyte(WiSE).It was found that α-MoO_(3) electrode exhibits significantly different cycling stabilities in both electrolytes with capacity retentions of 8% using the former and87% using the *** is because α-MoO_(3) electrode maintains its crystal structure upon cycling in WiSE,but experiences substantial structural collapses and partial dissolution upon cycling in *** behaviour was inferred from both operando electrogravimetry and ex situ *** results suggest that the predominant charge-storage mechanism in a-MoO_(3) electrode using WiSE is the intercalation of protons produced from electrolyte hydrolysis with some contribution from surface pseudocapacitance enabled by Al3+ions.A two-volt full cell fabricated from α-MoO_(3) electrode as anode and copper hexacyanoferrate(CuHCf) electrode as cathode using WiSE delivers volumetric and gravimetric energies of 10.4 Wh/L and 26.5 Wh/kg,respectively,with 78% capacity retention after 2500 *** study provides an insightful understanding of the electrochemical performance of α-MoO_(3) electrode in Al(OTf)_(3)-based electrolytes.

关键词： Molybdenum oxide Aqueous electrolyte Water-in-salt electrolyte Aqueous batteries Pseudocapacitance

Role of copper in tarnishing process of silver alloys in sulphide media

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Transactions of Nonferrous Metals Society of China 2019年第12期29卷 2646-2657页

作者： j.ORTíZ-CORONA f.j.RODRíGUEZ-GóMEZ Departamento de Ingeniería Metalúrgica Facultad de QuímicaUniversidad Nacional Autónoma de México

Silver and silver alloys usually tarnish,which causes some changes in their aesthetic appearance and electrical properties,due to their exposure to sulphide environments(H2S),and this is a problem in the field of corrosion and conservation of cultural heritage metallic *** this study,the role of copper content in the tarnishing process of 0.925,0.800 and 0.720 silver alloys in a 0.07 vol.%ammonium sulphide solution for different immersion periods was analyzed by electrochemical impedance spectroscopy(EIS)and scanning electron microscopy(SEM).The polarisation curves showed that the copper content and sulphide increased the corrosion current density and delayed the passivation of silver *** impedance spectra collected at the open circuit potential(OCP)showed a single capacitive,incomplete and depressed loop,indicating that the charge transfer resistance decreased as the copper content increased in the *** contrast,the double-layer capacitance increased as the copper content *** SEM-EDS analysis confirmed that the copper-rich phase in the silver alloys was selectively dissolved due to the preference of S to react with Cu,resulting in a localised attack,thus delaying the formation of a passive film.A marked localised attack was observed in alloys with lower copper *** mechanism for the tarnishing of silver alloys in sulphide media was dependent on the nature of the alloy and the greater affinity of copper for *** dissolution of Ag and Cu to form corrosion products was proposed as the rate determining step.

关键词： silver conservation and restoration tarnishing electrochemical impedance spectroscopy silver alloys corrosion mechanism

Surface-enhanced Raman scattering technology based on TiO_(2)/Nb_(2)C coated microfluidic chip for monitoring glioma cells invasion in real time

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Chinese Chemical Letters 2023年第6期34卷 293-297页

作者： jie zhao Xiaoyan Liu Yan Zhou Tingting Zheng Yang Tian Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China

Glioma is a malignant primary brain tumor that is extremely harmful to human ***,studying the invasiveness of glioma cells is of great significance for the diagnosis and treatment of *** this work,TiO_(2)/Nb_(2)C was prepared as a SERS substrate and combined with microfluidic chip to construct an invasion model capable of monitoring glioma invasion in real *** experimental data and density function theory(DfT)calculations showed that the significant SERS-enhancing effect of TiO_(2)/Nb_(2)C on methylene blue(MB)originated from the chemical magnification(CM)mechanism when MB was used as the adsorbed *** on this,we achieved a highly sensitive and targeted detection of vascular endothelial growth factor(VEGf),a biomarker for glioma with a low detection limit of 3.7 pg/m L,then quantified the invasive process in real time by detecting ***,the depletion of reactive oxygen species(ROS)by TiO_(2)/Nb_(2)C can inhibit the invasion of glioma *** the first time,the invasion model combines SERS technology with microfluidic technology,while monitoring the cell invasion process in real time,the invasion process can be quantified by detecting the VEGf secreted by glioma cells during the invasion process,realizing the integration of diagnosis and treatment,and establish a new model for the biomedical analysis,clinical diagnosis and treatment of glioma.

关键词： Surface-enhanced Raman spectroscopy Microfluidic chips VEGf Glioma cells Integration of diagnosis and treatment

Event-triggered state estimation for cyber-physical systems with partially observed injection attacks

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Science China(Information Sciences) 2023年第6期66卷 295-296页

作者： Le LIU Xudong zhao Bohui WANG Yuanqing WU Wei XING The Key Laboratory of Intelligent Control and Optimization for Industrial Equipment (Dalian University of Technology) Ministry of Education School of Aerospace Science and Technology Xidian University School of Automation Guangdong University of Technology

Dear editor,Recently,because of the high-efficiency requirements of modern industrial engineering,cyber-physical systems(CPSs) have received increasing attention. A CPS often contains a huge communication network,making it work more efficiently. Owing to CPSs’ high efficiency in industrial engineering,they have been extensively studied and explored in practice.

关键词： Cyber Physical System