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Transportation Safety and Environment 2021年第2期3卷 123-131页

作者： Linda Lee Ho j́ulio silvio de souza bueno filho Walquiria Yumiko Fujii Cludia A.S.Machado Liedi Legi Bariani Bernucci joséAlberto Quintanilha University of São Paulo Department of Production EngineeringSo Paulo 05508-070Brazil Federal University of Lavras Department of Exact SciencesMinas Gerais 37200-900Brazil University of São Paulo Department of Transport EngineeringSão Paulo 05508-070Brazil Institute of Energy and Environment São Paulo 05508-010Brazil

In this paper we present relevant contributions and important features related to the study of the retroreflectivity performance of pavement *** contribution of this paper is ***,we propose an artificial scheme to allow some randomization of the treatments owing to several restrictions imposed on the choice of the experimental *** is an experiment involving one fixed factor(three types of materials)in a randomized block design executed on a high-traffic-volume *** this condition,the traffic volume works as a stress factor and the degradation of the retroreflectivity of pavement markings is faster than the degradation on rural roads or *** is related to the second contribution:the possibility of a reduction of experimental *** current experiment spent 20 weeks to collect the *** finally a mixed linear model considering three random effects and several fixed effects is fitted and the most relevant effects pointed *** study can help highway managers to improve road safety by scheduling the maintenance of pavement marks at the appropriate time,choosing adequate material for the pavement markings and applying the proposed artificial scheme in future studies.

关键词： highway safety design of experiment mixed linear model longitudinal experiment pavement markings

determining the effective elastic thickness through cross-correlation between isostatic disturbances

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Geodesy and Geodynamics 2024年第3期15卷 241-251页

作者： Nelson Ribeiro-filho Cristiano Mendel Martins Raissa Moraes Baldez Ivaldevingles Rodrigues de souza júnior Franck Eitel Kemgang Ghomsi Instituto Federal do Pará(IFPA) AltamiraParáBrazil Universidade Federal do Pará(UFPA) BelemParáBrazil Nansen-Tutu Center for Marine Environmental Research Department of OceanographyUniversity of Cape TownSouth Africa Geodesy Research Laboratory National Institute of CartographyYaoundeCameroon

The elastic thickness parameter was estimated using the mobile correlation technique between the observed isostatic disturbance and the gravity disturbance calculated through direct gravimetric modeling. We computed the vertical flexure value of the crust for a specific elastic thickness using a given topographic dataset. The gravity disturbance due to the topography was determined after the calculation. A grid of values for the elastic thickness parameter was generated. Then, a moving correlation was performed between the observed gravity data(representing actual surface data) and the calculated data from the forward modeling. The optimum elastic thickness of the particular point corresponded to the highest correlation coefficient. The methodology was tested on synthetic data and showed that the synthetic depth closely matched the original depth, including the elastic thickness value. To validate the results, the described procedure was applied to a real dataset from the Barreirinhas Basin, situated in the northeastern region of Brazil. The results show that the obtained crustal depth is highly correlated with the depth from known models. Additionally, we noted that the elastic thickness behaves as expected, decreasing from the continent towards the ocean. Based on the results, this method has the potential to be employed as a direct estimate of crustal depth and elastic thickness for any region.

关键词： Isostasy Elastic thickness Isostatic disturbance Moho depth Cross-correlation

Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe bueno Lemos Caroline Tianeze de Castro Marcel Silva Luz Gabriel Reis Rocha Gabriel Lima Correa Santos Luís Guilherme de Oliveira Silva Mariana Santos Calmon Cláudio Lima souza Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

Influence of Omega 3 Fatty Acid Supplementation on Phase Angle Values of People Living with HIV/AIDS with Lipodystrophy Secondary to Antiretroviral Therapy: A Randomized Clinical Trial

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Food and Nutrition Sciences 2024年第1期15卷 58-70页

作者： Thalita Bandeira Dantas Alline Peralta Castro Fernando de souza Flexa Ribeiro filho Rosana Maria Feio Libonati Núcleo de Medicina Tropical do Pará Programa de Pós gradua&ccedil&atildeo em Patologia das Doen&ccedilas Tropicais Universidade Federal do Pará Pará Brasil Instituto de Ciências Biológicas e da Saúde Faculdade de Medicina Universidade Federal do Pará Pará Brasil Centro de Ciências Biológicas e da Saúde Universidade Estadual do Pará Pará Brasil

Objective: The measurement of phase angles is an important monitoring parameter and supplementation with omega-3 could promote benefits by modulating the electrical potential of membranes and increasing body cell mass. This study aimed to evaluate the effectiveness of omega-3 fatty acid supplementation on the phase angle of people living with HIV/AIDS. Methods: In this study, 63 individuals of all genders who were undergoing outpatient follow-up and showed lipodystrophy due to highly active antiretroviral therapy were analyzed. Our sample consisted of two groups, one that received supplementation containing 2550 mg of omega-3/day (1080 mg of eicosapentaenoic acid and 720 mg of docosahexaenoic acid) for three months (n = 32) and another that underwent nutrition guidance (n = 31). Phase angle and body cell mass were assessed for both groups and compared at the beginning of research (T0) and after our intervention (T1) for each group separately. Results: Phase angle averaged 6.45° ± 1.06 SD. The comparison between T0 and T1 showed a significant increase in phase angle and body cell mass, whereas the guidance group showed a decrease in body cell mass at T1 in relation to T0, with a significant p-value. Variance in phase angle between moments showed significant values between T0 and T1 in the supplementation group for all genders. Conclusion: Omega-3 positively modulated patients phase angle and body cell mass, but we emphasize the need for other studies that can solidify knowledge about supplementation dosage and intervention time.

关键词： HIV Lipodystrophy Omega-3 Phase Angle

Resection of Intracranial Giant Cavernous Malformation: Case Report and Literature Review

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Surgical Science 2024年第2期15卷 28-35页

作者： Vinicios Rivelli Da Fonseca Cleverson Martins Kill Mariana Alcantara Hugo Fialho Leonnan de Sa Oliveira Lucidio souza filho department of Neurosurgery Hospital Santa Rita Belo Horizonte Brazil

Cerebral cavernous malformations are a rare and congenital vascular malformation that can present as a challenge in neurosurgical management. The term “giant cerebral cavernous malformations” still does not have a clear definition in the literature, with a wide variety of results. It is known, however, that there is an association between the size of the cavernoma and postoperative sequelae, especially in those with a size greater than 3 cm in its largest diameter. We present a case report of resection of a giant brain cavernoma measuring approximately 8 cm in its largest diameter, emphasizing on clinical presentation, diagnoses and postoperative evolution. Additionally, we performed a comprehensive review of the existing literature on the subject, addressing the epidemiology, pathophysiology, diagnostic methods, treatment options, and prognosis associated with this condition.

关键词： Cavernous Malformation Cerebral Cavernous Malformation Giant Cavernous Malformation Cavernous Hemangioma Cavernous Angioma Cavernoma Giant Cavernoma

Crop residues: applications of lignocellulosic biomass in the context of a biorefinery

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Frontiers in Energy 2022年第2期16卷 224-245页

作者： Maria Carolina ANDRAde Caio de Oliveira GORGULHO SILVA Leonora Rios de souza MOREIRA Edivaldo Ximenes FERREIRA filho Laboratory of Enzymology Department of Cellular BiologyUniversity of BrasiliaBrasiliaDFBrazil

Interest in lignocellulosic biomass conversion technologies has increased recently because of their potential to reduce the dependency on non-renewable feedstocks. Residues from a variety of crops are the major source of lignocellulose, which is being produced in increasingly large quantities worldwide. The commercial exploitation of crop residues as feedstocks for biorefineries which could be used to produce a variety of goods such as biofuels, biochemicals, bioplastics, and enzymes is an attractive approach not only for adding value to residues but also for providing renewable products required by the expanding bioeconomy market. Moreover, the implementation of biorefineries in different regions has the potential to add value to the specific crop residues produced in the region. In this review, several aspects of crop residue application in biorefineries are discussed, including the role of crop residues in the bioeconomy and circular economy concepts, the main technical aspects of crop residue conversion in biorefineries, the main crop residues generated in different regions of the world and their availability, the potential value-added bioproducts that can be extracted or produced from each crop residue, and the major advantages and challenges associated with crop residue utilization in biorefineries. despite their potential, most biomass refining technologies are not sufficiently advanced or financially viable. Several technical obstacles, especially with regard to crop residue collection, handling, and pre-treatment, prevent the implementation of biorefineries on a commercial scale. Further research is needed to resolve these scale-up-related challenges. Increased governmental incentives and bioeconomic strategies are expected to boost the biorefinery market and the cost competitiveness of biorefinery products.

关键词： crop residue biorefinery bioproduct biomass circular bioeconomy enzyme

Unwrapping reworked crust at the Columbia supercontinent margin within central southern Amazon Craton using multi-source geophysics and geochronology data synergy

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Geoscience Frontiers 2022年第3期13卷 35-52页

作者： joão G.Motta P.G.Betts V.T.Meira V.G.Trevisan C.R.de souza filho Institute of Geosciences University of CampinasCampinasSão PauloBrazil Camborne School of Mines University of ExeterPenryn CampusPenrynCornwallUnited Kingdom School of Earth Atmosphere and EnvironmentMonash University(Clayton Campus)ClaytonVICAustralia Anglo American Níquel Brasil Ltda. Avenida Interlândia502 QD 87LST 68 e 10GoiâniaGoiásBrazil

The geometry and evolution of pre-existing basement in accretionary belts bordering supercontinents are often *** interpretation of long-wavelength potential field satellite data can image deep crust structure,improving our understanding of lithospheric processes that formed these margins ***,we present a multidisciplinary interpretation of the lithospheric architecture of the central southern Amazon Craton,a fragment of an accretionary belt at the southwestern Columbia supercontinent ***-borne gravity and magnetic data,airborne magnetic data,passive seismic(V_(p)/V_(s) ratio,crustal thickness)and seismic tomography data reveals that basement terranes from the interior of the craton extend into the accretionary margin of *** demonstrate a vertically heterogeneous structure with an underlying strongly reworked pre-Columbia tectonic wedge that sustained prolonged modification during the supercontinent assembly as corroborated by Nd isotope and geochronology *** isotope data suggest that the protracted orogenic wedge was influenced by subduction angle shifts over time,including addition of substantial juvenile material during slab retreat *** interplay promoted Craton growth at the supercontinent margin while keeping a subtle record of the pre-existing *** findings point to the possible misrepresentation of basement extension and geometry of supercontinent margins elsewhere.

关键词： Satellite gravity Satellite magnetics Columbia Accretionary belt Amazon Craton Geochronology

Role of nickel-regulated small RNA in modulation of Helicobacter pylori virulence factors

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World journal of Clinical Cases 2022年第31期10卷 11283-11291页

作者： Fabrício Freire de Melo Hanna Santos Marques Fabian Fellipe bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Lorena Sousa de Carvalho Cláudio Lima souza Márcio Vasconcelos Oliveira Institution Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900Brazil

Helicobacter pylori(***)is a Gram-negative bacterium that infects about half of the world's *** infection prevails by several mechanisms of adaptation of the bacteria and by its virulence factors including the cytotoxin associated antigen A(CagA).CagA is an oncoprotein that is the protagonist of gastric carcinogenesis associated with prolonged *** *** this sense,small regulatory RNAs(sRNAs)are important macromolecules capable of inhibiting and activating gene *** function allows sRNAs to act in adjusting to unstable environmental conditions and in responding to cellular stresses in bacterial *** discoveries have shown that nickelregulated small RNA(NikS)is a post-transcriptional regulator of virulence properties of ***,including the oncoprotein ***,high concentrations of nickel cause the reduction of NikS expression and consequently this increases the levels of *** addition,NikS expression appears to be lower in clinical isolates from patients with gastric cancer when compared to patients *** that in mind,this minireview approaches,in an accessible way,the most important and current aspects about the role of NikS in the control of virulence factors of *** and the potential clinical repercussions of this modulation.

关键词： Helicobacter pylori Small regulatory RNAs Nickel-regulated small RNA Virulence factors Cytotoxin associated antigen A Gastric cancer

Authigenic titanite in weathered basalts: Implications for paleoatmospheric reconstructions

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Geoscience Frontiers 2020年第6期11卷 2183-2196页

作者： Alexey A.Novoselov Dailto Silva Carlos Roberto de souza filho Institute of Applied Economic Geology Universidad de ConcepcionConcepcionChile Institute of Geosciences University of CampinasCampinasSPBrazil

The stability of titanite is sensitive to temperature and partial pressure of *** finding of authigenic titanite grains in weathering regolith formed on Parana basalts,Brazil,under tropical climatic conditions,reveals the thermodynamically-driven conversion from calcite to titanite at elevated ambient *** unusual nowadays,this phase transition provides important implications for the understanding of silicate weathering in earlier geological *** types of secondary titanites were identified in the weathering profile of the study *** tiny grains of 10 μm are forming in the microscopic voids in the ***,large fractures filled with Fe-rich clay minerals contain bigger specimens of up to 170μ*** titanites of second type often coexist with chalcedony and *** carbonate minerals were found in the weathering *** sphene can be discriminated from other titanite types by its strong positive Eu anomaly,increased Al2 O3 content and low content of trace *** specific chemical composition and reactive transport modeling link this secondary mineral with dissolution of *** titanite precipitation is controlled by slow diffusion in poorly-aerated,highly-alkaline pore *** subaerial weathering of basaltic rocks provides a significant reservoir for atmospheric ***,the deposition of carbonate minerals is thermodynamically avoided at the stability field of *** demonstrate a complex feedback between CO2 and soil *** rise in pCO2 triggers the precipitation of calcite in the weathering regolith,but the greenhouse effect increasing the temperature can cease carbonate *** titanites were found in several paleosols and at least a part of them can be of weathering origin.

关键词： Titanite Sphene Calcite Paleosols Weathering Paleoclimates

Antioxidant,hypolipidemic and hypoglycemic effect of red wine in wistar rats fed with obesogenic diet

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Food Bioscience 2022年第3期47卷 756-764页

作者： Cornélio Mucaca josé Henrique Tavares filho Luciana Lima Arruda André Martins Galvão Maria Bernadete de Sousa Maia Eryka Maria dos Santos Alves Eryvelton de souza Franco Elizabeth do Nascimento department of Nutrition Center of Health SciencesFederal University of Pernambuco (UFPE)Cidade Universitaria50670-901RecifePEBrazil Rural Technology department Federal Rural University of Pernambuco (UFRPE)AD.Manoel de Medeiros Ave.s/nDois Irmãos52171-900RecifePEBrazil department of Physiology and Pharmacology Center of Biological SciencesFederal University of Pernambuco (UFPE)Cidade Universitaria50670-901RecifePEBrazil

The health benefits resulting from the usual ingestion of red wines have been studied in humans and ***,the evaluation of benefits in antioxidant,hypoglycemic and hypolipemic activity concomitant with the use of an obesogenic diet in adult Wistar rats has been little *** present study investigated the use of red wine derived from Northeast Brazil in adult rats fed with an obesogenic diet on antioxidant activity,glucose tolerance,adipose,glycemic and lipemic *** 45-day old male Wistar rats formed two groups:standard diet and westernized *** changes in body mass and glycemic levels,the animals were subdivided into six subgroups (n = 10 per group) and received water,red wine or hydroalcoholic solution by *** data reveal that the moderate and chronic use of red wine improves the glycemic,lipid and oxidative stress profile,being favorable in preventing the risk of cardiovascular diseases in rats fed with an obesogenic diet.

关键词： Dyslipidemia Obesity Rats Westernized diet Red wine