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Sperm retrieval and intracytoplasmic sperm injection outcomes in men with cystic fibrosis disease versus congenital bilateral absence of the vas deferens

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Asian journal of Andrology 2021年第2期23卷 140-145页

作者： j abram mcbride Taylor P Kohn Daniel j Mazur Larry I Lipshultz R Matthew Coward Scott Department of Urology Baylor College of MedicineHoustonTX 77030USA Department of Urology UNC School of MedicineChapel HillNC 27599USA UNC Fertility RaleighNC 27617USA

Recent data suggest that cystic fibrosis transmembrane conductance regulator(CFTR)gene alterations negatively impact male fertility beyond obstruction.We sought to compare gene alterations,sperm retrieval rates,and intracytoplasmic sperm injection(ICSI)outcomes among men with cystic fibrosis(CF)disease and congenital bilateral absence of the vas deferens(CBAVD)only.We retrospectively evaluated all men who underwent surgical sperm retrieval at two academic,high-volume andrology centers from 2010 to 2018.Only men with documented CFTR alterations and obstructive azoospermia from either CBAVD or CF were included.Differences between groups for CFTR abnormality,sperm retrieval,and ICSI outcomes were statistically analyzed.Overall,39 patients were included with 10 in the CF and 29 in the CBAVD groups.Surgical sperm retrieval rates were significantly lower in the CF group for sperm concentration(14.8×10^(6)ml^(-1)vs 61.4×10^(6)ml^(−1),P=0.02)and total motile sperm count(2.9 million vs 11.4 million,P=0.01).This difference was only predicted by homozygous delta F508 CFTR mutations(P<0.05).The CF group also demonstrated a significantly higher rate of rescue testicular sperm extraction(70.0%vs 27.6%,P<0.03)and lower fertilization rate with ICSI(32.5%vs 68.9%,P<0.01).In conclusion,those with CF demonstrated lower sperm quality,greater difficulty with sperm retrieval,and worse ICSI outcomes compared with CBAVD-only patients.Homozygous delta F508 CFTR mutations appear to significantly impair spermatogenesis and sperm function.

关键词： congenital bilateral absence of the vas deferens cystic fibrosis intracytoplasmic sperm injection outcomes male infertility obstructive azoospermia

A note on quantum odometers

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Science China Mathematics 2023年第7期66卷 1555-1568页

作者： Slawomir Klimek Matt mcbride j.Wilson Peoples Department of Mathematical Sciences Indiana University-Purdue University IndianapolisIndianapolisIN46202USA Department of Mathematics and Statistics Mississippi State UniversityMississippi StateMS 39762USA Department of Mathematics The Pennsylvania State UniversityUniversity ParkPA 16802USA

We discuss various aspects of noncommutative geometry of smooth subalgebras of Bunce-Deddens-Toeplitz algebras.

关键词： noncommutative geometry derivation smooth subalgebra K-theory

Author Correction:Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24

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Cellular & Molecular Immunology 2024年第1期21卷 100-100页

作者： Zhengzhou Ying Swanand Hardikar joshua B.Plummer Tewfik Hamidi Bin Liu Yueping Chen jianjun Shen Yunxiang Mu Kevin M.mcbride Taiping Chen Department of Epigenetics and Molecular Carcinogenesis The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Program in Genetics and Epigenetics The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Houston TX 77030 USA

In the sentence beginning‘To trace cell proliferation,FO and MZ B cells’and the sentence beginning‘For cell activation,naïve B cells or CH12F3 cells’in this article,the[10 ng/ml]‘F(ab’)_(2)fragment goat anti-mouse IgM’should have read‘10μg/ml F(ab’)_(2)fragment goat anti-mouse IgM’.The original article has been corrected.

关键词： immunodeficiency CD19 deficient

Typhoon disaster risk zoning for China’s coastal area

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Frontiers of Earth Science 2022年第2期16卷 291-303页

作者： jing ZHU Yi LU Fumin REN john L mcbride Longbin YE Xiamen Key Laboratory of Straits Meteorology Xiamen Meteorological BureauXiamen 361012China Shanghai Typhoon Institute of China Meteorological Administration Shanghai 200030China State Key Laboratory of severe weather Chinese Academy of Meteorological SciencesBeijing 10081China School of Earth Science (Honorary)University of MelbourneMelbourne 3010Australia Research and Development Division(Emeritus Scientist) Bureau of MeteorologyMelbourne 3010Australia

Previous studies on typhoon disaster risk zoning in China have focused on individual provinces or small-scale areas and lack county-level results.In this study,typhoon disaster risk zoning is conducted for China’s coastal area,based on data at the county level.Using precipitation and wind data for China and typhoon disaster and social data at the county level for China’s coastal area from 2004 to 2013,first we analyze the characteristics of typhoon disasters in China’s coastal area and then develop an intensity index of factors causing typhoon disasters and a comprehensive social vulnerability index.Finally,by combining the two indices,we obtain a comprehensive risk index for typhoon disasters and conduct risk zoning.The results show that the maximum intensity areas are mainly the most coastal areas of both Zhejiang and Guangdong,and parts of Hainan Island,which is similar to the distribution of typhoon disasters.The maximum values of vulnerability in the northwest of Guangxi,parts of Fujian coastal areas and parts of the Shandong Peninsula.The comprehensive risk index generally decreases from coastal areas to inland areas.The high-risk areas are mainly distributed over Hainan Island,south-western Guangdong,most coastal Zhejiang,the coastal areas between Zhejiang and Fujian and parts of the Shandong Peninsula.

关键词： typhoon disaster risk zoning comprehensive social vulnerability index China’s coastal area

Epidemiology of isolated foot burns in children presenting to a Queensland paediatric burns centre—a two-year study in warmer climate

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Burns & Trauma 2017年第1期5卷 58-63页

作者： Florence Ngu Bhaveshkumar Patel Craig mcbride Pegg Leditschke Children’s Burns Centre Department of Paediatric SurgeryLady Cilento Children’s Hospital501 Stanley StreetSouth Brisbane QLD 4101Australia Centre for Children’s Burns and Trauma Research Queensland Children’s Medical Research InstituteUniversity of QueenslandQueenslandAustralia

Background: European studies of paediatric foot burns report scalds as the leading cause. Mechanisms of injury are different in warmer climates. We sought to characterize the mechanisms and outcomes of isolated foot burns in our population. Methods: Retrospective review of a prospectively collected database of all children aged 0–15 years presenting to a Queensland paediatric burns centre over a 26-month period. Non-parametric analyses such as the Mann-Whitney U and Pearson Chi-square were used. Results: There were 218 children with foot burns treated over a period of 2 years and 2 months of which 214 had complete records. There were significantly more boys than girls (n=134, 62.6% cf. n=80, 37.4%, pjury was a contact burn accounting for 63.1% (n=135) followed by scalds (23.8%, n=51). Friction, flame and chemical burns were a minority but were significantly deeper (p=0.03) and significantly more likely to require grafting (p=0.04) and scar management (pjury causing burns to the feet. The leading aetiology is campfire burns, which account for one-third of all burns to the feet. Prevention campaigns targeted at this population could significantly reduce the burden of morbidity from these burns. Friction, flame and chemical burns constitute a minority of patients but are deeper and more likely to require skin grafting and scar management.

关键词： Epidemiology Foot burns Paediatric Scald Australia Campfire

Derivations and reflection positivity on the quantum cylinder

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Science China Mathematics 2020年第10期63卷 2037-2054页

作者： Slawomir Klimek Matt mcbride Department of Mathematical Sciences Indiana University-Purdue University IndianapolisIndianapolisIN 46202USA Department of Mathematics and Statistics Mississippi State UniversityMississippi StateMS 39762USA

We describe the general structure of unbounded derivations in the quantum cylinder.We prove a noncommutative analog of reflection positivity for Laplace-type operators in a noncommutative cylinder following the ideas of the proof by jaffe and Ritter(2008)of reflection positivity for Laplace operators on manifolds equipped with a reflection.

关键词： derivations reflection positivity noncommutative cylinder

Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24

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Cellular & Molecular Immunology 2023年第12期20卷 1487-1498页

作者： Zhengzhou Ying Swanand Hardikar joshua B.Plummer Tewfik Hamidi Bin Liu Yueping Chen jianjun Shen Yunxiang Mu Kevin M.mcbride Taiping Chen Department of Epigenetics and Molecular Carcinogenesis The University of Texas MD Anderson Cancer CenterHoustonTX77030USA Program in Genetics and Epigenetics The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical SciencesHoustonTX77030USA

Immunodeficiency,centromeric instability,and facial anomalies(ICF)syndrome is a rare autosomal recessive disorder characterized by DNA hypomethylation and antibody deficiency.It is caused by mutations in DNMT3B,ZBTB24,CDCA7,or HELLS.While progress has been made in elucidating the roles of these genes in regulating DNA methylation,little is known about the pathogenesis of the life-threatening hypogammaglobulinemia phenotype.Here,we show that mice deficient in Zbtb24 in the hematopoietic lineage recapitulate the major clinical features of patients with ICF syndrome.Specifically,Vav-Cre-mediated ablation of Zbtb24 does not affect lymphocyte development but results in reduced plasma cells and low levels of IgM,IgG1,and IgA.Zbtb24-deficient mice are hyper and hypo-responsive to T-dependent and T-independent type 2 antigens,respectively,and marginal zone B-cell activation is impaired.Mechanistically,Zbtb24-deficient B cells show severe loss of DNA methylation in the promoter region of Il5ra(interleukin-5 receptor subunit alpha),and Il5ra derepression leads to elevated CD19 phosphorylation.Heterozygous disruption of Cd19 can revert the hypogammaglobulinemia phenotype of Zbtb24-deficient mice.Our results suggest the potential role of enhanced CD19 activity in immunodeficiency in ICF syndrome.

关键词： ICF syndrome ZBTB24 CD19 IL-5Ra hypogammaglobulinemia

Systematic literature review of topical local anaesthesia or analgesia to donor site wounds

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Burns & Trauma 2022年第1期10卷 294-305页

作者： Craig A.mcbride Marilyn Wong Bhaveshkumar Patel Pegg Leditschke Children’s Burns Centre Queensland Children’s HospitalSouth BrisbaneQueenslandAustralia Centre for Children’s Burns and Trauma Research Queensland Children’s Medical Research InstituteUniversity of QueenslandAustralia

Background:Topical local analgesic and anaesthetic agents have been used both pre-and imme-diately post-harvest on split-thickness skin graft(STSG)donor site wounds(DSW).There is no systematic review of their effectiveness in providing post-harvest analgesia,or of the possible toxic effects of systemic absorption.This study is designed to address the question of which agent,if any,is favoured over the others and whether there are any safety data regarding their use.Methods:Systematic literature review of randomised controlled trials of topical agents applied to STSG DSWs,with a view to providing analgesia.Studies identified via search of Cochrane and EBSCO databases.No restrictions on language or publication year.Primary outcomes:pain at the time of(awake)STSG,and post-harvest pain(up to first dressing change).Secondary outcome was serum medication levels relative to published data on toxic doses.Cochrane risk of bias assessment tool utilised in assessment of included studies.At least 2 reviewers screened and reviewed included studies.A narrative review is presented.Results:There were 11 studies meeting inclusion criteria.Overall methodological quality and patient numbers were low.Topical eutectic mixture of lidocaine and prilocaine pre-harvest affords good local anaesthesia in awake STSG harvesting.Topical bupivacaine(5 studies)or lidocaine(1 study)gave significantly better post-harvest anaesthesia/analgesia than placebo.Topical morphine performs no better than placebo.Topical local anaesthetic agents at reported doses were all well below toxic serum levels.Conclusions:Topical local anaesthetics(lidocaine or bupivacaine)provide good analgesia,both during and after STSG harvest,at well below toxic serum levels,but there are no good data determining the best local anaesthetic agent to use.There is no evidence morphine performs better than placebo.

关键词： Local anaesthetic Donor site wound Topical analgesia Lidocaine Bupivacaine Morphine split-thickness skin graft EMLA

Derivations and spectral triples on quantum domains Ⅱ: Quantum annulus

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Science China Mathematics 2019年第12期62卷 2463-2486页

作者： Slawomir Klimek Matt mcbride Sumedha Rathnayake Department of Mathematical Sciences Indiana University-Purdue University IndianapolisIndianapolisIN 46202USA Department of Mathematics and Statistics Mississippi State UniversityStarkvilleMS 39762USA Department of Mathematics University of MichiganAnn ArborMI 48109USA

Continuing our study of spectral triples on quantum domains,we look at unbounded invariant and covariant derivations in the quantum annulus.In particular,we investigate whether such derivations can be implemented by o... 详细信息

关键词： noncommutative annulus unbounded derivations spectral triples